Read by QxMD icon Read

Huntington's Disease

shared collection
6 papers 0 to 25 followers
By Abraham Nunes Psychiatry resident interested in computational neuroscience, forensic psychiatry, and neuropsychiatry.
Udo Rüb, Jean Paul G Vonsattel
The deleterious action of the unstable CAG repeat expansion in the Huntington's disease (HD) gene (also called IT15) located on the short arm of chromosome 4 involves widespread areas of the brain including sites of increased vulnerability or sites that are relatively resistant, but not spared (Andrew et al. 1993; Duyao et al. 1993; Myers et al. 1991; The Huntington's disease Collaborative Research Group 1993). Therefore, the intensity of the degenerative process of HD is topographically variable. The neuropathological phenotype of adult HD can be almost cryptic or outstanding within the same nucleus, but at different sites...
2015: Advances in Anatomy, Embryology, and Cell Biology
Maria Dale, Erik van Duijn
Anxiety is common in Huntington's disease (HD), though it has been under-researched. The authors conducted a systematic review of anxiety in HD. The prevalence of anxiety in manifest HD ranged from 13% to 71%. No significant difference in anxiety between manifest and premanifest HD carriers was revealed. Anxiety appears to be associated with depression, suicide, irritability, quality of life (QoL), pain, illness beliefs, and coping styles but does not seem to be linked with measures of disease progression. From the few pilot studies available, interventions that show promise include olanzapine and psychosocial approaches...
2015: Journal of Neuropsychiatry and Clinical Neurosciences
Rebecca A G De Souza, Blair R Leavitt
Of the neurodegenerative diseases presented in this book, Huntington's disease (HD) stands as the archetypal autosomal dominantly inherited neurodegenerative disorder. Its occurrence through generations of affected families was noted long before the basic genetic underpinnings of hereditary diseases was understood. The early classification of HD as a distinct hereditary neurodegenerative disorder allowed the study of this disease to lead the way in the development of our understanding of the mechanisms of human genetic disorders...
2015: Current Topics in Behavioral Neurosciences
Azadeh A Rikani, Zia Choudhry, Adnan M Choudhry, Nasir Rizvi, Huma Ikram, Nusrat J Mobassarah, Sagun Tulli
The pattern of neurodegeneration in Huntington's disease (HD) is very characteristic of regional locations as well as that of neuronal types in striatum. The different striatal neuronal populations demonstrate different degree of degeneration in response to various pathological events in HD. In the striatum, medium spiny GABA neurons (MSN) are preferentially degenerate while others are relatively spared. Vulnerability of specific neuronal populations within the striatum to pathological events constitutes an important hallmark of degeneration in HD...
July 2014: Annals of Neurosciences
Joshua L Plotkin, D James Surmeier
Huntington's disease (HD) is a progressive neurodegenerative disorder that profoundly impairs corticostriatal information processing. While late stage pathology includes cell death, the appearance of motor symptoms parallels more subtle changes in neuronal function and synaptic integration. Because of the difficulty in modeling the disease and the complexity of the corticostriatal network, understanding the mechanisms driving pathology has been slow to develop. In recent years, advances in animal models and network analysis tools have begun to shed light on the circuit-specific deficits...
August 2015: Current Opinion in Neurobiology
Mahmoud A Pouladi, A Jennifer Morton, Michael R Hayden
Since the identification of the causative gene in Huntington's disease (HD), a number of animal models of this disorder have been developed. A frequently asked question is: which of these models most closely recapitulates the human disease? In this Review, we provide an overview of the currently available animal models of HD in the context of the clinical features of the disease. In doing so, we highlight their strengths and limitations for modelling specific symptoms of the disease. This should highlight the animal model that is best suited to address a particular question of interest and, ultimately, to expedite the discovery of treatments that will prevent or slow the progression of HD...
October 2013: Nature Reviews. Neuroscience
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"