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16 papers 25 to 100 followers
Jeanne D Johansen, Kristiina Aalto-Korte, Tove Agner, Klaus E Andersen, Andreas Bircher, Magnus Bruze, Alicia Cannavó, Ana Giménez-Arnau, Margarida Gonçalo, An Goossens, Swen M John, Carola Lidén, Magnus Lindberg, Vera Mahler, Mihály Matura, Thomas Rustemeyer, Jørgen Serup, Radoslaw Spiewak, Jacob P Thyssen, Martine Vigan, Ian R White, Mark Wilkinson, Wolfgang Uter
The present guideline summarizes all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering, or having been suffering, from allergic contact dermatitis or other delayed-type hypersensitivity skin and mucosal conditions. Sections with brief descriptions and discussions of different pertinent topics are followed by a highlighted short practical recommendation. Topics comprise, after an introduction with important definitions, materials, technique, modifications of epicutaneous testing, individual factors influencing the patch test outcome or necessitating special considerations, children, patients with occupational contact dermatitis and drug eruptions as special groups, patch testing of materials brought in by the patient, adverse effects of patch testing, and the final evaluation and patient counselling based on this judgement...
October 2015: Contact Dermatitis
Hidehisa Saeki, Shinichi Imafuku, Masatoshi Abe, Yoichi Shintani, Daisuke Onozuka, Akihito Hagihara, Norito Katoh, Hiroyuki Murota, Satoshi Takeuchi, Makoto Sugaya, Miki Tanioka, Sakae Kaneko, Koji Masuda, Takaaki Hiragun, Naoko Inomata, Yuki Kitami, Yuichiro Tsunemi, Shinya Abe, Miwa Kobayashi, Donald E Morisky, Masutaka Furue
Previously we assessed the medication adherence for oral and topical remedies by a translated Japanese version of the Morisky Medication Adherence Scale-8 (MMAS-8) together with socioeconomic backgrounds in 3096 Japanese dermatological patients, and found the medication adherence, especially to topical drugs, was poor in these patients. In order to elucidate the disease-specific sociomedical factors, we further sub-analyzed the medication adherence in 237 psoriasis patients and compared it with that in other dermatological diseases such as atopic dermatitis, urticaria or tinea...
April 2015: Journal of Dermatology
Ilario Fulco, Sylvie Miot, Martin D Haug, Andrea Barbero, Anke Wixmerten, Sandra Feliciano, Francine Wolf, Gernot Jundt, Anna Marsano, Jian Farhadi, Michael Heberer, Marcel Jakob, Dirk J Schaefer, Ivan Martin
BACKGROUND: Autologous native cartilage from the nasal septum, ear, or rib is the standard material for surgical reconstruction of the nasal alar lobule after two-layer excision of non-melanoma skin cancer. We assessed whether engineered autologous cartilage grafts allow safe and functional alar lobule restoration. METHODS: In a first-in-human trial, we recruited five patients at the University Hospital Basel (Basel, Switzerland). To be eligible, patients had to be aged at least 18 years and have a two-layer defect (≥50% size of alar subunit) after excision of non-melanoma skin cancer on the alar lobule...
July 26, 2014: Lancet
K Yazar, M D Lundov, A Faurschou, M Matura, A Boman, J D Johansen, C Lidén
BACKGROUND: In recent years, the prevalence of contact allergy to the preservative methylisothiazolinone (MI) has increased dramatically. Cosmetic products are one of the major sources of exposure. OBJECTIVES: To examine whether allowed concentrations of MI in cosmetic rinse-off products have the potential to cause allergic contact dermatitis. METHODS: Nineteen MI-allergic subjects and 19 controls without MI allergy applied two liquid hand soaps five times per day on areas of 5 × 10 cm(2) on the ventral side of their forearms...
July 2015: British Journal of Dermatology
C B van Lee, B Graafland, S Koljenović, H A M Neumann, K Nasserinejad, T E C Nijsten, R R van den Bos, K Munte
BACKGROUND: One significant risk factor for recurrence after Mohs surgery is misinterpretation of slides. OBJECTIVES: To determine how often pathologists detected incompletely excised basal cell carcinoma (BCC) on Mohs slides and to determine risk factors for incompletely excised BCCs. METHODS: This retrospective study included 1653 BCCs treated with Mohs surgery in a university hospital between 2007 and 2011. For routine quality assurance, all slides were additionally reviewed by a pathologist within 1 week of the procedure...
July 2015: British Journal of Dermatology
Noriki Fujimoto, Gen Nakanishi, Miho Kabuto, Toshiaki Nakano, Hikaru Eto, Hideki Nakajima, Shigetoshi Sano, Toshihiro Tanaka
We present a cases of Merkel cell carcinoma (MCC) with Merkel cell polyomavirus that showed complete regression after biopsy. The exact mechanism of regression in MCC has remained unclear. It has been reported that apoptosis caused by T-cell immunity was implicated in the regression, and programmed cell death 1 (PD-1), an inhibitory receptor, was expressed in approximately half of tumor-infiltrating T cells in MCC. However, the contribution of PD-1-positive cells for the regression of MCC has not been evaluated...
May 2015: Journal of Dermatology
S Alison Basak, Andrea L Zaenglein
No abstract text is available yet for this article.
November 2013: Pediatrics in Review
Akiko Imanishi, Chiharu Tateishi, Hisayoshi Imanishi, Junko Sowa-Osako, Hiroshi Koga, Daisuke Tsuruta, Takashi Hashimoto
Both anti-laminin γ1 pemphigoid and bullous pemphigoid are autoimmune subepidermal blistering diseases. The former is rare and characterized by autoantibodies to laminin γ1, a 200-kDa dermal protein, while the latter is common among the elderly and characterized by autoantibodies to BP180 and BP230, both of which are hemidesmosomal proteins. We experienced a 69-year-old Japanese male patient with blister formation secondary to erythrodermic psoriasis, which was successfully treated with cyclosporin. The histopathology of erythema corresponded with psoriasis and that of a blistering lesion showed infiltration of neutrophils and eosinophils in and around the subepidermal blisters...
April 2015: Journal of Dermatology
Ali Alikhan, Omar A Ibrahimi, Daniel B Eisen
Congenital melanocytic nevi (CMN) are present at birth or arise during the first few weeks of life. They are quite common, may have a heritable component, and can present with marked differences in size, shape, color, and location. Histologic and dermatoscopic findings may help suggest the diagnosis, but they are not entirely specific. CMN are categorized based on size, and larger lesions can have a significant psychosocial impact and other complications. They are associated with a variety of dermatologic lesions, ranging from benign to malignant...
October 2012: Journal of the American Academy of Dermatology
K G Nevin, T Rajamohan
OBJECTIVES: The present study was undertaken to evaluate the effect of a topical application of virgin coconut oil (VCO) on excision wounds in young rats. METHODS: Three sets of experiments with 3 groups of female Sprague-Dawley rats each consisting of 6 animals were used for studying wound closure time, antioxidant status and biochemical parameters. Group 1 was the control; groups 2 and 3 were treated with 0.5 and 1.0 ml VCO, respectively, 24 h after wound creation for 10 days...
2010: Skin Pharmacology and Physiology
Enno Schmidt, Detlef Zillikens
Pemphigoid diseases are a group of well defined autoimmune disorders that are characterised by autoantibodies against structural proteins of the dermal-epidermal junction and, clinically, by tense blisters and erosions on skin or mucous membranes close to the skin surface. The most common of these diseases is bullous pemphigoid, which mainly affects older people and the reported incidence of which in Europe has more than doubled in the past decade. Prognosis and treatments vary substantially between the different disorders and, since clinical criteria are usually not sufficient, direct immunofluorescence microscopy of a perilesional biopsy specimen or serological tests are needed for exact diagnosis...
January 26, 2013: Lancet
Chuong D Dang, Linda Beets-Shay, Estelle C Kahn
We present a case of toxic epidermal necrolysis (TEN) triggered by clobazam in a 13-year-old girl who was subsequently treated with intravenous immunoglobulin. In December 2013 the U.S. Food and Drug Administration released a warning that clobazam might cause "serious skin reactions" such as Stevens-Johnson syndrome or TEN and approved label changes.
May 2015: Pediatric Dermatology
Jérôme Coulombe, Sara-Elizabeth Jean, Afshin Hatami, Julie Powell, Danielle Marcoux, Victor Kokta, Catherine McCuaig
Pigmentary purpuras (PPs) are a group of chronic disorders of unknown origin seldom described in children. With this study we sought to better characterize PP eruptions, including clinical evolution and management. A retrospective chart review from 2003 to 2013 querying characteristics of children with a biopsy-proven diagnosis of PP in the Centre Hospitalier Universitaire Ste-Justine dermatology clinic (Montreal, Quebec, Canada) was performed. Follow-up was obtained through telephone interviews. Descriptive statistical analysis was used...
May 2015: Pediatric Dermatology
Rena C Zuo, Daniella M Schwartz, Chyi-Chia Richard Lee, Milan J Anadkat, Edward W Cowen, Haley B Naik
Key teaching points • Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is characterized by distinctive osteoarticular manifestations and a spectrum of neutrophilic dermatoses. • The most common dermatologic manifestations include palmoplantar pustulosis, acne conglobata, and acne fulminans. • SAPHO syndrome should be considered in patients presenting osteoarticular pain, particularly involving the anterior chest wall and/or spine, and neutrophilic skin lesions.
March 2015: Journal of the American Academy of Dermatology
Tien V Nguyen, Edward W Cowen, Kieron S Leslie
Autoinflammation is characterized by aberrant regulation of the innate immune system and often manifests as periodic fevers and systemic inflammation involving multiple organs, including the skin. Mutations leading to abnormal behavior or activity of the interleukin 1 beta (IL-1ß)-processing inflammasome complex have been found in several rare autoinflammatory syndromes, for which anticytokine therapy such as IL-1 or tumor necrosis factor-alfa inhibition may be effective. It is becoming clear that features of autoinflammation also affect common dermatoses, some of which were previously thought to be solely autoimmune in origin (eg, vitiligo, systemic lupus erythematosus)...
May 2013: Journal of the American Academy of Dermatology
David M Pariser, Terri Lynn Meinking, Margie Bell, William G Ryan
BACKGROUND: The emergence of resistance to treatment complicates the public health problem of head-louse infestations and drives the need for continuing development of new treatments. There are limited data on the activity of ivermectin as a topical lousicide. METHODS: In two multisite, randomized, double-blind studies, we compared a single application of 0.5% ivermectin lotion with vehicle control for the elimination of infestations without nit combing in patients 6 months of age or older...
November 2012: New England Journal of Medicine
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