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Acupuncture and neurologic disorders

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224 papers 25 to 100 followers Use of acupuncture to modulate the neuroplastic changes ocurred in the peripheral and central nervous Systems in crônica and açude pain patients
By Hugo Silva Pinto Sports medicine MD, neuromuscular pain and dysfunctions private practice
https://www.readbyqxmd.com/read/25797991/successful-transplantation-of-motoneurons-into-the-peripheral-nerve-depends-on-the-number-of-transplanted-cells
#1
Shuichi Kato, Shigeru Kurimoto, Tomonori Nakano, Hidemasa Yoneda, Hisao Ishii, Satoka Mita-Sugiura, Hitoshi Hirata
Transplantation of motoneurons (MN) into the peripheral nerve to provide a source of neurons for muscle reinnervation, termed motoneuron integrated striated muscle (MISM), may provide the potential to restore functional muscle activity, when combined with computer-programmed functional electrical stimulation (FES). The number of MNs required to restore innervation to denervated muscles in adult Fischer 344 rats was investigated by comparing two groups, one transplanted with 2 × 10(5) cells (group A) and the other with 1 × 10(6) cells (group B)...
February 2015: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/25839841/microcirculation-in-the-foot-is-augmented-by-neuromuscular-stimulation-via-the-common-peroneal-nerve-in-different-lower-limb-postures-a-potential-treatment-for-leg-ulcers
#2
D Warwick, A Shaikh, P Worsley, S Gadola, D Bain, A Tucker, S D Gadola, M Stokes
AIM: Aim of the study was to examine the effects of the geko™ device (a portable electical nerve stimulator) on microcirculatory flow on the dorsum of the foot, and whether this is influenced by lower limb postures and application of a plaster cast. METHODS: This was a cross-sectional, healthy cohort, open label, physiological response study. In 10 healthy volunteers, aged 19 to 24 years, laser Doppler fluxmetry measurements were made on the dorsum of the foot in four postures: standing (weight bearing and non-weight bearing) and supine lying (with the lower limb horizontal and then elevated)...
April 2015: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29250675/acupuncture-causes-serotonin-release-by-mast-cells
#3
Nikolay Dimitrov, Dimitrinka Atanasova, Nikola Tomov, Dimitar Sivrev, Nikolai Lazarov
Mast cells (MCs) are important object in experimental acupuncture due to their putative involvement in local reactions to needling. In the rat, they are shown to contain in their granules, among other tissue mediators, serotonin, also called 5-hydroxytryptamine (5-HT). The aim of this study is to examine the normal distribution of 5-HT-containing MCs in soft tissues of Zusanli (ST36) acupuncture point (acupoint) and their morphological changes caused by experimental acupuncture. We observed 5-HT-immunopositive MCs in the tissues and in the vicinity of the needle tract formed after acupuncture...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29325883/a-functional-neuroimaging-study-of-expectancy-effects-on-pain-response-in-patients-with-knee-osteoarthritis
#4
Randy L Gollub, Irving Kirsch, Nasim Maleki, Ajay D Wasan, Robert R Edwards, Yiheng Tu, Ted J Kaptchuk, Jian Kong
Placebo treatments and healing rituals share much in common, such as the effects of expectancy, and have been used since the beginning of human history to treat pain. Previous mechanistic neuroimaging studies investigating the effects of expectancy on placebo analgesia have used young, healthy volunteers. Using functional magnetic resonance imaging (fMRI), we aimed to investigate the neural mechanisms by which expectancy evokes analgesia in older adults living with a chronic pain disorder and determine whether there are interactions with active treatment...
January 8, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29302197/amygdala-plasticity-and-pain
#5
REVIEW
Jeremy M Thompson, Volker Neugebauer
The amygdala is a limbic brain region that plays a key role in emotional processing, neuropsychiatric disorders, and the emotional-affective dimension of pain. Preclinical and clinical studies have identified amygdala hyperactivity as well as impairment of cortical control mechanisms in pain states. Hyperactivity of basolateral amygdala (BLA) neurons generates enhanced feedforward inhibition and deactivation of the medial prefrontal cortex (mPFC), resulting in pain-related cognitive deficits. The mPFC sends excitatory projections to GABAergic neurons in the intercalated cell mass (ITC) in the amygdala, which project to the laterocapsular division of the central nucleus of the amygdala (CeLC; output nucleus) and serve gating functions for amygdala output...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29178034/pharmacotherapy-for-neuropathic-pain-a-review
#6
REVIEW
Diego Fornasari
Neuropathic pain, comprising a range of heterogeneous conditions, is often severe and difficult to manage, and this may result in a chronic condition that negatively affects the overall functioning and quality of life in patients. The pharmacotherapy of neuropathic pain is challenging and for many patients effective treatment is lacking; therefore, evidence-based recommendations are essential. Currently, there is general agreement on which drugs are appropriate for the first-line treatment of neuropathic pain, whereas debate continues regarding second- and third-line treatments...
December 2017: Pain and Therapy
https://www.readbyqxmd.com/read/29276402/ganglion-blocks-as-a-treatment-of-pain-current-perspectives
#7
REVIEW
Osman Hakan Gunduz, Ozge Kenis-Coskun
The inputs from sympathetic ganglia have been known to be involved in the pathophysiology of various painful conditions such as complex regional pain syndrome, cancer pain of different origin, and coccygodynia. Sympathetic ganglia blocks are used to relieve patients who suffer from these conditions for over a century. Many numbers of local anesthetics such as bupivacaine or neurolytic agents such as alcohol can be chosen for a successful block. The agent is selected according to its duration of effect and the purpose of the injection...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29251663/pain-or-nociception-subjective-experience-mediates-the-effects-of-acute-noxious-heat-on-autonomic-responses
#8
Dominik Mischkowski, Esther E Palacios-Barrios, Lauren Banker, Troy C Dildine, Lauren Y Atlas
Nociception reliably elicits an autonomic nervous system (ANS) response. Because pain and ANS circuitry interact on multiple spinal, subcortical, and cortical levels, it remains unclear whether autonomic responses are simply a reflexive product of noxious stimulation regardless of how stimulation is consciously perceived or whether the experience of pain mediates ANS responses to noxious stimulation. To test these alternative predictions, we examined the relative contribution of noxious stimulation and individual pain experience to ANS responses in healthy volunteers who underwent one or two pain assessment tasks...
December 13, 2017: Pain
https://www.readbyqxmd.com/read/29249383/neuropathic-pain-and-sci-identification-and-treatment-strategies-in-the-21st-century
#9
REVIEW
Maya N Hatch, Timothy R Cushing, Gregory D Carlson, Eric Y Chang
Pain is a common complication in patients following spinal cord injury (SCI), with studies citing up to 80% of patients reporting some form of pain. Neuropathic pain (NP) makes up a substantial percentage of all pain symptoms in patients with SCI and is often complex. Given the high prevalence of NP in patients with SCI, proper identification and treatment is imperative. Indeed, identification of pain subtypes is a vital step toward determining appropriate treatment. A variety of pharmacological and non-pharmacological treatments can be undertaken including antiepileptics, tricyclic antidepressants, opioids, transcranial direct current stimulation, and invasive surgical procedures...
January 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29282613/regulation-of-pain-and-itch-by-trp-channels
#10
REVIEW
Carlene Moore, Rupali Gupta, Sven-Eric Jordt, Yong Chen, Wolfgang B Liedtke
Nociception is an important physiological process that detects harmful signals and results in pain perception. In this review, we discuss important experimental evidence involving some TRP ion channels as molecular sensors of chemical, thermal, and mechanical noxious stimuli to evoke the pain and itch sensations. Among them are the TRPA1 channel, members of the vanilloid subfamily (TRPV1, TRPV3, and TRPV4), and finally members of the melastatin group (TRPM2, TRPM3, and TRPM8). Given that pain and itch are pro-survival, evolutionarily-honed protective mechanisms, care has to be exercised when developing inhibitory/modulatory compounds targeting specific pain/itch-TRPs so that physiological protective mechanisms are not disabled to a degree that stimulus-mediated injury can occur...
December 27, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29246472/muscle-tension-increases-impact-force-but-decreases-energy-absorption-and-pain-during-visco-elastic-impacts-to-human-thighs
#11
Felix Tsui, Matthew T G Pain
Despite uncertainty of its exact role, muscle tension has shown an ability to alter human biomechanical response and may have the ability to reduce impact injury severity. The aim of this study was to examine the effects of muscle tension on human impact response in terms of force and energy absorbed and the subjects' perceptions of pain. Seven male martial artists had a 3.9 kg medicine ball dropped vertically from seven different heights, 1.0-1.6 m in equal increments, onto their right thigh. Subjects were instructed to either relax or tense the quadriceps via knee extension (≥60% MVC) prior to each impact...
December 6, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28979762/ketamine-for-pain
#12
REVIEW
Kelly Jonkman, Albert Dahan, Tine van de Donk, Leon Aarts, Marieke Niesters, Monique van Velzen
The efficacy of the N-methyl-D-aspartate receptor antagonist ketamine as an analgesic agent is still under debate, especially for indications such as chronic pain. To understand the efficacy of ketamine for relief of pain, we performed a literature search for relevant narrative and systematic reviews and meta-analyses. We retrieved 189 unique articles, of which 29 were deemed appropriate for use in this review. Ketamine treatment is most effective for relief of postoperative pain, causing reduced opioid consumption...
2017: F1000Research
https://www.readbyqxmd.com/read/29172647/clinical-utility-of-the-sport-concussion-assessment-tool-3-scat3-tandem-gait-test-in-high-school-athletes
#13
Ashley Santo, Robert C Lynall, Kevin M Guskiewicz, Jason P Mihalik
CONTEXT:   Dynamic balance during functional movement may provide important clinical information after concussion. The Sport Concussion Assessment Tool version 3 (SCAT3) includes a timed tandem-gait test (heel-to-toe walking) administered with a pass-fail scoring system. Minimal evidence supports inclusion of the tandem-gait test in the SCAT3, especially in high school athletes. OBJECTIVE:   To determine (1) the percentage of healthy high school athletes who passed (best trial ≤14 seconds) the tandem-gait test at baseline, (2) the association between sex and test performance (pass versus fail), and (3) the relationship among sex, age, height, and tandem-gait test score...
November 27, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/27632349/the-effects-of-electroacupuncture-on-the-apelin-apj-system-in-the-spinal-cord-of-rats-with-inflammatory-pain
#14
Ke Wang, Ziyong Ju, Yue Yong, Tongyu Chen, Jiangang Song, Jia Zhou
BACKGROUND: Electroacupuncture (EA) is widely applied for pain management, but the analgesic effects of EA have not been fully elucidated. In this study, we investigated the effect of EA on inflammatory pain caused by intraplantar injection of complete Freund's adjuvant (CFA) and apelin/APJ expression in the spinal cord of rats. METHODS: The study was conducted in 3 parts. In part 1, Sprague-Dawley rats were divided into 4 groups (n = 10): sham, CFA, EA (CFA + 2 Hz EA at acupoints), and NA-EA (CFA + acupuncture without electrical stimulation)...
December 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27908839/the-transition-of-acute-postoperative-pain-to-chronic-pain-an-integrative-overview-of-research-on-mechanisms
#15
REVIEW
C Richard Chapman, Charles J Vierck
The nature of the transition from acute to chronic pain still eludes explanation, but chronic pain resulting from surgery provides a natural experiment that invites clinical epidemiological investigation and basic scientific inquiry into the mechanisms of this transition. The primary purpose of this article is to review current knowledge and hypotheses on the transition from acute to persistent postsurgical pain, summarizing literature on clinical epidemiological studies of persistent postsurgical pain development, as well as basic neurophysiological studies targeting mechanisms in the periphery, spinal cord, and brain...
April 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28129218/neurobiological-basis-for-pain-vulnerability-why-me
#16
Franziska Denk, Stephen B McMahon
No abstract text is available yet for this article.
April 2017: Pain
https://www.readbyqxmd.com/read/28254585/the-potential-role-of-sensory-testing-skin-biopsy-and-functional-brain-imaging-as-biomarkers-in-chronic-pain-clinical-trials-immpact-considerations
#17
REVIEW
Shannon M Smith, Robert H Dworkin, Dennis C Turk, Ralf Baron, Michael Polydefkis, Irene Tracey, David Borsook, Robert R Edwards, Richard E Harris, Tor D Wager, Lars Arendt-Nielsen, Laurie B Burke, Daniel B Carr, Amy Chappell, John T Farrar, Roy Freeman, Ian Gilron, Veeraindar Goli, Juergen Haeussler, Troels Jensen, Nathaniel P Katz, Jeffrey Kent, Ernest A Kopecky, David A Lee, William Maixner, John D Markman, Justin C McArthur, Michael P McDermott, Lav Parvathenani, Srinivasa N Raja, Bob A Rappaport, Andrew S C Rice, Michael C Rowbotham, Jeffrey K Tobias, Ajay D Wasan, James Witter
Valid and reliable biomarkers can play an important role in clinical trials as indicators of biological or pathogenic processes or as a signal of treatment response. Currently, there are no biomarkers for pain qualified by the U.S. Food and Drug Administration or the European Medicines Agency for use in clinical trials. This article summarizes an Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials meeting in which 3 potential biomarkers were discussed for use in the development of analgesic treatments: 1) sensory testing, 2) skin punch biopsy, and 3) brain imaging...
July 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28301400/the-role-of-calcitonin-gene-related-peptide-in-peripheral-and-central-pain-mechanisms-including-migraine
#18
REVIEW
Smriti Iyengar, Michael H Ossipov, Kirk W Johnson
Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide found primarily in the C and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the central nervous system. Calcitonin gene-related peptide was found to play important roles in cardiovascular, digestive, and sensory functions. Although the vasodilatory properties of CGRP are well documented, its somatosensory function regarding modulation of neuronal sensitization and of enhanced pain has received considerable attention recently...
April 2017: Pain
https://www.readbyqxmd.com/read/28403399/the-role-of-microglia-in-the-pathobiology-of-neuropathic-pain-development-what-do-we-know
#19
H Zhao, A Alam, Q Chen, M A Eusman, A Pal, S Eguchi, L Wu, D Ma
Neuropathic pain, a maladaptive and chronic condition that can develop after a lesion or disease affecting the somatosensory system, is characterized by allodynia, hyperalgesia and spontaneous pain, and comorbidities such as sleep deprivation, depression and anxiety. The activation of microglial cells in response to nerve injury has been implicated in the development of neuropathic pain. Mediators such as Neuregulin-1, matrix metalloproteinase (MMP)-2, MMP-9, The chemokine (C-C motif) ligand 2 (CCL2) and fractalkine are released after nerve injury and are involved in the activation of microglial cells...
April 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28400293/the-dorsolateral-prefrontal-cortex-in-acute-and-chronic-pain
#20
David A Seminowicz, Massieh Moayedi
The dorsolateral prefrontal cortex (DLPFC) is a functionally and structurally heterogeneous region and a key node of several brain networks, implicated in cognitive, affective, and sensory processing. As such, the DLPFC is commonly activated in experimental pain studies, and shows abnormally increased function in chronic pain populations. Furthermore, several studies have shown that some chronic pains are associated with decreased left DLPFC gray matter and that successful interventions can reverse this structural abnormality...
September 2017: Journal of Pain: Official Journal of the American Pain Society
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