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CTE

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142 papers 25 to 100 followers
By David Rhine MD FRCPC. Emergency medicine. Special interest in concussion management.
https://www.readbyqxmd.com/read/29665736/fear-avoidance-and-clinical-outcomes-from-mild-traumatic-brain-injury
#1
Noah D Silverberg, William Panenka, Grant L Iverson
Characterizing psychological factors that contribute to persistent symptoms after mild traumatic brain injury (MTBI) can inform early intervention. To determine whether fear avoidance, a known risk factor for chronic disability after musculoskeletal injury, is associated with worse clinical outcomes from MTBI, adults were recruited from four outpatient MTBI clinics and assessed at their first clinic visit (M=2.7, SD=1.5 weeks post-injury) and again 4-5 months later. Of 273 patients screened, 102 completed the initial assessment and 87 returned for the outcome assessment...
April 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29666148/single-mild-concussion-increases-risk-of-parkinson-s-disease-study-suggests
#2
Ingrid Torjesen
No abstract text is available yet for this article.
April 17, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29526776/sub-concussive-trauma-acute-concussion-and-history-of-multiple-concussions-effects-on-quiet-stance-postural-control-stability
#3
J K Dierijck, A D Wright, J D Smirl, K Bryk, P van Donkelaar
Although balance control has been studied extensively following acute concussion, little is known regarding repetitive sub-concussive head impacts or chronic exposure to multiple concussive events. Quiet stance postural control was characterized in contact sport athletes at pre-season (n = 135) and post-season (n = 48) to evaluate the effects of subconcussive trauma to the head. To determine the impact of acute concussion on postural control, athletes diagnosed with a concussion during the season (n = 12) were tested at 72-h, 2-weeks, and 1-month post-injury...
March 8, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29521703/athletic-suicide-separating-fact-from-fiction-and-navigating-the-challenging-road-ahead
#4
Ashwin L Rao
No abstract text is available yet for this article.
March 2018: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/29402530/subconcussive-head-impacts-in-sport-a-systematic-review-of-the-evidence
#5
Lynda Mainwaring, Kaleigh M Ferdinand Pennock, Sandhya Mylabathula, Benjamin Z Alavie
PURPOSE: To identify and evaluate the evidence that examines subconcussive impacts in sport-specific settings, and address two objectives: a) to determine how 'subconcussion' is characterized in the current literature, and b) to identify directions for future research. RESEARCH DESIGN: Systematic review. METHODS AND PROCEDURES: CINAHL, EMBASE, MedLine, PsycINFO, SportDiscus, and Web of Science were searched for articles that sought to assess subconcussive impacts or outcomes related to non-concussive head impact exposure...
February 2, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29385179/population-based-cohort-study-of-the-impacts-of-mild-traumatic-brain-injury-in-adults-four-years-post-injury
#6
Alice Theadom, Nicola Starkey, Suzanne Barker-Collo, Kelly Jones, Shanthi Ameratunga, Valery Feigin
There is increasing evidence that some people can experience persistent symptoms for up to a year following mild TBI. However, few longitudinal studies of mild TBI exist and the longer-term impact remains unclear. The purpose of this study is to determine if there are long-term effects of mild traumatic brain injury (TBI) four-years later. Adults (aged ≥16 years) identified as part of a TBI incidence study who experienced a mild-TBI four-years ago (N = 232) were compared to age-sex matched controls (N = 232)...
2018: PloS One
https://www.readbyqxmd.com/read/29388850/neurophysiological-and-cognitive-impairment-following-repeated-sports-concussion-injuries-in-retired-professional-rugby-league-players
#7
Alan J Pearce, Billymo Rist, Clare L Fraser, Adrian Cohen, Jerome J Maller
BACKGROUND: Concussion is regarded as a common injury in rugby league, however no studies have explored the long-term neurophysiological and cognitive effects of repeated concussion injuries in this sport. METHODS: Former professional rugby athletes (n = 25) were compared to 25 age-matched participants with no history of a concussion. All participants completed standardised motor dexterity, reaction time, and cognitive tasks for working memory, associative learning and rule acquisition and reversal...
February 1, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29213985/dementia-resulting-from-traumatic-brain-injury
#8
REVIEW
Joana Ramalho, Mauricio Castillo
Traumatic brain injury (TBI) represents a significant public health problem in modern societies. It is primarily a consequence of traffic-related accidents and falls. Other recently recognized causes include sports injuries and indirect forces such as shock waves from battlefield explosions. TBI is an important cause of death and lifelong disability and represents the most well-established environmental risk factor for dementia. With the growing recognition that even mild head injury can lead to neurocognitive deficits, imaging of brain injury has assumed greater importance...
October 2015: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/27029716/cumulative-head-impact-exposure-predicts-later-life-depression-apathy-executive-dysfunction-and-cognitive-impairment-in-former-high-school-and-college-football-players
#9
Philip H Montenigro, Michael L Alosco, Brett M Martin, Daniel H Daneshvar, Jesse Mez, Christine E Chaisson, Christopher J Nowinski, Rhoda Au, Ann C McKee, Robert C Cantu, Michael D McClean, Robert A Stern, Yorghos Tripodis
The term "repetitive head impacts" (RHI) refers to the cumulative exposure to concussive and subconcussive events. Although RHI are believed to increase risk for later-life neurological consequences (including chronic traumatic encephalopathy), quantitative analysis of this relationship has not yet been examined because of the lack of validated tools to quantify lifetime RHI exposure. The objectives of this study were: 1) to develop a metric to quantify cumulative RHI exposure from football, which we term the "cumulative head impact index" (CHII); 2) to use the CHII to examine the association between RHI exposure and long-term clinical outcomes; and 3) to evaluate its predictive properties relative to other exposure metrics (i...
January 15, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29310134/chief-concern-i-m-worried-i-have-chronic-traumatic-encephalopathy
#10
David L Brody
No abstract text is available yet for this article.
February 20, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29256818/motor-function-in-former-professional-football-players-with-history-of-multiple-concussions
#11
Apameh Tarazi, Charles H Tator, Richard Wennberg, Ahmed Ebraheem, Robin E A Green, Brenda Collela, Christina Saverino, Mozghan Khodadadi, Karen Misquitta, Maria Carmela Tartaglia
The objective of this study was to assess the incidence of motor impairment in former professional Canadian Football League (ex-CFL) players with multiple concussions. We investigated motor symptoms and signs in 45 ex-CFL players with multiple concussions and 25 age- and education-matched healthy controls with no history of concussion. Neurological assessment included items from the SCAT3 (Sport Concussion Assessment Tool 3) and the Unified Parkinson's Disease Rating Scale part III (UPDRS-Part III). A performance-based measurement of manual motor function was undertaken using the Grooved Pegboard test...
March 1, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29077582/neuroimaging-in-the-diagnosis-of-chronic-traumatic-encephalopathy-a-systematic-review
#12
Philip Sparks, Tim Lawrence, Stephan Hinze
OBJECTIVE: Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repeated subconcussive and concussive head injury. Clinical features include cognitive, behavioral, mood, and motor impairments. Definitive diagnosis is only possible at postmortem. Here, the utility of neuroimaging in the diagnosis of CTE is evaluated by systematically reviewing recent evidence for changes in neuroimaging biomarkers in suspected cases of CTE compared with controls. DATA SOURCES: Providing an update on a previous systematic review of articles published until December 2014, we searched for articles published between December 2014 and July 2016...
October 25, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29064869/vision-and-vestibular-system-dysfunction-predicts-prolonged-concussion-recovery-in-children
#13
Christina L Master, Stephen R Master, Douglas J Wiebe, Eileen P Storey, Julia E Lockyer, Olivia E Podolak, Matthew F Grady
OBJECTIVE: Up to one-third of children with concussion have prolonged symptoms lasting beyond 4 weeks. Vision and vestibular dysfunction is common after concussion. It is unknown whether such dysfunction predicts prolonged recovery. We sought to determine which vision or vestibular problems predict prolonged recovery in children. DESIGN: A retrospective cohort of pediatric patients with concussion. SETTING: A subspecialty pediatric concussion program...
October 20, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29036831/dementia-pugilistica-revisited
#14
Rudy J Castellani, George Perry
 Extensive exposure of boxers to neurotrauma in the early 20th century led to the so-called punch drunk syndrome, which was formally recognized in the medical literature in 1928. "Punch drunk" terminology was replaced by the less derisive 'dementia pugilistica' in 1937. In the early case material, the diagnosis of dementia pugilistica required neurological deficits, including slurring dysarthria, ataxia, pyramidal signs, extrapyramidal signs, memory impairment, and personality changes, although the specific clinical substrate has assumed lesser importance in recent years with a shift in focus on molecular pathogenesis...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28742910/clinicopathological-evaluation-of-chronic-traumatic-encephalopathy-in-players-of-american-football
#15
Jesse Mez, Daniel H Daneshvar, Patrick T Kiernan, Bobak Abdolmohammadi, Victor E Alvarez, Bertrand R Huber, Michael L Alosco, Todd M Solomon, Christopher J Nowinski, Lisa McHale, Kerry A Cormier, Caroline A Kubilus, Brett M Martin, Lauren Murphy, Christine M Baugh, Phillip H Montenigro, Christine E Chaisson, Yorghos Tripodis, Neil W Kowall, Jennifer Weuve, Michael D McClean, Robert C Cantu, Lee E Goldstein, Douglas I Katz, Robert A Stern, Thor D Stein, Ann C McKee
Importance: Players of American football may be at increased risk of long-term neurological conditions, particularly chronic traumatic encephalopathy (CTE). Objective: To determine the neuropathological and clinical features of deceased football players with CTE. Design, Setting, and Participants: Case series of 202 football players whose brains were donated for research. Neuropathological evaluations and retrospective telephone clinical assessments (including head trauma history) with informants were performed blinded...
July 25, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28981345/injury-cascades-in-tbi-related-neurodegeneration
#16
Steven T DeKosky, Breton M Asken
Traumatic brain injury (TBI) is a widely recognized risk factor for neurodegenerative disease. The purpose of this review is to provide an update on the state of the science related to injury cascades in TBI-related neurodegeneration. Acute and chronic pathological outcomes of TBI are similar to those seen in several neurodegenerative conditions, suggesting common linking pathways. Initial research described severe TBI patients with post-mortem identification of abnormal proteins, such as amyloid deposits. History of mild TBI (mTBI) is less consistently associated with heightened risk of neurodegenerative outcomes, but specific populations with complicated medical histories and comorbidities may be more susceptible...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28975240/research-gaps-and-controversies-in-chronic-traumatic-encephalopathy-a-review
#17
REVIEW
Breton M Asken, Molly J Sullan, Steven T DeKosky, Michael S Jaffee, Russell M Bauer
Importance: Scientific and lay interest in negative outcomes associated with exposure to repetitive brain trauma (RBT) continues to strengthen. Concerns about the association between RBT and dementia began more than a century ago, but have resurfaced in the last decade with the more recently described chronic traumatic encephalopathy (CTE). Chronic traumatic encephalopathy is a tauopathy associated with RBT that has become inextricably linked to conversations about sport-related concussion and mild traumatic brain injury...
October 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28920887/the-chronic-and-evolving-neurological-consequences-of-traumatic-brain-injury
#18
REVIEW
Lindsay Wilson, William Stewart, Kristen Dams-O'Connor, Ramon Diaz-Arrastia, Lindsay Horton, David K Menon, Suzanne Polinder
Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing. Research on the long-term consequences emphasises that, for many patients, TBI should be conceptualised as a chronic health condition. Evidence suggests that functional outcomes after TBI can show improvement or deterioration up to two decades after injury, and rates of all-cause mortality remain elevated for many years. Furthermore, TBI represents a risk factor for a variety of neurological illnesses, including epilepsy, stroke, and neurodegenerative disease...
October 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28914886/multiple-sclerosis-concussion-during-adolescence-linked-to-increased-risk-of-ms
#19
Peter Sidaway
No abstract text is available yet for this article.
November 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28885451/visual-structure-and-function-in-collision-sport-athletes
#20
Danielle Leong, Christina Morettin, Leonard V Messner, Robert J Steinmetz, Yi Pang, Steven L Galetta, Laura J Balcer
BACKGROUND: Vision-based measures have been shown to be useful markers in multiple sclerosis (MS), Alzheimer and Parkinson disease. Therefore, these testing paradigms may have applications to populations explaining repetitive head trauma that has been associated with long-term neurodegenerative sequelae. We investigated retinal structure and visual function in professional collision sport athletes compared to age- and race-matched control participants. METHODS: In this cross-sectional study, participants underwent spectral-domain optical coherence tomography (OCT) measurements of peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC = ganglion cell + inner plexiform layers) thickness...
September 6, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
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