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39 papers 0 to 25 followers Interested in managing lipid disorders? Check it out-
By Michael Kelly Assistant Professor
https://www.readbyqxmd.com/read/30054248/ethnic-differences-in-plasma-lipid-levels-in-a-large-multiethnic-cohort-the-helius-study
#1
Katia Gazzola, Marieke B Snijder, G Kees Hovingh, Erik S G Stroes, Ron J G Peters, Bert-Jan H van den Born
BACKGROUND: There is limited information on differences in plasma lipid levels among the major ethnic groups in Europe. OBJECTIVE: We investigated ethnic differences in plasma lipid levels in a large multiethnic cohort and explored the contribution of obesity and other determinants to ethnic differences in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels. METHODS: We compared lipid profiles among 21,617 participants (aged 18 to 70 years) of Moroccan, Ghanaian, South Asian Surinamese, African Surinamese, Turkish and Dutch ethnic origin, living in Amsterdam, the Netherlands...
July 4, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29903845/adiponectin-free-fatty-acids-and-cardiovascular-outcomes-in-patients-with-type-2-diabetes-and-acute-coronary-syndrome
#2
Ilse C Schrieks, Anna Nozza, Barbara E Stähli, John B Buse, Robert R Henry, Klas Malmberg, Bruce Neal, Stephen J Nicholls, Lars Rydén, Linda Mellbin, Anders Svensson, Hans Wedel, Arlette Weichert, A Michael Lincoff, Jean-Claude Tardif, Diederick E Grobbee, Gregory G Schwartz
OBJECTIVE: In observational cohorts, adiponectin is inversely associated and free fatty acids (FFAs) are directly associated with incident coronary heart disease (CHD). Adiponectin tends to be reduced and FFAs elevated in type 2 diabetes. We investigated relationships of adiponectin and FFA and major adverse cardiovascular events (MACEs) and death in patients with acute coronary syndrome (ACS) and type 2 diabetes using data from the AleCardio (Effect of Aleglitazar on Cardiovascular Outcomes After Acute Coronary Syndrome in Patients With Type 2 Diabetes Mellitus) trial, which compared the PPAR-α/γ agonist aleglitazar with placebo...
August 2018: Diabetes Care
https://www.readbyqxmd.com/read/29290500/palmitic-and-oleic-acid-the-yin-and-yang-of-fatty-acids-in-type-2-diabetes-mellitus
#3
REVIEW
Xavier Palomer, Javier Pizarro-Delgado, Emma Barroso, Manuel Vázquez-Carrera
Increased plasma non-esterified fatty acids (NEFAs) link obesity with insulin resistance and type 2 diabetes mellitus (T2DM). However, in contrast to the saturated FA (SFA) palmitic acid, the monounsaturated FA (MUFA) oleic acid elicits beneficial effects on insulin sensitivity, and the dietary palmitic acid:oleic acid ratio impacts diabetes risk in humans. Here we review recent mechanistic insights into the beneficial effects of oleic acid compared with palmitic acid on insulin resistance and T2DM, including its anti-inflammatory actions, and its capacity to inhibit endoplasmic reticulum (ER) stress, prevent attenuation of the insulin signaling pathway, and improve β cell survival...
March 2018: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29760220/quantifying-atherogenic-lipoproteins-current-and-future-challenges-in-the-era-of-personalized-medicine-and-very-low-concentrations-of-ldl-cholesterol-a-consensus-statement-from-eas-and-eflm
#4
Michel R Langlois, M John Chapman, Christa Cobbaert, Samia Mora, Alan T Remaley, Emilio Ros, Gerald F Watts, Jan Borén, Hannsjörg Baum, Eric Bruckert, Alberico Catapano, Olivier S Descamps, Arnold von Eckardstein, Pia R Kamstrup, Genovefa Kolovou, Florian Kronenberg, Anne Langsted, Kari Pulkki, Nader Rifai, Grazyna Sypniewska, Olov Wiklund, Børge G Nordestgaard
BACKGROUND: The European Atherosclerosis Society-European Federation of Clinical Chemistry and Laboratory Medicine Consensus Panel aims to provide recommendations to optimize atherogenic lipoprotein quantification for cardiovascular risk management. CONTENT: We critically examined LDL cholesterol, non-HDL cholesterol, apolipoprotein B (apoB), and LDL particle number assays based on key criteria for medical application of biomarkers. ( a ) Analytical performance: Discordant LDL cholesterol quantification occurs when LDL cholesterol is measured or calculated with different assays, especially in patients with hypertriglyceridemia >175 mg/dL (2 mmol/L) and low LDL cholesterol concentrations <70 mg/dL (1...
July 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29699917/high-density-lipoprotein-cholesterol-and-causes-of-death-in-chronic-kidney-disease
#5
Sankar D Navaneethan, Jesse D Schold, Carl P Walther, Susana Arrigain, Stacey E Jolly, Salim S Virani, Wolfgang C Winkelmayer, Joseph V Nally
BACKGROUND: Recent data suggest a U-shaped association between high-density lipoprotein cholesterol (HDL-c) and death in chronic kidney disease (CKD). However, whether the increased mortality in patients with extreme levels is explained by specific causes of death remains unclear. OBJECTIVES: We studied the associations between HDL-c and cause-specific deaths in CKD. METHODS: We included 38,377 patients with estimated glomerular filtration rate 15-59 mL/min/1...
July 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29685592/clinical-features-and-outcomes-of-severe-very-severe-and-extreme-hypertriglyceridemia-in-a-regional-health-service
#6
Barak Zafrir, Ayman Jubran, Rawan Hijazi, Chen Shapira
BACKGROUND: Comprehensive data on severe hypertriglyceridemia (HTG) in the general population setting are limited and of importance due to the increase in metabolic risk factors and novel therapies under development. OBJECTIVE: To investigate contributing causes and outcomes of severe to extreme HTG. METHODS: Regional database retrospectively analyzed for subjects with severe HTG. Adverse outcomes were investigated in correlation to HTG severity, with follow-up initiating at first documentation of HTG > 1000 mg/dL...
March 30, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29454678/treatment-of-coenzyme-q10-for-24-weeks-improves-lipid-and-glycemic-profile-in-dyslipidemic-individuals
#7
Peiwen Zhang, Chen Yang, Honghui Guo, Jiaji Wang, Shengqiang Lin, Huamei Li, Yan Yang, Wenhua Ling
BACKGROUND: The use of coenzyme Q10 (CoQ10) as an adjuvant treatment with routine clinical therapy against metabolic diseases has shown benefit. However, the effect of CoQ10 as a primary preventive agent against cardiovascular diseases (CVDs) has not been well studied. OBJECTIVE: The objective of this study was to investigate the effect of CoQ10 on CVD risk factors in dyslipidemic patients. METHODS: In this randomized, double-blinded, placebo-controlled trial, 101 dyslipidemic subjects without taking any hypoglycemic or hypolipidemic drugs were administrated to 120 mg CoQ10 or placebo daily for 24 weeks...
March 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29398429/clinical-and-pathophysiological-evidence-supporting-the-safety-of-extremely-low-ldl-levels-the-zero-ldl-hypothesis
#8
REVIEW
Luis Masana, Josefa Girona, Daiana Ibarretxe, Ricardo Rodríguez-Calvo, Roser Rosales, Joan-Carles Vallvé, Cèlia Rodríguez-Borjabad, Montserrat Guardiola, Marina Rodríguez, Sandra Guaita-Esteruelas, Iris Oliva, Neus Martínez-Micaelo, Mercedes Heras, Raimon Ferré, Josep Ribalta, Núria Plana
While the impact of very low concentrations of low-density lipoprotein cholesterol (LDL-C) on cardiovascular prevention is very reassuring, it is intriguing to know what effect these extremely low LDL-C concentrations have on lipid homoeostasis. The evidence supporting the safety of extremely low LDL levels comes from genetic studies and clinical drug trials. Individuals with lifelong low LDL levels due to mutations in genes associated with increased LDL-LDL receptor (LDLR) activity reveal no safety issues...
March 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29298800/effects-of-pemafibrate-a-novel-selective-ppar%C3%AE-modulator-on-lipid-and-glucose-metabolism-in-patients-with-type-2-diabetes-and-hypertriglyceridemia-a-randomized-double-blind-placebo-controlled-phase-3-trial
#9
RANDOMIZED CONTROLLED TRIAL
Eiichi Araki, Shizuya Yamashita, Hidenori Arai, Koutaro Yokote, Jo Satoh, Toyoshi Inoguchi, Jiro Nakamura, Hiroshi Maegawa, Narihito Yoshioka, Yukio Tanizawa, Hirotaka Watada, Hideki Suganami, Shun Ishibashi
OBJECTIVE: Type 2 diabetes is frequently complicated with atherogenic dyslipidemia. This study aimed to evaluate the efficacy and safety of pemafibrate (K-877) in patients with type 2 diabetes comorbid with hypertriglyceridemia. RESEARCH DESIGN AND METHODS: Patients were randomly assigned to three groups and received placebo ( n = 57), 0.2 mg/day pemafibrate ( n = 54), or 0.4 mg/day pemafibrate ( n = 55) for 24 weeks (treatment period 1). Subsequently, the patients received follow-up treatment for another 28 weeks (treatment period 2), in which the placebo was switched to 0...
March 2018: Diabetes Care
https://www.readbyqxmd.com/read/29246729/a-comparison-of-the-effects-of-low-and-high-dose-atorvastatin-on-lipoprotein-metabolism-and-inflammatory-cytokines-in-type-2-diabetes-results-from-the-protection-against-nephropathy-in-diabetes-with-atorvastatin-panda-randomized-trial
#10
Handrean Soran, Yifen Liu, Safwaan Adam, Tarza Siahmansur, Jan H Ho, Jonathan D Schofield, See Kwok, Matthew Gittins, Michael France, Naveed Younis, J Martin Gibson, Paul N Durrington, Martin K Rutter
BACKGROUND: Statin therapy is recommended in type 2 diabetes (T2DM) although views on treatment intensity and therapeutic targets remain divided. OBJECTIVES: Our objectives were to compare the effects of high-intensity and moderate-intensity atorvastatin treatment on lipoprotein metabolism and inflammatory markers and how frequently treatment goals are met in high-risk T2DM patients. METHODS: Patients with T2DM and albuminuria (urinary albumin:creatinine ratio >5 mg/mmol, total cholesterol <7 mmol/L, proteinuria <2 g/d, creatinine <200 μmol/L) were randomized to receive atorvastatin 10 mg (n = 59) or 80 mg (n = 60) daily...
January 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29217412/glucagon-like-peptide-1-receptor-agonists-reduced-the-low-density-lipoprotein-cholesterol-in-japanese-patients-with-type-2-diabetes-mellitus-treated-with-statins
#11
Yukiko Hasegawa, Mika Hori, Tomoko Nakagami, Mariko Harada-Shiba, Yasuko Uchigata
BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) often have hypercholesterolemia, and their serum low-density lipoprotein cholesterol (LDL-C) levels are not always well-controlled even by statin treatment. The glucose-lowering glucagon-like peptide-1 receptor agonists (GLP-1RAs) are reported to change the lipid profiles in T2DM patients, but their effects have been unclear. OBJECTIVE: We examined whether GLP-1RAs affect serum cholesterol levels in T2DM patients with/without statin treatment...
January 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29129666/effect-of-soy-isoflavone-supplementation-on-plasma-lipoprotein-a-concentrations-a-meta-analysis
#12
REVIEW
Luis E Simental-Mendía, Antonio M Gotto, Stephen L Atkin, Maciej Banach, Matteo Pirro, Amirhossein Sahebkar
BACKGROUND: Soy supplementation has been shown to reduce total and low-density lipoprotein cholesterol, while increasing high-density lipoprotein cholesterol. However, contradictory effects of soy isoflavone supplementation on lipoprotein(a) [Lp(a)] have been reported suggesting the need for a meta-analysis to be undertaken. OBJECTIVE: The aim of the study was to investigate the impact of supplementation with soy isoflavones on plasma Lp(a) levels through a systematic review and meta-analysis of eligible randomized placebo-controlled trials...
January 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29128242/early-changes-of-blood-lipid-levels-during-psychotropic-drug-treatment-as-predictors-of-long-term-lipid-changes-and-of-new-onset-dyslipidemia
#13
Aurélie Delacrétaz, Frederik Vandenberghe, Mehdi Gholam-Rezaee, Nuria Saigi Morgui, Anaïs Glatard, Jacques Thonney, Alessandra Solida-Tozzi, Stéphane Kolly, Sylfa Fassassi Gallo, Philipp Baumann, Sylvie Berney, Sandrine Valloton Zulauff, Jean-Michel Aubry, Roland Hasler, Karsten Ebbing, Armin von Gunten, Philippe Conus, Chin B Eap
BACKGROUND: Cardiovascular diseases and dyslipidemia represent a major health issue in psychiatry. Many psychotropic drugs can induce a rapid and substantial increase of blood lipid levels. OBJECTIVE: This study aimed to determine the potential predictive power of an early change of blood lipid levels during psychotropic treatment on long-term change and on dyslipidemia development. METHODS: Data were obtained from a prospective study including 181 psychiatric patients with metabolic parameters monitored during the first year of treatment and with adherence ascertained...
January 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29050979/comparison-of-3-risk-estimators-to-guide-initiation-of-statin-therapy-for-primary-prevention-of-cardiovascular-disease
#14
Sandra Ofori, Sotonye Dodiyi-Manuel, Maclean R Akpa
BACKGROUND: Among high-risk individuals, statins are beneficial for primary prevention of cardiovascular disease (CVD). In Nigeria, currently, there are no CVD prevention guidelines, so the use of CVD risk estimation to guide statin therapy is left to the discretion of the physician. OBJECTIVE: The objective of the study was to compare 3 CVD risk estimation tools in the evaluation of patients presenting to a tertiary hospital in Nigeria. METHODS: Cross-sectional study involving 295 patients with any CVD risk factors but not taking statins...
November 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28887086/the-effects-of-cinnamon-supplementation-on-blood-lipid-concentrations-a-systematic-review-and-meta-analysis
#15
REVIEW
Serban M Maierean, Maria-Corina Serban, Amirhossein Sahebkar, Sorin Ursoniu, Alexandru Serban, Peter Penson, Maciej Banach
BACKGROUND: Cinnamon is a rich botanical source of polyphenols, whose positive effects on blood lipid concentrations have been hypothesized, but have not been conclusively studied. OBJECTIVE: The objective of the study was to systematically review and evaluate the effect of administration of cinnamon on blood lipid concentrations. METHODS: We assessed 13 randomized controlled trials with 750 participants investigating the effect of cinnamon supplementation on blood lipid concentrations...
November 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28738423/continued-statin-prescriptions-after-adverse-reactions-and-patient-outcomes-a-cohort-study
#16
MULTICENTER STUDY
Huabing Zhang, Jorge Plutzky, Maria Shubina, Alexander Turchin
Background: Many patients discontinue statin treatment, often after having a possible adverse reaction. The risks and benefits of continued statin therapy after an adverse reaction are not known. Objective: To examine the relationship between continuation of statin therapy (any prescription within 12 months after an adverse reaction) and clinical outcomes. Design: Retrospective cohort study. Setting: Primary care practices affiliated with 2 academic medical centers...
August 15, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28754224/residual-atherosclerotic-cardiovascular-disease-risk-in-statin-treated-adults-the-multi-ethnic-study-of-atherosclerosis
#17
Nathan D Wong, Yanglu Zhao, Ruben G W Quek, Roger S Blumenthal, Matthew J Budoff, Mary Cushman, Parveen Garg, Veit Sandfort, Michael Tsai, J Antonio G Lopez
BACKGROUND: Residual atherosclerotic cardiovascular disease (ASCVD) risk in statin-treated US adults without known ASCVD is not well described. OBJECTIVE: To quantitate residual ASCVD risk and its predictors in statin-treated adults. METHODS: We studied 1014 statin-treated adults (53.3% female, mean 66.0 years) free of clinical ASCVD in the Multi-Ethnic Study of Atherosclerosis. We examined ASCVD event rates by National Lipid Association risk groups over 11-year follow-up and the relation of standard risk factors, biomarkers, and subclinical atherosclerosis measures with residual ASCVD event risk...
September 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28673802/regular-activity-breaks-combined-with-physical-activity-improve-postprandial-plasma-triglyceride-nonesterified-fatty-acid-and-insulin-responses-in-healthy-normal-weight-adults-a-randomized-crossover-trial
#18
RANDOMIZED CONTROLLED TRIAL
Ashleigh R Homer, Stephen P Fenemor, Tracy L Perry, Nancy J Rehrer, Claire M Cameron, C Murray Skeaff, Meredith C Peddie
BACKGROUND: Compared with prolonged sitting, regular activity breaks immediately lower postprandial glucose and insulin, but not triglyceride responses. Postprandial triglycerides can be lowered by physical activity but the effect is often delayed by ∼12 to 24 hours. OBJECTIVE: The objective of the study was to determine whether regular activity breaks affect postprandial triglyceride response in a delayed manner similar to physical activity. METHODS: In a randomized crossover trial, 36 adults (body mass index 23...
September 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28669686/pharmacologic-approaches-for-the-management-of-patients-with-moderately-elevated-triglycerides-150-499-mg-dl
#19
REVIEW
Michael S Kelly, Craig Beavers, John D Bucheit, Evan M Sisson, Dave L Dixon
Hypertriglyceridemia, defined as serum triglyceride (TG) levels >150 mg/dL, now affects over one-quarter of the US adult population and is associated with an increased risk of atherosclerotic cardiovascular disease. Available guidelines for managing hypertriglyceridemia vary with respect to TG thresholds and severity of disease. Lifestyle modifications and management of secondary causes (eg, diabetes) remain the first step in managing hypertriglyceridemia, with pharmacotherapy reserved to reduce the risk of pancreatitis and/or further reduce TG levels...
July 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28627235/translating-guidelines-into-practice-interpreting-the-2016-acc-expert-consensus-decision-pathway-on-the-role-of-non-statin-therapies-for-ldl-cholesterol-lowering-in-the-management-of-atherosclerotic-cardiovascular-disease-risk
#20
Laura H Waite, Yvonne L Phan, Sarah A Spinler
OBJECTIVE: In 2016, the American College of Cardiology released a decision pathway, based on expert consensus, to guide use of non-statin agents in the management of atherosclerotic cardiovascular disease risk. The purpose of this article is to assist practitioners, health systems and managed care entities with interpreting this consensus statement in order to simplify implementation of the recommendations into patient care. METHODS: Major themes from the consensus statement are briefly summarized and explained...
October 2017: Annals of Pharmacotherapy
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