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New Addictive Substances

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2 papers 25 to 100 followers
By Christopher Cook Addiction professional. LPC, CADC, CRNP- student, Interventionist, project manager, owner, Director, eval/refer for SUDs/Eating D/o's, 60000 beds referral base
Krystyna Gołembiowska, Alexandra Jurczak, Katarzyna Kamińska, Karolina Noworyta-Sokołowska, Anna Górska
New psychoactive "designer drugs" are synthetic compounds developed to provide similar effects to illicit drugs of abuse, but not subjected to legal control. The rapidly changing legal status of novel psychoactive drugs triggers the development of new compounds, analogs of well-known amphetamine or mescaline. New designer drugs used as substitutes in ecstasy pills are the least investigated and can cause life-threatening effects on users. The aim of our research was to examine the effects of acute administration of 4-methoxyamphetamine (PMA, 5 and 10 mg/kg), 4-methoxy-N-methylamphetamine (PMMA, 5 and 10 mg/kg), and mephedrone (MEPH, 5, 10 and 20 mg/kg) on extracellular and tissue level of dopamine (DA), 5-hydroxytryptamine (5-HT) and their metabolites in rat brain, by microdialysis method in freely moving animals and HPLC...
April 2016: Neurotoxicity Research
Carolina Costa, Alberto Araujo, Marco Brasil, Marcelo Cruz
OBJECTIVE: Alert for the risk of oral bupropion addiction in patients with cocaine dependence. METHODS: Single-case study. RESULTS: After a period of cocaine and alcohol abstinence, a 42-year-old patient started taking oral bupropion to relieve the symptoms of cocaine craving. He increased the bupropion dose up to 2250 mg/d without seizures. CONCLUSION: This case highlights the possibility of oral bupropion addiction after cocaine dependence...
March 2015: Journal of Addiction Medicine
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