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Tiotropium and asthma

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5 papers 0 to 25 followers
By Jason Mann No BS pulmonary critical care fellow
https://www.readbyqxmd.com/read/26491494/tiotropium-bromide-in-chronic-obstructive-pulmonary-disease-and-bronchial-asthma
#1
REVIEW
Alcibey Alvarado-Gonzalez, Isabel Arce
Inhaled bronchodilators are the mainstay of pharmacological treatment for stable chronic obstructive pulmonary disease (COPD), including β2-agonists and muscarinic antagonists. Tiotropium bromide, a long-acting antimuscarinic bronchodilator (LAMA), is a treatment choice for moderate-to-severe COPD; its efficacy and safety have been demonstrated in recent trials. Studies also point to a beneficial role of tiotropium in the treatment of difficult-to-control asthma and a potential function in the asthma-COPD overlap syndrome (ACOS)...
November 2015: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/24890738/tiotropium-respimat%C3%A2-in-asthma-a-double-blind-randomised-dose-ranging-study-in-adult-patients-with-moderate-asthma
#2
RANDOMIZED CONTROLLED TRIAL
Kai-Michael Beeh, Petra Moroni-Zentgraf, Othmar Ablinger, Zuzana Hollaenderova, Anna Unseld, Michael Engel, Stephanie Korn
BACKGROUND: Tiotropium, a once-daily long-acting anticholinergic bronchodilator, when administered via Respimat® SoftMist™ inhaler (tiotropium Respimat®) significantly reduces the risk of severe exacerbations and improves lung function in patients with severe persistent asthma that is not fully controlled despite using inhaled corticosteroids (ICS) and long-acting β2-agonists. To further explore the dose-response curve in asthma, we investigated the efficacy and safety of three different doses of tiotropium Respimat® as add-on to ICS in symptomatic patients with moderate persistent asthma...
June 3, 2014: Respiratory Research
https://www.readbyqxmd.com/read/22938706/tiotropium-in-asthma-poorly-controlled-with-standard-combination-therapy
#3
RANDOMIZED CONTROLLED TRIAL
Huib A M Kerstjens, Michael Engel, Ronald Dahl, Pierluigi Paggiaro, Ekkehard Beck, Mark Vandewalker, Ralf Sigmund, Wolfgang Seibold, Petra Moroni-Zentgraf, Eric D Bateman
BACKGROUND: Some patients with asthma have frequent exacerbations and persistent airflow obstruction despite treatment with inhaled glucocorticoids and long-acting beta-agonists (LABAs). METHODS: In two replicate, randomized, controlled trials involving 912 patients with asthma who were receiving inhaled glucocorticoids and LABAs, we compared the effect on lung function and exacerbations of adding tiotropium (a total dose of 5 μg) or placebo, both delivered by a soft-mist inhaler once daily for 48 weeks...
September 27, 2012: New England Journal of Medicine
https://www.readbyqxmd.com/read/20979471/tiotropium-bromide-step-up-therapy-for-adults-with-uncontrolled-asthma
#4
RANDOMIZED CONTROLLED TRIAL
Stephen P Peters, Susan J Kunselman, Nikolina Icitovic, Wendy C Moore, Rodolfo Pascual, Bill T Ameredes, Homer A Boushey, William J Calhoun, Mario Castro, Reuben M Cherniack, Timothy Craig, Loren Denlinger, Linda L Engle, Emily A DiMango, John V Fahy, Elliot Israel, Nizar Jarjour, Shamsah D Kazani, Monica Kraft, Stephen C Lazarus, Robert F Lemanske, Njira Lugogo, Richard J Martin, Deborah A Meyers, Joe Ramsdell, Christine A Sorkness, E Rand Sutherland, Stanley J Szefler, Stephen I Wasserman, Michael J Walter, Michael E Wechsler, Vernon M Chinchilli, Eugene R Bleecker
BACKGROUND: Long-acting beta-agonist (LABA) therapy improves symptoms in patients whose asthma is poorly controlled by an inhaled glucocorticoid alone. Alternative treatments for adults with uncontrolled asthma are needed. METHODS: In a three-way, double-blind, triple-dummy crossover trial involving 210 patients with asthma, we evaluated the addition of tiotropium bromide (a long-acting anticholinergic agent approved for the treatment of chronic obstructive pulmonary disease but not asthma) to an inhaled glucocorticoid, as compared with a doubling of the dose of the inhaled glucocorticoid (primary superiority comparison) or the addition of the LABA salmeterol (secondary noninferiority comparison)...
October 28, 2010: New England Journal of Medicine
https://www.readbyqxmd.com/read/24600237/tiotropium-in-asthma-a-systematic-review
#5
REVIEW
Elizabeth Befekadu, Claudia Onofrei, Gene L Colice
INTRODUCTION: The objective of this paper is to systematically review the existing evidence of the effectiveness and safety profile of a long-acting inhaled muscarinic antagonist as add-on therapy in patients with asthma that is uncontrolled despite inhaled corticosteroid (ICS) use. METHODS: With the assistance of two experienced research librarians, we searched Ovid MEDLINE/PubMed (1946 to September 12, 2013), the Cochrane Library review, and the TRIP database...
2014: Journal of Asthma and Allergy
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