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Airway_Pharmacology

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14 papers 0 to 25 followers
https://www.readbyqxmd.com/read/25676819/ketamine-and-propofol-combination-ketofol-for-endotracheal-intubations-in-critically-ill-patients-a-case-series
#1
Alice Gallo de Moraes, Carlos J Racedo Africano, Sumedh S Hoskote, Dereddi Raja S Reddy, Rudy Tedja, Lokendra Thakur, Jasleen K Pannu, Elizabeth C Hassebroek, Nathan J Smischney
BACKGROUND: Endotracheal intubation is a common procedure performed for critically ill patients that can have immediate life-threatening complications. Induction medications are routinely given to facilitate the procedure, but most of these medications are associated with hypotension. While etomidate is known for its neutral hemodynamic profile, it has been linked with increased mortality in septic patients and increased morbidity in trauma patients. Ketamine and propofol are effective anesthetics with counteracting cardiovascular profiles...
February 13, 2015: American Journal of Case Reports
https://www.readbyqxmd.com/read/25568981/single-induction-dose-of-etomidate-versus-other-induction-agents-for-endotracheal-intubation-in-critically-ill-patients
#2
REVIEW
Eric A Bruder, Ian M Ball, Stacy Ridi, William Pickett, Corinne Hohl
BACKGROUND: The use of etomidate for emergency airway interventions in critically ill patients is very common. In one large registry trial, etomidate was the most commonly used agent for this indication. Etomidate is known to suppress adrenal gland function, but it remains unclear whether or not this adrenal gland dysfunction affects mortality. OBJECTIVES: The primary objective was to assess, in populations of critically ill patients, whether a single induction dose of etomidate for emergency airway intervention affects mortality...
January 8, 2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25386450/-comparative-efficacy-of-different-doses-of-fentanyl-on-cardiovascular-responses-to-laryngoscopy-and-tracheal-intubation
#3
Vinod Hosalli, Adarsh Es, S Y Hulkund, Chhaya Joshi
BACKGROUND: This study was conducted to determine an effective bolus dose of fentanyl, which would attenuate the cardiovascular response to laryngoscopy and tracheal intubation. MATERIALS AND METHODS: A randomised double blind controlled study was carried out on 50 healthy adult patients (ASA I and II) undergoing elective surgery under general anaesthesia. The patients were randomly allocated into two groups of 25 each i.e. group A and group B receiving fentanyl 3 μg/kg, 5 μg/kg intravenously three minutes before intubation respectively...
September 2014: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/25255427/single-dose-etomidate-does-not-increase-mortality-in-patients-with-sepsis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-and-observational-studies
#4
REVIEW
Wan-Jie Gu, Fei Wang, Lu Tang, Jing-Chen Liu
BACKGROUND: The effect of single-dose etomidate on mortality in patients with sepsis remains controversial. We systematically reviewed the literature to investigate whether a single dose of etomidate for rapid sequence intubation increased mortality in patients with sepsis. METHODS: PubMed, Embase, and CENTRAL (Cochrane Central Register of Controlled Trials) were searched for randomized controlled trials (RCTs) and observational studies regarding the effect of single-dose etomidate on mortality in adults with sepsis...
February 2015: Chest
https://www.readbyqxmd.com/read/25245275/ketamine-and-intracranial-pressure-no-contraindication-except-hydrocephalus
#5
EDITORIAL
Steven M Green, Gary Andolfatto, Baruch S Krauss
No abstract text is available yet for this article.
January 2015: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/25125547/intranasal-ketamine-for-procedural-sedation
#6
Dani Hall, Alison Robinson
OBJECTIVES & BACKGROUND: The safety of intravenous ketamine in procedural sedation is well described.(1 2) Guidelines produced by NICE(3) and the College of Emergency Medicine(4) are used by Emergency Departments (ED) nationwide. To avoid cannulation, opioids are frequently administered to children intranasally(5), avoiding first-pass metabolism.(6) Intranasal ketamine (INK) is an effective analgesic in children(7) and has been successfully utilised in prehospital and military settings...
September 2014: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/25064742/the-effect-of-ketamine-on-intracranial-and-cerebral-perfusion-pressure-and-health-outcomes-a-systematic-review
#7
REVIEW
Lindsay Cohen, Valerie Athaide, Maeve E Wickham, Mary M Doyle-Waters, Nicholas G W Rose, Corinne M Hohl
STUDY OBJECTIVE: We synthesize the available evidence on the effect of ketamine on intracranial and cerebral perfusion pressures, neurologic outcomes, ICU length of stay, and mortality. METHODS: We developed a systematic search strategy and applied it to 6 electronic reference databases. We completed a gray literature search and searched medical journals as well as the bibliographies of relevant articles. We included randomized and nonrandomized prospective studies that compared the effect of ketamine with another intravenous sedative in intubated patients and reported at least 1 outcome of interest...
January 2015: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/24963149/rapid-sequence-induction-of-anaesthesia-via-the-intraosseous-route-a-prospective-observational-study
#8
E B G Barnard, R J Moy, A D Kehoe, V S Bebarta, J E Smith
BACKGROUND: Intraosseous (IO) drug infusion has been reported to have similar pharmacokinetics to intravenous (IV) infusion. In military and civilian trauma, the IO route is often used to obtain rapid and reliable parenteral access for drug administration. Only a few case reports have described the use of IO infusion to administer drugs for rapid sequence induction of anaesthesia (RSI). OBJECTIVE: We aimed to assess the feasibility of the administration of RSI drugs via an IO catheter in a prospective observational study...
June 2015: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/24865567/intravenous-magnesium-sulfate-for-treating-adults-with-acute-asthma-in-the-emergency-department
#9
REVIEW
Kayleigh M Kew, Liza Kirtchuk, Clare I Michell
BACKGROUND: Asthma is a chronic respiratory condition characterised by airways inflammation, constriction of airway smooth muscle and structural alteration of the airways that is at least partially reversible. Exacerbations of asthma can be life threatening and place a significant burden on healthcare services. Various guidelines have been published to inform management personnel in the acute setting; several include the use of a single bolus of intravenous magnesium sulfate (IV MgSO4) in cases that do not respond to first-line treatment...
2014: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/24859931/ketamine-does-not-increase-intracranial-pressure-compared-with-opioids-meta-analysis-of-randomized-controlled-trials
#10
COMPARATIVE STUDY
Xin Wang, Xibing Ding, Yao Tong, Jiaying Zong, Xiang Zhao, Hao Ren, Quan Li
BACKGROUND: Ketamine is traditionally avoided in sedation management of patients with risk of intracranial hypertension. However, results from many clinical trials contradict this concern. We critically analyzed the published data of the effects of ketamine on intracranial pressure (ICP) and other cerebral hemodynamics to determine whether ketamine was safe for patients with hemodynamic instability and brain injuries. METHODS: We systematically searched the online databases of PubMed, Medline, Embase, Current Controlled Trials, and Cochrane Central (last search performed on January 15, 2014)...
December 2014: Journal of Anesthesia
https://www.readbyqxmd.com/read/24723214/the-impact-of-etomidate-on-mortality-in-trauma-patients
#11
Chris Hinkewich, Robert Green
INTRODUCTION: Etomidate has a neutral hemodynamic profile which has made it an attractive medication for emergent intubation. Despite theoretical advantages of etomidate administration in the trauma patient, there are incomplete data to support its use. This study examined the association of etomidate use for emergent intubation in traumatic illness with patient mortality. METHODS: This is a historical cohort study using the Nova Scotia Trauma Registry. It included all major adult trauma patients who required tracheal intubation at the Queen Elizabeth II Health Sciences Centre in Halifax, Canada from January 23, 2000 to March 25, 2012...
July 2014: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/24552528/retrospective-analysis-of-etomidate-versus-ketamine-for-first-pass-intubation-success-in-an-academic-emergency-department
#12
COMPARATIVE STUDY
Asad E Patanwala, Courtney B McKinney, Brian L Erstad, John C Sakles
OBJECTIVES: The objective of this study was to compare first-pass intubation success between patients who received etomidate versus ketamine for rapid sequence intubation (RSI) in the emergency department (ED). METHODS: This was a retrospective analysis of prospectively collected data recorded in a quality improvement database between July 1, 2007, and December 31, 2012. The study was conducted in an academic ED in the United States. All patients who received etomidate or ketamine as part of RSI were included...
January 2014: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/24515638/the-ketamine-effect-on-icp-in-traumatic-brain-injury
#13
REVIEW
F A Zeiler, J Teitelbaum, M West, L M Gillman
Our goal was to perform a systematic review of the literature on the use of ketamine in traumatic brain injury (TBI) and its effects on intracranial pressure (ICP). All articles from MEDLINE, BIOSIS, EMBASE, Global Health, HealthStar, Scopus, Cochrane Library, the International Clinical Trials Registry Platform (inception to November 2013), reference lists of relevant articles, and gray literature were searched. Two reviewers independently identified all manuscripts pertaining to the administration of ketamine in human TBI patients that recorded effects on ICP...
August 2014: Neurocritical Care
https://www.readbyqxmd.com/read/21846380/succinylcholine-versus-rocuronium-for-rapid-sequence-intubation-in-intensive-care-a-prospective-randomized-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Stephan C Marsch, Luzius Steiner, Evelyne Bucher, Hans Pargger, Martin Schumann, Timothy Aebi, Patrick R Hunziker, Martin Siegemund
INTRODUCTION: Succinylcholine and rocuronium are widely used to facilitate rapid sequence induction (RSI) intubation in intensive care. Concerns relate to the side effects of succinylcholine and to slower onset and inferior intubation conditions associated with rocuronium. So far, succinylcholine and rocuronium have not been compared in an adequately powered randomized trial in intensive care. Accordingly, the aim of the present study was to compare the incidence of hypoxemia after rocuronium or succinylcholine in critically ill patients requiring an emergent RSI...
August 16, 2011: Critical Care: the Official Journal of the Critical Care Forum
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