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CTE

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107 papers 25 to 100 followers
By David Rhine MD FRCPC. Emergency medicine. Special interest in concussion management.
https://www.readbyqxmd.com/read/28077006/longitudinal-assessment-of-health-related-quality-of-life-following-adolescent-sports-related-concussion
#1
Kelly Russell, Erin Selci, Stephanie Chu, Samuel Fineblit, Lesley Ritchie, Michael Ellis
OBJECTIVE: To examine initial and longitudinal health-related quality of life (HRQOL) in adolescent sports-related concussion (SRC) patients. STUDY: A prospective observational case-series study was conducted among adolescent SRC patients who were evaluated at a multi-disciplinary pediatric concussion program. Health-related quality of life was measured using the child self-report Pediatric Quality of Life Inventory (PedsQL) generic score scale (age 13-18 version) and the PedsQL Cognitive Functioning scale...
January 11, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28067738/does-a-unique-neuropsychiatric-profile-currently-exist-for-chronic-traumatic-encephalopathy
#2
Faith M Hanlon, Christopher A McGrew, Andrew R Mayer
There is evidence that repetitive mild traumatic brain injury leads to specific patterns of neuropathological findings, labeled chronic traumatic encephalopathy (CTE). However, questions remain about whether these neuropathological changes produce changes in behavior, cognition, and emotional status that are associated with a unique neuropsychiatric profile that can be assessed using currently available clinical tools. Our review of the literature indicates that insufficient evidence currently exists to suggest a distinct neuropsychiatric profile for CTE...
January 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/27979411/high-school-football-and-late-life-risk-of-neurodegenerative-syndromes-1956-1970
#3
Pieter H H Janssen, Jay Mandrekar, Michelle M Mielke, J Eric Ahlskog, Bradley F Boeve, Keith Josephs, Rodolfo Savica
OBJECTIVE: To assess whether athletes who played American varsity high school football between 1956 and 1970 have an increased risk of neurodegenerative diseases later in life. PATIENTS AND METHODS: We identified all male varsity football players between 1956 and 1970 in the public high schools of Rochester, Minnesota, and non-football-playing male varsity swimmers, wrestlers, and basketball players. Using the medical records linkage system of the Rochester Epidemiology Project, we ascertained the incidence of late-life neurodegenerative diseases: dementia, parkinsonism, and amyotrophic lateral sclerosis...
January 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27906973/detecting-mild-traumatic-brain-injury-using-resting-state-magnetoencephalographic-connectivity
#4
Vasily A Vakorin, Sam M Doesburg, Leodante da Costa, Rakesh Jetly, Elizabeth W Pang, Margot J Taylor
Accurate means to detect mild traumatic brain injury (mTBI) using objective and quantitative measures remain elusive. Conventional imaging typically detects no abnormalities despite post-concussive symptoms. In the present study, we recorded resting state magnetoencephalograms (MEG) from adults with mTBI and controls. Atlas-guided reconstruction of resting state activity was performed for 90 cortical and subcortical regions, and calculation of inter-regional oscillatory phase synchrony at various frequencies was performed...
December 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27886529/autobiographical-and-episodic-memory-deficits-in-mild-traumatic-brain-injury
#5
Jeffrey D Wammes, Tyler J Good, Myra A Fernandes
Those who have suffered a concussion, otherwise known as a mild traumatic brain injury (mTBI), often complain of lingering memory problems. However, there is little evidence in the behavioral literature reliably demonstrating memory deficits. Thus, in the present study, cognitive profiles including measures of general executive functioning and processing speed, as well as episodic and semantic memory were collected in younger and older adult participants with or without a remote (>1year prior to testing) mTBI...
February 2017: Brain and Cognition
https://www.readbyqxmd.com/read/27867100/the-independent-influence-of-concussive-and-sub-concussive-impacts-on-soccer-players-neurophysiological-and-neuropsychological-function
#6
R Davis Moore, Julien Lepine, Dave Ellemberg
Accumulating research demonstrates that repetitive sub-concussive impacts can alter the structure, function and connectivity of the brain. However, the functional significance of these alterations as well as the independent contribution of concussive and sub-concussive impacts to neurophysiological and neuropsychological health are unclear. Accordingly, we compared the neurophysiological and neuropsychological function of contact athletes with (concussion group) and without (sub-concussion group) a history of concussion, to non-contact athletes...
November 17, 2016: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/27843436/lifetime-multiple-mild-traumatic-brain-injuries-are-associated-with-cognitive-and-mood-symptoms-in-young-healthy-college-students
#7
Kyle C Vynorius, Alyssa M Paquin, Daniel R Seichepine
BACKGROUND/OBJECTIVES: Repetitive mild traumatic brain injury (mTBI, also known as concussion) has been associated with a range of long-term mood and cognitive deficits, including executive dysfunction. Previous research in athletes suggests that cognitive and mood problems are associated with a history of repetitive mTBI. However, to date, no studies have examined the impact of a lifetime accumulation of repetitive mTBIs on cognition, particularly executive functioning, and mood in a sample of young adults who were not athletes...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27829969/chronic-traumatic-encephalopathy-in-athletes-involved-with-high-impact-sports
#8
Cyrus Safinia, Eric M Bershad, H Brent Clark, Karen SantaCruz, Naila Alakbarova, Jose I Suarez, Afshin A Divani
BACKGROUND AND PURPOSE: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease occurring most commonly in athletes and is caused by repeated concussive or subconcussive blows to the head. The main purpose of this review is to evaluate the published literature on chronic traumatic encephalopathy (CTE) in athletes participating in high-impact sports. In particular, we highlight the significance of concussive and subconcussive impacts in multiple sports, elucidate the differences between clinical/pathological features of CTE and related neurodegenerative diseases, and provide an explanation for the variation in clinical presentation between athletes of different sports...
October 2016: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/27815240/persistent-effects-of-playing-football-and-associated-subconcussive-head-trauma-on-brain-structure-and-function-a-systematic-review-of-the-literature
#9
REVIEW
A A Tarnutzer, D Straumann, P Brugger, N Feddermann-Demont
AIM/OBJECTIVE: There is ongoing controversy about persistent neurological deficits in active and former football (soccer) players. We reviewed the literature for associations between football activities (including heading/head injuries) and decline in brain structure/function. DESIGN: Systematic literature review. DATA SOURCES: MEDLINE, Embase, PsycINFO, CINAHL, Cochrane-CRCT, SportDiscus, Cochrane-DSR=4 (accessed 2 August 2016). ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Original studies reporting on football-related persistent effects on brain structure/function...
November 4, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27686843/does-neuroinflammation-drive-the-relationship-between-tau-hyperphosphorylation-and-dementia-development-following-traumatic-brain-injury
#10
REVIEW
Lyndsey E Collins-Praino, Frances Corrigan
A history of traumatic brain injury (TBI) is linked to an increased risk for the later development of dementia. This encompasses a variety of neurodegenerative diseases including Alzheimer's Disease (AD) and chronic traumatic encephalopathy (CTE), with AD linked to history of moderate-severe TBI and CTE to a history of repeated concussion. Of note, both AD and CTE are characterized by the abnormal accumulation of hyperphosphorylated tau aggregates, which are thought to play an important role in the development of neurodegeneration...
February 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27654455/cerebrospinal-fluid-biomarkers-in-postconcussion-syndrome-measuring-neuronal-injury-and-distinguishing-individuals-at-risk-for-persistent-postconcussion-syndrome-or-chronic-traumatic-encephalopathy
#11
https://www.readbyqxmd.com/read/27587800/sports-concussion-research-chronic-traumatic-encephalopathy-and-the-media-repairing-the-disconnect
#12
Andrew W Kuhn, Aaron M Yengo-Kahn, Zachary Y Kerr, Scott L Zuckerman
No abstract text is available yet for this article.
September 1, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27474382/multiple-past-concussions-in-high-school-football-players-are-there-differences-in-cognitive-functioning-and-symptom-reporting
#13
Brian L Brooks, Rebekah Mannix, Bruce Maxwell, Ross Zafonte, Paul D Berkner, Grant L Iverson
BACKGROUND: There is increasing concern about the possible long-term effects of multiple concussions, particularly on the developing adolescent brain. Whether the effect of multiple concussions is detectable in high school football players has not been well studied, although the public health implications are great in this population. PURPOSE: To determine if there are measureable differences in cognitive functioning or symptom reporting in high school football players with a history of multiple concussions...
December 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27432348/the-impact-of-traumatic-brain-injury-on-the-aging-brain
#14
REVIEW
Jacob S Young, Jonathan G Hobbs, Julian E Bailes
Traumatic brain injury (TBI) has come to the forefront of both the scientific and popular culture. Specifically, sports-related concussions or mild TBI (mTBI) has become the center of scientific scrutiny with a large amount of research focusing on the long-term sequela of this type of injury. As the populace continues to age, the impact of TBI on the aging brain will become clearer. Currently, reports have come to light that link TBI to neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, as well as certain psychiatric diseases...
September 2016: Current Psychiatry Reports
https://www.readbyqxmd.com/read/27400367/association-of-traumatic-brain-injury-with-late-life-neurodegenerative-conditions-and-neuropathologic-findings
#15
Paul K Crane, Laura E Gibbons, Kristen Dams-O'Connor, Emily Trittschuh, James B Leverenz, C Dirk Keene, Joshua Sonnen, Thomas J Montine, David A Bennett, Sue Leurgans, Julie A Schneider, Eric B Larson
IMPORTANCE: The late effects of traumatic brain injury (TBI) are of great interest, but studies characterizing these effects are limited. OBJECTIVE: To determine whether TBI with loss of consciousness (LOC) is associated with an increased risk for clinical and neuropathologic findings of Alzheimer disease (AD), Parkinson disease (PD), and other dementias. DESIGN, SETTING, AND PARTICIPANTS: This study analyzed data from the Religious Orders Study (ROS), Memory and Aging Project (MAP), and Adult Changes in Thought study (ACT)...
September 1, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27364748/sports-related-concussions-media-science-and-policy
#16
REVIEW
Rebekah Mannix, William P Meehan, Alvaro Pascual-Leone
Although growing awareness about the potential long-term deleterious effects of sport-related concussion has led to increased attention to the risks of collision sports, calls to ban these sports, such as American football, might be premature. Collision sports have a relatively high incidence of concussions, but participation in these sports also confers a host of benefits. In addition, the associated risks of participation, including concussion, have not been definitively shown to outweigh the benefits they provide, and the risk-benefit ratio might vary among individuals...
August 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27350072/novel-method-of-weighting-cumulative-helmet-impacts-improves-correlation-with-brain-white-matter-changes-after-one-football-season-of-sub-concussive-head-blows
#17
Kian Merchant-Borna, Patrick Asselin, Darren Narayan, Beau Abar, Courtney M C Jones, Jeffrey J Bazarian
One football season of sub-concussive head blows has been shown to be associated with subclinical white matter (WM) changes on diffusion tensor imaging (DTI). Prior research analyses of helmet-based impact metrics using mean and peak linear and rotational acceleration showed relatively weak correlations to these WM changes; however, these analyses failed to account for the emerging concept that neuronal vulnerability to successive hits is inversely related to the time between hits (TBH). To develop a novel method for quantifying the cumulative effects of sub-concussive head blows during a single season of collegiate football by weighting helmet-based impact measures for time between helmet impacts...
December 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/24366527/the-neuropathology-of-sport
#18
REVIEW
Ann C McKee, Daniel H Daneshvar, Victor E Alvarez, Thor D Stein
The benefits of regular exercise, physical fitness and sports participation on cardiovascular and brain health are undeniable. Physical activity reduces the risk for cardiovascular disease, type 2 diabetes, hypertension, obesity, and stroke, and produces beneficial effects on cholesterol levels, antioxidant systems, inflammation, and vascular function. Exercise also enhances psychological health, reduces age-related loss of brain volume, improves cognition, reduces the risk of developing dementia, and impedes neurodegeneration...
January 2014: Acta Neuropathologica
https://www.readbyqxmd.com/read/27304663/a-head-on-collision-with-the-national-football-league
#19
Esther Lau
No abstract text is available yet for this article.
June 2016: Lancet Neurology
https://www.readbyqxmd.com/read/24553561/how-are-you-really-feeling-a-prospective-evaluation-of-cognitive-function-following-trauma
#20
Erin C Hall, Eric Lund, Diane Brown, Karen R Murdock, Lisa Gettings, Thomas M Scalea, Deborah M Stein
BACKGROUND: Mild traumatic brain injury is associated with persistent cognitive difficulties. However, these symptoms may not be specific to the head injury itself. We sought to evaluate the prevalence of these symptoms in patients following trauma. METHODS: A prospective analysis of patients who were seen in the outpatient trauma clinic during a 20-month period and completed self-administered Rivermead Post-Concussion Symptoms Questionnaire was conducted. "Significant" difficulty with cognition was defined by two or more symptoms reported as severe or four or more symptoms reported as moderate...
March 2014: Journal of Trauma and Acute Care Surgery
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