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https://www.readbyqxmd.com/read/27590096/assessing-acid-base-status-physiologic-versus-physicochemical-approach
#1
Horacio J Adrogué, Nicolaos E Madias
The physiologic approach has long been used in assessing acid-base status. This approach considers acids as hydrogen ion donors and bases as hydrogen ion acceptors and the acid-base status of the organism as reflecting the interaction of net hydrogen ion balance with body buffers. In the physiologic approach, the carbonic acid/bicarbonate buffer pair is used for assessing acid-base status and blood pH is determined by carbonic acid (ie, Paco2) and serum bicarbonate levels. More recently, the physicochemical approach was introduced, which has gained popularity, particularly among intensivists and anesthesiologists...
November 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27532622/evidence-for-transmission-of-zika-virus-by-platelet-transfusion
#2
LETTER
Iara J F Motta, Bryan R Spencer, Suely G Cordeiro da Silva, Monica B Arruda, Jane A Dobbin, Yung B M Gonzaga, Ingrid P Arcuri, Rita C B S Tavares, Elias H Atta, Regina F M Fernandes, Deise A Costa, Liane J Ribeiro, Fabio Limonte, Luiza M Higa, Carolina M Voloch, Rodrigo M Brindeiro, Amilcar Tanuri, Orlando C Ferreira
To the Editor: Zika virus (ZIKV) is a mosquito-borne virus that has important secondary means of transmission that include perinatal and sexual modes. The potential for transmission in transfused donated blood components has been a concern owing to the detection of ZIKV viremia in healthy blood..
September 15, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27322982/nomogram-for-predicting-pulmonary-hypertension-in-patients-without-pulmonary-embolism
#3
Yanqi Huang, Changhong Liang, Zaiyi Liu
No abstract text is available yet for this article.
July 2016: Radiology
https://www.readbyqxmd.com/read/27338855/the-benefit-of-exercise-training-in-pulmonary-hypertension-a-clinical-review
#4
Karen Sw Chia, Peter Kk Wong, Steven Faux, Craig S McLachlan, Eugene Kotlyar
Pulmonary hypertension (PH) is a clinical condition characterized by raised pulmonary artery pressure which results in increased right ventricular afterload and dyspnea. This is accompanied by reduced exercise capacity, quality of life and eventually, death. An increasing range of targeted medications has transformed the treatment of pulmonary arterial hypertension, a specific type of PH. Supervised exercise training is recommended as part of a multi-faceted management plan for PH. However, many questions remain regarding how exercise training improves exercise capacity and quality of life...
June 24, 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/25732200/low-c-reactive-protein-values-at-admission-predict-mortality-in-patients-with-severe-community-acquired-pneumonia-caused-by-streptococcus-pneumoniae-that-require-intensive-care-management
#5
Yok-Ai Que, Virginie Virgini, Elise Dupuis Lozeron, Géraldine Paratte, Guy Prod'hom, Jean-Pierre Revelly, Jean-Luc Pagani, Emmanuel Charbonney, Philippe Eggimann
PURPOSE: To identify risk factors associated with mortality in patients with severe community-acquired pneumonia (CAP) caused by S. pneumoniae who require intensive care unit (ICU) management, and to assess the prognostic values of these risk factors at the time of admission. METHODS: Retrospective analysis of all consecutive patients with CAP caused by S. pneumoniae who were admitted to the 32-bed medico-surgical ICU of a community and referral university hospital between 2002 and 2011...
April 2015: Infection
https://www.readbyqxmd.com/read/25599328/association-of-amiodarone-use-with-acute-pancreatitis-in-patients-with-atrial-fibrillation-a-nested-case-control-study
#6
Alvaro Alonso, Richard F MacLehose, Pamela L Lutsey, Suma Konety, Lin Y Chen
No abstract text is available yet for this article.
March 2015: JAMA Internal Medicine
https://www.readbyqxmd.com/read/25633465/serum-derived-bovine-immunoglobulin-protein-isolate-should-be-considered-in-patients-with-hiv-gut-barrier-dysfunction
#7
LETTER
M S Gelfand, B P Burnett
No abstract text is available yet for this article.
April 2015: Infection
https://www.readbyqxmd.com/read/25616312/acute-pancreatitis
#8
REVIEW
Paul Georg Lankisch, Minoti Apte, Peter A Banks
Acute pancreatitis, an inflammatory disorder of the pancreas, is the leading cause of admission to hospital for gastrointestinal disorders in the USA and many other countries. Gallstones and alcohol misuse are long-established risk factors, but several new causes have emerged that, together with new aspects of pathophysiology, improve understanding of the disorder. As incidence (and admission rates) of acute pancreatitis increase, so does the demand for effective management. We review how to manage patients with acute pancreatitis, paying attention to diagnosis, differential diagnosis, complications, prognostic factors, treatment, and prevention of second attacks, and the possible transition from acute to chronic pancreatitis...
July 4, 2015: Lancet
https://www.readbyqxmd.com/read/25552355/what-the-dead-can-teach-the-living-systemic-nature-of-heart-failure-with-preserved-ejection-fraction
#9
EDITORIAL
Dalane W Kitzman, Bharathi Upadhya, Sujethra Vasu
No abstract text is available yet for this article.
February 10, 2015: Circulation
https://www.readbyqxmd.com/read/25540889/multiple-myeloma
#10
REVIEW
Christoph Röllig, Stefan Knop, Martin Bornhäuser
Multiple myeloma is a malignant disease characterised by proliferation of clonal plasma cells in the bone marrow and typically accompanied by the secretion of monoclonal immunoglobulins that are detectable in the serum or urine. Increased understanding of the microenvironmental interactions between malignant plasma cells and the bone marrow niche, and their role in disease progression and acquisition of therapy resistance, has helped the development of novel therapeutic drugs for use in combination with cytostatic therapy...
May 30, 2015: Lancet
https://www.readbyqxmd.com/read/25536258/metformin-in-patients-with-type-2-diabetes-and-kidney-disease-a-systematic-review
#11
REVIEW
Silvio E Inzucchi, Kasia J Lipska, Helen Mayo, Clifford J Bailey, Darren K McGuire
IMPORTANCE: Metformin is widely viewed as the best initial pharmacological option to lower glucose concentrations in patients with type 2 diabetes mellitus. However, the drug is contraindicated in many individuals with impaired kidney function because of concerns of lactic acidosis. OBJECTIVE: To assess the risk of lactic acidosis associated with metformin use in individuals with impaired kidney function. EVIDENCE ACQUISITION: In July 2014, we searched the MEDLINE and Cochrane databases for English-language articles pertaining to metformin, kidney disease, and lactic acidosis in humans between 1950 and June 2014...
December 24, 2014: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/25514312/causes-of-ferritin-elevation
#12
LETTER
Lisa B VanWagner, Richard M Green
No abstract text is available yet for this article.
December 17, 2014: JAMA: the Journal of the American Medical Association
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