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Endothelial Function and Disease

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111 papers 0 to 25 followers
By Gregory Gustafson Interventional Cardiologist
https://www.readbyqxmd.com/read/27663770/association-of-cyp2c19-variants-and-epoxyeicosatrienoic-acids-on-patients-with-microvascular-angina
#1
Tomonori Akasaka, Daisuke Sueta, Yuichiro Arima, Noriaki Tabata, Seiji Takashio, Yasuhiro Izumiya, Eiichiro Yamamoto, Megumi Yamamuro, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Ayami Kajiwara, Kazunori Morita, Kentaro Oniki, Junji Saruwatari, Kazuko Nakagawa, Yasuhiro Ogata, Kunihiko Matsui, Seiji Hokimoto
Categorization as a cytochrome P450 (CYP) 2C19 poor metabolizer (PM) is reported to be an independent risk factor for cardiovascular disease. Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by CYP2C19 epoxygenases and anti-inflammatory properties, especially in microvascular tissues. We examined the association of CYP2C19 polymorphisms and EETs on microvascular angina (MVA) caused by coronary microvascular dysfunction. We examined CYP2C19 genotypes in patients with MVA (n = 71) and healthy subjects as control (n = 71)...
December 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27153489/thoughts-on-obesity-and-brain-glucose
#2
COMMENT
Michael T Heneka, Pierluigi Nicotera
Homeostatic control of brain metabolism is essential for neuronal activity. Jais et al., (2016) report that reduced brain glucose uptake elicited by a high-fat diet self-corrects by the recruitment of peripheral, VEGF-producing macrophages to the blood-brain barrier. Their findings further suggest that restoring brain glucose availability might help protect from cognitive impairment in Alzheimer's disease.
May 5, 2016: Cell
https://www.readbyqxmd.com/read/27322095/association-between-achieved-low-density-lipoprotein-levels-and-major-adverse-cardiac-events-in-patients-with-stable-ischemic-heart-disease-taking-statin-treatment
#3
Morton Leibowitz, Tomas Karpati, Chandra J Cohen-Stavi, Becca S Feldman, Moshe Hoshen, Haim Bitterman, Samy Suissa, Ran D Balicer
IMPORTANCE: International guidelines recommend treatment with statins for patients with preexisting ischemic heart disease to prevent additional cardiovascular events but differ regarding target levels of low-density lipoprotein cholesterol (LDL-C). Trial data on this question are inconclusive and observational data are lacking. OBJECTIVE: To assess the relationship between levels of LDL-C achieved with statin treatment and cardiovascular events in adherent patients with preexisting ischemic heart disease...
August 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27259882/the-dream-of-imaging-coronary-artery-inflammation-with-fdg-pet-ct-imaging
#4
R Glenn Wells, Terrence D Ruddy
No abstract text is available yet for this article.
June 3, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27059805/selective-vascular-endothelial-protection-reduces-cardiac-dysfunction-in-chronic-heart-failure
#5
Julie Maupoint, Marie Besnier, Elodie Gomez, Najime Bouhzam, Jean-Paul Henry, Olivier Boyer, Lionel Nicol, Paul Mulder, Jérémie Martinet, Vincent Richard
BACKGROUND: Chronic heart failure (CHF) induces endothelial dysfunction in part because of decreased nitric oxide (NO(·)) production, but the direct link between endothelial dysfunction and aggravation of CHF is not directly established. We previously reported that increased NO production via inhibition of protein tyrosine phosphatase 1B (PTP1B) is associated with reduced cardiac dysfunction in CHF. Investigation of the role of endothelial PTP1B in these effects may provide direct evidence of the link between endothelial dysfunction and CHF...
April 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27030444/influence-of-cigarette-smoking-on-cardiac-biomarkers-the-atherosclerosis-risk-in-communities-aric-study
#6
Wilson Nadruz, Alexandra Gonçalves, Brian Claggett, Gabriela Querejeta Roca, Amil M Shah, Susan Cheng, Gerardo Heiss, Christie M Ballantyne, Scott D Solomon
AIMS: Cigarette smoking has been associated with incident heart failure independent of coronary artery disease (CAD), but the mechanisms linking smoking to cardiac damage are not well understood. This study sought to evaluate the relationship between smoking and N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity Troponin T (hs-TnT), which are, respectively, biomarkers of myocardial wall stress and injury, in a large community-based cohort. METHODS AND RESULTS: We examined the association between smoking history and NT-proBNP and hs-TnT in 9649 participants free of overt CAD or heart failure from the Atherosclerosis Risk in Communities (ARIC) Study who attended Visit 4 (1996-1998), as well as the association with change in these biomarkers from Visit 4 to Visit 5 (2011-2013) in 3151 participants...
June 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27125953/esc-working-group-position-paper-on-myocardial-infarction-with-non-obstructive-coronary-arteries
#7
Stefan Agewall, John F Beltrame, Harmony R Reynolds, Alexander Niessner, Giuseppe Rosano, Alida L P Caforio, Raffaele De Caterina, Marco Zimarino, Marco Roffi, Keld Kjeldsen, Dan Atar, Juan C Kaski, Udo Sechtem, Per Tornvall
No abstract text is available yet for this article.
April 28, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27038735/liraglutide-protects-cardiac-microvascular-endothelial-cells-against-hypoxia-reoxygenation-injury-through-the-suppression-of-the-sr-ca-2-xo-ros-axis-via-activation-of-the-glp-1r-pi3k-akt-survivin-pathways
#8
Ying Zhang, Hao Zhou, Wenbo Wu, Chen Shi, Shunying Hu, Tong Yin, Qiang Ma, Tianwen Han, Yingqian Zhang, Feng Tian, Yundai Chen
Microvascular endothelial cells (CMECs) oxidative damage resulting from hypoxia/reoxygenation (H/R) injury is responsible for microcirculation perfusion disturbances and the progression of cardiac dysfunction. However, few strategies are available to reverse such pathologies. Here, we studied the effects and mechanisms of liraglutide on CEMCs oxidative damage, focusing in particular on calcium overload-triggered free radical injury signals and the GLP-1R/PI3K/Akt/survivin survival pathways. The results indicate that H/R increased IP3R expression but reduced SERCA2a expression, which rapidly raised intracellular Ca(2+) levels, subsequently leading to Ca(2+)-dependent xanthine oxidase (XO) activation, reactive oxygen species (ROS) production and the cellular apoptosis of CMECs...
June 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/26896247/treatment-of-microvascular-angina-the-need-for-precision-medicine
#9
EDITORIAL
Filippo Crea, Gaetano Antonio Lanza
No abstract text is available yet for this article.
May 14, 2016: European Heart Journal
https://www.readbyqxmd.com/read/26480027/different-definition-of-microvascular-angina
#10
REVIEW
Hiroshi Suzuki
We sometimes encounter patients with microvascular angina (MVA), a disease characterized by anginal pain without abnormal coronary arteriographic findings or coronary spasm. More than 40 years have passed since MVA was first confirmed. The terms 'syndrome X', 'cardiac syndrome X' and 'microvascular dysfunction' have also been used to describe conditions similar to MVA, but all with slightly different definitions. The cause of MVA seems almost certain to be organic and functional abnormalities of the small arteries of the heart...
December 2015: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/26545603/left-ventricular-end-diastolic-pressure-for-detection-of-intracoronary-ergonovine-induced-myocardial-ischemia
#11
H-J Jang, T-H Kim, S W Kwon, J-Y Kim, J S Kim, H J Lee, J S Park, R K Choi, Y J Choi, W-H Shim
BACKGROUND: Recent consensus on variant angina defines significant spasm as total or subtotal occlusion of a coronary artery. However, the clinical significance of "less-than-subtotal" spasm needs to be reappraised, especially if the coronary spasm is combined with chest pain. Therefore, we evaluated the feasibility of left ventricular end diastolic pressure (LVEDP) as a tool to detect myocardial ischemia during ergonovine provocation testing. METHODS: After achieving two access sites, 29 patients underwent successful LVEDP monitoring using 5-Fr pigtail catheters during ergonovine provocation tests...
June 2016: Herz
https://www.readbyqxmd.com/read/26636160/kounis-syndrome
#12
P M Ntuli, E Makambwa
Kounis syndrome is characterised by a group of symptoms that manifest as unstable vasospastic or non-vasospastic angina secondary to a hypersensitivity reaction. It was first described by Kounis and Zavras in 1991 as the concurrence of an allergic response with an anaphylactoid or anaphylactic reaction and coronary artery spasm or even myocardial infarction. Since then, this condition has evolved to include a number of mast cell activation disorders associated with acute coronary syndrome. There are many triggering factors, including reactions to multiple medications, exposure to radiological contrast media, poison ivy, bee stings, shellfish and coronary stents...
October 2015: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/26646509/myocardia-ischemia-associated-with-a-myocardial-bridge-with-no-significant-atherosclerotic-stenosis
#13
Min Yu, Lihong Zhou, Tingting Chen, Kaihong Yi, Chujuan Zeng, Xuerui Tan
BACKGROUND: Myocardial bridge refers to the myocardial tissue with which the coronary artery is partly covered. Though it has long been regarded to be benign, patients with myocardial bridges may present with myocardial ischemia, acute coronary syndromes, coronary spasm, sudden cardiac arrest or even sudden death. CASE PRESENTATION: In present study, we reviewed four cases with myocardial bridge and no stenosis of coronary artery, which included acute coronary syndrome and sudden cardiac arrest...
2015: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/26652824/-establishment-and-characterization-of-a-minipig-model-of-microvascular-coronary-artery-spasm
#14
Xiao Li, Yongjian Wu, Ping Jiang, Xue Wang, Shijie You, Lei Zheng, Zankai Ye, Guangyuan Song
OBJECTIVE: To observe the feasibility of establishing a porcine model of microvascular coronary artery spasm by intracoronary neuropeptide Y (NPY) infusion, and to analyze the characterization of this model. METHODS: Minipigs were divided into four groups (n = 4 each): normal saline (NS) group, 1 nmol NPY group, 3 nmol NPY group, and 6 nmol NPY group. Arterial sheaths were planted into bilateral femoral arteries of minipigs. A pigtail catheter was placed at the left sheath to determine the hemodynamic parameters...
September 2015: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/26656861/determinants-of-myocardial-lactate-production-during-acetylcholine-provocation-test-in-patients-with-coronary-spasm
#15
Koichi Kaikita, Masanobu Ishii, Koji Sato, Masafumi Nakayama, Yuichiro Arima, Tomoko Tanaka, Koichi Sugamura, Kenji Sakamoto, Yasuhiro Izumiya, Eiichiro Yamamoto, Kenichi Tsujita, Megumi Yamamuro, Sunao Kojima, Hirofumi Soejima, Seiji Hokimoto, Kunihiko Matsui, Hisao Ogawa
BACKGROUND: Myocardial lactate production in the coronary circulation during acetylcholine (ACh)-provocation test (abbreviated as lactate production) provides supporting evidence for coronary spasm-induced myocardial ischemia. The purpose of this study was to examine the clinical features, predictive factors, and prognosis of patients with coronary vasospastic angina (VSA) and lactate production. METHODS AND RESULTS: We examined all 712 patients who underwent both myocardial lactate measurement during ACh-provocation test in the left coronary artery and genetic screening test of a -786T/C polymorphism in the 5'-flanking region of the endothelial nitric oxide synthase (eNOS) gene between January 1991 and December 2010...
December 2015: Journal of the American Heart Association
https://www.readbyqxmd.com/read/9643687/angina-pectoris-caused-by-coronary-microvascular-spasm
#16
M Mohri, M Koyanagi, K Egashira, H Tagawa, T Ichiki, H Shimokawa, A Takeshita
BACKGROUND: Microvascular angina can occur during exercise and at rest. Reduced vasodilator capacity of the coronary microvessels is implicated as a cause of angina during exercise, but the mechanism of angina at rest is not known. Our aim was to test the hypothesis that primary hyperconstriction (spasm) of coronary microvessels causes myocardial ischaemia at rest. METHODS: Acetylcholine induces coronary artery spasm in patients with variant angina. We tested the effects of intracoronary acetylcholine at graded doses in 117 consecutive patients with chest pain (at rest, during exertion, or both) and no flow-limiting (>50%) organic stenosis in the large epicardial coronary arteries...
April 18, 1998: Lancet
https://www.readbyqxmd.com/read/26004935/angina-pectoris-in-patients-without-flow-limiting-coronary-artery-disease-cardiac-syndrome-x-a-forest-of-a-variety-of-trees
#17
Giuseppe Cocco, Paul Jerie
Coronary heart disease (CHD) represents an important problem worldwide. At present, more women than men are evaluated for CHD and it has been recognized that the prevalence of this pathology in women is at least the same as in men. We have learned that cardiac syndrome X (CSX) is frequent because worldwide each year millions of people (mostly women) with angina pectoris without flow-limiting epicardial pathology are identified. Data from large myocardial infarction registries suggest a 5% to 25% prevalence of cases without flow-limiting coronary pathology...
2015: Cardiology Journal
https://www.readbyqxmd.com/read/25405929/acetylcholine-induced-coronary-spasm-in-patients-with-unobstructed-coronary-arteries-is-associated-with-elevated-concentrations-of-soluble-cd40-ligand-and-high-sensitivity-c-reactive-protein
#18
Peter Ong, Amelia Carro, Anastasios Athanasiadis, Gabor Borgulya, Tim Schäufele, Dieter Ratge, David Gaze, Udo Sechtem, Juan Carlos Kaski
OBJECTIVES: To assess whether epicardial and microvascular coronary artery spasm in response to acetylcholine (ACH) is associated with markers of inflammation, platelet stimulation, and endothelial activation in patients with angina and unobstructed coronary arteries. BACKGROUND: Patients with angina pectoris despite angiographically normal coronary arteries represent a diagnostic and therapeutic challenge. Both impaired coronary microvascular dilatory responses as well as diffuse distal epicardial and microvascular coronary artery spasm have been described as possible pathogenic mechanisms...
March 2015: Coronary Artery Disease
https://www.readbyqxmd.com/read/25075937/coronary-microvascular-spasm-triggers-transient-ischemic-left-ventricular-diastolic-abnormalities-in-patients-with-chest-pain-and-angiographically-normal-coronary-arteries
#19
Antonio Luis Arrebola-Moreno, Juan Pedro Arrebola, Antonio Moral-Ruiz, Jose Antonio Ramirez-Hernandez, Rafael Melgares-Moreno, Juan Carlos Kaski
AIMS: Impaired coronary microvascular dilatory function can lead to exercise induced myocardial ischemia and angina pectoris even in patients without significant (>50%) obstructive coronary atherosclerosis (APWOCA). Diffuse distal vessel epicardial spasm and microvascular spasm have been also proposed as a plausible explanation for angina at rest in these patients. However, objective systematic evidence for the latter i.e. echocardiographic wall motion abnormalities during angina, is lacking at present...
September 2014: Atherosclerosis
https://www.readbyqxmd.com/read/25454903/microvascular-coronary-dysfunction-and-ischemic-heart-disease-where-are-we-in-2014
#20
REVIEW
John W Petersen, Carl J Pepine
Many patients with angina and signs of myocardial ischemia on stress testing have no significant obstructive epicardial coronary disease. There are many potential coronary and non-coronary mechanisms for ischemia without obstructive epicardial coronary disease, and prominent among these is coronary microvascular and/or endothelial dysfunction. Patients with coronary microvascular and/or endothelial dysfunction are often at increased risk of adverse cardiovascular events, including ischemic events and heart failure despite preserved ventricular systolic function...
February 2015: Trends in Cardiovascular Medicine
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