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RHSC Urology

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68 papers 25 to 100 followers RHSC Paediatric Urology interesting papers
By Martyn Flett Consultant paediatric urologist. Glasgow UK.
https://www.readbyqxmd.com/read/16458416/early-start-to-therapy-preserves-kidney-function-in-spina-bifida-patients
#1
COMPARATIVE STUDY
Pieter Dik, Aart J Klijn, Jan D van Gool, Catherine C E de Jong-de Vos van Steenwijk, Tom P V M de Jong
OBJECTIVE: Renal scarring and renal failure remain life-threatening for children born with spinal dysraphism. We reviewed our data of spina bifida patients to evaluate whether optimal treatment of the neurogenic bladder from birth onwards can preserve kidney function. METHODS: We reviewed data on all newborns with spinal dysraphism who were referred to our hospital between January 1988 and June 2001. We looked at their situations at referral and at follow-up: the type of treatment, antimuscarinic agents, clean intermittent catheterisation (CIC), antibiotic prophylaxis, and operations (sling procedures, bladder augmentations, antireflux procedures)...
May 2006: European Urology
https://www.readbyqxmd.com/read/22371315/aetiology-of-hypospadias-a-systematic-review-of-genes-and-environment
#2
REVIEW
L F M van der Zanden, I A L M van Rooij, W F J Feitz, B Franke, N V A M Knoers, N Roeleveld
BACKGROUND: Hypospadias is a common congenital malformation of the male external genitalia. Most cases have an unknown aetiology, which is probably a mix of monogenic and multifactorial forms, implicating both genes and environmental factors. This review summarizes current knowledge about the aetiology of hypospadias. METHODS: Pubmed was used to identify studies on hypospadias aetiology published between January 1995 and February 2011. Reference lists of the selected manuscripts were also searched to identify additional studies, including those published before 1995...
May 2012: Human Reproduction Update
https://www.readbyqxmd.com/read/25725611/environmental-parental-and-gestational-factors-that-influence-the-occurrence-of-hypospadias-in-male-patients
#3
REVIEW
Giacinto Marrocco, Paola Grammatico, Santiago Vallasciani, Caterina Gulia, Andrea Zangari, Francesca Marrocco, Zhoobin Heidari Bateni, Alessandro Porrello, Roberto Piergentili
OBJECTIVE: Hypospadias is a congenital defect, which affects normal development of the male urogenital external tract. In this malformation, the urethral orifice of the penis is positioned ventrally, thus interfering with normal urination and creating, in some adults, problems during sexual intercourse. Heritability of hypospadias has been shown in some reports, and the abnormality has been associated with the presence of mutations in one of the genes involved in urogenital development...
February 2015: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27908364/management-of-urethral-strictures-after-hypospadias-repair
#4
REVIEW
Warren T Snodgrass, Nicol C Bush
Strictures of the neourethra after hypospadias surgery are more common after skin flap repairs than urethral plate or neo-plate tubularizations. The diagnosis of stricture after hypospadias repair is suspected based on symptoms of stranguria, urinary retention, and/or urinary tract infection. It is confirmed by urethroscopy during anticipated repair, without preoperative urethrography. The most common repairs for neourethra stricture after hypospadias surgery are single-stage dorsal inlay graft and 2-stage labial mucosa replacement urethroplasty...
February 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/27989535/history-of-hypospadias-lost-in-translation
#5
Ahmed T Hadidi
The evolution of hypospadias surgery can be classified under 3 periods that were closely related to advances in surgical instruments, introduction of anesthesia, and newer suture materials. Stretching dominated the early period, tunneling during the Middle Ages, and flaps during the modern period. Suture materials have included at various time silver wires, horsehair, and stainless steel. Examination and translation of the original manuscripts showed that Galen recommended stretching and suturing of glanular hypospadias and not amputation or partial penectomy as has been currently reported...
February 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27990598/disorders-of-sex-development-dsd-not-only-babies-with-ambiguous-genitalia-a-practical-guide-for-surgeons
#6
REVIEW
Irene Kearsey, John M Hutson
INTRODUCTION AND METHODS: In this review, we describe the common clinical scenarios that may be present to a paediatric surgeon when a patient has a disorder of sex development (DSD). Our aim was to prepare surgeons so that they can respond with correct approaches to diagnose and manage the given situations. RESULTS: DSD present in three distinct clinical situations: in the neonate with some abnormality of the external genitalia; in the child undergoing surgical treatment for inguinal hernia or during open or laparoscopic orchidopexy or during hypospadias correction; and at or after puberty, which may be precocious or delayed or in an adolescent girl with masculinisation at puberty...
March 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28036072/maternal-exposure-to-domestic-hair-cosmetics-and-occupational-endocrine-disruptors-is-associated-with-a-higher-risk-of-hypospadias-in-the-offspring
#7
Elodie Haraux, Karine Braun, Philippe Buisson, Erwan Stéphan-Blanchard, Camille Devauchelle, Jannick Ricard, Bernard Boudailliez, Pierre Tourneux, Richard Gouron, Karen Chardon
Pregnant women are exposed to various chemical products at home and at work. Some of these products contain endocrine-disrupting chemicals (EDCs) such as cosmetics, pesticides, industrial chemicals, heavy metals, plastics or medications that could alter sexual differentiation and increase the risk of hypospadias. We evaluated maternal occupational and household exposures that could constitute risk factors for hypospadias. From 2011 to 2014, we enrolled 57 full-term newborns with hypospadias and three randomly selected controls per case (162 control newborns), matched for gestational age, from 11 maternity units in Picardy, France...
December 29, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28043016/flutamide-induced-hypospadias-in-rats-a-critical-assessment
#8
Adriane Watkins Sinclair, Mei Cao, Andrew Pask, Laurence Baskin, Gerald R Cunha
This paper provides the first detailed description of flutamide-induced hypospadias in the rat based upon wholemount, histologic, three-dimensional reconstruction, scanning electron microscopic, and immunocytochemical analysis. The penile malformations elicited by this potent anti-androgen include a substantial proximal shift in the urethral meatus that clearly conforms to the definition of hypospadias based upon specific morphological criteria for this malformation. Through examination of the normal penile development and flutamide-induced abnormal penile development observed in prenatally oil- and flutamide-treated rats, our analysis provides insights into the morphogenetic mechanism of development of hypospadias...
March 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/28043766/re-operative-urethroplasty-after-failed-hypospadias-repair-how-prior-surgery-impacts-risk-for-additional-complications
#9
W Snodgrass, N C Bush
PURPOSE: The primary aim of this report was to compare urethroplasty complications for primary distal and proximal repairs with those after 1, 2, 3, and 4 or more re-operations. METHODS: Prospectively collected data on consecutive hypospadias repairs (tubularized incised plate (TIP), inlay, two-stage graft) from 2000 to 2015 were reviewed. Isolated fistula closures were excluded. Extracted information included patient age, meatal location, repair type, primary vs...
December 7, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28057982/primary-hypospadias-repair-techniques-a-review-of-the-evidence
#10
REVIEW
Warren Snodgrass, Nicol Bush
This review summarizes data regarding commonly used surgical techniques to repair distal and proximal hypospadias. We review evidence concerning indications for various procedures used in primary hypospadias repair, and their complications, urinary function and esthetic results. Available evidence suggests TIP is preferable to Mathieu for distal hypospadias correction. Current data do not identify a clear preference between TIP and onlay flap for proximal repair when there is ventral curvature <30°, or between various flap and graft options when curvature is >31°...
October 2016: Urology Annals
https://www.readbyqxmd.com/read/28089110/recurrence-after-management-of-meatal-balanitis-xerotica-obliterans
#11
Warren Snodgrass, Juan Soto Blanquel, Nicol Corbin Bush
INTRODUCTION: We review outcomes after management of meatal balanitis xerotica obliterans (BXO). The primary outcome was recurrent meatal BXO. METHODS: A database comprising mostly hypospadias patients was queried for meatal BXO. The disease was confirmed histologically in all cases. Management included topical steroids and/or immunosuppressants, and/or surgical excision of BXO with two-stage oral mucosa graft circumferential replacement urethroplasty. RESULTS: A total of 12 patients had meatal BXO (8 boys and 4 adults)...
November 23, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/2079080/management-of-neurogenic-bladder-dysfunction-secondary-to-myelomeningocele
#12
M Castro-Gago, I Novo, A Cimadevila, J Peña, A Rodriguez-Núñez, A Marqués'-Queimadelos
We investigated 55 children, aged from 24 months to 14 years with neurogenic bladder dysfunction secondary to myelomeningocele, by serial urodynamic. They were serially evaluation over 2-5 years. Management consisted of drug therapy together with intermittent vesical catheterization in different combinations on the basis of initial urodynamic assessment. In 5 children with a hypotonic sphincter, it was necessary to implant an artificial sphincter. With this regimen control or frank improvement of micturition was achieved in 53 patients, urodynamic function became normal or improved in 54, and recurrent urinary tract infections persisted only in 5 patients...
November 1990: European Journal of Pediatrics
https://www.readbyqxmd.com/read/650768/the-role-of-adjunctive-drug-therapy-for-intermittent-catheterization-and-self-catheterization-in-children-with-vesical-dysfunction
#13
N Hilwa, A D Perlmutter
Thirty-nine children with vesical dysfunction were managed with clean intermittent catheterization. Most children achieved effective urinary continence, the majority with the help of adjunctive drug therapy to relax the detrusor, contract the bladder neck or both. Intermittent catheterization had a generally favourable effect on infection, reflux and hydronephrosis. Intermittent catheterization in childhood is a perferred alternative to urinary diversion in cases of neurogenic bladder dysfunction.
April 1978: Journal of Urology
https://www.readbyqxmd.com/read/3439656/-combination-of-drugs-and-clean-intermittent-catheterization-in-the-treatment-of-neurogenic-bladder-effect-on-continence
#14
J Jiménez, D Arruebarrena, J Rodríguez, M A Urbieta, M Arriola, R Aresès
We report the results obtained with the association of drugs with clean intermittent catheterization (CIC) in 13 patients with neurogenic bladder due to spina bifida. The drugs used were bladder muscle relaxants (imipramine), anticholinergic (probanthine) and/or alpha-adrenergic (ephedrine). CIC alone led to acceptable continence in only 24% of cases, whereas with the addition of drugs this proportion increased to 80%. All along the treatment upper urinary tract remained stable in all patients, there were no changes in asymptomatic bacteriuria when present and collateral effects were minimal...
November 1987: Anales Españoles de Pediatría
https://www.readbyqxmd.com/read/1129889/ephedrine-in-treatment-of-urinary-incontinence
#15
A C Diokno, M Taub
Patients with urinary incontinence caused by various urologic disorders were evaluated and treated with oral ephedrine sulfate. The drug was found to improve continence in those patients with mild degrees of wetting due to urethral dysfunction regardless of cause. The failures occurred in severely damaged posterior urethras or denervated bladders and urogenital diaphragms.
May 1975: Urology
https://www.readbyqxmd.com/read/4591726/continence-training-of-children-with-neurogenic-bladder-dysfunction
#16
A Nergårdh, C von Hedenberg, B Hellström, N O Ericsson
No abstract text is available yet for this article.
February 1974: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27798415/recent-findings-on-the-genetics-of-disorders-of-sex-development
#17
Jessica Kremen, Yee-Ming Chan, Jonathan M Swartz
PURPOSE OF REVIEW: Disorders of sex development (DSD) are a diverse group of conditions affecting gonadal development, sexual differentiation, or chromosomal sex. In this review, we will discuss recent literature on the genetic causes of DSD, with a focus on novel genetic sequencing technologies, new phenotypes associated with known DSD genes, and increasing recognition of the role of genetic regulatory elements in DSD. RECENT FINDINGS: We performed a comprehensive search of PubMed through August 2016 to identify important peer-reviewed publications from 2015 to 2016 on the topic of DSD genetics...
January 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/26496454/remote-ischemic-preconditioning-and-protection-of-the-kidney-a-novel-therapeutic-option
#18
Alexander Zarbock, John A Kellum
OBJECTIVE: Acute kidney injury is a common complication in critically ill patients and is associated with increased morbidity and mortality. Sepsis, major surgery, and nephrotoxic drugs are the most common causes of acute kidney injury. There is currently no effective strategy available to prevent or treat acute kidney injury. Therefore, novel treatment regimens are required to decrease acute kidney injury prevalence and to improve clinical outcomes. Remote ischemic preconditioning, triggered by brief episodes of ischemia and reperfusion applied in distant tissues or organs before the injury of the target organ, attempts to invoke adaptive responses that protect against acute kidney injury...
March 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/24309187/remote-ischemic-preconditioning-and-renoprotection-from-myth-to-a-novel-therapeutic-option
#19
REVIEW
Natig Gassanov, Amir M Nia, Evren Caglayan, Fikret Er
There is currently no effective prophylactic regimen available to prevent contrast-induced AKI (CI-AKI), a frequent and life-threatening complication after cardiac catheterization. Therefore, novel treatment strategies are required to decrease CI-AKI incidence and to improve clinical outcomes in these patients. Remote ischemic preconditioning (rIPC), defined as transient brief episodes of ischemia at a remote site before a subsequent prolonged ischemia/reperfusion injury of the target organ, is an adaptational response that protects against ischemic and reperfusion insult...
February 2014: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/25772695/the-standardization-of-terminology-of-lower-urinary-tract-function-in-children-and-adolescents-update-report-from-the-standardization-committee-of-the-international-children-s-continence-society
#20
Paul F Austin, Stuart B Bauer, Wendy Bower, Janet Chase, Israel Franco, Piet Hoebeke, Søren Rittig, Johan Vande Walle, Alexander von Gontard, Anne Wright, Stephen S Yang, Tryggve Nevéus
AIM: The impact of the original International Children's Continence Society (ICCS) terminology document on lower urinary tract (LUT) function resulted in the global establishment of uniformity and clarity in the characterization of LUT function and dysfunction in children across multiple healthcare disciplines. The present document serves as a stand-alone terminology update reflecting refinement and current advancement of knowledge on pediatric LUT function. METHODS: A variety of worldwide experts from multiple disciplines within the ICCS leadership who care for children with LUT dysfunction were assembled as part of the standardization committee...
April 2016: Neurourology and Urodynamics
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