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12 papers 0 to 25 followers
By Jj Cc
Yuhree Kim, Gaya Spolverato, Aslam Ejaz, Malcolm H Squires, George Poultsides, Ryan C Fields, Mark Bloomston, Sharon M Weber, Konstantinos Votanopoulos, Alexandra W Acher, Linda X Jin, William G Hawkins, Carl Schmidt, David Kooby, David Worhunsky, Neil Saunders, Edward A Levine, Clifford S Cho, Shishir K Maithel, Timothy M Pawlik
BACKGROUND: The American Cancer Society projects there will be over 22,000 new cases, resulting in nearly 11,000 deaths, related to gastric adenocarcinoma in the US in 2014. The aim of the current study was to find clinicopathologic variables associated with disease-free survival (DFS) and overall survival (OS) following curative resection of gastric adenocarcinoma, and create a nomogram for individual risk prediction. METHODS: A nomogram to predict DFS and OS following surgical resection of gastric adenocarcinoma was constructed using a multi-institutional cohort of patients who underwent surgery for primary gastric adenocarcinoma at seven major institutions in the US between January 2000 and August 2013...
2015: Annals of Surgical Oncology
Christian Ertmer, Tim-Gerald Kampmeier, Thomas Volkert, Heiner Wolters, Sebastian Rehberg, Andrea Morelli, Hartmut Schmidt, Matthias Lange, Matthias Boschin, Hugo Van Aken, Klaus Hahnenkamp
BACKGROUND: The purpose of this study was to retrospectively analyze the impact of human albumin (HA) substitution on organ function in patients undergoing orthotopic liver transplantation (OLT). METHODS: We retrospectively analyzed chart data of 15 hypoalbuminemic patients who received continuous infusion of HA (100 g/d) for seven d following OLT and matched them with 15 control patients for severity scores at admission. Primary endpoint was a difference in mean "sequential organ failure assessment" (SOFA) score during 14 d following OLT...
January 2015: Clinical Transplantation
E S Woodle, D M Rothstein
B cells play a complex role in the immune response. In addition to giving rise to plasma cells (PCs) and promoting T cell responses via antigen presentation, they perform immunoregulatory functions. This knowledge has created concerns regarding nonspecific B cell depletional therapy because of the potential to paradoxically augment immune responses. Recent studies now indicate that PCs have immune functions beyond immunoglobulin synthesis. Evidence for a new role for PCs as potent regulatory cells (via IL-10 and IL-35 production) is discussed including the implications for PC-targeted therapies currently being developed for clinical transplantation...
January 2015: American Journal of Transplantation
Jan P Lerut, Rafael S Pinheiro, Quirino Lai, Valentine Stouffs, Giuseppe Orlando, Juan Manuel Rico Juri, Olga Ciccarelli, Christine Sempoux, Francine M Roggen, Chantal De Reyck, Dominique Latinne, Pierre Gianello
OBJECTIVE: To investigate the safety of minimal immunosuppression (IS) in liver transplantation (LT). BACKGROUND: The lack of long-term follow-up studies, including pathologic data, has led to a protean handling of IS in LT. METHODS: Between February 2000 and September 2004, 156 adults were enrolled in a prospective, randomized, double-blind, placebo-controlled minimization trial comparing tacrolimus placebo (TAC-PLAC) and TAC short-term steroid (TAC-STER) IS...
November 2014: Annals of Surgery
Andrea Schlegel, Mickael Lesurtel, Emmanuel Melloul, Perparim Limani, Christoph Tschuor, Rolf Graf, Bostjan Humar, Pierre A Clavien
OBJECTIVES: To develop a reproducible animal model mimicking a novel 2-staged hepatectomy (ALPPS: Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy) and explore the underlying mechanisms. BACKGROUND: ALPPS combines portal vein ligation (PVL) with liver transection (step I), followed by resection of the deportalized liver (step II) within 2 weeks after the first surgery. This approach induces accelerated hypertrophy of the liver remnant to enable resection of massive tumor load...
November 2014: Annals of Surgery
Shigeru Marubashi, Kunihito Gotoh, Hirofumi Akita, Hidenori Takahashi, Keijiro Sugimura, Norikatsu Miyoshi, Masaaki Motoori, Kentaro Kishi, Shingo Noura, Yoshiyuki Fujiwara, Masayuki Ohue, Tetsuro Nakazawa, Katsuyuki Nakanishi, Yuri Ito, Masahiko Yano, Osamu Ishikawa, Masato Sakon
BACKGROUND: Recurrence patterns after hepatic resection has been poorly understood in view of tumor blood flow drainage (TBFD) area. Our goal was to clarify the recurrence patterns after anatomical versus nonanatomical hepatic resection for hepatocellular carcinoma (HCC). METHODS: A total of 424 consecutive patients with HCC, who were treated by curative resection (R0) at our hospital from 2001 to 2012, were evaluated. Among these, we compared the outcomes of the anatomical resection group (AR group, n = 243) and the nonanatomical resection group (NR group, n = 181)...
July 2015: Annals of Surgical Oncology
G A Eschenauer, E J Kwak, A Humar, B A Potoski, L G Clarke, R K Shields, R Abdel-Massih, F P Silveira, P Vergidis, C J Clancy, M H Nguyen
Guidelines recommend targeted antifungal prophylaxis for liver transplant (LT) recipients based on tiers of risk, rather than universal prophylaxis. The feasibility and efficacy of tiered, targeted prophylaxis is not well established. We performed a retrospective study of LT recipients who received targeted prophylaxis (n = 145; voriconazole [VORI; 54%], fluconazole [8%], no antifungal [38%]) versus universal VORI prophylaxis (n = 237). Median durations of targeted and universal prophylaxis were 11 and 6 days, respectively (p < 0...
January 2015: American Journal of Transplantation
K Singh, L Stempora, R D Harvey, A D Kirk, C P Larsen, B R Blazar, L S Kean
Many critical issues remain concerning how best to deploy adoptive regulatory T cell (Treg) immunotherapy to the clinic. These include a determination of their pharmacokinetic characteristics, their optimal dose, their phenotypic stability and the best therapies with which to pair Tregs. By performing a CFSE-labeled autologous Treg pulse experiment, we determined that the accessible peripheral blood Treg pool in rhesus macaques is quite large (75 ± 11 × 10(6) Tregs/kg). Pharmacokinetic analysis revealed that Tregs have two phases of elimination: an α phase, with a T1/2 in the peripheral blood of 32...
December 2014: American Journal of Transplantation
S-G Lee
The growing disparity between the number of liver transplant candidates and the supply of deceased donor organs has motivated the development of living donor liver transplantation (LDLT). Over the last two decades, the operation has been markedly improved by innovations rendering modern results comparable with those of deceased donor liver transplantation (DDLT). However, there remains room for further innovation, particularly in adult living donor liver transplantation (ALDLT). Unlike whole-size DDLT and pediatric LDLT, size-mismatching between ALDLT graft and recipient body weight and changing dynamics of posttransplant allograft regeneration have remained major challenges...
January 2015: American Journal of Transplantation
Yakup Kulu, Ignazio Tarantio, Rene Warschkow, Sandra Kny, Martin Schneider, Bruno M Schmied, Markus W Büchler, Alexis Ulrich
BACKGROUND: Whether anastomotic leakage (AL) has a negative impact on survival remains a matter of debate. This study aimed to assess the impact of AL on the overall and disease-free survival of patients undergoing curative resection of stages 1-3 rectal cancer using propensity-scoring methods. METHODS: In a single-center study, 570 patients undergoing curative resection of stages 1-3 rectal cancer between January 2002 and December 2011 were assessed. The mean follow-up period was 4...
2015: Annals of Surgical Oncology
Moustafa Mabrouk Mourad, Christos Liossis, Senthil Kumar, Bridget K Gunson, Hynek Mergental, John Isaac, Simon R Bramhall, Paolo Muiesan, Darius F Mirza, M Thamara P R Perera
Split liver transplantation (SLT) compensates for the organ shortage and provides an alternative solution for recipients disadvantaged by a smaller body size. Variations in the hepatic arterial anatomy and reconstructive techniques may lead to more technical complications, and we sought to analyze the incidence and risk factors of vasculobiliary complications with respect to reconstructive techniques. We identified 171 adult right lobe SLT procedures and 1412 whole liver transplantation (WLT) procedures between January 2000 and June 2012 and compared the results of these 2 groups...
January 2015: Liver Transplantation
Rojymon Jacob, Falynn Turley, David T Redden, Souheil Saddekni, Ahmed K A Aal, Kimberly Keene, Eddy Yang, Jessica Zarzour, David Bolus, J Kevin Smith, Stephen Gray, Jared White, Devin E Eckhoff, Derek A DuBay
OBJECTIVES: The optimal locoregional treatment for non-resectable hepatocellular carcinoma (HCC) of ≥ 3 cm in diameter is unclear. Transarterial chemoembolization (TACE) is the initial intervention most commonly performed, but it rarely eradicates HCC. The purpose of this study was to measure survival in HCC patients treated with adjuvant stereotactic body radiotherapy (SBRT) following TACE. METHODS: A retrospective study of patients with HCC of ≥ 3 cm was conducted...
February 2015: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
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