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Medical comorbidities of mental illness

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7 papers 0 to 25 followers
By Abraham Nunes Psychiatry resident interested in computational neuroscience, forensic psychiatry, and neuropsychiatry.
M Beatriz Currier, Charles B Nemeroff
Innate immune activation and inflammation have been posited to play a role in the pathophysiology of both depression and neoplastic growth. Cancer patients experience a threefold higher rate of depression than the general population within the first five years of diagnosis. Chronic depression is associated with increased cancer risk and shortened survival. Although the precise cellular and molecular mechanisms of this bidirectional relationship remain unclear, elevated concentrations of circulating plasma proinflammatory cytokines associated with depression may mediate the neuroendocrine, neural, and immune pathways that account for the relationship...
2014: Annual Review of Medicine
Wayne Katon, Henrik Sondergaard Pedersen, Anette Riisgaard Ribe, Morten Fenger-Grøn, Dimitry Davydow, Frans Boch Waldorff, Mogens Vestergaard
IMPORTANCE: Although depression and type 2 diabetes mellitus (DM) may independently increase the risk for dementia, no studies have examined whether the risk for dementia among people with comorbid depression and DM is higher than the sum of each exposure individually. OBJECTIVE: To examine the risk for all-cause dementia among persons with depression, DM, or both compared with persons with neither exposure. DESIGN, SETTING, AND PARTICIPANTS: We performed a national population-based cohort study of 2 454 532 adults, including 477 133 (19...
June 2015: JAMA Psychiatry
Aroldo A Dargél, Ophelia Godin, Flávio Kapczinski, David J Kupfer, Marion Leboyer
OBJECTIVE: There is growing evidence that bipolar disorder (BD) is associated with inflammation, including abnormal levels of acute-phase C-reactive protein (CRP). Our meta-analysis was conducted to estimate the size of the association between CRP levels and BD, accounting also for subgroup differences (mood phases and treatment). DATA SOURCES: MEDLINE, EMBASE, PsycINFO, and ISI Web of Science and references of identified articles were searched up to June 2013 using the keywords (bipolar disorder) AND (C-reactive protein OR CRP)...
February 2015: Journal of Clinical Psychiatry
Elizabeth Reisinger Walker, Robin E McGee, Benjamin G Druss
IMPORTANCE: Despite the potential importance of understanding excess mortality among people with mental disorders, no comprehensive meta-analyses have been conducted quantifying mortality across mental disorders. OBJECTIVE: To conduct a systematic review and meta-analysis of mortality among people with mental disorders and examine differences in mortality risks by type of death, diagnosis, and study characteristics. DATA SOURCES: We searched EMBASE, MEDLINE, PsychINFO, and Web of Science from inception through May 7, 2014, including references of eligible articles...
April 2015: JAMA Psychiatry
Y Joseph Hwang, Stephanie N Dixon, Jeffrey P Reiss, Ron Wald, Chirag R Parikh, Sonja Gandhi, Salimah Z Shariff, Neesh Pannu, Danielle M Nash, Faisal Rehman, Amit X Garg
BACKGROUND: Several adverse outcomes attributed to atypical antipsychotic drugs, specifically quetiapine, risperidone, and olanzapine, are known to cause acute kidney injury (AKI). Such outcomes include hypotension, acute urinary retention, and the neuroleptic malignant syndrome or rhabdomyolysis. OBJECTIVE: To investigate the risk for AKI and other adverse outcomes associated with use of atypical antipsychotic drugs versus nonuse. DESIGN: Population-based cohort study...
August 19, 2014: Annals of Internal Medicine
Mu-Hong Chen, Tai-Long Pan, Cheng-Ta Li, Wei-Chen Lin, Ying-Sheue Chen, Ying-Chiao Lee, Shih-Jen Tsai, Ju-Wei Hsu, Kai-Lin Huang, Chia-Fen Tsai, Wen-Han Chang, Tzeng-Ji Chen, Tung-Ping Su, Ya-Mei Bai
BACKGROUND: Previous evidence has shown positive associations between post-traumatic stress disorder (PTSD) and hypertension, dyslipidaemia and diabetes mellitus, which are all risk factors for stroke, but the role of PTSD in the subsequent development of stroke is still unknown. AIMS: To investigate the temporal association between PTSD and the development of stroke. METHOD: Identified from the Taiwan National Health Insurance Research Database, 5217 individuals aged ≥18 years, with PTSD but with no history of stroke, and 20 868 age- and gender-matched controls were enrolled between 2002 and 2009, and followed up until the end of 2011 to identify the development of stroke...
April 2015: British Journal of Psychiatry: the Journal of Mental Science
Anette Riisgaard Ribe, Mogens Vestergaard, Wayne Katon, Morten Charles, Michael Eriksen Benros, Erik Vanderlip, Merete Nordentoft, Thomas Munk Laursen
OBJECTIVE: Persons with severe mental illness die 15-20 years earlier on average than persons without severe mental illness. Although infection is one of the leading overall causes of death, no studies have evaluated whether persons with severe mental illness have a higher mortality after infection than those without. METHOD: The authors studied mortality rate ratios and cumulative mortality proportions after an admission for infection for persons with severe mental illness compared with persons without severe mental illness by linking data from Danish national registries...
August 1, 2015: American Journal of Psychiatry
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