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Antidepressant medication

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14 papers 100 to 500 followers
By Abraham Nunes Psychiatry resident interested in computational neuroscience, forensic psychiatry, and neuropsychiatry.
Christiane E Angermann, Götz Gelbrich, Stefan Störk, Hilka Gunold, Frank Edelmann, Rolf Wachter, Heribert Schunkert, Tobias Graf, Ingrid Kindermann, Markus Haass, Stephan Blankenberg, Sabine Pankuweit, Christiane Prettin, Martin Gottwik, Michael Böhm, Hermann Faller, Jürgen Deckert, Georg Ertl
IMPORTANCE: Depression is frequent in patients with heart failure and is associated with adverse clinical outcomes. Long-term efficacy and safety of selective serotonin reuptake inhibitors in these patients are unknown. OBJECTIVE: To determine whether 24 months of treatment with escitalopram improves mortality, morbidity, and mood in patients with chronic systolic heart failure and depression. DESIGN, SETTING, AND PARTICIPANTS: The Effects of Selective Serotonin Re-Uptake Inhibition on Morbidity, Mortality, and Mood in Depressed Heart Failure Patients (MOOD-HF) study was a double-blind, placebo-controlled randomized clinical trial conducted at 16 tertiary medical centers in Germany...
June 28, 2016: JAMA: the Journal of the American Medical Association
D Jeffrey Newport, Linda L Carpenter, William M McDonald, James B Potash, Mauricio Tohen, Charles B Nemeroff
OBJECTIVE: The authors conducted a systematic review and meta-analysis of ketamine and other N-methyl-d-aspartate (NMDA) receptor antagonists in the treatment of major depression. METHOD: Searches of MEDLINE, PsycINFO, and other databases were conducted for placebo-controlled, double-blind, randomized clinical trials of NMDA antagonists in the treatment of depression. Primary outcomes were rates of treatment response and transient remission of symptoms. Secondary outcomes included change in depression symptom severity and the frequency and severity of dissociative and psychotomimetic effects...
October 2015: American Journal of Psychiatry
Chadi G Abdallah, Gerard Sanacora, Ronald S Duman, John H Krystal
Ketamine is the prototype for a new generation of glutamate-based antidepressants that rapidly alleviate depression within hours of treatment. Over the past decade, there has been replicated evidence demonstrating the rapid and potent antidepressant effects of ketamine in treatment-resistant depression. Moreover, preclinical and biomarker studies have begun to elucidate the mechanism underlying the rapid antidepressant effects of ketamine, offering a new window into the biology of depression and identifying a plethora of potential treatment targets...
2015: Annual Review of Medicine
Walter A Brown, Maria Rosdolsky
The major classes of psychotropic drugs were introduced in an extraordinary decade of discovery between the late 1940s and late 1950s. In the present climate of pessimism about the absence of new drug development, it may be instructive to look back at the research methods used during that era. The study that identified the first antidepressant is a case in point. It was conducted by Roland Kuhn, a Swiss psychiatrist working in a remote psychiatric hospital. Kuhn, like the other pioneering researchers of his day, was given access to new drug entities, and the method he used to discover their clinical effects was open-minded, exploratory, comprehensive, clinical observation...
May 2015: American Journal of Psychiatry
Anjali L Varigonda, Ewgeni Jakubovski, Matthew J Taylor, Nick Freemantle, Catherine Coughlin, Michael H Bloch
OBJECTIVE: Selective serotonin reuptake inhibitors (SSRIs) are the first-line pharmacological treatment for pediatric major depressive disorder (MDD). We conducted a meta-analysis to examine the following: the time-course of response to SSRIs in pediatric depression; whether higher doses of SSRIs are associated with an improved response in pediatric depression; differences in efficacy between SSRI agents; and whether the time-course and magnitude of response to SSRIs is different in pediatric and adult patients with MDD...
July 2015: Journal of the American Academy of Child and Adolescent Psychiatry
Arpan Dutta, Shane McKie, J F William Deakin
The need for rapid acting antidepressants is widely recognised. There has been much interest in glutamate mechanisms in major depressive disorder (MDD) as a promising target for the development of new antidepressants. A single intravenous infusion of ketamine, a N-methyl-d-aspartate (NMDA) receptor antagonist anaesthetic agent, can alleviate depressive symptoms in patients within hours of administration. The mechanism of action appears to be in part through glutamate release onto non-NMDA receptors including α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and metabotropic receptors...
January 30, 2015: Psychiatry Research
Andrea Cipriani, Toshi A Furukawa, Antonio Veronese, Norio Watanabe, Rachel Churchill, Hugh McGuire, Corrado Barbui
This is the protocol for a review and there is no abstract. The objectives are as follows: To determine the efficacy of paroxetine in comparison with other anti-depressive agents in alleviating the acute symptoms of major depressive disorder.To review acceptability of treatment with paroxetine in comparison with other anti-depressive agents.To investigate the adverse effects of paroxetine in comparison with other anti-depressive agents.
2007: Cochrane Database of Systematic Reviews
Andrea Cipriani, Alessandra Signoretti, Toshi A Furukawa, Rachel Churchill, Silva Tomelleri, Ichiro M Omori, Hugh McGuire, Corrado Barbui
This is the protocol for a review and there is no abstract. The objectives are as follows: To determine the efficacy of venlafaxine in comparison with other anti-depressive agents in alleviating the acute symptoms of major depressive disorder.To review acceptability of treatment with venlafaxine in comparison with other anti-depressive agents.To investigate the adverse effects of venlafaxine in comparison with other anti-depressive agents.
2007: Cochrane Database of Systematic Reviews
Leslie Hearn, R Andrew Moore, Sheena Derry, Philip J Wiffen, Tudor Phillips
BACKGROUND: Antidepressants are widely used to treat chronic neuropathic pain (pain due to nerve damage), usually in doses below those at which they exert antidepressant effects. An earlier review that included all antidepressants for neuropathic pain is being replaced by new reviews of individual drugs examining individual neuropathic pain conditions.Desipramine is a tricyclic antidepressant that is occasionally used for treating neuropathic pain. OBJECTIVES: To assess the analgesic efficacy of desipramine for chronic neuropathic pain in adults, and to assess the associated adverse events...
2014: Cochrane Database of Systematic Reviews
John Otasowie, Xavier Castells, Umonoibalo P Ehimare, Clare H Smith
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is a chronic neurodevelopmental disorder of childhood onset, which may persist into adulthood. ADHD has a significant impact on a child's daily life, affecting relationships and academic performance. Its core symptoms include developmentally inappropriate levels of inattention, hyperactivity, and impulsive behaviour. Tricyclic antidepressants (TCAs) are sometimes used as second line of treatment in the reduction of ADHD symptoms in children and adolescents with ADHD...
September 19, 2014: Cochrane Database of Systematic Reviews
Emma Molyneaux, Louise M Howard, Helen R McGeown, Amar M Karia, Kylee Trevillion
BACKGROUND: Postnatal depression is a common disorder that can have adverse short- and long-term effects on maternal morbidity, the new infant and the family as a whole. Treatment is often largely by social support and psychological interventions. It is not known whether antidepressants are an effective and safe choice for treatment of this disorder. This review was undertaken to evaluate the effectiveness of different antidepressants and to compare their effectiveness with other forms of treatment, placebo or treatment as usual...
September 11, 2014: Cochrane Database of Systematic Reviews
Andrea Cipriani, Markus Koesters, Toshi A Furukawa, Michela Nosè, Marianna Purgato, Ichiro M Omori, Carlotta Trespidi, Corrado Barbui
BACKGROUND: Although pharmacological and psychological interventions are both effective for major depression, in primary and secondary care settings antidepressant drugs remain the mainstay of treatment. Amongst antidepressants many different agents are available. Duloxetine hydrochloride is a dual reuptake inhibitor of serotonin and norepinephrine and has been licensed by the Food and Drug Administration in the US for major depressive disorder (MDD), generalised anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia and chronic musculoskeletal pain...
October 17, 2012: Cochrane Database of Systematic Reviews
Molly Wimbiscus, Olga Kostenko, Donald Malone
Monoamine oxidase (MAO) inhibitors were the first antidepressants introduced, but their use has dwindled because of their reported side effects, their food and drug interactions, and the introduction of other classes of agents. However, interest in MAO inhibitors is reviving. Here, we discuss their use, risks, and benefits in clinical medicine.
December 2010: Cleveland Clinic Journal of Medicine
Marc Stone, Thomas Laughren, M Lisa Jones, Mark Levenson, P Chris Holland, Alice Hughes, Tarek A Hammad, Robert Temple, George Rochester
OBJECTIVE: To examine the risk of suicidal behaviour within clinical trials of antidepressants in adults. DESIGN: Meta-analysis of 372 double blind randomised placebo controlled trials. SETTING: Drug development programmes for any indication in adults. PARTICIPANTS: 99 231 adults assigned to antidepressants or placebo. Median age was 42 and 63.1% were women. Indications for treatment were major depression (45.6%), other depression (4...
August 11, 2009: BMJ: British Medical Journal
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