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https://www.readbyqxmd.com/read/20472939/early-cpap-versus-surfactant-in-extremely-preterm-infants
#1
RANDOMIZED CONTROLLED TRIAL
Neil N Finer, Waldemar A Carlo, Michele C Walsh, Wade Rich, Marie G Gantz, Abbot R Laptook, Bradley A Yoder, Roger G Faix, Abhik Das, W Kenneth Poole, Edward F Donovan, Nancy S Newman, Namasivayam Ambalavanan, Ivan D Frantz, Susie Buchter, Pablo J Sánchez, Kathleen A Kennedy, Nirupama Laroia, Brenda B Poindexter, C Michael Cotten, Krisa P Van Meurs, Shahnaz Duara, Vivek Narendran, Beena G Sood, T Michael O'Shea, Edward F Bell, Vineet Bhandari, Kristi L Watterberg, Rosemary D Higgins
BACKGROUND: There are limited data to inform the choice between early treatment with continuous positive airway pressure (CPAP) and early surfactant treatment as the initial support for extremely-low-birth-weight infants. METHODS: We performed a randomized, multicenter trial, with a 2-by-2 factorial design, involving infants who were born between 24 weeks 0 days and 27 weeks 6 days of gestation. Infants were randomly assigned to intubation and surfactant treatment (within 1 hour after birth) or to CPAP treatment initiated in the delivery room, with subsequent use of a protocol-driven limited ventilation strategy...
May 27, 2010: New England Journal of Medicine
https://www.readbyqxmd.com/read/30072808/introduction-to-neonatologist-performed-echocardiography
#2
REVIEW
Alan M Groves, Yogen Singh, Eugene Dempsey, Zoltan Molnar, Topun Austin, Afif El-Khuffash, Willem P de Boode
Cardiac ultrasound techniques are increasingly used in the neonatal intensive care unit to guide cardiorespiratory care of the sick newborn. This is the first in a series of eight review articles discussing the current status of "neonatologist-performed echocardiography" (NPE). The aim of this introductory review is to discuss four key elements of NPE. Indications for scanning are summarized to give the neonatologist with echocardiography skills a clear scope of practice. The fundamental physics of ultrasound are explained to allow for image optimization and avoid erroneous conclusions from artifacts...
July 2018: Pediatric Research
https://www.readbyqxmd.com/read/30076109/a-new-wrinkle-umbilical-cord-management-how-when-who
#3
REVIEW
Anup Katheria, Shigeharu Hosono, Walid El-Naggar
In the past five years, umbilical cord management in both term and preterm infants has come full circle, going from the vast majority of infants receiving immediate cord clamping to virtually all governing organizations promoting placental transfusion, mainly in the form of delayed cord clamping (DCC). Placental transfusion refers to the transfer of more blood components to the infant during the first few minutes after birth. The different strategies for ensuring placental transfusion to the baby include delayed (deferred) cord clamping, milking of the attached cord before clamping, and milking of the cut cord...
July 20, 2018: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30092772/early-intervention-program-for-very-low-birth-weight-preterm-infants-and-their-parents-a-study-protocol
#4
Rita C Silveira, Eliane Wagner Mendes, Rubia Nascimento Fuentefria, Nadia Cristina Valentini, Renato S Procianoy
BACKGROUND: Preterm infants are high risk for delayed neurodevelopment. The main goal is to develop a program of early intervention for very preterm infants that allows families to apply it continuously at home, and quantify the results of early parental stimulation on improvement of cognition and motor skills. METHODS: Randomized clinical Trial including inborn preterm infants with gestational age less than 32 weeks or birth weight less than 1500 g at 48 h after birth...
August 9, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29970110/kawasaki-disease-in-the-neonate-case-report-and-literature-review
#5
REVIEW
Fajer Altammar, Bianca Lang
BACKGROUND: Kawasaki Disease (KD), the leading cause of acquired heart disease in children in the developed world, is extremely rare in neonates. We present a case of incomplete KD in a neonate and a review of the literature on neonatal KD. CASE PRESENTATION: A previously healthy full term 15 day old Caucasian male with an unremarkable antenatal and perinatal history, presented on Day 2 of illness with fever, rash, irritability, and poor feeding. Examination revealed fever (39...
July 3, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/30013381/evaluating-the-use-of-corticosteroids-in-preventing-and-treating-bronchopulmonary-dysplasia-in-preterm-neonates
#6
REVIEW
Oreoluwa Olaloko, Raihan Mohammed, Utkarsh Ojha
Approximately 15 million babies worldwide are born premature, and complications of prematurity are one of the leading causes of death in neonates. Neonatal respiratory distress syndrome (NRDS) and bronchopulmonary dysplasia (BPD) are two of the most common and serious consequences of prematurity. Synthetic corticosteroids, including dexamethasone, have been central in efforts to treat and prevent BPD. There is strong evidence to show that prenatal corticosteroids reduce infant mortality and the incidence of NRDS, leading to their widespread use in obstetric units...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/30029531/current-and-emerging-therapies-in-the-management-of-hypoxic-ischemic-encephalopathy-in-neonates
#7
REVIEW
Jayasree Nair, Vasantha H S Kumar
Neonatal hypoxic ischemic encephalopathy (HIE) presents a significant clinical burden with its high mortality and morbidity rates globally. Therapeutic hypothermia (TH) is now standard of care for infants with moderate to severe HIE, but has not definitively changed outcomes in severe HIE. In this review, we discuss newer promising markers that may help the clinician identify severity of HIE. Therapies that are beneficial and agents that hold promise for neuroprotection are described, both for use either alone or as adjuncts to TH...
July 19, 2018: Children
https://www.readbyqxmd.com/read/30025408/perinatal-anemia-is-associated-with-neonatal-and-neurodevelopmental-outcomes-in-infants-with-moderate-to-severe-perinatal-asphyxia
#8
Willemien S Kalteren, Hendrik J Ter Horst, Anne E den Heijer, Leanne de Vetten, Elisabeth M W Kooi, Arend F Bos
BACKGROUND: Perinatal anemia may cause perinatal asphyxia. Its pathophysiology and neurodevelopmental effects are theoretically different from other causes of perinatal asphyxia. OBJECTIVE: The study aimed to determine whether perinatal anemia results in different short-term and long-term outcomes than other causes of perinatal asphyxia treated with therapeutic hypothermia. METHODS: We retrospectively included infants with moderate to severe hypoxic-ischemic encephalopathy, born between May 2009 and October 2015...
July 19, 2018: Neonatology
https://www.readbyqxmd.com/read/29996136/risk-factors-for-necrotizing-enterocolitis-a-prospective-multicenter-case-control-study
#9
Daniel J C Berkhout, Patrick Klaassen, Hendrik J Niemarkt, Willem P de Boode, Veerle Cossey, Johannes B van Goudoever, Christiaan V Hulzebos, Peter Andriessen, Anton H van Kaam, Boris W Kramer, Richard A van Lingen, Daniel C Vijlbrief, Mirjam M van Weissenbruch, Marc Benninga, Nanne K H de Boer, Tim G J de Meij
BACKGROUND: The identification of independent clinical risk factors for necrotizing enterocolitis (NEC) may contribute to early selection of infants at risk, allowing for the development of targeted strategies aimed at the prevention of NEC. OBJECTIVE: The objective of this study was to identify independent risk factors contributing to the development of NEC in a large multicenter cohort. METHODS: This prospective cohort study was performed in 9 neonatal intensive care units...
2018: Neonatology
https://www.readbyqxmd.com/read/19568999/infant-neurological-examination-from-3-to-12-months-predictive-value-of-the-single-items
#10
A Pizzardi, D M M Romeo, M Cioni, M G Romeo, A Guzzetta
The prognostic value of the single items of a standardised neurological examination, the Hammersmith Infant Neurologic Examination (HINE), was explored longitudinally in 658 infants at 3, 6, 9 and 12 months post-term age. ROC curves were built based on the presence/absence of cerebral palsy at 2 years of age. Global HINE scores showed very high prediction (ROC curve areas above 0.9) at all ages. The items with the highest predictive value were always movement quality and quantity. In the first semester, among the most predictive items were those assessing tone, while beyond that time they were reflexes and reactions...
December 2008: Neuropediatrics
https://www.readbyqxmd.com/read/28390243/neonatal-neurological-examination-during-the-first-6h-after-birth
#11
Domenico M Romeo, Sarah Bompard, Carmen Cocca, Francesca Serrao, Maria Pia De Carolis, Antonio A Zuppa, Daniela Ricci, Francesca Gallini, Chiara Maddaloni, Costantino Romagnoli, Eugenio Mercuri
BACKGROUND: Few neurological assessments are easily performed during the first 6h after birth. AIMS: To assess a cohort of low risk term born newborns within the first 6h and at 48h after birth using the Hammersmith Neonatal Neurological Examination. STUDY DESIGN AND SUBJECTS: A population of low risk term born newborns was examined within 3h from birth or between 3 and 6h. Each infant was re-assessed at 48h, establishing the range and frequency distribution of neonatal neurological scores at each time point...
May 2017: Early Human Development
https://www.readbyqxmd.com/read/17604195/neuromotor-development-in-infants-with-cerebral-palsy-investigated-by-the-hammersmith-infant-neurological-examination-during-the-first-year-of-age
#12
Domenico M M Romeo, Matteo Cioni, Mariacristina Scoto, Luigi Mazzone, Filippo Palermo, Mario G Romeo
BACKGROUND: The Hammersmith Infant Neurological Examination (HINE) is a simple and scorable method for assessing infants between 2 and 24 months of age. AIMS: The purpose of this retrospective study was firstly, to evaluate the neuromotor development of infants with cerebral palsy (CP) by the HINE, during the first year of age; secondly, to correlate the scoring of this neurological tool with levels of the Gross Motor Function Classification System (GMFCS). METHODS: A cohort of 70 infants with a diagnosis of CP at 2 years of age was evaluated by the HINE at 3, 6, 9 and 12 months of corrected age and by GMFCS at 2 years of age...
January 2008: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27765470/implementation-of-the-hammersmith-infant-neurological-examination-in-a-high-risk-infant-follow-up-program
#13
Nathalie L Maitre, Olena Chorna, Domenico M Romeo, Andrea Guzzetta
BACKGROUND: High-risk infant follow-up programs provide early identification and referral for treatment of neurodevelopmental delays and impairments. In these programs, a standardized neurological examination is a critical component of evaluation for clinical and research purposes. METHODS: To address primary challenges of provider educational diversity and standardized documentation, we designed an approach to training and implementation of the Hammersmith Infant Neurological Examination with precourse materials, a workshop model, and adaptation of the electronic medical record...
December 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/26306473/use-of-the-hammersmith-infant-neurological-examination-in-infants-with-cerebral-palsy-a-critical-review-of-the-literature
#14
REVIEW
Domenico M Romeo, Daniela Ricci, Claudia Brogna, Eugenio Mercuri
The Hammersmith Infant Neurological Examination (HINE) has been proposed as one of the early neurological examination tools for the diagnosis of cerebral palsy (CP). The aim of the present study was to critically review the existing literature and our experience with the use of the HINE in infants at risk of CP. The published papers confirm that the HINE can play an important role in the diagnosis and prognosis of infants at risk of developing CP, and provide information on aspects of neurological findings impaired in different forms of CP and brain lesions...
March 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29960997/quality-of-life-of-extremely-preterm-school-age-children-without-major-handicap-a-cross-sectional-observational-study
#15
Catherine Gire, Noémie Resseguier, Véronique Brévaut-Malaty, Stéphane Marret, Gilles Cambonie, Isabelle Souksi-Medioni, Jean-Baptiste Müller, Patricia Garcia, Julie Berbis, Barthélémy Tosello, Pascal Auquier
OBJECTIVE: To determine the quality of life (QoL) of school-aged children who were born <28+0 weeks of gestation and who have no resultant major disabilities. DESIGN, SETTING AND PATIENTS: A cross-sectional multicentre study of extremely preterm (EPT) infants born <28+0 weeks, discharged alive and free from severe impairments (cerebral palsy, autism, major cognitive disabilities). Two generic, self-evaluation and hetero-evaluation (by parent) QoL measurement questionnaires (Kidscreen 10/VSP-A) were used and then compared with French population reference...
June 30, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29936499/head-ultrasound-in-neonatal-hypoxic-ischemic-injury-and-its-mimickers-for-clinicians-a-review-of-the-patterns-of-injury-and-the-evolution-of-findings-over-time
#16
REVIEW
Jacqueline Salas, Aylin Tekes, Misun Hwang, Frances J Northington, Thierry A G M Huisman
Hypoxic-ischemic injury (HII) of the neonatal brain and resulting clinical hypoxic-ischemic encephalopathy remains a significant cause of morbidity and mortality in the neonatal population. Ultrasound (US) has emerged as a powerful screening tool for evaluation of a neonate with suspected HII. The pattern of injury on brain imaging has crucial implications in therapies and predicted neurodevelopmental outcomes. US has become increasingly effective at determining the pattern, timing, and extent of injury in HII as well as differentiating these findings from a host of diagnoses that can result in a similarly appearing clinical picture...
2018: Neonatology
https://www.readbyqxmd.com/read/29791315/incidence-of-early-onset-sepsis-in-infants-born-to-women-with-clinical-chorioamnionitis
#17
Tara M Randis, Madeline Murguia Rice, Leslie Myatt, Alan T N Tita, Kenneth J Leveno, Uma M Reddy, Michael W Varner, John M Thorp, Brian M Mercer, Mara J Dinsmoor, Susan M Ramin, Marshall W Carpenter, Philip Samuels, Anthony Sciscione, Jorge E Tolosa, George Saade, Yoram Sorokin
Objective To determine the frequency of sepsis and other adverse neonatal outcomes in women with a clinical diagnosis of chorioamnionitis. Methods We performed a secondary analysis of a multi-center placebo-controlled trial of vitamins C/E to prevent preeclampsia in low risk nulliparous women. Clinical chorioamnionitis was defined as either the "clinical diagnosis" of chorioamnionitis or antibiotic administration during labor because of an elevated temperature or uterine tenderness in the absence of another cause...
October 25, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29789445/thermal-effect-of-a-woolen-cap-in-low-birth-weight-infants-during-kangaroo-care
#18
Francesco Cavallin, Giulia Segafredo, Damiano Pizzol, William Massavon, Marta Lusiani, Olivier Wingi, Manuela De Vivo, Liviana Da Dalt, Chiara Boscardin, Fabio Manenti, Giovanni Putoto, Daniele Trevisanuto
BACKGROUND AND OBJECTIVES: World Health Organization guidelines recommend covering the head during kangaroo mother care (KMC), but the effect of a cap on neonatal thermal control during KMC remains to be defined. Our objective was to assess the effectiveness and safety of a woolen cap in maintaining low birth weight infants (LBWIs) in normal thermal range during KMC. METHODS: Three hundred LBWI candidates for KMC in 3 African hospitals were randomly assigned to KMC with (CAP group) or without (NOCAP group) a woolen cap in a 1:1 ratio during the first week after birth...
June 2018: Pediatrics
https://www.readbyqxmd.com/read/29691284/a-modified-algorithm-for-critical-congenital-heart-disease-screening-using-pulse-oximetry
#19
Christina L Diller, Michael S Kelleman, Kenneth G Kupke, Sharon C Quary, Lazaros K Kochilas, Matthew E Oster
: media-1vid110.1542/5727212367001PEDS-VA_2017-4065 Video Abstract OBJECTIVES: Determine the performance of the American Academy of Pediatrics (AAP) critical congenital heart disease (CCHD) newborn screening algorithm and the impact of an alternative algorithm. METHODS: Screening was performed on term infants without a known CCHD diagnosis at or near 24 hours of age at a tertiary birth hospital by using the AAP algorithm from 2013 to 2016. Retrospective review from the birth hospital and the area's sole pediatric cardiac center identified true- and false-positives and true- and false-negatives...
May 2018: Pediatrics
https://www.readbyqxmd.com/read/29675941/anticoagulation-in-the-management-of-neonatal-cerebral-sinovenous-thrombosis-a-systematic-review-and-meta-analysis
#20
REVIEW
Thomas Rossor, Tomoki Arichi, Sanjay Bhate, Anthony R Hart, Rahul Raman Singh
AIM: To determine whether anticoagulation therapy (ACT) in the treatment of neonatal cerebral sinovenous thrombosis (CSVT) improves outcomes, in the presence or absence of pre-existing intracerebral haemorrhage (ICH). METHOD: We searched CENTRAL, MEDLINE, Embase, CINAHL, the Web of Science, and clinical trial databases. We considered data from retrospective and prospective cohort studies, case series, and randomized controlled studies evaluating outcomes of CSVT treated with anticoagulation or no anticoagulation...
September 2018: Developmental Medicine and Child Neurology
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