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7 papers 25 to 100 followers
By Alessandro Franciscon doctor
Chirag Shah, Vivek Verma, Radhika Takiar, Ramya Vajapey, Sudha Amarnath, Erin Murphy, Nathan W Mesko, Steven Lietman, Michael Joyce, Peter Anderson, Dale Shepard, Thomas Budd
Radiation therapy represents a vital component in the multidisciplinary management of soft tissue sarcomas. Combined with limb-preserving surgery, radiation therapy represents a standard of care treatment option for patients with high-grade sarcomas. Radiation therapy for soft tissue sarcoma continues to evolve with changes in timing, techniques, and targets. Over the past 2 decades, increasing data have supported the role of preoperative radiotherapy with the potential for lower total doses of radiation and improved long-term function coming at the cost of increased wound complications for certain locations...
July 18, 2016: American Journal of Clinical Oncology
J C Yang, A E Chang, A R Baker, W F Sindelar, D N Danforth, S L Topalian, T DeLaney, E Glatstein, S M Steinberg, M J Merino, S A Rosenberg
PURPOSE: This randomized, prospective study assesses the impact of postoperative external-beam radiation therapy on local recurrence (LR), overall survival (OS), and quality of life after limb-sparing resection of extremity sarcomas. PATIENTS AND METHODS: Patients with extremity tumors and a limb-sparing surgical option were randomized to receive or not receive postoperative adjuvant external-beam radiotherapy. Patients with high-grade sarcomas received postoperative adjuvant chemotherapy whereas patients with low-grade sarcomas or locally aggressive nonmalignant tumors were randomized after surgery alone...
January 1998: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Rick L M Haas, Aisha B Miah, Cécile LePechoux, Thomas F DeLaney, Elizabeth H Baldini, Kaled Alektiar, Brian O'Sullivan
INTRODUCTION: This critical review aims to summarize published data on limb sparing surgery for extremity soft tissue sarcoma in combination with pre-operative radiotherapy (RT). METHODS: This review is based on peer-reviewed publications using a PubMed search on the MeSH headings "soft tissue sarcoma" AND "preoperative radiotherapy". Titles and abstracts screened for data including "fraction size AND/OR total dose AND/OR overall treatment time", "chemotherapy", "targeted agents AND/OR tyrosine kinase inhibitors", are collated...
April 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Elizabeth H Baldini, Ross A Abrams, Walter Bosch, David Roberge, Rick L M Haas, Charles N Catton, Daniel J Indelicato, Jeffrey R Olsen, Curtiland Deville, Yen-Lin Chen, Steven E Finkelstein, Thomas F DeLaney, Dian Wang
PURPOSE: The purpose of this study was to evaluate the variability in target volume and organ at risk (OAR) contour delineation for retroperitoneal sarcoma (RPS) among 12 sarcoma radiation oncologists. METHODS AND MATERIALS: Radiation planning computed tomography (CT) scans for 2 cases of RPS were distributed among 12 sarcoma radiation oncologists with instructions for contouring gross tumor volume (GTV), clinical target volume (CTV), high-risk CTV (HR CTV: area judged to be at high risk of resulting in positive margins after resection), and OARs: bowel bag, small bowel, colon, stomach, and duodenum...
August 1, 2015: International Journal of Radiation Oncology, Biology, Physics
Dian Wang, Qiang Zhang, Burton L Eisenberg, John M Kane, X Allen Li, David Lucas, Ivy A Petersen, Thomas F DeLaney, Carolyn R Freeman, Steven E Finkelstein, Ying J Hitchcock, Manpreet Bedi, Anurag K Singh, George Dundas, David G Kirsch
PURPOSE: We performed a multi-institutional prospective phase II trial to assess late toxicities in patients with extremity soft tissue sarcoma (STS) treated with preoperative image-guided radiation therapy (IGRT) to a reduced target volume. PATIENTS AND METHODS: Patients with extremity STS received IGRT with (cohort A) or without (cohort B) chemotherapy followed by limb-sparing resection. Daily pretreatment images were coregistered with digitally reconstructed radiographs so that the patient position could be adjusted before each treatment...
July 10, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Rick L M Haas, Thomas F Delaney, Brian O'Sullivan, Ronald B Keus, Cécile Le Pechoux, Patricia Olmi, Jan-Peter Poulsen, Beatrice Seddon, Dian Wang
This critical review will focus on published data on the indications for radiotherapy in patients with extremity soft tissue sarcomas and its role in local control, survival, and treatment complications. The differences between pre- and postoperative radiotherapy will be discussed and consensus recommendations on target volume delineation proposed.
November 1, 2012: International Journal of Radiation Oncology, Biology, Physics
Dian Wang, Walter Bosch, David Roberge, Steven E Finkelstein, Ivy Petersen, Michael Haddock, Yen-Lin E Chen, Naoyuki G Saito, David G Kirsch, Ying J Hitchcock, Aaron H Wolfson, Thomas F DeLaney
OBJECTIVE: To develop a Radiation Therapy Oncology Group (RTOG) atlas delineating gross tumor volume (GTV) and clinical target volume (CTV) to be used for preoperative radiotherapy of primary extremity soft tissue sarcoma (STS). METHODS AND MATERIALS: A consensus meeting was held during the RTOG meeting in January 2010 to reach agreement about GTV and CTV delineation on computed tomography (CT) images for preoperative radiotherapy of high-grade large extremity STS...
November 15, 2011: International Journal of Radiation Oncology, Biology, Physics
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