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Neurocognitive disorders

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14 papers 100 to 500 followers
By Abraham Nunes Psychiatry resident interested in computational neuroscience, forensic psychiatry, and neuropsychiatry.
https://www.readbyqxmd.com/read/26595641/frontotemporal-dementia
#1
REVIEW
Jee Bang, Salvatore Spina, Bruce L Miller
Frontotemporal dementia is an umbrella clinical term that encompasses a group of neurodegenerative diseases characterised by progressive deficits in behaviour, executive function, or language. Frontotemporal dementia is a common type of dementia, particularly in patients younger than 65 years. The disease can mimic many psychiatric disorders because of the prominent behavioural features. Various underlying neuropathological entities lead to the frontotemporal dementia clinical phenotype, all of which are characterised by the selective degeneration of the frontal and temporal cortices...
October 24, 2015: Lancet
https://www.readbyqxmd.com/read/26595642/lewy-body-dementias
#2
REVIEW
Zuzana Walker, Katherine L Possin, Bradley F Boeve, Dag Aarsland
The broad importance of dementia is undisputed, with Alzheimer's disease justifiably getting the most attention. However, dementia with Lewy bodies and Parkinson's disease dementia, now called Lewy body dementias, are the second most common type of degenerative dementia in patients older than 65 years. Despite this, Lewy body dementias receive little attention and patients are often misdiagnosed, leading to less than ideal management. Over the past 10 years, considerable effort has gone into improving diagnostic accuracy by refining diagnostic criteria and using imaging and other biomarkers...
October 24, 2015: Lancet
https://www.readbyqxmd.com/read/26595643/vascular-dementia
#3
REVIEW
John T O'Brien, Alan Thomas
Vascular dementia is one of the most common causes of dementia after Alzheimer's disease, causing around 15% of cases. However, unlike Alzheimer's disease, there are no licensed treatments for vascular dementia. Progress in the specialty has been difficult because of uncertainties over disease classification and diagnostic criteria, controversy over the exact nature of the relation between cerebrovascular pathology and cognitive impairment, and the paucity of identifiable tractable treatment targets. Although there is an established relation between vascular and degenerative Alzheimer's pathology, the mechanistic link between the two has not yet been identified...
October 24, 2015: Lancet
https://www.readbyqxmd.com/read/26583316/deep-clinical-and-neuropathological-phenotyping-of-pick-disease
#4
David J Irwin, Johannes Brettschneider, Corey T McMillan, Felicia Cooper, Christopher Olm, Steven E Arnold, Vivianna M Van Deerlin, William W Seeley, Bruce L Miller, Edward B Lee, Virginia M-Y Lee, Murray Grossman, John Q Trojanowski
OBJECTIVE: To characterize sequential patterns of regional neuropathology and clinical symptoms in a well-characterized cohort of 21 patients with autopsy-confirmed Pick disease. METHODS: Detailed neuropathological examination using 70μm and traditional 6μm sections was performed using thioflavin-S staining and immunohistochemistry for phosphorylated tau, 3R and 4R tau isoforms, ubiquitin, and C-terminally truncated tau. Patterns of regional tau deposition were correlated with clinical data...
February 2016: Annals of Neurology
https://www.readbyqxmd.com/read/26347604/disease-modifying-therapeutic-directions-for-lewy-body-dementias
#5
REVIEW
Qiang Zhang, Young-Cho Kim, Nandakumar S Narayanan
Dementia with Lewy bodies (DLB) is the second leading cause of dementia following Alzheimer's disease (AD) and accounts for up to 25% of all dementia. DLB is distinct from AD in that it involves extensive neuropsychiatric symptoms as well as motor symptoms, leads to enormous societal costs in terms of direct medical care and is associated with high financial and caregiver costs. Although, there are no disease-modifying therapies for DLB, we review several new therapeutic directions in treating DLB. We discuss progress in strategies to decrease the level of alpha-synuclein, to prevent the cell to cell transmission of misfolded alpha-synuclein, and the potential of brain stimulation in DLB...
2015: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/26324301/clinical-approach-to-the-differential-diagnosis-between-behavioral-variant-frontotemporal-dementia-and-primary-psychiatric-disorders
#6
Simon Ducharme, Bruce H Price, Mykol Larvie, Darin D Dougherty, Bradford C Dickerson
No abstract text is available yet for this article.
September 1, 2015: American Journal of Psychiatry
https://www.readbyqxmd.com/read/26107053/clinical-practice-advanced-dementia
#7
REVIEW
Susan L Mitchell
New England Journal of Medicine, Volume 372, Issue 26, Page 2533-2540, June 2015.
June 25, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/25958088/psychiatric-symptoms-in-frontotemporal-dementia-epidemiology-phenotypes-and-differential-diagnosis
#8
REVIEW
Daniela Galimberti, Bernardo Dell'Osso, A Carlo Altamura, Elio Scarpini
Frontotemporal dementia (FTD) is the most frequently occurring dementia in the presenile population. Despite epidemiologic data showing that patients with FTD may have experienced previous psychiatric disorders and that patients with psychotic disorders may develop dementia more often than expected in the nonaffected population, the overlap between these two conditions has been underestimated. Nevertheless, the identification in recent years of several genetic causes of FTD associated with heterogeneous and atypical presentations, including pure psychiatric symptoms, has shifted scientific interest back to obtaining a better understanding of common mechanisms between FTD and psychotic disorders...
November 15, 2015: Biological Psychiatry
https://www.readbyqxmd.com/read/25799928/statins-cognition-and-dementia%C3%A2-systematic-review-and-methodological-commentary
#9
REVIEW
Melinda C Power, Jennifer Weuve, A Richey Sharrett, Deborah Blacker, Rebecca F Gottesman
Firm conclusions about whether mid-life or long-term statin use has an impact on cognitive decline and dementia remain elusive. Here, our objective was to systematically review, synthesize and critique the epidemiological literature that examines the relationship between statin use and cognition, so as to assess the current state of knowledge, identify gaps in our understanding, and make recommendations for future research. We summarize the findings of randomized controlled trials (RCTs) and observational studies, grouped according to study design...
April 2015: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/25875310/effect-of-depression-and-diabetes-mellitus-on-the-risk-for-dementia-a-national-population-based-cohort-study
#10
Wayne Katon, Henrik Sondergaard Pedersen, Anette Riisgaard Ribe, Morten Fenger-Grøn, Dimitry Davydow, Frans Boch Waldorff, Mogens Vestergaard
IMPORTANCE: Although depression and type 2 diabetes mellitus (DM) may independently increase the risk for dementia, no studies have examined whether the risk for dementia among people with comorbid depression and DM is higher than the sum of each exposure individually. OBJECTIVE: To examine the risk for all-cause dementia among persons with depression, DM, or both compared with persons with neither exposure. DESIGN, SETTING, AND PARTICIPANTS: We performed a national population-based cohort study of 2 454 532 adults, including 477 133 (19...
June 2015: JAMA Psychiatry
https://www.readbyqxmd.com/read/25795538/suicidal-ideation-and-related-factors-among-dementia-patients
#11
Asuka Koyama, Noboru Fujise, Masateru Matsushita, Tomohisa Ishikawa, Mamoru Hashimoto, Manabu Ikeda
BACKGROUND: It is generally thought that people with dementia are not able to attempt suicide because of impaired executive function. Little research is available about suicidal ideation among dementia patients. The present study examines 1) the sociodemographic and clinical features of dementia patients with suicidal ideation and 2) the effect of suicidal ideation on caregiver burden. METHODS: A total of 634 dementia outpatients and their family caregivers participated in this study...
June 1, 2015: Journal of Affective Disorders
https://www.readbyqxmd.com/read/25514304/the-diagnosis-and-management-of-mild-cognitive-impairment-a-clinical-review
#12
REVIEW
Kenneth M Langa, Deborah A Levine
IMPORTANCE: Cognitive decline is a common and feared aspect of aging. Mild cognitive impairment (MCI) is defined as the symptomatic predementia stage on the continuum of cognitive decline, characterized by objective impairment in cognition that is not severe enough to require help with usual activities of daily living. OBJECTIVE: To present evidence on the diagnosis, treatment, and prognosis of MCI and to provide physicians with an evidence-based framework for caring for older patients with MCI and their caregivers...
December 17, 2014: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/25698435/modifiable-predictors-of-dementia-in-mild-cognitive-impairment-a-systematic-review-and-meta-analysis
#13
REVIEW
Claudia Cooper, Andrew Sommerlad, Constantine G Lyketsos, Gill Livingston
OBJECTIVE: Public health campaigns encouraging early help seeking have increased rates of mild cognitive impairment (MCI) diagnosis in Western countries, but we know little about how to treat or predict dementia outcomes in persons with the condition. METHOD: The authors searched electronic databases and references for longitudinal studies reporting potentially modifiable risk factors for incident dementia after MCI. Two authors independently evaluated study quality using a checklist...
April 2015: American Journal of Psychiatry
https://www.readbyqxmd.com/read/23949827/dementia-and-mild-cognitive-impairment-in-adults-with-intellectual-disability-issues-of-diagnosis
#14
REVIEW
Sharon J Krinsky-McHale, Wayne Silverman
Individuals with intellectual disability (ID) are now living longer with the majority of individuals reaching middle and even "old age." As a consequence of this extended longevity they are vulnerable to the same age-associated health problems as elderly adults in the general population without ID. This includes dementia, a general term referring to a variety of diseases and conditions causing substantial loss of cognitive ability and functional declines; adults with Down syndrome are at especially high risk...
2013: Developmental Disabilities Research Reviews
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