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CTE

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147 papers 25 to 100 followers
By David Rhine MD FRCPC. Emergency medicine. Special interest in concussion management.
https://www.readbyqxmd.com/read/30120477/association-between-traumatic-brain-injury-and-risk-of-suicide
#1
Trine Madsen, Annette Erlangsen, Sonja Orlovska, Ramy Mofaddy, Merete Nordentoft, Michael E Benros
Importance: Traumatic brain injuries (TBIs) can have serious long-term consequences, including psychiatric disorders. However, few studies have assessed the association between TBI and risk of suicide. Objective: To examine the association between TBI and subsequent suicide. Design, Setting, and Participants: Retrospective cohort study using nationwide registers covering 7 418 391 individuals (≥10 years) living in Denmark (1980-2014) with 164 265 624 person-years' follow-up; 567 823 (7...
August 14, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/30080799/multimodal-imaging-of-retired-professional-contact-sport-athletes-does-not-provide-evidence-of-structural-and-functional-brain-damage
#2
Robert Zivadinov, Paul Polak, Ferdinand Schweser, Niels Bergsland, Jesper Hagemeier, Michael G Dwyer, Deepa P Ramasamy, John G Baker, John J Leddy, Barry S Willer
BACKGROUND: Long-term consequences of playing professional football and hockey on brain function and structural neuronal integrity are unknown. OBJECTIVES: To investigate multimodal metabolic and structural brain magnetic resonance imaging (MRI) differences in retired professional contact sport athletes compared with noncontact sport athletes. METHODS: Twenty-one male contact sport athletes and 21 age-matched noncontact sport athletes were scanned on a 3 tesla (3T) MRI using a multimodal imaging approach...
September 2018: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/30080797/evaluation-of-executive-function-and-mental-health-in-retired-contact-sport-athletes
#3
Barry S Willer, Michael R Tiso, Mohammad N Haider, Andrea L Hinds, John G Baker, Jeffery C Miecznikowski, John J Leddy
OBJECTIVE: To compare retired professional contact sport athletes with age-matched noncontact sport athletes on measures of executive function and mental health. SETTING: The University Concussion Management Clinic. PARTICIPANTS: Twenty-one retired National Football League (NFL) and National Hockey League (NHL) players (mean age 56 years) and 21 age-matched noncontact sport athlete controls. DESIGNS: Case control. MAIN MEASURE: The self- and informant-reported Behavior Rating Inventory of Executive Function-Adult form (BRIEF-A); Wisconsin Card Sorting Test; Delis-Kaplan Executive Function System; Trail Making Part A and B; Wechsler Adult Intelligence Scale; Neuropsychological Assessment Battery; List Learning; Controlled Oral Word Association Test; Beck Depression Inventory; Beck Anxiety Inventory; and Personality Inventory of the DSM-5...
September 2018: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/30080796/a-preliminary-study-of-early-onset-dementia-of-former-professional-football-and-hockey-players
#4
Barry S Willer, Robert Zivadinov, Mohammad N Haider, Jeffrey C Miecznikowski, John J Leddy
OBJECTIVE: To provide an overview of 3 studies of the same population of retired professional contact sport athletes compared with age-matched noncontact sport athlete controls on cognition, executive function, behavior, and advanced brain imaging. SETTING: University Concussion Management Clinic. PARTICIPANTS: Twenty-two retired professional hockey and football athletes (average age 56 years) and 21 age-matched noncontact sport athlete controls...
September 2018: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/29987335/building-good-policy-from-good-science-the-case-for-concussion-and-chronic-traumatic-encephalopathy
#5
Christopher C Giza, William Stewart, Mayumi L Prins
No abstract text is available yet for this article.
September 1, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29665736/fear-avoidance-and-clinical-outcomes-from-mild-traumatic-brain-injury
#6
Noah D Silverberg, William J Panenka, Grant L Iverson
Characterizing psychological factors that contribute to persistent symptoms after mild traumatic brain injury (MTBI) can inform early intervention. To determine whether fear avoidance, a known risk factor for chronic disability after musculoskeletal injury, is associated with worse clinical outcomes from MTBI, adults were recruited from four outpatient MTBI clinics and assessed at their first clinic visit (mean = 2.7, standard deviation = 1.5 weeks post-injury) and again four to five months later. Of 273 patients screened, 102 completed the initial assessment, and 87 returned for the outcome assessment...
August 15, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29666148/single-mild-concussion-increases-risk-of-parkinson-s-disease-study-suggests
#7
Ingrid Torjesen
No abstract text is available yet for this article.
April 17, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29526776/sub-concussive-trauma-acute-concussion-and-history-of-multiple-concussions-effects-on-quiet-stance-postural-control-stability
#8
J K Dierijck, A D Wright, J D Smirl, K Bryk, P van Donkelaar
Although balance control has been studied extensively following acute concussion, little is known regarding repetitive sub-concussive head impacts or chronic exposure to multiple concussive events. Quiet stance postural control was characterized in contact sport athletes at pre-season (n = 135) and post-season (n = 48) to evaluate the effects of subconcussive trauma to the head. To determine the impact of acute concussion on postural control, athletes diagnosed with a concussion during the season (n = 12) were tested at 72-h, 2-weeks, and 1-month post-injury...
March 8, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29521703/athletic-suicide-separating-fact-from-fiction-and-navigating-the-challenging-road-ahead
#9
Ashwin L Rao
No abstract text is available yet for this article.
March 2018: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/29402530/subconcussive-head-impacts-in-sport-a-systematic-review-of-the-evidence
#10
Lynda Mainwaring, Kaleigh M Ferdinand Pennock, Sandhya Mylabathula, Benjamin Z Alavie
PURPOSE: To identify and evaluate the evidence that examines subconcussive impacts in sport-specific settings, and address two objectives: a) to determine how 'subconcussion' is characterized in the current literature, and b) to identify directions for future research. RESEARCH DESIGN: Systematic review. METHODS AND PROCEDURES: CINAHL, EMBASE, MedLine, PsycINFO, SportDiscus, and Web of Science were searched for articles that sought to assess subconcussive impacts or outcomes related to non-concussive head impact exposure...
February 2, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29385179/population-based-cohort-study-of-the-impacts-of-mild-traumatic-brain-injury-in-adults-four-years-post-injury
#11
Alice Theadom, Nicola Starkey, Suzanne Barker-Collo, Kelly Jones, Shanthi Ameratunga, Valery Feigin
There is increasing evidence that some people can experience persistent symptoms for up to a year following mild TBI. However, few longitudinal studies of mild TBI exist and the longer-term impact remains unclear. The purpose of this study is to determine if there are long-term effects of mild traumatic brain injury (TBI) four-years later. Adults (aged ≥16 years) identified as part of a TBI incidence study who experienced a mild-TBI four-years ago (N = 232) were compared to age-sex matched controls (N = 232)...
2018: PloS One
https://www.readbyqxmd.com/read/29388850/neurophysiological-and-cognitive-impairment-following-repeated-sports-concussion-injuries-in-retired-professional-rugby-league-players
#12
Alan J Pearce, Billymo Rist, Clare L Fraser, Adrian Cohen, Jerome J Maller
BACKGROUND: Concussion is regarded as a common injury in rugby league, however no studies have explored the long-term neurophysiological and cognitive effects of repeated concussion injuries in this sport. METHODS: Former professional rugby athletes (n = 25) were compared to 25 age-matched participants with no history of a concussion. All participants completed standardised motor dexterity, reaction time, and cognitive tasks for working memory, associative learning and rule acquisition and reversal...
2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29213985/dementia-resulting-from-traumatic-brain-injury
#13
REVIEW
Joana Ramalho, Mauricio Castillo
Traumatic brain injury (TBI) represents a significant public health problem in modern societies. It is primarily a consequence of traffic-related accidents and falls. Other recently recognized causes include sports injuries and indirect forces such as shock waves from battlefield explosions. TBI is an important cause of death and lifelong disability and represents the most well-established environmental risk factor for dementia. With the growing recognition that even mild head injury can lead to neurocognitive deficits, imaging of brain injury has assumed greater importance...
October 2015: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/27029716/cumulative-head-impact-exposure-predicts-later-life-depression-apathy-executive-dysfunction-and-cognitive-impairment-in-former-high-school-and-college-football-players
#14
Philip H Montenigro, Michael L Alosco, Brett M Martin, Daniel H Daneshvar, Jesse Mez, Christine E Chaisson, Christopher J Nowinski, Rhoda Au, Ann C McKee, Robert C Cantu, Michael D McClean, Robert A Stern, Yorghos Tripodis
The term "repetitive head impacts" (RHI) refers to the cumulative exposure to concussive and subconcussive events. Although RHI are believed to increase risk for later-life neurological consequences (including chronic traumatic encephalopathy), quantitative analysis of this relationship has not yet been examined because of the lack of validated tools to quantify lifetime RHI exposure. The objectives of this study were: 1) to develop a metric to quantify cumulative RHI exposure from football, which we term the "cumulative head impact index" (CHII); 2) to use the CHII to examine the association between RHI exposure and long-term clinical outcomes; and 3) to evaluate its predictive properties relative to other exposure metrics (i...
January 15, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29310134/chief-concern-i-m-worried-i-have-chronic-traumatic-encephalopathy
#15
David L Brody
No abstract text is available yet for this article.
February 20, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29256818/motor-function-in-former-professional-football-players-with-history-of-multiple-concussions
#16
Apameh Tarazi, Charles H Tator, Richard Wennberg, Ahmed Ebraheem, Robin E A Green, Brenda Collela, Christina Saverino, Mozghan Khodadadi, Karen Misquitta, Maria Carmela Tartaglia
The objective of this study was to assess the incidence of motor impairment in former professional Canadian Football League (ex-CFL) players with multiple concussions. We investigated motor symptoms and signs in 45 ex-CFL players with multiple concussions and 25 age- and education-matched healthy controls with no history of concussion. Neurological assessment included items from the SCAT3 (Sport Concussion Assessment Tool 3) and the Unified Parkinson's Disease Rating Scale part III (UPDRS-Part III). A performance-based measurement of manual motor function was undertaken using the Grooved Pegboard test...
April 15, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29077582/neuroimaging-in-the-diagnosis-of-chronic-traumatic-encephalopathy-a-systematic-review
#17
Philip Sparks, Tim Lawrence, Stephan Hinze
OBJECTIVE: Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repeated subconcussive and concussive head injury. Clinical features include cognitive, behavioral, mood, and motor impairments. Definitive diagnosis is only possible at postmortem. Here, the utility of neuroimaging in the diagnosis of CTE is evaluated by systematically reviewing recent evidence for changes in neuroimaging biomarkers in suspected cases of CTE compared with controls. DATA SOURCES: Providing an update on a previous systematic review of articles published until December 2014, we searched for articles published between December 2014 and July 2016...
October 25, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29064869/vision-and-vestibular-system-dysfunction-predicts-prolonged-concussion-recovery-in-children
#18
Christina L Master, Stephen R Master, Douglas J Wiebe, Eileen P Storey, Julia E Lockyer, Olivia E Podolak, Matthew F Grady
OBJECTIVE: Up to one-third of children with concussion have prolonged symptoms lasting beyond 4 weeks. Vision and vestibular dysfunction is common after concussion. It is unknown whether such dysfunction predicts prolonged recovery. We sought to determine which vision or vestibular problems predict prolonged recovery in children. DESIGN: A retrospective cohort of pediatric patients with concussion. SETTING: A subspecialty pediatric concussion program...
March 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29036831/dementia-pugilistica-revisited
#19
REVIEW
Rudy J Castellani, George Perry
 Extensive exposure of boxers to neurotrauma in the early 20th century led to the so-called punch drunk syndrome, which was formally recognized in the medical literature in 1928. "Punch drunk" terminology was replaced by the less derisive 'dementia pugilistica' in 1937. In the early case material, the diagnosis of dementia pugilistica required neurological deficits, including slurring dysarthria, ataxia, pyramidal signs, extrapyramidal signs, memory impairment, and personality changes, although the specific clinical substrate has assumed lesser importance in recent years with a shift in focus on molecular pathogenesis...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28742910/clinicopathological-evaluation-of-chronic-traumatic-encephalopathy-in-players-of-american-football
#20
Jesse Mez, Daniel H Daneshvar, Patrick T Kiernan, Bobak Abdolmohammadi, Victor E Alvarez, Bertrand R Huber, Michael L Alosco, Todd M Solomon, Christopher J Nowinski, Lisa McHale, Kerry A Cormier, Caroline A Kubilus, Brett M Martin, Lauren Murphy, Christine M Baugh, Phillip H Montenigro, Christine E Chaisson, Yorghos Tripodis, Neil W Kowall, Jennifer Weuve, Michael D McClean, Robert C Cantu, Lee E Goldstein, Douglas I Katz, Robert A Stern, Thor D Stein, Ann C McKee
Importance: Players of American football may be at increased risk of long-term neurological conditions, particularly chronic traumatic encephalopathy (CTE). Objective: To determine the neuropathological and clinical features of deceased football players with CTE. Design, Setting, and Participants: Case series of 202 football players whose brains were donated for research. Neuropathological evaluations and retrospective telephone clinical assessments (including head trauma history) with informants were performed blinded...
July 25, 2017: JAMA: the Journal of the American Medical Association
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