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30 papers 25 to 100 followers
By Alessandro Franciscon doctor
https://www.readbyqxmd.com/read/28865517/management-of-radiation-toxicity-in-head-and-neck-cancers
#1
REVIEW
Farzan Siddiqui, Benjamin Movsas
Head and neck cancers account for approximately 3% of all cancers in the United States with 62,000 new cases diagnosed annually. The global incidence is approximately 700,000 new cases a year. There has also been a recent increase in human papilloma virus-related oropharyngeal cancers. External beam radiation therapy (RT) is commonly used as an effective therapy for head and neck (H&N) cancers. This is used as a definitive treatment (alone or in combination with chemotherapy) or as an adjuvant treatment after surgical resection of the tumors...
October 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/29071801/common-oral-complications-of-head-and-neck-cancer-radiation-therapy-mucositis-infections-saliva-change-fibrosis-sensory-dysfunctions-dental-caries-periodontal-disease-and-osteoradionecrosis
#2
REVIEW
Herve Y Sroussi, Joel B Epstein, Rene-Jean Bensadoun, Deborah P Saunders, Rajesh V Lalla, Cesar A Migliorati, Natalie Heaivilin, Zachary S Zumsteg
Patients undergoing radiation therapy for the head and neck are susceptible to a significant and often abrupt deterioration in their oral health. The oral morbidities of radiation therapy include but are not limited to an increased susceptibility to dental caries and periodontal disease. They also include profound and often permanent functional and sensory changes involving the oral soft tissue. These changes range from oral mucositis experienced during and soon after treatment, mucosal opportunistic infections, neurosensory disorders, and tissue fibrosis...
October 25, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29064744/radiation-therapy-for-oropharyngeal-squamous-cell-carcinoma-american-society-of-clinical-oncology-endorsement-of-the-american-society-for-radiation-oncology-evidence-based-clinical-practice-guideline
#3
Harry Quon, Neha Vapiwala, Arlene Forastiere, Erin B Kennedy, David J Adelstein, Holly Boykin, Joseph A Califano, F Chris Holsinger, Brian Nussenbaum, David I Rosenthal, Lillian L Siu, John N Waldron
Purpose The American Society for Radiation Oncology (ASTRO) produced an evidence-based guideline on radiation therapy in oropharyngeal squamous cell carcinoma (OPSCC) that was determined to be relevant to the American Society of Clinical Oncology (ASCO) membership. After applying standard critical appraisal policy and endorsement procedures, ASCO chose to endorse the ASTRO guideline. Methods The ASTRO guideline was reviewed by ASCO content experts for clinical accuracy and by ASCO methodologists for developmental rigor...
October 24, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28864073/treatment-outcomes-after-reduction-of-the-target-volume-of-intensity-modulated-radiotherapy-following-induction-chemotherapy-in-patients-with-locoregionally-advanced-nasopharyngeal-carcinoma-a-prospective-multi-center-randomized-clinical-trial
#4
Hongru Yang, Xin Chen, Sheng Lin, Jinfeng Rong, Mi Yang, Qinglian Wen, Changling Shang, Lijia He, Peirong Ren, Shan Xu, Jianwen Zhang, Qiaoli Liu, Haowen Pang, Xiangxiang Shi, Juan Fan, Xiaoyang Sun, Daiyuan Ma, Bangxian Tan, Tao Zhang, Ling Zhang, Defeng Hu, Xiaobo Du, Yu Zhang, Shiming Wen, Xinping Zhang, Jingbo Wu
PURPOSE: To investigate whether reducing the target volume of intensity-modulated radiotherapy (IMRT) after induction chemotherapy (IC) improves the quality of life (QOL) in locoregionally advanced nasopharyngeal carcinoma (NPC) without decreasing the local control and survival rate. PATIENTS AND METHODS: A total number of 212 NPC patients staged as III-IVb were randomly assigned to group A (n=97) or group B (n=115) in this prospective clinical trial. All patients received IC followed by cisplatin concurrent with IMRT...
August 29, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28757375/role-of-radiotherapy-fractionation-in-head-and-neck-cancers-march-an-updated-meta-analysis
#5
Benjamin Lacas, Jean Bourhis, Jens Overgaard, Qiang Zhang, Vincent Grégoire, Matthew Nankivell, Björn Zackrisson, Zbigniew Szutkowski, Rafał Suwiński, Michael Poulsen, Brian O'Sullivan, Renzo Corvò, Sarbani Ghosh Laskar, Carlo Fallai, Hideya Yamazaki, Werner Dobrowsky, Kwan Ho Cho, Adam S Garden, Johannes A Langendijk, Celia Maria Pais Viegas, John Hay, Mohamed Lotayef, Mahesh K B Parmar, Anne Aupérin, Carla van Herpen, Philippe Maingon, Andy M Trotti, Cai Grau, Jean-Pierre Pignon, Pierre Blanchard
BACKGROUND: The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radiotherapy over other altered fractionation radiotherapy regimens and to assess the benefit of altered fractionation within the context of concomitant chemotherapy with the inclusion of new trials...
September 2017: Lancet Oncology
https://www.readbyqxmd.com/read/27007578/pet-ct-surveillance-versus-neck-dissection-in-advanced-head-and-neck-cancer
#6
RANDOMIZED CONTROLLED TRIAL
Hisham Mehanna, Wai-Lup Wong, Christopher C McConkey, Joy K Rahman, Max Robinson, Andrew G J Hartley, Christopher Nutting, Ned Powell, Hoda Al-Booz, Martin Robinson, Elizabeth Junor, Mohammed Rizwanullah, Sandra V von Zeidler, Hulya Wieshmann, Claire Hulme, Alison F Smith, Peter Hall, Janet Dunn
BACKGROUND: The role of image-guided surveillance as compared with planned neck dissection in the treatment of patients with squamous-cell carcinoma of the head and neck who have advanced nodal disease (stage N2 or N3) and who have received chemoradiotherapy for primary treatment is a matter of debate. METHODS: In this prospective, randomized, controlled trial, we assessed the noninferiority of positron-emission tomography-computed tomography (PET-CT)-guided surveillance (performed 12 weeks after the end of chemoradiotherapy, with neck dissection performed only if PET-CT showed an incomplete or equivocal response) to planned neck dissection in patients with stage N2 or N3 disease...
April 14, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27918720/what-is-the-best-treatment-of-locally-advanced-nasopharyngeal-carcinoma-an-individual-patient-data-network-meta-analysis
#7
Laureen Ribassin-Majed, Sophie Marguet, Anne W M Lee, Wai Tong Ng, Jun Ma, Anthony T C Chan, Pei-Yu Huang, Guopei Zhu, Daniel T T Chua, Yong Chen, Hai-Qiang Mai, Dora L W Kwong, Shie-Lee Cheah, James Moon, Yuk Tung, Kwan-Hwa Chi, George Fountzilas, Jean Bourhis, Jean Pierre Pignon, Pierre Blanchard
Purpose The role of adjuvant chemotherapy (AC) or induction chemotherapy (IC) in the treatment of locally advanced nasopharyngeal carcinoma is controversial. The individual patient data from the Meta-Analysis of Chemotherapy in Nasopharynx Carcinoma database were used to compare all available treatments. Methods All randomized trials of radiotherapy (RT) with or without chemotherapy in nonmetastatic nasopharyngeal carcinoma were considered. Overall, 20 trials and 5,144 patients were included. Treatments were grouped into seven categories: RT alone (RT), IC followed by RT (IC-RT), RT followed by AC (RT-AC), IC followed by RT followed by AC (IC-RT-AC), concomitant chemoradiotherapy (CRT), IC followed by CRT (IC-CRT), and CRT followed by AC (CRT-AC)...
February 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28258895/re-evaluation-of-ipsilateral-radiation-for-t1-t2n0-n2b-tonsil-carcinoma-at-the-princess-margaret-hospital-in-the-human-papillomavirus-era-25%C3%A2-years-later
#8
Shao Hui Huang, John Waldron, Scott V Bratman, Jie Su, John Kim, Andrew Bayley, John Cho, Meredith Giuliani, Andrew Hope, Jolie Ringash, Aaron Hansen, John R de Almeida, David Goldstein, Bayardo Perez-Ordonez, Ilan Weinreb, Li Tong, Wei Xu, Brian O'Sullivan
PURPOSE: To report the outcome of ipsilateral radiation therapy (RT) in human papillomavirus (HPV)-positive (HPV+) patients and HPV-negative (HPV-) patients with T1-T2N0-N2b tonsillar cancer treated 25 years after our initial historical cohort. METHODS AND MATERIALS: Patients with T1-T2N0-N2b tonsillar cancer who received ipsilateral RT or bilateral RT between 1999 and 2014 were reviewed. Overall survival (OS), local control (LC), regional control (RC), and grade 3 to 4 late toxicity (LT) were compared between ipsilateral RT and bilateral RT within HPV+ and HPV- patients, separately...
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/25012836/dorsal-vagal-complex-of-the-brainstem-conformal-avoidance-to-reduce-nausea
#9
Alan T Monroe, Sathya C Reddy, Anuj V Peddada
PURPOSE: To investigate the role of dose to the dorsal vagal complex (DVC) as an emetic stimulus in head-and-neck cancer patients treated with intensity modulated radiation therapy but without chemotherapy. METHODS AND MATERIALS: Seventy consecutively treated patients were analyzed for factors associated with nausea. The DVC was contoured on treatment planning scans using a previously published template and mean dose to the structure was analyzed for dose response...
July 2014: Practical Radiation Oncology
https://www.readbyqxmd.com/read/25771076/high-metastatic-node-number-not-extracapsular-spread-or-n-classification-is-a-node-related-prognosticator-in-transorally-resected-neck-dissected-p16-positive-oropharynx-cancer
#10
Parul Sinha, Dorina Kallogjeri, Hiram Gay, Wade L Thorstad, James S Lewis, Rebecca Chernock, Brian Nussenbaum, Bruce H Haughey
BACKGROUND: Due to unique biology and prognosis, precise identification of predictive parameters is critical for p16+ oropharyngeal squamous cell carcinoma (OPSCC). Prior studies showing absence of prognostication from extracapsular spread (ECS) and/or high N-classification in surgically-treated p16+ OPSCC necessitate new, evidence-based prognosticators. METHODS: A prospectively assembled cohort of 220, transoral surgery+neck dissection±adjuvant therapy-treated, p16+ OPSCC patients was analyzed...
May 2015: Oral Oncology
https://www.readbyqxmd.com/read/26936027/development-and-validation-of-a-staging-system-for-hpv-related-oropharyngeal-cancer-by-the-international-collaboration-on-oropharyngeal-cancer-network-for-staging-icon-s-a-multicentre-cohort-study
#11
Brian O'Sullivan, Shao Hui Huang, Jie Su, Adam S Garden, Erich M Sturgis, Kristina Dahlstrom, Nancy Lee, Nadeem Riaz, Xin Pei, Shlomo A Koyfman, David Adelstein, Brian B Burkey, Jeppe Friborg, Claus A Kristensen, Anita B Gothelf, Frank Hoebers, Bernd Kremer, Ernst-Jan Speel, Daniel W Bowles, David Raben, Sana D Karam, Eugene Yu, Wei Xu
BACKGROUND: Human papillomavirus-related (HPV+) oropharyngeal cancer is a rapidly emerging disease with generally good prognosis. Many prognostic algorithms for oropharyngeal cancer incorporate HPV status as a stratification factor, rather than recognising the uniqueness of HPV+ disease. The International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S) aimed to develop a TNM classification specific to HPV+ oropharyngeal cancer. METHODS: The ICON-S study included patients with non-metastatic oropharyngeal cancer from seven cancer centres located across Europe and North America; one centre comprised the training cohort and six formed the validation cohorts...
April 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27502431/intensity-modulated-radiotherapy-for-early-glottic-cancer-transition-to-a-new-standard-of-care
#12
REVIEW
Michael A Samuels, Laura M Freedman, Nagy Elsayyad
For decades, the standard of care for radiation treatment of early larynx cancers has been conventional treatment using opposed lateral fields encompassing the larynx and overlying neck structures, including the adjacent carotid arteries. While intensity-modulated radiotherapy (IMRT) has replaced conventional radiotherapy for all other head/neck cancer situations, the use of IMRT to treat early glottic cancers remains controversial. The article reviews the published experience with IMRT for this clinical situation and provides a detailed review of the literature on radiation-induced carotid toxicity and how it might apply to the controversy...
November 2016: Future Oncology
https://www.readbyqxmd.com/read/21684027/meta-analysis-of-chemotherapy-in-head-and-neck-cancer-mach-nc-a-comprehensive-analysis-by-tumour-site
#13
Pierre Blanchard, Bertrand Baujat, Victoria Holostenco, Abderrahmane Bourredjem, Charlotte Baey, Jean Bourhis, Jean-Pierre Pignon
INTRODUCTION: The recently updated meta-analysis of chemotherapy in head and neck cancer (MACH-NC) demonstrated the benefit of the addition of chemotherapy in terms of overall survival in head and neck squamous cell carcinoma (HNSCC). The magnitude of the benefit according to tumour site is unknown as well as their potential interactions with patient or trial characteristics. METHODS: Eighty seven randomized trials performed between 1965 and 2000 were included in the present analysis...
July 2011: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/19467801/dosimetric-factors-associated-with-long-term-dysphagia-after-definitive-radiotherapy-for-squamous-cell-carcinoma-of-the-head-and-neck
#14
Jimmy J Caudell, Philip E Schaner, Renee A Desmond, Ruby F Meredith, Sharon A Spencer, James A Bonner
PURPOSE: Intensification of radiotherapy and chemotherapy for head-and-neck cancer may lead to increased rates of dysphagia. Dosimetric predictors of objective findings of long-term dysphagia were sought. METHODS AND MATERIALS: From an institutional database, 83 patients were identified who underwent definitive intensity-modulated radiotherapy for squamous cell carcinoma of the head and neck, after exclusion of those who were treated for a second or recurrent head-and-neck primary lesion, had locoregional recurrence at any time, had less than 12 months of follow-up, or had postoperative radiotherapy...
February 1, 2010: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/22687949/biology-and-management-of-salivary-gland-cancers
#15
REVIEW
David J Adelstein, Shlomo A Koyfman, Adel K El-Naggar, Ehab Y Hanna
The salivary gland cancers are uncommon neoplasms of the head and neck, which exhibit considerable pathologic, biological, and clinical diversity. Surgical resection, often with postoperative radiation, is the standard therapeutic approach, and the results after treatment vary widely depending on the tumor histology. Chemotherapy has been of only limited palliative benefit in patients with advanced disease, and there has been little exploration of its use in definitive management. Recent investigation has focused on identification of the characteristic molecular signatures and genomic alterations of the specific histologic subtypes...
July 2012: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/25348370/dose-volume-related-dysphagia-after-constrictor-muscles-definition-in-head-and-neck-cancer-intensity-modulated-radiation-treatment
#16
R Mazzola, F Ricchetti, A Fiorentino, S Fersino, N Giaj Levra, S Naccarato, G Sicignano, S Albanese, G Di Paola, D Alterio, R Ruggieri, F Alongi
OBJECTIVE: Dysphagia remains a side effect influencing the quality of life of patients with head and neck cancer (HNC) after radiotherapy. We evaluated the relationship between planned dose involvement and acute and late dysphagia in patients with HNC treated with intensity-modulated radiation therapy (IMRT), after a recontouring of constrictor muscles (PCs) and the cricopharyngeal muscle (CM). METHODS: Between December 2011 and December 2013, 56 patients with histologically proven HNC were treated with IMRT or volumetric-modulated arc therapy...
December 2014: British Journal of Radiology
https://www.readbyqxmd.com/read/23182993/long-term-results-of-rtog-91-11-a-comparison-of-three-nonsurgical-treatment-strategies-to-preserve-the-larynx-in-patients-with-locally-advanced-larynx-cancer
#17
RANDOMIZED CONTROLLED TRIAL
Arlene A Forastiere, Qiang Zhang, Randal S Weber, Moshe H Maor, Helmuth Goepfert, Thomas F Pajak, William Morrison, Bonnie Glisson, Andy Trotti, John A Ridge, Wade Thorstad, Henry Wagner, John F Ensley, Jay S Cooper
PURPOSE: To report the long-term results of the Intergroup Radiation Therapy Oncology Group 91-11 study evaluating the contribution of chemotherapy added to radiation therapy (RT) for larynx preservation. PATIENTS AND METHODS: Patients with stage III or IV glottic or supraglottic squamous cell cancer were randomly assigned to induction cisplatin/fluorouracil (PF) followed by RT (control arm), concomitant cisplatin/RT, or RT alone. The composite end point of laryngectomy-free survival (LFS) was the primary end point...
March 1, 2013: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/22422597/jugular-and-vagal-paragangliomas-systematic-study-of-management-with-surgery-and-radiotherapy
#18
REVIEW
Carlos Suárez, Juan P Rodrigo, Carsten C Bödeker, José L Llorente, Carl E Silver, Jeroen C Jansen, Robert P Takes, Primoz Strojan, Phillip K Pellitteri, Alessandra Rinaldo, William M Mendenhall, Alfio Ferlito
BACKGROUND: The definitive treatment for head and neck paraganglioma (PG) is surgical excision. Unfortunately, surgery, particularly of vagal paraganglioma (VPG; "glomus vagale") and foramen jugulare ("glomus jugulare") tumors, may be complicated by injuries to the lower cranial nerves, a high price to pay for treatment for a benign tumor. Alternatively these tumors may be followed without treatment, or irradiated. The purpose of this review was to compare the existing evidence concerning the efficacy and safety of surgery, external beam radiotherapy (EBRT), and stereotactic radiosurgery (SRS), for jugular paragangliomas (JPGs) and VPGs...
August 2013: Head & Neck
https://www.readbyqxmd.com/read/26215712/oral-cavity-and-oropharyngeal-squamous-cell-carcinoma-an-update
#19
REVIEW
Angela C Chi, Terry A Day, Brad W Neville
Oral cavity squamous cell carcinoma (OC-SCC) is the most common malignancy of the head and neck (excluding nonmelanoma skin cancer). Recent trends have shown a dramatic rise in the incidence of oropharyngeal squamous cell carcinoma (OP-SCC), with a marked increase in lesions related to human papillomavirus infection. This update presents the latest evidence regarding OC-SCC and OP-SCC. In particular, the authors compare and contrast tumors at these two sites with respect to epidemiology, etiopathogenesis, clinicopathologic presentation, clinical assessment, imaging, management, and prognosis...
September 2015: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/26712589/pain-management-in-head-and-neck-cancer-patients-undergoing-chemo-radiotherapy-clinical-practical-recommendations
#20
REVIEW
A Mirabile, M Airoldi, C Ripamonti, A Bolner, B Murphy, E Russi, G Numico, L Licitra, P Bossi
Pain in head and neck cancer represents a major issue, before, during and after the oncological treatments. The most frequent cause of pain is chemo/radiation related oral mucositis, which involves 80% of the patients and worsens their quality of life inhibiting speaking, eating, drinking or swallowing and sometimes reducing the treatment compliance, the maximum dose intensity and thus the potential efficacy of treatment. Nevertheless pain is still often under estimated and undertreated. An Italian multidisciplinary group of head and neck cancer specialists met with the aim of reaching a consensus on pain management in this setting...
March 2016: Critical Reviews in Oncology/hematology
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