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Dementia

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116 papers 25 to 100 followers
https://www.readbyqxmd.com/read/27393566/functional-disability-in-mild-cognitive-impairment-a-systematic-review-and-meta-analysis
#1
REVIEW
Cutter A Lindbergh, Rodney K Dishman, L Stephen Miller
Accumulating evidence suggests that the pre-dementia syndrome mild cognitive impairment (MCI) is characterized by decrements in instrumental activities of daily living (IADL). The current review was a quantitative synthesis of the available literature to objectively characterize IADL disability in MCI while clarifying inconsistencies in findings across studies. It was hypothesized that individuals with MCI would display significantly greater functional impairment relative to cognitively intact controls. Candidate moderators specified a priori included functional assessment approach, MCI subtype, depressive symptoms, and language conducted...
June 2016: Neuropsychology Review
https://www.readbyqxmd.com/read/27440936/glycated-haemoglobin-hba1c-diabetes-and-trajectories-of-change-in-episodic-memory-performance
#2
Colleen Pappas, Ross Andel, Frank J Infurna, Shyam Seetharaman
BACKGROUND: As the ageing population grows, it is important to identify strategies to moderate cognitive ageing. OBJECTIVE: We examined glycated haemoglobin (HbA1c) and diabetes in relation to level and change in episodic memory in older adults with and without diabetes. METHODS: Data from 4419 older adults with (n=950) and without (n=3469) diabetes participating in a nationally representative longitudinal panel study (the Health and Retirement Study) were examined...
July 20, 2016: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/27432942/changes-in-insulin-and-insulin-signaling-in-alzheimer-s-disease-cause-or-consequence
#3
REVIEW
Molly Stanley, Shannon L Macauley, David M Holtzman
Individuals with type 2 diabetes have an increased risk for developing Alzheimer's disease (AD), although the causal relationship remains poorly understood. Alterations in insulin signaling (IS) are reported in the AD brain. Moreover, oligomers/fibrils of amyloid-β (Aβ) can lead to neuronal insulin resistance and intranasal insulin is being explored as a potential therapy for AD. Conversely, elevated insulin levels (ins) are found in AD patients and high insulin has been reported to increase Aβ levels and tau phosphorylation, which could exacerbate AD pathology...
July 25, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27350397/cerebral-hypoperfusion-and-glucose-hypometabolism-key-pathophysiological-modulators-promote-neurodegeneration-cognitive-impairment-and-alzheimer-s-disease
#4
Mak Adam Daulatzai
Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse pathological mechanisms including cerebral hypoperfusion and glucose hypometabolism. These risk factors trigger neuroinflammation and oxidative-nitrosative stress that in turn decrease nitric oxide and enhance endothelin, Amyloid-β deposition, cerebral amyloid angiopathy, and blood-brain barrier disruption. Proinflammatory cytokines, endothelin-1, and oxidative-nitrosative stress trigger several pathological feedforward and feedback loops...
June 27, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/26883213/mild-versus-moderate-stages-of-alzheimer-s-disease-three-year-outcomes-in-a-routine-clinical-setting-of-cholinesterase-inhibitor-therapy
#5
Carina Wattmo, Lennart Minthon, Åsa K Wallin
BACKGROUND: There is an increasing interest in cognitive and functional outcomes in the respective stages of Alzheimer's disease (AD) and in novel therapies particularly for the milder phases of AD. Our aim was to describe and compare various aspects of disease progression in patients with mild versus moderate AD in routine clinical practice of cholinesterase inhibitor (ChEI) therapy. METHODS: This 3-year, prospective, observational, multicentre study included 1021 participants...
2016: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/26710236/differences-in-and-correlations-between-cognitive-abilities-and-brain-volumes-in-healthy-control-mild-cognitive-impairment-and-alzheimer-disease-groups
#6
Soon-Cheol Chung, Mi-Hyun Choi, Hyung-Sik Kim, Jung-Chul Lee, Sung-Jun Park, Ul-Ho Jeong, Ji-Hye Baek, Seon-Young Gim, Young Chil Choi, Beob-Yi Lee, Dae-Woon Lim, Boseong Kim
The purpose of this study is to investigate differences in and correlations between cognitive abilities and brain volumes in healthy control (HC), mild cognitive impairment (MCI), and Alzheimer's disease (AD) groups. The Korean Version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K), which is used to diagnose AD, was used to measure the cognitive abilities of the study subjects, and the volumes of typical brain components related to AD diagnosis-cerebrospinal fluid (CSF), gray matter (GM), and white matter (WM)-were acquired...
May 2016: Clinical Anatomy
https://www.readbyqxmd.com/read/26527049/roles-of-arterial-stiffness-and-blood-pressure-in-hypertension-associated-cognitive-decline-in-healthy-adults
#7
Ihab Hajjar, Felicia C Goldstein, Greg S Martin, Arshed A Quyyumi
Although there is strong evidence that hypertension leads to cognitive decline, especially in the executive domain, the relationship between blood pressure and cognition has been conflicted. Hypertension is characterized by blood pressure elevation and increased arterial stiffness. We aimed at investigating whether arterial stiffness would be superior to blood pressure in predicting cognitive decline and explaining the hypertension-executive decline association. A randomly selected asymptomatic population (n=591, age=49...
January 2016: Hypertension
https://www.readbyqxmd.com/read/26530222/relationship-between-glycated-hemoglobin-a1c-and-cognitive-function-in-nondemented-elderly-patients-with-type-2-diabetes
#8
Lingning Huang, Liyong Yang, Ximei Shen, Sunjie Yan
Elderly patients with type 2 diabetes are at a greater risk for cognitive decline. The purpose of this study was to assess the relationship between the degree of hyperglycemia and cognitive status in nondemented, elderly diabetics. Between Jan 2013 and Dec 2014, 1174 geriatric patients with type 2 diabetes were enrolled in the study (579 males; age ≥ 60 years; from Fuzhou, Fujian, China). Cognitive function was measured with the Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA)...
April 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/26425386/metabolic-alterations-associated-to-brain-dysfunction-in-diabetes
#9
REVIEW
João M N Duarte
From epidemiological studies it is known that diabetes patients display increased risk of developing dementia. Moreover, cognitive impairment and Alzheimer's disease (AD) are also accompanied by impaired glucose homeostasis and insulin signalling. Although there is plenty of evidence for a connection between insulin-resistant diabetes and AD, definitive linking mechanisms remain elusive. Cerebrovascular complications of diabetes, alterations in glucose homeostasis and insulin signalling, as well as recurrent hypoglycaemia are the factors that most likely affect brain function and structure...
September 2015: Aging and Disease
https://www.readbyqxmd.com/read/26412218/neurobiology-of-alzheimer-s-disease-integrated-molecular-physiological-anatomical-biomarker-and-cognitive-dimensions
#10
REVIEW
Joel Raskin, Jeffrey Cummings, John Hardy, Kory Schuh, Robert A Dean
BACKGROUND: Alzheimer's disease (AD), the most common form of dementia, is a progressive neurodegenerative disorder with interrelated molecular, physiological, anatomical, biomarker, and cognitive dimensions. METHODS: This article reviews the biological changes (genetic, molecular, and cellular) underlying AD and their correlation with the clinical syndrome. RESULTS: Dementia associated with AD is related to the aberrant production, processing, and clearance of beta-amyloid and tau...
2015: Current Alzheimer Research
https://www.readbyqxmd.com/read/26478889/the-road-ahead-to-cure-alzheimer-s-disease-development-of-biological-markers-and-neuroimaging-methods-for-prevention-trials-across-all-stages-and-target-populations
#11
E Cavedo, S Lista, Z Khachaturian, P Aisen, P Amouyel, K Herholz, C R Jack, R Sperling, J Cummings, K Blennow, S O'Bryant, G B Frisoni, A Khachaturian, M Kivipelto, W Klunk, K Broich, S Andrieu, M Thiebaut de Schotten, J-F Mangin, A A Lammertsma, K Johnson, S Teipel, A Drzezga, A Bokde, O Colliot, H Bakardjian, H Zetterberg, B Dubois, B Vellas, L S Schneider, H Hampel
Alzheimer's disease (AD) is a slowly progressing non-linear dynamic brain disease in which pathophysiological abnormalities, detectable in vivo by biological markers, precede overt clinical symptoms by many years to decades. Use of these biomarkers for the detection of early and preclinical AD has become of central importance following publication of two international expert working group's revised criteria for the diagnosis of AD dementia, mild cognitive impairment (MCI) due to AD, prodromal AD and preclinical AD...
December 2014: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/26359171/traumatic-brain-injury-history-is-associated-with-earlier-age-of-onset-of-frontotemporal-dementia
#12
Christian LoBue, Kristin Wilmoth, C Munro Cullum, Heidi C Rossetti, Laura H Lacritz, Linda S Hynan, John Hart, Kyle B Womack
OBJECTIVE: We retrospectively examined whether a history of traumatic brain injury (TBI) is associated with an earlier age of symptom onset and diagnosis in a large sample of patients with behavioural variant frontotemporal dementia (bvFTD). METHODS: Data on patients with bvFTD (n=678) were obtained from the National Alzheimer's Coordinating Center Uniform Data Set. TBI was categorised based on reported lifetime history of TBI with loss of consciousness (LOC) but no chronic deficits occurring more than 1 year prior to diagnosis of bvFTD...
August 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/26362285/longitudinal-study-of-normal-cognition-in-parkinson-disease
#13
Kara Pigott, Jacqueline Rick, Sharon X Xie, Howard Hurtig, Alice Chen-Plotkin, John E Duda, James F Morley, Lama M Chahine, Nabila Dahodwala, Rizwan S Akhtar, Andrew Siderowf, John Q Trojanowski, Daniel Weintraub
OBJECTIVE: To report the rates and predictors of progression from normal cognition to either mild cognitive impairment (MCI) or dementia using standardized neuropsychological methods. METHODS: A prospective cohort of patients diagnosed with Parkinson disease (PD) and baseline normal cognition was assessed for cognitive decline, performance, and function for a minimum of 2 years, and up to 6. A panel of movement disorders experts classified patients as having normal cognition, MCI, or dementia, with 55/68 (80...
October 13, 2015: Neurology
https://www.readbyqxmd.com/read/26383062/practical-application-of-brief-cognitive-tests
#14
J Olazarán, M C Hoyos-Alonso, T del Ser, A Garrido Barral, J L Conde-Sala, F Bermejo-Pareja, S López-Pousa, D Pérez-Martínez, A Villarejo-Galende, J Cacho, E Navarro, A Oliveros-Cid, J Peña-Casanova, C Carnero-Pardo
INTRODUCTION: Brief cognitive tests (BCT) may help detect cognitive impairment (CI) in the clinical setting. Several BCT have been developed and/or validated in our country, but we lack specific recommendations for use. DEVELOPMENT: Review of studies on the diagnostic accuracy of BCT for CI, using studies conducted in Spain with BCT which take less than 20 min. We provide recommendations of use based on expert consensus and established on the basis of BCT characteristics and study results...
April 2016: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/26389654/association-between-atrial-fibrillation-and-dementia-in-the-general-population
#15
Renée F A G de Bruijn, Jan Heeringa, Frank J Wolters, Oscar H Franco, Bruno H C Stricker, Albert Hofman, Peter J Koudstaal, M Arfan Ikram
IMPORTANCE: Atrial fibrillation (AF) has been suggested as a risk factor for dementia since it may lead to chronic cerebral hypoperfusion and stroke. However, longitudinal studies assessing the association between AF and dementia have shown inconsistent results. OBJECTIVE: To determine the effect of AF on the risk of developing dementia during 20 years of follow-up. DESIGN, SETTING, AND PARTICIPANTS: The association of prevalent and incident AF with incident dementia was assessed from July 6, 1989, to February 4, 2010, in 6514 dementia-free participants in the prospective population-based Rotterdam Study...
November 2015: JAMA Neurology
https://www.readbyqxmd.com/read/26388768/phenotypic-heterogeneity-of-monogenic-frontotemporal-dementia
#16
REVIEW
Alberto Benussi, Alessandro Padovani, Barbara Borroni
Frontotemporal dementia (FTD) is a genetically and pathologically heterogeneous disorder characterized by personality changes, language impairment, and deficits of executive functions associated with frontal and temporal lobe degeneration. Different phenotypes have been defined on the basis of presenting clinical symptoms, i.e., the behavioral variant of FTD, the agrammatic variant of primary progressive aphasia, and the semantic variant of PPA. Some patients have an associated movement disorder, either parkinsonism, as in progressive supranuclear palsy and corticobasal syndrome, or motor neuron disease (FTD-MND)...
2015: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/26346644/relationship-between-the-montreal-cognitive-assessment-and-mini-mental-state-examination-for-assessment-of-mild-cognitive-impairment-in-older-adults
#17
Paula T Trzepacz, Helen Hochstetler, Shufang Wang, Brett Walker, Andrew J Saykin
BACKGROUND: The Montreal Cognitive Assessment (MoCA) was developed to enable earlier detection of mild cognitive impairment (MCI) relative to familiar multi-domain tests like the Mini-Mental State Exam (MMSE). Clinicians need to better understand the relationship between MoCA and MMSE scores. METHODS: For this cross-sectional study, we analyzed 219 healthy control (HC), 299 MCI, and 100 Alzheimer's disease (AD) dementia cases from the Alzheimer's Disease Neuroimaging Initiative (ADNI)-GO/2 database to evaluate MMSE and MoCA score distributions and select MoCA values to capture early and late MCI cases...
September 7, 2015: BMC Geriatrics
https://www.readbyqxmd.com/read/26338173/alcohol-consumption-dementia-and-cognitive-decline-an-overview-of-systematic-reviews
#18
REVIEW
Jenni Ilomaki, Natali Jokanovic, Edwin C K Tan, Eija Lonnroos
There is uncertainty in relation to the effect of alcohol consumption on the incidence of dementia and cognitive decline. This review critically evaluated published systematic reviews on the epidemiology of alcohol consumption and the risk of dementia or cognitive decline. MEDLINE, EMBASE and PsycINFO were searched from inception to February 2014. Systematic reviews of longitudinal observational studies were considered. Two reviewers independently completed the 11-item Assessment of Multiple Systematic Reviews (AMSTAR) tool to assess the quality...
2015: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/26280379/cognitive-and-functional-correlates-of-npi-q-scores-and-symptom-clusters-in-mildly-demented-alzheimer-patients
#19
Jennifer N Travis Seidl, Paul J Massman
Previous research has demonstrated an association between the emotional and behavioral symptoms of dementia, known as neuropsychiatric symptoms, and cognitive and functional decline among patients with Alzheimer disease (AD). The present study aimed to identify associations between neuropsychiatric symptoms as measured by the Neuropsychiatric Inventory-Questionnaire (NPI-Q) and cognitive and functional performance. Participants were 256 AD patients enrolled in the Alzheimer's Disease and Memory Disorders Center at Baylor College of Medicine...
April 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/26232551/phonological-short-term-memory-in-logopenic-variant-primary-progressive-aphasia-and-mild-alzheimer-s-disease
#20
COMPARATIVE STUDY
Aaron M Meyer, Sarah F Snider, Rachael E Campbell, Rhonda B Friedman
It has been argued that individuals with logopenic variant primary progressive aphasia (lvPPA) have an impairment of the phonological loop, which is a component of the short-term memory (STM) system. In contrast, this type of impairment is not thought to be present in mild typical Alzheimer's disease (AD). Thus, one would predict that people with lvPPA would score significantly lower than a matched AD group on tasks that require phonological STM. In the current study, an lvPPA group was compared with a mild AD group that was matched on age, education, and general cognitive functioning...
October 2015: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
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