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Endothelial Function and Disease

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153 papers 25 to 100 followers
By Gregory Gustafson Interventional Cardiologist
https://www.readbyqxmd.com/read/30295766/inflammation-the-new-cardiovascular-risk-factor
#1
Thomas F Lüscher
No abstract text is available yet for this article.
October 7, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30167649/advances-in-understanding-the-pathophysiology-of-lacunar-stroke-a-review
#2
Robert W Regenhardt, Alvin S Das, Eng H Lo, Louis R Caplan
Importance: Stroke is the second leading cause of death in the world, and nearly one-third of ischemic strokes are lacunar strokes (LSs) or small subcortical infarcts. Although smaller in size, they create large problems, leaving many patients with intellectual and physical disabilities. Because there are limitations in understanding the underlying pathophysiology of LS, the development of novel therapies has been slow. Observations: When the term lacune was described in the 1800s, its underlying pathophysiological basis was obscure...
October 1, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/30178172/association-between-primary-sjogren-s-syndrome-arterial-stiffness-and-subclinical-atherosclerosis-a-systematic-review-and-meta-analysis
#3
Wai Chung Yong, Anawin Sanguankeo, Sikarin Upala
In rheumatoid arthritis and systemic lupus erythematosus, cardiovascular disease is frequently one of the leading causes of mortality or morbidity. Studies have shown that acute systemic inflammation and chronic systemic vasculitis are associated with endothelial dysfunction and atherosclerotic plaque formation, subsequently leading to cardiovascular disease. This meta-analysis aimed to explore the association of subclinical atherosclerosis and arterial stiffness in primary Sjogren's syndrome. A comprehensive search of the MEDLINE and Embase databases was performed from date of inception through August 2017...
September 3, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/30178377/polyunsaturated-fatty-acids-induce-ros-synthesis-in-microvascular-endothelial-cells
#4
Simon Trommer, Anja Leimert, Michael Bucher, Julia Schumann
In sepsis, endothelial dysfunction is a crucial driver known to limit the survival rate of affected patients. For this, ROS-mediated signaling plays an important role in endothelial communication and functionality. In the management of sepsis, polyunsaturated fatty acids (PUFA) have received increasing attention regarding their anti-inflammatory potential neglecting the oxidative properties of these substances. Therefore, in the present study we examined the capacity of PUFA to interfere with the expression of major ROS-producing enzymes, as well as endothelial ROS production itself...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30102639/manipulating-the-microcirculation-in-sepsis-the-impact-of-vasoactive-medications-on-microcirculatory-blood-flow-a-systematic-review
#5
Elizabeth K Potter, Luke Hodgson, Ben Creagh-Brown, Lui G Forni
BACKGROUND: Sepsis is life-threatening organ dysfunction due to a dysregulated host response to infection. Disturbed microvascular blood flow is associated with excess mortality and is a potential future target for interventions. This review addresses the evidence for pharmacological manipulation of the microcirculation in sepsis assessed by techniques that evaluate the sublingual microvasculature. METHODS: Systematic review using a published protocol. Eligibility criteria were studies of septic patients published from Jan 2000 - February 2018...
August 10, 2018: Shock
https://www.readbyqxmd.com/read/29957262/predictors-of-poor-clinical-outcomes-in-patients-with-acute-myocardial-infarction-and-non-obstructed-coronary-arteries-minoca
#6
Giuseppe Ciliberti, Stefano Coiro, Isabella Tritto, Martina Benedetti, Federico Guerra, Maurizio Del Pinto, Gherardo Finocchiaro, Claudio Cavallini, Alessandro Capucci, Juan Carlos Kaski, Giuseppe Ambrosio
OBJECTIVE: To assess the characteristics and prognosis of patients with myocardial infarction and non-obstructed coronary arteries (MINOCA). METHODS: MINOCA was defined as acute myocardial infarction (AMI) with angiographic coronary stenosis <50%.Cardiomyopathies and myocarditis were - a priori - excluded from the study. Stenoses <30% were considered normal coronary arteries (NCA); stenoses ≥30% but <50% were considered mild coronary artery disease (MCAD)...
September 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30075114/argininosuccinate-lyase-deficiency-causes-an-endothelial-dependent-form-of-hypertension
#7
Jordan Kho, Xiaoyu Tian, Wing-Tak Wong, Terry Bertin, Ming-Ming Jiang, Shan Chen, Zixue Jin, Oleg A Shchelochkov, Lindsay C Burrage, Anilkumar K Reddy, Hong Jiang, Reem Abo-Zahrah, Shuangtao Ma, Ping Zhang, Karl-Dimiter Bissig, Jean J Kim, Sridevi Devaraj, George G Rodney, Ayelet Erez, Nathan S Bryan, Sandesh C S Nagamani, Brendan H Lee
Primary hypertension is a major risk factor for ischemic heart disease, stroke, and chronic kidney disease. Insights obtained from the study of rare Mendelian forms of hypertension have been invaluable in elucidating the mechanisms causing primary hypertension and development of antihypertensive therapies. Endothelial cells play a key role in the regulation of blood pressure; however, a Mendelian form of hypertension that is primarily due to endothelial dysfunction has not yet been described. Here, we show that the urea cycle disorder, argininosuccinate lyase deficiency (ASLD), can manifest as a Mendelian form of endothelial-dependent hypertension...
August 2, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29957236/the-role-of-nutraceuticals-in-statin-intolerant-patients
#8
REVIEW
Maciej Banach, Angelo Maria Patti, Rosaria Vincenza Giglio, Arrigo F G Cicero, Atanas G Atanasov, Gani Bajraktari, Eric Bruckert, Olivier Descamps, Dragan M Djuric, Marat Ezhov, Zlatko Fras, Stephan von Haehling, Niki Katsiki, Michel Langlois, Gustavs Latkovskis, G B John Mancini, Dimitri P Mikhailidis, Olena Mitchenko, Patrick M Moriarty, Paul Muntner, Dragana Nikolic, Demosthenes B Panagiotakos, Gyorgy Paragh, Bernhard Paulweber, Daniel Pella, Christos Pitsavos, Željko Reiner, Giuseppe M C Rosano, Robert S Rosenson, Jacek Rysz, Amirhossein Sahebkar, Maria-Corina Serban, Dragos Vinereanu, Michal Vrablík, Gerald F Watts, Nathan D Wong, Manfredi Rizzo
Statins are the most common drugs administered for patients with cardiovascular disease. However, due to statin-associated muscle symptoms, adherence to statin therapy is challenging in clinical practice. Certain nutraceuticals, such as red yeast rice, bergamot, berberine, artichoke, soluble fiber, and plant sterols and stanols alone or in combination with each other, as well as with ezetimibe, might be considered as an alternative or add-on therapy to statins, although there is still insufficient evidence available with respect to long-term safety and effectiveness on cardiovascular disease prevention and treatment...
July 3, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29905819/hdl-cholesterol-genetics-and-coronary-artery-disease-the-myth-of-the-good-cholesterol
#9
Ulf Landmesser, Stan Hazen
No abstract text is available yet for this article.
June 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29878171/connecting-the-pieces-of-takotsubo-broken-heart
#10
Andros Tofield
No abstract text is available yet for this article.
June 7, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29883529/the-protective-activities-of-dietary-sea-cucumber-cerebrosides-against-atherosclerosis-through-regulating-inflammation-and-cholesterol-metabolism-in-male-mice
#11
Lingyu Zhang, Tiantian Zhang, Lin Ding, Jie Xu, Changhu Xue, Teruyoshi Yanagita, Yaoguang Chang, Yuming Wang
SCOPE: Cerebroside is an active component extracted from sea cucumber (SCC), which is a traditional tonic food in China. In this study, the protective effect of SCC on atherogenesis is investigated and the possible underlying mechanism is determined. METHOD AND RESULTS: Male C57BL/6J obese mice were first used to explore the impact of SCC at different doses on alleviating lipid disorders and insulin sensitivity. Then ApoE-/- mice were used to evaluate the protective activities of SCC on atherosclerosis...
August 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29902700/ticagrelor-a-p2y12-antagonist-attenuates-vascular-dysfunction-and-inhibits-atherogenesis-in-apolipoprotein-e-deficient-mice
#12
Byambasuren Ganbaatar, Daiju Fukuda, Hotimah Masdan Salim, Sachiko Nishimoto, Kimie Tanaka, Yasutomi Higashikuni, Yoichiro Hirata, Shusuke Yagi, Takeshi Soeki, Masataka Sata
BACKGROUND AND AIMS: Ticagrelor reduces cardiovascular events in patients with acute coronary syndrome (ACS). Recent studies demonstrated the expression of P2Y12 on vascular cells including endothelial cells, as well as platelets, and suggested its contribution to atherogenesis. We investigated whether ticagrelor attenuates vascular dysfunction and inhibits atherogenesis in apolipoprotein E-deficient (apoe-/- ) mice. METHODS: Eight-week-old male apoe-/- mice were fed a western-type diet (WTD) supplemented with 0...
August 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29853488/perivascular-adipose-tissue-and-coronary-atherosclerosis
#13
REVIEW
Jennifer Mancio, Evangelos K Oikonomou, Charalambos Antoniades
Adipose tissue (AT) is no longer viewed as a passive, energy-storing depot, and a growing body of evidence supports the concept that both quantitative and qualitative aspects of AT are critical in determining an individual's cardiometabolic risk profile. Among all AT sites, perivascular AT (PVAT) has emerged as a depot with a distinctive biological significance in cardiovascular disease given its close anatomical proximity to the vasculature. Recent studies have suggested the presence of complex, bidirectional paracrine and vasocrine signalling pathways between the vascular wall and its PVAT, with far-reaching implications in cardiovascular diagnostics and therapeutics...
October 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29791828/diagnosis-and-management-of-the-antiphospholipid-syndrome
#14
REVIEW
David Garcia, Doruk Erkan
New England Journal of Medicine, Volume 378, Issue 21, Page 2010-2021, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29766750/clopidogrel-and-aspirin-in-acute-ischemic-stroke-and-high-risk-tia
#15
RANDOMIZED CONTROLLED TRIAL
S Claiborne Johnston, J Donald Easton, Mary Farrant, William Barsan, Robin A Conwit, Jordan J Elm, Anthony S Kim, Anne S Lindblad, Yuko Y Palesch
BACKGROUND: Combination antiplatelet therapy with clopidogrel and aspirin may reduce the rate of recurrent stroke during the first 3 months after a minor ischemic stroke or transient ischemic attack (TIA). A trial of combination antiplatelet therapy in a Chinese population has shown a reduction in the risk of recurrent stroke. We tested this combination in an international population. METHODS: In a randomized trial, we assigned patients with minor ischemic stroke or high-risk TIA to receive either clopidogrel at a loading dose of 600 mg on day 1, followed by 75 mg per day, plus aspirin (at a dose of 50 to 325 mg per day) or the same range of doses of aspirin alone...
July 19, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29571427/myocardial-infarction-with-no-obstructive-coronary-artery-disease-angiographic-and-clinical-insights-in-patients-with-premature-presentation
#16
Valeria Raparelli, Malik Elharram, Avi Shimony, Mark J Eisenberg, Asim N Cheema, Louise Pilote
BACKGROUND: Premature myocardial infarction (MI) is an increasingly prevalent cause of morbidity and mortality worldwide. A subset of patients, predominantly young women, present with MI with no obstructive coronary artery disease (MINOCA), a nomenclature gaining recognition. However, few data exist on presentation and prognosis according to the severity of coronary artery disease (CAD). METHODS: We studied patients with premature (younger than 55 years of age) acute MI enrolled in a large cohort in 24 centres across Canada...
April 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29773586/seafood-long-chain-n-3-polyunsaturated-fatty-acids-and-cardiovascular-disease-a-science-advisory-from-the-american-heart-association
#17
REVIEW
Eric B Rimm, Lawrence J Appel, Stephanie E Chiuve, Luc Djoussé, Mary B Engler, Penny M Kris-Etherton, Dariush Mozaffarian, David S Siscovick, Alice H Lichtenstein
Since the 2002 American Heart Association scientific statement "Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease," evidence from observational and experimental studies and from randomized controlled trials continues to emerge to further substantiate the beneficial effects of seafood long-chain n-3 polyunsaturated fatty acids and cardiovascular disease. A recent American Heart Association science advisory addressed the specific effect of n-3 polyunsaturated fatty acid supplementation on clinical cardiovascular events...
July 3, 2018: Circulation
https://www.readbyqxmd.com/read/29746260/confirmed-coronary-spasm-at-the-culprit-vessel-of-plaque-erosion-in-a-patient-with-new-onset-ventricular-fibrillation
#18
Kazuma Tashiro, Hiroyoshi Mori, Hiromoto Sone, Yousuke Takei, Masahiro Sasai, Atsuo Maeda, Tokutada Sato, Hiroshi Suzuki
No abstract text is available yet for this article.
November 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29627296/relationship-between-lipoprotein-subfraction-cholesterol-and-residual-risk-for-cardiovascular-outcomes-a-post-hoc-analysis-of-the-aim-high-trial
#19
Peter P Toth, Steven R Jones, April Slee, Jerome Fleg, Santica M Marcovina, Megan Lacy, Ruth McBride, William E Boden
BACKGROUND: The AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides and Impact on Global Health Outcomes) trial failed to demonstrate incremental clinical benefit of extended-release niacin (ERN) in 3414 statin-treated patients with established cardiovascular (CV) disease who had low baseline levels of high-density lipoprotein cholesterol (HDL-C) as compared to placebo. A previous secondary analysis suggested that ERN provided outcome benefits in ERN-treated patients with high triglycerides (TGs; >200 mg/dL) and very low HDL-C (<32 mg/dL) at baseline...
May 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29526680/endothelial-dysfunction-of-coronary-arteries-in-subjects-without-diabetes-an-association-with-both-insulin-resistance-and-impaired-insulin-secretion-response
#20
Katarina Lalić, Milan Nedeljković, Alekasandra Jotić, Rade Babić, Nataša Rajković, Ljiljana Popović, Ljiljana Lukić, Tanja Miličić, Sandra Singh Lukač, Ljubica Stošić, Marija Maćešić, Iva Rasulić, Jelena Stanarčić Gajović, Nebojša M Lalić
AIMS: This study was aimed to compare insulin sensitivity and secretion response, lipoprotein and plasminogen activator inhibitor 1 (PAI-1) levels between the subjects with and without coronary artery endothelial dysfunction (ED). METHODS: ED was detected by intracoronary injection of acetylcholine (ACh) in 47 nondiabetes subjects without stenotic coronary arteries, selected from 316 consecutive patients with coronary angiography performed for suspected coronary artery disease...
May 2018: Diabetes Research and Clinical Practice
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