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Metabolic syndrome

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82 papers 25 to 100 followers Issues surrounding prevention, treatment, complications, outcomes of metabolic syndrome, insulin resistance, cardiovascular risk factors, etc.
By Jamie Jarmul Md / PhD student at UNC - Chapel Hill, PhD in Health Policy and Management
Chiyo Tsutsumi, Tatsuyuki Kakuma
Associations have been reported between periodontal disease and increased cardiovascular disease risk, as well as between healthy self-reported tooth brushing behavior and reduced cardiovascular disease risk. We examined the association between self-reported tooth brushing behavior and the risk of metabolic syndrome (MetS) using a large medical check-up database. A total of 12,548 medical checkup records from a medical screening center in a city in southwest Japan were assessed. Subjects were aged 30 to 59 years...
2015: Kurume Medical Journal
Mohamed H Ahmed, Nazik Elmalaika Os Husain, Ahmed O Almobarak
Nonalcoholic fatty liver disease (NAFLD) is emerging as the most common chronic liver condition in Western World and across the globe. NAFLD prevalence is estimated to be around one-third of the total population. There are no published data that project the future prevalence of NAFLD, but with an increase in epidemic of diabetes and obesity, it is possible to suggest an increase in a number of individuals with NAFLD. NAFLD is associated with insulin resistance and occurs with an increase in cluster of features of metabolic syndrome and type 2 diabetes...
January 2015: Journal of Family Medicine and Primary Care
David Fitchett
Traditional risk factors can underestimate the true risk of developing atherosclerotic cardiovascular disease. Abdominal obesity is associated with a cluster of risk factors that include dyslipidemia, dysglycemia, and hypertension, termed metabolic syndrome (MS). The presence of MS increases cardiovascular risk 50%-100% beyond that defined according to traditional risk factors, and increases the risk of developing type 2 diabetes. Recognition of patients with MS is important to: (1) identify patients at increased risk beyond that conveyed by traditional risk factors; and (2) understand that the metabolic abnormalities associated with MS are largely reversed by measures that reduce abdominal obesity...
May 2015: Canadian Journal of Cardiology
Ricardo Ladeiras-Lopes, Ricardo Fontes-Carvalho, Nuno Bettencourt, Francisco Sampaio, Vasco Gama, Adelino Leite-Moreira
INTRODUCTION: Metformin is a widely used drug in the treatment of type 2 diabetes mellitus (T2DM). However, it is becoming an attractive drug to manage patients with pre-diabetes and to possibly prevent cardiac remodeling and fibrosis and heart failure. AREAS COVERED: In this review, we highlight the novel therapeutic targets of metformin with a special emphasis on cardiovascular disease. We discuss its key mechanisms of action and new signaling pathways that could partially account for its effect...
July 2015: Expert Opinion on Therapeutic Targets
Anna E Greer, Xuemei Sui, Andréa L Maslow, Beau Kjerulf Greer, Steven N Blair
BACKGROUND: To date, no longitudinal studies have examined the influence of sedentary behavior on metabolic syndrome development while accounting for cardiorespiratory fitness. PURPOSE AND METHODS: This prospective study examined the relationship between sedentary behavior and incident metabolic syndrome while considering the effects of physical activity and cardiorespiratory fitness on the association among 930 men enrolled in the Aerobics Center Longitudinal Study...
January 2015: Journal of Physical Activity & Health
William Arguelles, Maria M Llabre, Ralph L Sacco, Frank J Penedo, Mercedes Carnethon, Linda C Gallo, David J Lee, Diane J Catellier, Hector M González, Christina Holub, Laura R Loehr, Elsayed Z Soliman, Neil Schneiderman
BACKGROUND/OBJECTIVES: Empirical investigation of the adequacy of metabolic syndrome (MetS) diagnostic criteria, and whether meaningful subtypes of MetS exist, is needed among Hispanics/Latinos. METHODS: In 15,825 US Hispanics/Latinos from HCHS/SOL, latent class analysis of MetS components (waist circumference, systolic and diastolic blood pressure, HDL cholesterol, triglycerides, glucose, and antihypertensive, lipid- and glucose-lowering medication use) was used to investigate (1) whether distinct subtypes of MetS could be identified, and how component levels differed between them, and (2) how identified subtypes related to covariates and cardiovascular disease (CVD) prevalence...
April 1, 2015: International Journal of Cardiology
Amedeo Lonardo, Stefano Ballestri, Giulio Marchesini, Paul Angulo, Paola Loria
The conventional paradigm of nonalcoholic fatty liver disease representing the "hepatic manifestation of the metabolic syndrome" is outdated. We identified and summarized longitudinal studies that, supporting the association of nonalcoholic fatty liver disease with either type 2 diabetes mellitus or metabolic syndrome, suggest that nonalcoholic fatty liver disease precedes the development of both conditions. Online Medical databases were searched, relevant articles were identified, their references were further assessed and tabulated data were checked...
March 2015: Digestive and Liver Disease
Tsogzolbaatar Enkh-Oyun, Kazuhiko Kotani, Dambadarjaa Davaalkham, Gombojav Davaa, Ulziibayar Ganchimeg, Dayan Angarmurun, Nanjid Khuderchuluun, Bayartsogt Batzorig, Satoshi Tsuboi, Ryusuke Ae, Yasuko Aoyama, Yosikazu Nakamura
BACKGROUND: Although cardiovascular health is a crucial problem for Mongolian people, little information about metabolic syndrome, which is well known to be associated with the development of cardiovascular disease, is available in Mongolia. The aim of this study was to observe the epidemiological features of metabolic syndrome in a general Mongolian population. METHODS: This cross-sectional study was performed in 1911 general Mongolian subjects (717 men, 1194 women), who were ≥40 years old and free of ischemic heart disease, by using a dataset from a nationwide population-based cohort study in Mongolia...
May 2015: Metabolic Syndrome and related Disorders
Giovanni Targher, Christopher D Byrne
Nonalcoholic fatty liver disease (NAFLD) is increasingly being diagnosed worldwide and is strongly associated with the features of metabolic syndrome. In this brief review, we discuss two key questions relating to NAFLD and metabolic syndrome: (1) Does NAFLD predict the development of type 2 diabetes mellitus and metabolic syndrome, or is it simply an epiphenomenon? (2) Are there differences between metabolic syndrome-associated NAFLD and NAFLD associated with genetic variation in the patatin-like phospholipase domain-containing 3 (PNPLA3) gene? Accumulating evidence indicates that NAFLD is not simply the hepatic manifestation of the metabolic syndrome, but is a pathogenic determinant of the syndrome...
August 2015: Metabolic Syndrome and related Disorders
Mohamed Asrih, François R Jornayvaz
Metabolic syndrome (MetS) is a disease composed of different risk factors such as obesity, type 2 diabetes or dyslipidemia. The prevalence of this syndrome is increasing worldwide in parallel with the rise in obesity. Nonalcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in western countries, affecting more than 30% of the general population. NAFLD encompasses a spectrum of liver manifestations ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis, which may ultimately progress to hepatocellular carcinoma...
December 15, 2015: Molecular and Cellular Endocrinology
Bijan Iraj, Ramin Salami, Awat Feizi, Massoud Amini
BACKGROUND: The present study was designed to evaluate hypertension and dyslipidemia in prediabetic subjects with a family history of type 2 diabetes (first-degree relatives), and they were compared with the normal glucose-tolerance subjects. MATERIALS AND METHODS: Three thousand and eighty-six (788 men and 2298 women) subjects were selected from a consecutive sample of patients with Impaired Glucose Tolerance (IGT), Impaired Fasting Glucose (IFG), and Combined (IFG and IGT), and their first-degree relatives formed the control group...
2015: Advanced Biomedical Research
A Mousa, N Naderpoor, H J Teede, M P J De Courten, R Scragg, B De Courten
Obesity, type 2 diabetes, and cardiovascular disease (CVD) are the most common preventable causes of morbidity and mortality worldwide. Insulin resistance, which is a shared feature in these conditions, is also strongly linked to the development of polycystic ovary syndrome (PCOS), which is the most common endocrine disease in women of reproductive age and a major cause of infertility. Vitamin D deficiency has reached epidemic proportions worldwide, primarily due to the shift to sedentary, indoor lifestyles and sun avoidance behaviours to protect against skin cancer...
September 2015: Minerva Endocrinologica
Mohsen Hosseini, Nizal Sarrafzadegan, Roya Kelishadi, Mehri Monajemi, Sedigheh Asgary, Hossein Molavi Vardanjani
BACKGROUND: Metabolic syndrome (MetSy), an important predisposing factor for the most of noncommunicable diseases, has become a global pandemic. Given different definitions used for the MetSy, recently using a score termed "continuous MetSy risk score (CMetSyS)" is recommended. The aim of this study was to provide a CMetSyS in a population-based sample of Iranian adults and to assess its determinants. MATERIALS AND METHODS: We used the data of the baseline survey of a community trial entitled "the Isfahan health heart program...
December 2014: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Unjin Shim, Han-Na Kim, Yeon-Ah Sung, Hyung-Lae Kim
Metabolic syndrome (MetS) is a complex disorder related to insulin resistance, obesity, and inflammation. Genetic and environmental factors also contribute to the development of MetS, and through genome-wide association studies (GWASs), important susceptibility loci have been identified. However, GWASs focus more on individual single-nucleotide polymorphisms (SNPs), explaining only a small portion of genetic heritability. To overcome this limitation, pathway analyses are being applied to GWAS datasets. The aim of this study is to elucidate the biological pathways involved in the pathogenesis of MetS through pathway analysis...
December 2014: Genomics & Informatics
Birgit Gustafson, Shahram Hedjazifar, Silvia Gogg, Ann Hammarstedt, Ulf Smith
The adipose tissue is crucial in regulating insulin sensitivity and risk for diabetes through its lipid storage capacity and thermogenic and endocrine functions. Subcutaneous adipose tissue (SAT) stores excess lipids through expansion of adipocytes (hypertrophic obesity) and/or recruitment of new precursor cells (hyperplastic obesity). Hypertrophic obesity in humans, a characteristic of genetic predisposition for diabetes, is associated with abdominal obesity, ectopic fat accumulation, and the metabolic syndrome (MS), while the ability to recruit new adipocytes prevents this...
April 2015: Trends in Endocrinology and Metabolism: TEM
YuSong Ding, ShuGang Li, Ru-Lin Ma, Heng Guo, JingYu Zhang, Mei Zhang, JiaMing Liu, ShuXia Guo
OBJECTIVE: We examined the association between insulin resistance (IR), adiponectin, and inflammation markers and the development of metabolic syndrome (MetS). Furthermore, we aimed to establish the relationship between IR, serum adiponectin, and parameters of chronic inflammation. METHODS: MetS was assessed in 1628 Kazakh participants (768 men; 860 women) in Xinjiang, Northwestern China. RESULTS: Adiponectin, homeostasis model assessment of IR (HOMA-IR), interleukin-6 (IL-6), and C-reactive protein (CRP) remained significantly associated with MetS after further adjustment for sex, age, smoking status, low-density lipoprotein cholesterol, total cholesterol, and high-density lipoprotein cholesterol...
May 2015: Clinical Biochemistry
Michelle Alessandra de Castro, Valéria Troncoso Baltar, Dirce Maria Lobo Marchioni, Regina Mara Fisberg
OBJECTIVE: At elevated concentrations, circulating leptin has been associated with metabolic disturbances, namely insulin resistance, elevated blood pressure, inflammation, and endothelial dysfunction. Because women have higher leptin concentrations than men, it is possible that the effects of leptin on the metabolic profile are different between the sexes. The aim of this study was to investigate whether leptin is one of the key hormones to sex affect differences in the pathophysiology of cardiometabolic risk...
March 2015: Nutrition
Mari Nupponen, Katja Pahkala, Markus Juonala, Costan G Magnussen, Harri Niinikoski, Tapani Rönnemaa, Jorma S A Viikari, Maiju Saarinen, Hanna Lagström, Antti Jula, Olli Simell, Olli T Raitakari
BACKGROUND: Adolescent metabolic syndrome (MetS) predicts type 2 diabetes mellitus and subclinical atherosclerosis in adulthood. Our aim was to establish the relationship between an infancy-onset dietary intervention and risk of having MetS between 15 and 20 years of age. METHODS AND RESULTS: The Special Turku Coronary Risk Factor Intervention Project for Children (STRIP) study is a longitudinal, randomized atherosclerosis prevention trial in which repeated dietary counseling aiming at reducing intake of saturated fat took place from infancy to early adulthood...
February 17, 2015: Circulation
Sarah E Messiah, Denise C Vidot, Gabriel Somarriba, Kanathy Haney, Semra Aytur, Ruby A Natale, Jeffrey P Brosco, Kristopher L Arheart
AIM: To generate prevalence estimates of weight status and cardiometabolic disease risk factors among adolescents with and without disabilities. METHODS: Analysis of the 1999-2010 National Health and Nutrition Examination Survey data was conducted among 12-18 years old with (n = 256) and without disabilities (n = 5020). Mean values of waist circumference, fasting glucose, high-density-lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure and metabolic syndrome (MetS, ≥ 3 risk factors present) were examined by the following standardized body mass index (BMI) categories for those with and without disabilities; overweight (BMI ≥ 85(th) - < 95(th) percentile for age and sex), obesity (BMI ≥ 95(th) percentile) and severe obesity (BMI ≥35 kg/m(2))...
February 15, 2015: World Journal of Diabetes
Derya Atik, Cem Atik, Hilal Karatepe
INTRODUCTION: Metabolic Syndrome (MetS) is basically a cluster of cardiovascular risks that involve changes in metabolic and hemodynamic indicators; various organizations have defined it with small differences. Metabolic syndrome is a lethal endocrinopathy starting with insulin resistance and inviting a chain of systemic disorders such as abdominal obesity, glucose intolerance or diabetes mellitus (DM), dyslipidemia, hypertension (HT) and coronary artery disease (CAD). MATERIAL AND METHODS: This prospective and descriptive study was conducted at the Cardiology Clinic of a Private Hospital in Osmaniye between January 2014 and May 2014...
December 2014: Acta Informatica Medica: AIM
2015-02-20 16:12:29
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