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Larazotide in celiac disease

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By Manzoor Wani I am a physician with interest in gastroenterology and hepatology
Daniel A Leffler, Ciaran P Kelly, Peter H R Green, Richard N Fedorak, Anthony DiMarino, Wendy Perrow, Henrik Rasmussen, Chao Wang, Premysl Bercik, Natalie M Bachir, Joseph A Murray
BACKGROUND & AIMS: Celiac disease (CeD) is a prevalent autoimmune condition. Recurrent signs and symptoms are common despite treatment with a gluten-free diet (GFD), yet no approved or proven nondietary treatment is available. METHODS: In this multicenter, randomized, double-blind, placebo-controlled study, we assessed larazotide acetate 0.5, 1, or 2 mg 3 times daily to relieve ongoing symptoms in 342 adults with CeD who had been on a GFD for 12 months or longer and maintained their current GFD during the study...
June 2015: Gastroenterology
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