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Opioids

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1 papers 0 to 25 followers
By Abraham Nunes Psychiatry resident interested in computational neuroscience, forensic psychiatry, and neuropsychiatry.
https://www.readbyqxmd.com/read/25637939/understanding-opioid-reward
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Howard L Fields, Elyssa B Margolis
Opioids are the most potent analgesics in clinical use; however, their powerful rewarding properties can lead to addiction. The scientific challenge is to retain analgesic potency while limiting the development of tolerance, dependence, and addiction. Both rewarding and analgesic actions of opioids depend upon actions at the mu opioid (MOP) receptor. Systemic opioid reward requires MOP receptor function in the midbrain ventral tegmental area (VTA) which contains dopaminergic neurons. VTA dopaminergic neurons are implicated in various aspects of reward including reward prediction error, working memory, and incentive salience...
April 2015: Trends in Neurosciences
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