collection
MENU ▼
Read by QxMD icon Read
search

Cabeça e Pescoço

shared collection
39 papers 25 to 100 followers
By Alessandro Franciscon doctor
https://www.readbyqxmd.com/read/28428019/radiation-therapy-for-oropharyngeal-squamous-cell-carcinoma-executive-summary-of-an-astro-evidence-based-clinical-practice-guideline
#1
David J Sher, David J Adelstein, Gopal K Bajaj, David M Brizel, Ezra E W Cohen, Aditya Halthore, Louis B Harrison, Charles Lu, Benjamin J Moeller, Harry Quon, James W Rocco, Erich M Sturgis, Roy B Tishler, Andy Trotti, John Waldron, Avraham Eisbruch
PURPOSE: To present evidence-based guidelines for the treatment of oropharyngeal squamous cell carcinoma (OPSCC) with definitive or adjuvant radiation therapy (RT). METHODS AND MATERIALS: The American Society for Radiation Oncology convened the OPSCC Guideline Panel to perform a systematic literature review investigating the following key questions: (1) When is it appropriate to add systemic therapy to definitive RT in the treatment of OPSCC? (2) When is it appropriate to deliver postoperative RT with and without systemic therapy following primary surgery for OPSCC? (3) When is it appropriate to use induction chemotherapy in the treatment of OPSCC? (4) What are the appropriate dose, fractionation, and volume regimens with and without systemic therapy in the treatment of OPSCC? RESULTS: Patients with stage IV and stage T3 N0-1 OPSCC treated with definitive RT should receive concurrent high-dose intermittent cisplatin...
July 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28475848/beyond-positive-margins-and-extracapsular-extension-evaluating-the-utilization-and-clinical-impact-of-postoperative-chemoradiotherapy-in-resected-locally-advanced-head-and-neck-cancer
#2
Daniel M Trifiletti, Andrew Smith, Nandita Mitra, Surbhi Grover, John N Lukens, Roger B Cohen, Paul Read, William M Mendenhall, Alexander Lin, Samuel Swisher-McClure
Purpose To examine recent utilization and survival outcomes associated with use of adjuvant chemoradiotherapy (CRT) for patients with resected locally advanced head and neck cancer (LAHNC) with negative surgical margins (SM negative) and no extracapsular extension (ECE). Materials and Methods We conducted a retrospective observational cohort study using the National Cancer Database evaluating patients diagnosed in 2004 to 2012 with AJCC stage III to IVB squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx treated with definitive surgery and adjuvant radiotherapy (RT) or CRT...
May 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27686945/induction-chemotherapy-plus-concurrent-chemoradiotherapy-versus-concurrent-chemoradiotherapy-alone-in-locoregionally-advanced-nasopharyngeal-carcinoma-a-phase-3-multicentre-randomised-controlled-trial
#3
RANDOMIZED CONTROLLED TRIAL
Ying Sun, Wen-Fei Li, Nian-Yong Chen, Ning Zhang, Guo-Qing Hu, Fang-Yun Xie, Yan Sun, Xiao-Zhong Chen, Jin-Gao Li, Xiao-Dong Zhu, Chao-Su Hu, Xiang-Ying Xu, Yuan-Yuan Chen, Wei-Han Hu, Ling Guo, Hao-Yuan Mo, Lei Chen, Yan-Ping Mao, Rui Sun, Ping Ai, Shao-Bo Liang, Guo-Xian Long, Bao-Min Zheng, Xing-Lai Feng, Xiao-Chang Gong, Ling Li, Chun-Ying Shen, Jian-Yu Xu, Ying Guo, Yu-Ming Chen, Fan Zhang, Li Lin, Ling-Long Tang, Meng-Zhong Liu, Jun Ma
BACKGROUND: The value of adding cisplatin, fluorouracil, and docetaxel (TPF) induction chemotherapy to concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma is unclear. We aimed to compare TPF induction chemotherapy plus concurrent chemoradiotherapy with concurrent chemoradiotherapy alone in a suitably powered trial. METHODS: We did an open-label, phase 3, multicentre, randomised controlled trial at ten institutions in China. Patients with previously untreated, stage III-IVB (except T3-4N0) nasopharyngeal carcinoma, aged 18-59 years without severe comorbidities were enrolled...
November 2016: Lancet Oncology
https://www.readbyqxmd.com/read/29373181/the-role-of-stereotactic-body-radiotherapy-in-reirradiation-of-head-and-neck-cancer-recurrence
#4
REVIEW
A Román A, C Jodar, A Perez-Rozos, Y Lupiañez-Perez, J A Medina, J Gomez-Millan
INTRODUCTION: Head and neck cancer recurrence is a therapeutic challenge due to the anatomical and functional constraints of the head and neck area. Stereotactic body radiotherapy (SBRT) is a high-precision technique of radiotherapy that consists of delivering a high ablative biological dose in 1-5 high-dose fractions, requiring a very high precision of the radiotherapy process with potential application in this clinical setting METHODS: Different studies that investigate the role of SBRT in the treatment of recurrent head and neck cancer have been reviewed...
February 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28445581/definition-of-close-margin-in-oral-cancer-surgery-and-association-of-margin-distance-with-local-recurrence-rate
#5
Kendall K Tasche, Marisa R Buchakjian, Nitin A Pagedar, Steven M Sperry
No abstract text is available yet for this article.
December 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29172863/use-of-larynx-preservation-strategies-in-the-treatment-of-laryngeal-cancer-american-society-of-clinical-oncology-clinical-practice-guideline-update
#6
Arlene A Forastiere, Nofisat Ismaila, Jan S Lewin, Cherie Ann Nathan, David J Adelstein, Avraham Eisbruch, Gail Fass, Susan G Fisher, Scott A Laurie, Quynh-Thu Le, Bernard O'Malley, William M Mendenhall, Snehal Patel, David G Pfister, Anthony F Provenzano, Randy Weber, Gregory S Weinstein, Gregory T Wolf
Purpose To update the guideline recommendations on the use of larynx-preservation strategies in the treatment of laryngeal cancer. Methods An Expert Panel updated the systematic review of the literature for the period from January 2005 to May 2017. Results The panel confirmed that the use of a larynx-preservation approach for appropriately selected patients does not compromise survival. No larynx-preservation approach offered a survival advantage compared with total laryngectomy and adjuvant therapy as indicated...
April 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29180076/delineation-of-the-primary-tumour-clinical-target-volumes-ctv-p-in-laryngeal-hypopharyngeal-oropharyngeal-and-oral-cavity-squamous-cell-carcinoma-airo-caca-dahanca-eortc-georcc-gortec-hknpcsg-hncig-iag-kht-lprhht-ncic-ctg-ncri-nrg-oncology-phns-sbrt-somera
#7
Vincent Grégoire, Mererid Evans, Quynh-Thu Le, Jean Bourhis, Volker Budach, Amy Chen, Abraham Eisbruch, Mei Feng, Jordi Giralt, Tejpal Gupta, Marc Hamoir, Juliana K Helito, Chaosu Hu, Keith Hunter, Jorgen Johansen, Johannes Kaanders, Sarbani Ghosh Laskar, Anne Lee, Philippe Maingon, Antti Mäkitie, Francesco Micciche', Piero Nicolai, Brian O'Sullivan, Adela Poitevin, Sandro Porceddu, Krzysztof Składowski, Silke Tribius, John Waldron, Joseph Wee, Min Yao, Sue S Yom, Frank Zimmermann, Cai Grau
PURPOSE: Few studies have reported large inter-observer variations in target volume selection and delineation in patients treated with radiotherapy for head and neck squamous cell carcinoma. Consensus guidelines have been published for the neck nodes (see Grégoire et al., 2003, 2014), but such recommendations are lacking for primary tumour delineation. For the latter, two main schools of thoughts are prevailing, one based on geometric expansion of the Gross Tumour Volume (GTV) as promoted by DAHANCA, and the other one based on anatomical expansion of the GTV using compartmentalization of head and neck anatomy...
January 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29137654/conventional-fractionation-should-not-be-the-standard-of-care-for-t2-glottic-cancer
#8
Lynne M Dixon, Catriona M Douglas, Shazril Imran Shaukat, Kate Garcez, Lip Wai Lee, Andrew J Sykes, David Thomson, Nicholas J Slevin
BACKGROUND: The aim of this study was to report outcomes and late toxicity following hypofractionated accelerated radiotherapy for T2 glottic cancers. We highlight the importance of hypofractionated treatments with shorter overall treatment times, in improving outcomes for T2 glottic cancers. We also compare the biologically effective dose of hypofractionated regimes, with conventional fractionation. METHODS: One hundred twelve patients with T2 glottic cancer were treated between January 1999 and December 2005...
November 14, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28949800/an-algorithm-to-evaluate-suspected-lung-metastases-in-patients-with-hpv-associated-oropharyngeal-cancer
#9
Kyle K VanKoevering, Emily Marchiano, Heather M Walline, Thomas E Carey, Jonathan B McHugh, J Chad Brenner, Christine M Goudsmit, Emily Belille, Matthew E Spector, Andrew G Shuman
Distinguishing between distantly metastatic and metachronous lung primary carcinoma is challenging for patients with a history of head and neck cancer. There are implications for registry data, prognosis and related counseling, and management options, including eligibility for precision oncology trials. Patients with human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma who were treated under a uniform clinical protocol and achieved a complete response were identified in a single-institution prospective head and neck cancer epidemiology database (n = 205)...
January 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28865517/management-of-radiation-toxicity-in-head-and-neck-cancers
#10
REVIEW
Farzan Siddiqui, Benjamin Movsas
Head and neck cancers account for approximately 3% of all cancers in the United States with 62,000 new cases diagnosed annually. The global incidence is approximately 700,000 new cases a year. There has also been a recent increase in human papilloma virus-related oropharyngeal cancers. External beam radiation therapy (RT) is commonly used as an effective therapy for head and neck (H&N) cancers. This is used as a definitive treatment (alone or in combination with chemotherapy) or as an adjuvant treatment after surgical resection of the tumors...
October 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/29071801/common-oral-complications-of-head-and-neck-cancer-radiation-therapy-mucositis-infections-saliva-change-fibrosis-sensory-dysfunctions-dental-caries-periodontal-disease-and-osteoradionecrosis
#11
REVIEW
Herve Y Sroussi, Joel B Epstein, Rene-Jean Bensadoun, Deborah P Saunders, Rajesh V Lalla, Cesar A Migliorati, Natalie Heaivilin, Zachary S Zumsteg
Patients undergoing radiation therapy for the head and neck are susceptible to a significant and often abrupt deterioration in their oral health. The oral morbidities of radiation therapy include but are not limited to an increased susceptibility to dental caries and periodontal disease. They also include profound and often permanent functional and sensory changes involving the oral soft tissue. These changes range from oral mucositis experienced during and soon after treatment, mucosal opportunistic infections, neurosensory disorders, and tissue fibrosis...
December 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29064744/radiation-therapy-for-oropharyngeal-squamous-cell-carcinoma-american-society-of-clinical-oncology-endorsement-of-the-american-society-for-radiation-oncology-evidence-based-clinical-practice-guideline
#12
Harry Quon, Neha Vapiwala, Arlene Forastiere, Erin B Kennedy, David J Adelstein, Holly Boykin, Joseph A Califano, F Chris Holsinger, Brian Nussenbaum, David I Rosenthal, Lillian L Siu, John N Waldron
Purpose The American Society for Radiation Oncology (ASTRO) produced an evidence-based guideline on radiation therapy in oropharyngeal squamous cell carcinoma (OPSCC) that was determined to be relevant to the American Society of Clinical Oncology (ASCO) membership. After applying standard critical appraisal policy and endorsement procedures, ASCO chose to endorse the ASTRO guideline. Methods The ASTRO guideline was reviewed by ASCO content experts for clinical accuracy and by ASCO methodologists for developmental rigor...
December 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28864073/treatment-outcomes-after-reduction-of-the-target-volume-of-intensity-modulated-radiotherapy-following-induction-chemotherapy-in-patients-with-locoregionally-advanced-nasopharyngeal-carcinoma-a-prospective-multi-center-randomized-clinical-trial
#13
RANDOMIZED CONTROLLED TRIAL
Hongru Yang, Xin Chen, Sheng Lin, Jinfeng Rong, Mi Yang, Qinglian Wen, Changling Shang, Lijia He, Peirong Ren, Shan Xu, Jianwen Zhang, Qiaoli Liu, Haowen Pang, Xiangxiang Shi, Juan Fan, Xiaoyang Sun, Daiyuan Ma, Bangxian Tan, Tao Zhang, Ling Zhang, Defeng Hu, Xiaobo Du, Yu Zhang, Shiming Wen, Xinping Zhang, Jingbo Wu
PURPOSE: To investigate whether reducing the target volume of intensity-modulated radiotherapy (IMRT) after induction chemotherapy (IC) improves the quality of life (QOL) in locoregionally advanced nasopharyngeal carcinoma (NPC) without decreasing the local control and survival rate. PATIENTS AND METHODS: A total number of 212 NPC patients staged as III-IVb were randomly assigned to group A (n=97) or group B (n=115) in this prospective clinical trial. All patients received IC followed by cisplatin concurrent with IMRT...
January 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28757375/role-of-radiotherapy-fractionation-in-head-and-neck-cancers-march-an-updated-meta-analysis
#14
Benjamin Lacas, Jean Bourhis, Jens Overgaard, Qiang Zhang, Vincent Grégoire, Matthew Nankivell, Björn Zackrisson, Zbigniew Szutkowski, Rafał Suwiński, Michael Poulsen, Brian O'Sullivan, Renzo Corvò, Sarbani Ghosh Laskar, Carlo Fallai, Hideya Yamazaki, Werner Dobrowsky, Kwan Ho Cho, Beth Beadle, Johannes A Langendijk, Celia Maria Pais Viegas, John Hay, Mohamed Lotayef, Mahesh K B Parmar, Anne Aupérin, Carla van Herpen, Philippe Maingon, Andy M Trotti, Cai Grau, Jean-Pierre Pignon, Pierre Blanchard
BACKGROUND: The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radiotherapy over other altered fractionation radiotherapy regimens and to assess the benefit of altered fractionation within the context of concomitant chemotherapy with the inclusion of new trials...
September 2017: Lancet Oncology
https://www.readbyqxmd.com/read/27007578/pet-ct-surveillance-versus-neck-dissection-in-advanced-head-and-neck-cancer
#15
RANDOMIZED CONTROLLED TRIAL
Hisham Mehanna, Wai-Lup Wong, Christopher C McConkey, Joy K Rahman, Max Robinson, Andrew G J Hartley, Christopher Nutting, Ned Powell, Hoda Al-Booz, Martin Robinson, Elizabeth Junor, Mohammed Rizwanullah, Sandra V von Zeidler, Hulya Wieshmann, Claire Hulme, Alison F Smith, Peter Hall, Janet Dunn
BACKGROUND: The role of image-guided surveillance as compared with planned neck dissection in the treatment of patients with squamous-cell carcinoma of the head and neck who have advanced nodal disease (stage N2 or N3) and who have received chemoradiotherapy for primary treatment is a matter of debate. METHODS: In this prospective, randomized, controlled trial, we assessed the noninferiority of positron-emission tomography-computed tomography (PET-CT)-guided surveillance (performed 12 weeks after the end of chemoradiotherapy, with neck dissection performed only if PET-CT showed an incomplete or equivocal response) to planned neck dissection in patients with stage N2 or N3 disease...
April 14, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27918720/what-is-the-best-treatment-of-locally-advanced-nasopharyngeal-carcinoma-an-individual-patient-data-network-meta-analysis
#16
Laureen Ribassin-Majed, Sophie Marguet, Anne W M Lee, Wai Tong Ng, Jun Ma, Anthony T C Chan, Pei-Yu Huang, Guopei Zhu, Daniel T T Chua, Yong Chen, Hai-Qiang Mai, Dora L W Kwong, Shie-Lee Cheah, James Moon, Yuk Tung, Kwan-Hwa Chi, George Fountzilas, Jean Bourhis, Jean Pierre Pignon, Pierre Blanchard
Purpose The role of adjuvant chemotherapy (AC) or induction chemotherapy (IC) in the treatment of locally advanced nasopharyngeal carcinoma is controversial. The individual patient data from the Meta-Analysis of Chemotherapy in Nasopharynx Carcinoma database were used to compare all available treatments. Methods All randomized trials of radiotherapy (RT) with or without chemotherapy in nonmetastatic nasopharyngeal carcinoma were considered. Overall, 20 trials and 5,144 patients were included. Treatments were grouped into seven categories: RT alone (RT), IC followed by RT (IC-RT), RT followed by AC (RT-AC), IC followed by RT followed by AC (IC-RT-AC), concomitant chemoradiotherapy (CRT), IC followed by CRT (IC-CRT), and CRT followed by AC (CRT-AC)...
February 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28258895/re-evaluation-of-ipsilateral-radiation-for-t1-t2n0-n2b-tonsil-carcinoma-at-the-princess-margaret-hospital-in-the-human-papillomavirus-era-25-years-later
#17
Shao Hui Huang, John Waldron, Scott V Bratman, Jie Su, John Kim, Andrew Bayley, John Cho, Meredith Giuliani, Andrew Hope, Jolie Ringash, Aaron Hansen, John R de Almeida, David Goldstein, Bayardo Perez-Ordonez, Ilan Weinreb, Li Tong, Wei Xu, Brian O'Sullivan
PURPOSE: To report the outcome of ipsilateral radiation therapy (RT) in human papillomavirus (HPV)-positive (HPV+) patients and HPV-negative (HPV-) patients with T1-T2N0-N2b tonsillar cancer treated 25 years after our initial historical cohort. METHODS AND MATERIALS: Patients with T1-T2N0-N2b tonsillar cancer who received ipsilateral RT or bilateral RT between 1999 and 2014 were reviewed. Overall survival (OS), local control (LC), regional control (RC), and grade 3 to 4 late toxicity (LT) were compared between ipsilateral RT and bilateral RT within HPV+ and HPV- patients, separately...
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/25012836/dorsal-vagal-complex-of-the-brainstem-conformal-avoidance-to-reduce-nausea
#18
Alan T Monroe, Sathya C Reddy, Anuj V Peddada
PURPOSE: To investigate the role of dose to the dorsal vagal complex (DVC) as an emetic stimulus in head-and-neck cancer patients treated with intensity modulated radiation therapy but without chemotherapy. METHODS AND MATERIALS: Seventy consecutively treated patients were analyzed for factors associated with nausea. The DVC was contoured on treatment planning scans using a previously published template and mean dose to the structure was analyzed for dose response...
July 2014: Practical Radiation Oncology
https://www.readbyqxmd.com/read/25771076/high-metastatic-node-number-not-extracapsular-spread-or-n-classification-is-a-node-related-prognosticator-in-transorally-resected-neck-dissected-p16-positive-oropharynx-cancer
#19
Parul Sinha, Dorina Kallogjeri, Hiram Gay, Wade L Thorstad, James S Lewis, Rebecca Chernock, Brian Nussenbaum, Bruce H Haughey
BACKGROUND: Due to unique biology and prognosis, precise identification of predictive parameters is critical for p16+ oropharyngeal squamous cell carcinoma (OPSCC). Prior studies showing absence of prognostication from extracapsular spread (ECS) and/or high N-classification in surgically-treated p16+ OPSCC necessitate new, evidence-based prognosticators. METHODS: A prospectively assembled cohort of 220, transoral surgery+neck dissection±adjuvant therapy-treated, p16+ OPSCC patients was analyzed...
May 2015: Oral Oncology
https://www.readbyqxmd.com/read/26936027/development-and-validation-of-a-staging-system-for-hpv-related-oropharyngeal-cancer-by-the-international-collaboration-on-oropharyngeal-cancer-network-for-staging-icon-s-a-multicentre-cohort-study
#20
Brian O'Sullivan, Shao Hui Huang, Jie Su, Adam S Garden, Erich M Sturgis, Kristina Dahlstrom, Nancy Lee, Nadeem Riaz, Xin Pei, Shlomo A Koyfman, David Adelstein, Brian B Burkey, Jeppe Friborg, Claus A Kristensen, Anita B Gothelf, Frank Hoebers, Bernd Kremer, Ernst-Jan Speel, Daniel W Bowles, David Raben, Sana D Karam, Eugene Yu, Wei Xu
BACKGROUND: Human papillomavirus-related (HPV+) oropharyngeal cancer is a rapidly emerging disease with generally good prognosis. Many prognostic algorithms for oropharyngeal cancer incorporate HPV status as a stratification factor, rather than recognising the uniqueness of HPV+ disease. The International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S) aimed to develop a TNM classification specific to HPV+ oropharyngeal cancer. METHODS: The ICON-S study included patients with non-metastatic oropharyngeal cancer from seven cancer centres located across Europe and North America; one centre comprised the training cohort and six formed the validation cohorts...
April 2016: Lancet Oncology
label_collection
label_collection
3912
1
2
2017-03-20 23:19:54
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"