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https://www.readbyqxmd.com/read/27889710/effect-of-withholding-phenobarbitone-maintenance-in-neonatal-seizures-a-randomized-controlled-trial
#1
RANDOMIZED CONTROLLED TRIAL
Pranjali Saxena, Abhishek Singh, Amit Upadhyay, Priyanka Gupta, Sangeeta Sharma, Sreenivas Vishnubatla
OBJECTIVE: To compare the effect of withholding maintenance phenobarbitone on breakthrough seizures. DESIGN: A double blind randomized controlled trial. SETTING: Level II neonatal intensive care unit (NICU) of a teaching hospital in Northern India. PARTICIPANTS: 152 term and near term neonates (34 weeks of gestation age) with admission weight ≥2 kg with clinically apparent seizures who received intravenous (IV) loading dose of 20 mg/kg of phenobarbitone...
December 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/30496228/vitamin-a-to-prevent-bronchopulmonary-dysplasia-in-extremely-low-birth-weight-infants-a-systematic-review-and-meta-analysis
#2
Shunsuke Araki, Shin Kato, Fumihiko Namba, Erika Ota
BACKGROUND: Vitamin A (VA) supplementation reduces the risk of developing bronchopulmonary dysplasia (BPD). However, a previous meta-analysis showed that VA had minimal efficacy for preventing BPD in very low birth weight infants (VLBWIs). AIMS: To elucidate the effects of VA supplementation for BPD prevention in extremely low birth weight infants (ELBWIs). STUDY DESIGN: This systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
2018: PloS One
https://www.readbyqxmd.com/read/30455344/management-of-neonates-born-at-%C3%A2-34-6-7-weeks-gestation-with-suspected-or-proven-early-onset-bacterial-sepsis
#3
Karen M Puopolo, William E Benitz, Theoklis E Zaoutis
Early-onset sepsis (EOS) remains a serious and often fatal illness among infants born preterm, particularly among newborn infants of the lowest gestational age. Currently, most preterm infants with very low birth weight are treated empirically with antibiotics for risk of EOS, often for prolonged periods, in the absence of a culture-confirmed infection. Retrospective studies have revealed that antibiotic exposures after birth are associated with multiple subsequent poor outcomes among preterm infants, making the risk/benefit balance of these antibiotic treatments uncertain...
December 2018: Pediatrics
https://www.readbyqxmd.com/read/30478242/screening-examination-of-premature-infants-for-retinopathy-of-prematurity
#4
Walter M Fierson
This policy statement revises a previous statement on screening of preterm infants for retinopathy of prematurity (ROP) that was published in 2013. ROP is a pathologic process that occurs in immature retinal tissue and can progress to a tractional retinal detachment, which may then result in visual loss or blindness. For more than 3 decades, treatment of severe ROP that markedly decreases the incidence of this poor visual outcome has been available. However, severe, treatment-requiring ROP must be diagnosed in a timely fashion to be treated effectively...
December 2018: Pediatrics
https://www.readbyqxmd.com/read/30345236/nutritional-support-strategies-for-the-preterm-infant-in-the-neonatal-intensive-care-unit
#5
REVIEW
William W Hay
The goal of nutrition of the preterm infant is to "provide nutrients to approximate the rate of growth and composition of weight gain for a normal fetus of the same postmenstrual age and to maintain normal concentrations of blood and tissue nutrients" (American Academy of Pediatrics 2014). Failure to provide the necessary amounts of all of the essential nutrients to preterm infants has produced not only growth failure, but also increased morbidity and less than optimal neurodevelopment. This continues to be true despite many efforts to increase nutrition of the preterm infants...
October 2018: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/29346139/blood-biomarkers-for-evaluation-of-perinatal-encephalopathy-state-of-the-art
#6
REVIEW
Ernest M Graham, Allen D Everett, Jean-Christophe Delpech, Frances J Northington
PURPOSE OF REVIEW: The rapid progress in biomarker science is on the threshold of significantly changing clinical care for infants in the neonatal ICU. Infants with neonatal brain injuries will likely be the first group whose management is dramatically altered with point-of-care, rapidly available brain biomarker analysis. Providing an interim update on progress in this area is the purpose of this review. RECENT FINDINGS: Highlighted findings from the past 18 months of publications on biomarkers in neonatal brain injury include; Specific nonbrain markers of cardiac health and global asphyxia continue to provide information on brain injury after hypoxic-ischemic encephalopathy (HIE)...
April 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/20472939/early-cpap-versus-surfactant-in-extremely-preterm-infants
#7
RANDOMIZED CONTROLLED TRIAL
Neil N Finer, Waldemar A Carlo, Michele C Walsh, Wade Rich, Marie G Gantz, Abbot R Laptook, Bradley A Yoder, Roger G Faix, Abhik Das, W Kenneth Poole, Edward F Donovan, Nancy S Newman, Namasivayam Ambalavanan, Ivan D Frantz, Susie Buchter, Pablo J Sánchez, Kathleen A Kennedy, Nirupama Laroia, Brenda B Poindexter, C Michael Cotten, Krisa P Van Meurs, Shahnaz Duara, Vivek Narendran, Beena G Sood, T Michael O'Shea, Edward F Bell, Vineet Bhandari, Kristi L Watterberg, Rosemary D Higgins
BACKGROUND: There are limited data to inform the choice between early treatment with continuous positive airway pressure (CPAP) and early surfactant treatment as the initial support for extremely-low-birth-weight infants. METHODS: We performed a randomized, multicenter trial, with a 2-by-2 factorial design, involving infants who were born between 24 weeks 0 days and 27 weeks 6 days of gestation. Infants were randomly assigned to intubation and surfactant treatment (within 1 hour after birth) or to CPAP treatment initiated in the delivery room, with subsequent use of a protocol-driven limited ventilation strategy...
May 27, 2010: New England Journal of Medicine
https://www.readbyqxmd.com/read/30072808/introduction-to-neonatologist-performed-echocardiography
#8
REVIEW
Alan M Groves, Yogen Singh, Eugene Dempsey, Zoltan Molnar, Topun Austin, Afif El-Khuffash, Willem P de Boode
Cardiac ultrasound techniques are increasingly used in the neonatal intensive care unit to guide cardiorespiratory care of the sick newborn. This is the first in a series of eight review articles discussing the current status of "neonatologist-performed echocardiography" (NPE). The aim of this introductory review is to discuss four key elements of NPE. Indications for scanning are summarized to give the neonatologist with echocardiography skills a clear scope of practice. The fundamental physics of ultrasound are explained to allow for image optimization and avoid erroneous conclusions from artifacts...
July 2018: Pediatric Research
https://www.readbyqxmd.com/read/30076109/a-new-wrinkle-umbilical-cord-management-how-when-who
#9
REVIEW
Anup Katheria, Shigeharu Hosono, Walid El-Naggar
In the past five years, umbilical cord management in both term and preterm infants has come full circle, going from the vast majority of infants receiving immediate cord clamping to virtually all governing organizations promoting placental transfusion, mainly in the form of delayed cord clamping (DCC). Placental transfusion refers to the transfer of more blood components to the infant during the first few minutes after birth. The different strategies for ensuring placental transfusion to the baby include delayed (deferred) cord clamping, milking of the attached cord before clamping, and milking of the cut cord...
October 2018: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30092772/early-intervention-program-for-very-low-birth-weight-preterm-infants-and-their-parents-a-study-protocol
#10
Rita C Silveira, Eliane Wagner Mendes, Rubia Nascimento Fuentefria, Nadia Cristina Valentini, Renato S Procianoy
BACKGROUND: Preterm infants are high risk for delayed neurodevelopment. The main goal is to develop a program of early intervention for very preterm infants that allows families to apply it continuously at home, and quantify the results of early parental stimulation on improvement of cognition and motor skills. METHODS: Randomized clinical Trial including inborn preterm infants with gestational age less than 32 weeks or birth weight less than 1500 g at 48 h after birth...
August 9, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29970110/kawasaki-disease-in-the-neonate-case-report-and-literature-review
#11
REVIEW
Fajer Altammar, Bianca Lang
BACKGROUND: Kawasaki Disease (KD), the leading cause of acquired heart disease in children in the developed world, is extremely rare in neonates. We present a case of incomplete KD in a neonate and a review of the literature on neonatal KD. CASE PRESENTATION: A previously healthy full term 15 day old Caucasian male with an unremarkable antenatal and perinatal history, presented on Day 2 of illness with fever, rash, irritability, and poor feeding. Examination revealed fever (39...
July 3, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/30013381/evaluating-the-use-of-corticosteroids-in-preventing-and-treating-bronchopulmonary-dysplasia-in-preterm-neonates
#12
REVIEW
Oreoluwa Olaloko, Raihan Mohammed, Utkarsh Ojha
Approximately 15 million babies worldwide are born premature, and complications of prematurity are one of the leading causes of death in neonates. Neonatal respiratory distress syndrome (NRDS) and bronchopulmonary dysplasia (BPD) are two of the most common and serious consequences of prematurity. Synthetic corticosteroids, including dexamethasone, have been central in efforts to treat and prevent BPD. There is strong evidence to show that prenatal corticosteroids reduce infant mortality and the incidence of NRDS, leading to their widespread use in obstetric units...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/30029531/current-and-emerging-therapies-in-the-management-of-hypoxic-ischemic-encephalopathy-in-neonates
#13
REVIEW
Jayasree Nair, Vasantha H S Kumar
Neonatal hypoxic ischemic encephalopathy (HIE) presents a significant clinical burden with its high mortality and morbidity rates globally. Therapeutic hypothermia (TH) is now standard of care for infants with moderate to severe HIE, but has not definitively changed outcomes in severe HIE. In this review, we discuss newer promising markers that may help the clinician identify severity of HIE. Therapies that are beneficial and agents that hold promise for neuroprotection are described, both for use either alone or as adjuncts to TH...
July 19, 2018: Children
https://www.readbyqxmd.com/read/30025408/perinatal-anemia-is-associated-with-neonatal-and-neurodevelopmental-outcomes-in-infants-with-moderate-to-severe-perinatal-asphyxia
#14
Willemien S Kalteren, Hendrik J Ter Horst, Anne E den Heijer, Leanne de Vetten, Elisabeth M W Kooi, Arend F Bos
BACKGROUND: Perinatal anemia may cause perinatal asphyxia. Its pathophysiology and neurodevelopmental effects are theoretically different from other causes of perinatal asphyxia. OBJECTIVE: The study aimed to determine whether perinatal anemia results in different short-term and long-term outcomes than other causes of perinatal asphyxia treated with therapeutic hypothermia. METHODS: We retrospectively included infants with moderate to severe hypoxic-ischemic encephalopathy, born between May 2009 and October 2015...
2018: Neonatology
https://www.readbyqxmd.com/read/29996136/risk-factors-for-necrotizing-enterocolitis-a-prospective-multicenter-case-control-study
#15
Daniel J C Berkhout, Patrick Klaassen, Hendrik J Niemarkt, Willem P de Boode, Veerle Cossey, Johannes B van Goudoever, Christiaan V Hulzebos, Peter Andriessen, Anton H van Kaam, Boris W Kramer, Richard A van Lingen, Daniel C Vijlbrief, Mirjam M van Weissenbruch, Marc Benninga, Nanne K H de Boer, Tim G J de Meij
BACKGROUND: The identification of independent clinical risk factors for necrotizing enterocolitis (NEC) may contribute to early selection of infants at risk, allowing for the development of targeted strategies aimed at the prevention of NEC. OBJECTIVE: The objective of this study was to identify independent risk factors contributing to the development of NEC in a large multicenter cohort. METHODS: This prospective cohort study was performed in 9 neonatal intensive care units...
2018: Neonatology
https://www.readbyqxmd.com/read/19568999/infant-neurological-examination-from-3-to-12-months-predictive-value-of-the-single-items
#16
A Pizzardi, D M M Romeo, M Cioni, M G Romeo, A Guzzetta
The prognostic value of the single items of a standardised neurological examination, the Hammersmith Infant Neurologic Examination (HINE), was explored longitudinally in 658 infants at 3, 6, 9 and 12 months post-term age. ROC curves were built based on the presence/absence of cerebral palsy at 2 years of age. Global HINE scores showed very high prediction (ROC curve areas above 0.9) at all ages. The items with the highest predictive value were always movement quality and quantity. In the first semester, among the most predictive items were those assessing tone, while beyond that time they were reflexes and reactions...
December 2008: Neuropediatrics
https://www.readbyqxmd.com/read/28390243/neonatal-neurological-examination-during-the-first-6h-after-birth
#17
Domenico M Romeo, Sarah Bompard, Carmen Cocca, Francesca Serrao, Maria Pia De Carolis, Antonio A Zuppa, Daniela Ricci, Francesca Gallini, Chiara Maddaloni, Costantino Romagnoli, Eugenio Mercuri
BACKGROUND: Few neurological assessments are easily performed during the first 6h after birth. AIMS: To assess a cohort of low risk term born newborns within the first 6h and at 48h after birth using the Hammersmith Neonatal Neurological Examination. STUDY DESIGN AND SUBJECTS: A population of low risk term born newborns was examined within 3h from birth or between 3 and 6h. Each infant was re-assessed at 48h, establishing the range and frequency distribution of neonatal neurological scores at each time point...
May 2017: Early Human Development
https://www.readbyqxmd.com/read/17604195/neuromotor-development-in-infants-with-cerebral-palsy-investigated-by-the-hammersmith-infant-neurological-examination-during-the-first-year-of-age
#18
Domenico M M Romeo, Matteo Cioni, Mariacristina Scoto, Luigi Mazzone, Filippo Palermo, Mario G Romeo
BACKGROUND: The Hammersmith Infant Neurological Examination (HINE) is a simple and scorable method for assessing infants between 2 and 24 months of age. AIMS: The purpose of this retrospective study was firstly, to evaluate the neuromotor development of infants with cerebral palsy (CP) by the HINE, during the first year of age; secondly, to correlate the scoring of this neurological tool with levels of the Gross Motor Function Classification System (GMFCS). METHODS: A cohort of 70 infants with a diagnosis of CP at 2 years of age was evaluated by the HINE at 3, 6, 9 and 12 months of corrected age and by GMFCS at 2 years of age...
January 2008: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27765470/implementation-of-the-hammersmith-infant-neurological-examination-in-a-high-risk-infant-follow-up-program
#19
Nathalie L Maitre, Olena Chorna, Domenico M Romeo, Andrea Guzzetta
BACKGROUND: High-risk infant follow-up programs provide early identification and referral for treatment of neurodevelopmental delays and impairments. In these programs, a standardized neurological examination is a critical component of evaluation for clinical and research purposes. METHODS: To address primary challenges of provider educational diversity and standardized documentation, we designed an approach to training and implementation of the Hammersmith Infant Neurological Examination with precourse materials, a workshop model, and adaptation of the electronic medical record...
December 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/26306473/use-of-the-hammersmith-infant-neurological-examination-in-infants-with-cerebral-palsy-a-critical-review-of-the-literature
#20
REVIEW
Domenico M Romeo, Daniela Ricci, Claudia Brogna, Eugenio Mercuri
The Hammersmith Infant Neurological Examination (HINE) has been proposed as one of the early neurological examination tools for the diagnosis of cerebral palsy (CP). The aim of the present study was to critically review the existing literature and our experience with the use of the HINE in infants at risk of CP. The published papers confirm that the HINE can play an important role in the diagnosis and prognosis of infants at risk of developing CP, and provide information on aspects of neurological findings impaired in different forms of CP and brain lesions...
March 2016: Developmental Medicine and Child Neurology
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