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CTE

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120 papers 25 to 100 followers
By David Rhine MD FRCPC. Emergency medicine. Special interest in concussion management.
https://www.readbyqxmd.com/read/28620350/considerations-for-experimental-animal-models-of-concussion-traumatic-brain-injury-and-chronic-traumatic-encephalopathy-these-matters-matter
#1
REVIEW
Mark W Wojnarowicz, Andrew M Fisher, Olga Minaeva, Lee E Goldstein
Animal models of concussion, traumatic brain injury (TBI), and chronic traumatic encephalopathy (CTE) are widely available and routinely deployed in laboratories around the world. Effective animal modeling requires careful consideration of four basic principles. First, animal model use must be guided by clarity of definitions regarding the human disease or condition being modeled. Concussion, TBI, and CTE represent distinct clinical entities that require clear differentiation: concussion is a neurological syndrome, TBI is a neurological event, and CTE is a neurological disease...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28520686/clinical-correlates-to-assist-with-chronic-traumatic-encephalopathy-diagnosis-insights-from-a-novel-rodent-repeat-concussion-model
#2
Gretchen M Thomsen, Ara Ko, Megan Y Harada, Annie Ma, Livia Wyss, Patricia Haro, Jean-Philippe Vit, Pablo Avalos, Navpreet K Dhillon, Noell Cho, Oksana Shelest, Eric J Ley
INTRODUCTION: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to repetitive head injuries. Chronic traumatic encephalopathy symptoms include changes in mood, behavior, cognition, and motor function; however, CTE is currently diagnosed only postmortem. Using a rat model of recurrent traumatic brain injury (TBI), we demonstrate rodent deficits that predict the severity of CTE-like brain pathology. METHODS: Bilateral, closed-skull, mild TBI was administered once per week to 35 wild-type rats; eight rats received two injuries (2×TBI), 27 rats received five injuries (5×TBI), and 13 rats were sham controls...
June 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28509819/cortical-and-physical-function-after-mild-traumatic-brain-injury
#3
Alia L Yasen, David R Howell, Li-Shan Chou, Angela M Pazzaglia, Anita D Christie
PURPOSE: The aim of this study was to prospectively examine the association between intracortical inhibition and functional recovery after mild traumatic brain injury (mTBI). METHODS: Twenty individuals with mTBI and 20 matched control participants were assessed using transcranial magnetic stimulation, the Attentional Network Test, and gait analysis. Hierarchical linear modeling was used to longitudinally examine potential differences between groups and relationships in the pattern of recovery in cortical silent period (CSP) duration, cognitive reaction time, and single- and dual-task walking speeds across five testing time points...
June 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28506441/association-of-traumatic-brain-injury-and-alzheimer-disease-onset-a-systematic-review
#4
REVIEW
J Julien, S Joubert, M-C Ferland, L C Frenette, M M Boudreau-Duhaime, L Malo-Véronneau, E de Guise
BACKGROUND: Inconsistencies regarding the risk of developing Alzheimer disease after traumatic brain injury (TBI) remain in the literature. Indeed, why AD develops in certain TBI patients while others are unaffected is still unclear. OBJECTIVE: The aim of this study was to performed a systematic review to investigate whether certain variables related to TBI, such as TBI severity, loss of consciousness (LOC) and post-traumatic amnesia (PTA), are predictors of risk of AD in adults...
May 11, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28455362/a-systematic-review-of-potential-long-term-effects-of-sport-related-concussion
#5
REVIEW
Geoff Manley, Andrew J Gardner, Kathryn J Schneider, Kevin M Guskiewicz, Julian Bailes, Robert C Cantu, Rudolph J Castellani, Michael Turner, Barry D Jordan, Christopher Randolph, Jiří Dvořák, K Alix Hayden, Charles H Tator, Paul McCrory, Grant L Iverson
OBJECTIVE: Systematic review of possible long-term effects of sports-related concussion in retired athletes. DATA SOURCES: Ten electronic databases. STUDY SELECTION: Original research; incidence, risk factors or causation related to long-term mental health or neurological problems; individuals who have suffered a concussion; retired athletes as the subjects and possible long-term sequelae defined as >10 years after the injury. DATA EXTRACTION: Study population, exposure/outcome measures, clinical data, neurological examination findings, cognitive assessment, neuroimaging findings and neuropathology results...
June 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28446457/consensus-statement-on-concussion-in-sport-the-5-th-international-conference-on-concussion-in-sport-held-in-berlin-october-2016
#6
Paul McCrory, Willem Meeuwisse, Jiří Dvorak, Mark Aubry, Julian Bailes, Steven Broglio, Robert C Cantu, David Cassidy, Ruben J Echemendia, Rudy J Castellani, Gavin A Davis, Richard Ellenbogen, Carolyn Emery, Lars Engebretsen, Nina Feddermann-Demont, Christopher C Giza, Kevin M Guskiewicz, Stanley Herring, Grant L Iverson, Karen M Johnston, James Kissick, Jeffrey Kutcher, John J Leddy, David Maddocks, Michael Makdissi, Geoff T Manley, Michael McCrea, William P Meehan, Sinji Nagahiro, Jon Patricios, Margot Putukian, Kathryn J Schneider, Allen Sills, Charles H Tator, Michael Turner, Pieter E Vos
No abstract text is available yet for this article.
April 26, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28396360/concussion-dementia-and-cte-are-we-getting-it-very-wrong
#7
EDITORIAL
Alan Carson
No abstract text is available yet for this article.
June 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28337734/diffusion-tensor-imaging-dti-findings-in-adult-civilian-military-and-sport-related-mild-traumatic-brain-injury-mtbi-a-systematic-critical-review
#8
Breton Michael Asken, Steven T DeKosky, James R Clugston, Michael S Jaffee, Russell M Bauer
This review seeks to summarize diffusion tensor imaging (DTI) studies that have evaluated structural changes attributed to the mechanisms of mild traumatic brain injury (mTBI) in adult civilian, military, and athlete populations. Articles from 2002 to 2016 were retrieved from PubMed/MEDLINE, EBSCOhost, and Google Scholar, using a Boolean search string containing the following terms: "diffusion tensor imaging", "diffusion imaging", "DTI", "white matter", "concussion", "mild traumatic brain injury", "mTBI", "traumatic brain injury", and "TBI"...
March 24, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28298054/long-term-effects-of-adolescent-sport-concussion-across-the-age-spectrum
#9
Douglas N Martini, James T Eckner, Sean K Meehan, Steven P Broglio
BACKGROUND: Research in sport concussion has increased greatly over the previous decade due to increased scientific interest as well as the media and political spotlight that has been cast on this injury. However, a dearth of literature is available regarding the long-term (>1 year after concussion) effects of adolescent concussion on cognitive and motor performance of high school athletes. PURPOSE: To evaluate the potential for long-term effects of concussion sustained during high school on cognitive and motor performance across the lifespan...
May 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28254594/the-current-status-of-research-on-chronic-traumatic-encephalopathy
#10
REVIEW
Kenneth Perrine, Jacqueline Helcer, Apostolos John Tsiouris, David J Pisapia, Philip Stieg
Chronic traumatic encephalopathy (CTE) evolved from the term dementia pugilistica describing the dementia found in many boxers to its current use in describing the dementia and depression sometimes found in athletes subjected to multiple concussions or subconcussive blows to the head. Concurrently, the neuropathology evolved to specify a unique type of tauopathy found in perivascular spaces at the depth of sulci and other features not typically seen in neurodegenerative tauopathies. Four stages of CTE have been proposed, with 4 corresponding clinical syndromes of traumatic encephalopathy syndrome...
June 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28205009/mixed-pathologies-including-chronic-traumatic-encephalopathy-account-for-dementia-in-retired-association-football-soccer-players
#11
Helen Ling, Huw R Morris, James W Neal, Andrew J Lees, John Hardy, Janice L Holton, Tamas Revesz, David D R Williams
In retired professional association football (soccer) players with a past history of repetitive head impacts, chronic traumatic encephalopathy (CTE) is a potential neurodegenerative cause of dementia and motor impairments. From 1980 to 2010, 14 retired footballers with dementia were followed up regularly until death. Their clinical data, playing career, and concussion history were prospectively collected. Next-of-kin provided consent for six to have post-mortem brain examination. Of the 14 male participants, 13 were professional and 1 was a committed amateur...
March 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28144218/changes-in-cortical-plasticity-in-relation-to-a-history-of-concussion-during-adolescence
#12
Sean K Meehan, Jasmine L Mirdamadi, Douglas N Martini, Steven P Broglio
Adolescence and early adulthood is a critical period for neurophysiological development potentially characterized by an increased susceptibility to the long-term effects of traumatic brain injury. The current study investigated differences in motor cortical physiology and neuroplastic potential across a cohort of young adults with adolescent concussion history and those without. Transcranial magnetic stimulation (TMS) was used to assess motor evoked potential (MEP) amplitude, short-interval cortical inhibition (SICI) and intracortical facilitation (ICF) before and after intermittent theta burst stimulation (iTBS)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28096246/chronic-traumatic-encephalopathy-is-latency-in-symptom-onset-explained-by-tau-propagation
#13
Joshua Kriegel, Zachary Papadopoulos, Ann C McKee
Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive mild brain trauma. CTE, previously termed "dementia pugilistica," has been identified in American football, ice hockey, baseball, rugby and soccer players, boxers, wrestlers, and military personnel exposed to blast and other traumatic brain injuries. There is often a long latency period between an individual's exposure to repetitive brain trauma and the clinical symptoms of CTE. The pathology of CTE is characterized by a progression from isolated focal perivascular hyperphosphorylated tau lesions in the cerebral cortex to a widespread tauopathy that involves diffuse cortical and medial temporal lobe regions...
January 17, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28077006/longitudinal-assessment-of-health-related-quality-of-life-following-adolescent-sports-related-concussion
#14
Kelly Russell, Erin Selci, Stephanie Chu, Samuel Fineblit, Lesley Ritchie, Michael J Ellis
To examine initial and longitudinal health-related quality of life (HRQOL) in adolescent sports-related concussion (SRC) patients, a prospective observational case-series study was conducted among adolescent SRC patients who were evaluated at a multi-disciplinary pediatric concussion program. Health-related quality of life was measured using the child self-report Pediatric Quality of Life Inventory (PedsQL) generic score scale (age 13-18 version) and the PedsQL Cognitive Functioning scale. Initial and longitudinal HRQOL outcomes were compared between patients who did and did not develop post-concussion syndrome (PCS)...
March 1, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28067738/does-a-unique-neuropsychiatric-profile-currently-exist-for-chronic-traumatic-encephalopathy
#15
REVIEW
Faith M Hanlon, Christopher A McGrew, Andrew R Mayer
There is evidence that repetitive mild traumatic brain injury leads to specific patterns of neuropathological findings, labeled chronic traumatic encephalopathy (CTE). However, questions remain about whether these neuropathological changes produce changes in behavior, cognition, and emotional status that are associated with a unique neuropsychiatric profile that can be assessed using currently available clinical tools. Our review of the literature indicates that insufficient evidence currently exists to suggest a distinct neuropsychiatric profile for CTE...
January 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/27979411/high-school-football-and-late-life-risk-of-neurodegenerative-syndromes-1956-1970
#16
Pieter H H Janssen, Jay Mandrekar, Michelle M Mielke, J Eric Ahlskog, Bradley F Boeve, Keith Josephs, Rodolfo Savica
OBJECTIVE: To assess whether athletes who played American varsity high school football between 1956 and 1970 have an increased risk of neurodegenerative diseases later in life. PATIENTS AND METHODS: We identified all male varsity football players between 1956 and 1970 in the public high schools of Rochester, Minnesota, and non-football-playing male varsity swimmers, wrestlers, and basketball players. Using the medical records linkage system of the Rochester Epidemiology Project, we ascertained the incidence of late-life neurodegenerative diseases: dementia, parkinsonism, and amyotrophic lateral sclerosis...
January 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27906973/detecting-mild-traumatic-brain-injury-using-resting-state-magnetoencephalographic-connectivity
#17
Vasily A Vakorin, Sam M Doesburg, Leodante da Costa, Rakesh Jetly, Elizabeth W Pang, Margot J Taylor
Accurate means to detect mild traumatic brain injury (mTBI) using objective and quantitative measures remain elusive. Conventional imaging typically detects no abnormalities despite post-concussive symptoms. In the present study, we recorded resting state magnetoencephalograms (MEG) from adults with mTBI and controls. Atlas-guided reconstruction of resting state activity was performed for 90 cortical and subcortical regions, and calculation of inter-regional oscillatory phase synchrony at various frequencies was performed...
December 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27886529/autobiographical-and-episodic-memory-deficits-in-mild-traumatic-brain-injury
#18
Jeffrey D Wammes, Tyler J Good, Myra A Fernandes
Those who have suffered a concussion, otherwise known as a mild traumatic brain injury (mTBI), often complain of lingering memory problems. However, there is little evidence in the behavioral literature reliably demonstrating memory deficits. Thus, in the present study, cognitive profiles including measures of general executive functioning and processing speed, as well as episodic and semantic memory were collected in younger and older adult participants with or without a remote (>1year prior to testing) mTBI...
February 2017: Brain and Cognition
https://www.readbyqxmd.com/read/27867100/the-independent-influence-of-concussive-and-sub-concussive-impacts-on-soccer-players-neurophysiological-and-neuropsychological-function
#19
R Davis Moore, Julien Lepine, Dave Ellemberg
Accumulating research demonstrates that repetitive sub-concussive impacts can alter the structure, function and connectivity of the brain. However, the functional significance of these alterations as well as the independent contribution of concussive and sub-concussive impacts to neurophysiological and neuropsychological health are unclear. Accordingly, we compared the neurophysiological and neuropsychological function of contact athletes with (concussion group) and without (sub-concussion group) a history of concussion, to non-contact athletes...
February 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/27843436/lifetime-multiple-mild-traumatic-brain-injuries-are-associated-with-cognitive-and-mood-symptoms-in-young-healthy-college-students
#20
Kyle C Vynorius, Alyssa M Paquin, Daniel R Seichepine
BACKGROUND/OBJECTIVES: Repetitive mild traumatic brain injury (mTBI, also known as concussion) has been associated with a range of long-term mood and cognitive deficits, including executive dysfunction. Previous research in athletes suggests that cognitive and mood problems are associated with a history of repetitive mTBI. However, to date, no studies have examined the impact of a lifetime accumulation of repetitive mTBIs on cognition, particularly executive functioning, and mood in a sample of young adults who were not athletes...
2016: Frontiers in Neurology
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