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Cabeça e Pescoço

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19 papers 0 to 25 followers
By Alessandro Franciscon doctor
Michael A Samuels, Laura M Freedman, Nagy Elsayyad
For decades, the standard of care for radiation treatment of early larynx cancers has been conventional treatment using opposed lateral fields encompassing the larynx and overlying neck structures, including the adjacent carotid arteries. While intensity-modulated radiotherapy (IMRT) has replaced conventional radiotherapy for all other head/neck cancer situations, the use of IMRT to treat early glottic cancers remains controversial. The article reviews the published experience with IMRT for this clinical situation and provides a detailed review of the literature on radiation-induced carotid toxicity and how it might apply to the controversy...
August 9, 2016: Future Oncology
Pierre Blanchard, Bertrand Baujat, Victoria Holostenco, Abderrahmane Bourredjem, Charlotte Baey, Jean Bourhis, Jean-Pierre Pignon
INTRODUCTION: The recently updated meta-analysis of chemotherapy in head and neck cancer (MACH-NC) demonstrated the benefit of the addition of chemotherapy in terms of overall survival in head and neck squamous cell carcinoma (HNSCC). The magnitude of the benefit according to tumour site is unknown as well as their potential interactions with patient or trial characteristics. METHODS: Eighty seven randomized trials performed between 1965 and 2000 were included in the present analysis...
July 2011: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Jimmy J Caudell, Philip E Schaner, Renee A Desmond, Ruby F Meredith, Sharon A Spencer, James A Bonner
PURPOSE: Intensification of radiotherapy and chemotherapy for head-and-neck cancer may lead to increased rates of dysphagia. Dosimetric predictors of objective findings of long-term dysphagia were sought. METHODS AND MATERIALS: From an institutional database, 83 patients were identified who underwent definitive intensity-modulated radiotherapy for squamous cell carcinoma of the head and neck, after exclusion of those who were treated for a second or recurrent head-and-neck primary lesion, had locoregional recurrence at any time, had less than 12 months of follow-up, or had postoperative radiotherapy...
February 1, 2010: International Journal of Radiation Oncology, Biology, Physics
David J Adelstein, Shlomo A Koyfman, Adel K El-Naggar, Ehab Y Hanna
The salivary gland cancers are uncommon neoplasms of the head and neck, which exhibit considerable pathologic, biological, and clinical diversity. Surgical resection, often with postoperative radiation, is the standard therapeutic approach, and the results after treatment vary widely depending on the tumor histology. Chemotherapy has been of only limited palliative benefit in patients with advanced disease, and there has been little exploration of its use in definitive management. Recent investigation has focused on identification of the characteristic molecular signatures and genomic alterations of the specific histologic subtypes...
July 2012: Seminars in Radiation Oncology
R Mazzola, F Ricchetti, A Fiorentino, S Fersino, N Giaj Levra, S Naccarato, G Sicignano, S Albanese, G Di Paola, D Alterio, R Ruggieri, F Alongi
OBJECTIVE: Dysphagia remains a side effect influencing the quality of life of patients with head and neck cancer (HNC) after radiotherapy. We evaluated the relationship between planned dose involvement and acute and late dysphagia in patients with HNC treated with intensity-modulated radiation therapy (IMRT), after a recontouring of constrictor muscles (PCs) and the cricopharyngeal muscle (CM). METHODS: Between December 2011 and December 2013, 56 patients with histologically proven HNC were treated with IMRT or volumetric-modulated arc therapy...
December 2014: British Journal of Radiology
Arlene A Forastiere, Qiang Zhang, Randal S Weber, Moshe H Maor, Helmuth Goepfert, Thomas F Pajak, William Morrison, Bonnie Glisson, Andy Trotti, John A Ridge, Wade Thorstad, Henry Wagner, John F Ensley, Jay S Cooper
PURPOSE: To report the long-term results of the Intergroup Radiation Therapy Oncology Group 91-11 study evaluating the contribution of chemotherapy added to radiation therapy (RT) for larynx preservation. PATIENTS AND METHODS: Patients with stage III or IV glottic or supraglottic squamous cell cancer were randomly assigned to induction cisplatin/fluorouracil (PF) followed by RT (control arm), concomitant cisplatin/RT, or RT alone. The composite end point of laryngectomy-free survival (LFS) was the primary end point...
March 1, 2013: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Carlos Suárez, Juan P Rodrigo, Carsten C Bödeker, José L Llorente, Carl E Silver, Jeroen C Jansen, Robert P Takes, Primoz Strojan, Phillip K Pellitteri, Alessandra Rinaldo, William M Mendenhall, Alfio Ferlito
BACKGROUND: The definitive treatment for head and neck paraganglioma (PG) is surgical excision. Unfortunately, surgery, particularly of vagal paraganglioma (VPG; "glomus vagale") and foramen jugulare ("glomus jugulare") tumors, may be complicated by injuries to the lower cranial nerves, a high price to pay for treatment for a benign tumor. Alternatively these tumors may be followed without treatment, or irradiated. The purpose of this review was to compare the existing evidence concerning the efficacy and safety of surgery, external beam radiotherapy (EBRT), and stereotactic radiosurgery (SRS), for jugular paragangliomas (JPGs) and VPGs...
August 2013: Head & Neck
Angela C Chi, Terry A Day, Brad W Neville
Oral cavity squamous cell carcinoma (OC-SCC) is the most common malignancy of the head and neck (excluding nonmelanoma skin cancer). Recent trends have shown a dramatic rise in the incidence of oropharyngeal squamous cell carcinoma (OP-SCC), with a marked increase in lesions related to human papillomavirus infection. This update presents the latest evidence regarding OC-SCC and OP-SCC. In particular, the authors compare and contrast tumors at these two sites with respect to epidemiology, etiopathogenesis, clinicopathologic presentation, clinical assessment, imaging, management, and prognosis...
September 2015: CA: a Cancer Journal for Clinicians
A Mirabile, M Airoldi, C Ripamonti, A Bolner, B Murphy, E Russi, G Numico, L Licitra, P Bossi
Pain in head and neck cancer represents a major issue, before, during and after the oncological treatments. The most frequent cause of pain is chemo/radiation related oral mucositis, which involves 80% of the patients and worsens their quality of life inhibiting speaking, eating, drinking or swallowing and sometimes reducing the treatment compliance, the maximum dose intensity and thus the potential efficacy of treatment. Nevertheless pain is still often under estimated and undertreated. An Italian multidisciplinary group of head and neck cancer specialists met with the aim of reaching a consensus on pain management in this setting...
March 2016: Critical Reviews in Oncology/hematology
Paolo Bossi, Davide Farina, Gemma Gatta, Davide Lombardi, Piero Nicolai, Ester Orlandi
Paranasal sinus cancers are rare diseases, accounting for about 5% of all head and neck malignancies. The variety of histological types and the overlapping pathological features with other entities constitute difficulties in pathologic interpretation, often requiring a skilled interpretation or a second opinion. Treatment of locally advanced disease relies on surgery and radiation therapy for operable disease, with a possible role for systemic treatment in selected histologies within a multimodal approach; unresectable paranasal sinus cancers are generally treated with a combination of radiotherapy and chemotherapy...
February 2016: Critical Reviews in Oncology/hematology
Aymen Lagha, Nesrine Chraiet, Soumaya Labidi, Hela Rifi, Mouna Ayadi, Sarra Krimi, Bassem Allani, Henda Raies, Slim Touati, Hamouda Boussen, Lotfi Kochbati, Amel Mezlini
The concept of larynx preservation in locally advanced laryngeal or hypopharyngeal squamous cell carcinoma has evolved during the last three decades, especially with the advancement of nonsurgical strategies. These nonsurgical strategies include: (1) radiotherapy alone; (2) concomitant chemoradiotherapy (CCRT); and (3) induction chemotherapy followed by radiotherapy or CCRT and concurrent anti-epidermal growth factor receptor (EGFR). To date, the best approach for larynx preservation has yet to be defined. In this article, we review and discuss important recent randomized phase II/III trials investigating larynx preservation in order to facilitate the selection of an appropriate strategy in the clinical setting...
November 2013: Critical Reviews in Oncology/hematology
Hideya Yamazaki, Kinji Nishiyama, Eiichi Tanaka, Masahiko Koizumi, Masashi Chatani
PURPOSE: To investigate in a prospective randomized study the effect of radiation fraction size and overall treatment time on the local control of early glottic carcinoma. METHODS AND MATERIALS: Between December 1993 and December 2001, 180 patients with early glottic carcinoma (T1N0M0) were treated at our department. The patients were randomly allocated to either treatment arm A (radiation fraction size 2 Gy, n = 89) or B (2.25 Gy, n = 91). The total radiation dose administered was 60 Gy in 30 fraction within 6 weeks for minimal tumors (two-thirds of the vocal cord or less) or 66 Gy in 33 fractions in 6...
January 1, 2006: International Journal of Radiation Oncology, Biology, Physics
K K Fu, T F Pajak, A Trotti, C U Jones, S A Spencer, T L Phillips, A S Garden, J A Ridge, J S Cooper, K K Ang
PURPOSE: The optimal fractionation schedule for radiotherapy of head and neck cancer has been controversial. The objective of this randomized trial was to test the efficacy of hyperfractionation and two types of accelerated fractionation individually against standard fractionation. METHODS AND MATERIALS: Patients with locally advanced head and neck cancer were randomly assigned to receive radiotherapy delivered with: 1) standard fractionation at 2 Gy/fraction/day, 5 days/week, to 70 Gy/35 fractions/7 weeks; 2) hyperfractionation at 1...
August 1, 2000: International Journal of Radiation Oncology, Biology, Physics
Anne W M Lee, Brigette B Y Ma, Wai Tong Ng, Anthony T C Chan
Nasopharyngeal carcinoma of the undifferentiated subtype is endemic to southern China, and patient prognosis has improved significantly over the past three decades because of advances in disease management, diagnostic imaging, radiotherapy technology, and broader application of systemic therapy. Despite the excellent local control with modern radiotherapy, distant failure remains a key challenge. Advances in molecular technology have helped to decipher the molecular pathogenesis of nasopharyngeal carcinoma as well as its etiologic association with the Epstein-Barr virus...
October 10, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Thomas J Galloway, John A Ridge
Squamous cell carcinoma of an unknown primary (SCCUP) of the head and neck is a rare disease. As a diagnosis of exclusion, the manner in which it is assigned merits consideration. Despite the development and refinement of several techniques designed to locate an occult tumor, including cross-sectional anatomic imaging, functional imaging, and transoral surgical techniques, delineating SCCUP remains an active clinical problem. Its relative rarity has prevented prospective study of the entity. Hence, investigators must rely on retrospective analyses to understand the disease and its appropriate treatment...
October 10, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
K S Clifford Chao, Franz J Wippold, Gokhan Ozyigit, Binh N Tran, James F Dempsey
PURPOSE: We present the guidelines for target volume determination and delineation of head-and-neck lymph nodes based on the analysis of the patterns of nodal failure in patients treated with intensity-modulated radiotherapy (IMRT). METHODS AND MATERIALS: Data pertaining to the natural course of nodal metastasis for each head-and-neck cancer subsite were reviewed. A system was established to provide guidance for nodal target volume determination and delineation...
August 1, 2002: International Journal of Radiation Oncology, Biology, Physics
Carole Fakhry, Qiang Zhang, Phuc Felix Nguyen-Tan, David Rosenthal, Adel El-Naggar, Adam S Garden, Denis Soulieres, Andy Trotti, Vilija Avizonis, John Andrew Ridge, Jonathan Harris, Quynh-Thu Le, Maura Gillison
PURPOSE: Risk of cancer progression is reduced for patients with human papillomavirus (HPV) -positive oropharynx cancer (OPC) relative to HPV-negative OPC, but it is unknown whether risk of death after progression is similarly reduced. PATIENTS AND METHODS: Patients with stage III-IV OPC enrolled onto Radiation Therapy Oncology Group trials 0129 or RTOG 0522 who had known tumor p16 status plus local, regional, and/or distant progression after receiving platinum-based chemoradiotherapy were eligible for a retrospective analysis of the association between tumor p16 status and overall survival (OS) after disease progression...
October 20, 2014: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
François Janot, Dominique de Raucourt, Ellen Benhamou, Christophe Ferron, Gilles Dolivet, René-Jean Bensadoun, Marc Hamoir, Bernard Géry, Morbize Julieron, Marine Castaing, Etienne Bardet, Vincent Grégoire, Jean Bourhis
PURPOSE: Full-dose reirradiation combined with chemotherapy has been shown to be feasible after salvage surgery with acceptable toxicity. The Groupe d'Etude des Tumeurs de la Tête et du Cou and Groupe d'Oncologie Radiothérapie Tête Et Cou groups performed a randomized study to assess its efficacy. PATIENTS AND METHODS: Between 1999 and 2005, 130 patients with head and neck cancer were treated with salvage surgery and randomly assigned to full-dose reirradiation combined with chemotherapy (RT arm) or to observation (a "wait and see" approach; WS arm)...
December 1, 2008: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Nancy Lee, Kelvin Chan, Justin E Bekelman, Joanne Zhung, James Mechalakos, Ashwatha Narayana, Suzanne Wolden, Ennapadam S Venkatraman, David Pfister, Dennis Kraus, Jatin Shah, Michael J Zelefsky
PURPOSE: To present a retrospective review of treatment outcomes for recurrent head and neck (HN) cancer patients treated with re-irradiation (re-RT) at a single medical center. METHODS AND MATERIALS: From July 1996-September 2005, 105 patients with recurrent HN cancer underwent re-RT at our institution. Sites included were: the neck (n = 21), nasopharynx (n = 21), paranasal sinus (n = 18), oropharynx (n = 16), oral cavity (n = 9), larynx (n = 10), parotid (n = 6), and hypopharynx (n = 4)...
July 1, 2007: International Journal of Radiation Oncology, Biology, Physics
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