Jeffrey H Gertsch, Bryan Corbett, Peter S Holck, Allison Mulcahy, Melanie Watts, Nathan Thomas Stillwagon, Amanda Morgan Casto, Charles Hessel Abramson, Charles Peter Aloysius Vaughan, Christopher Macguire, Neda Nicole Farzan, Baotran Nguyen Vo, Rebecca Jean Norvelle, Kerstin May, Jessica Elizabeth Holly, Hillary Irons, Aaron Michael Stutz, Pradip Chapagain, Siddhartha Yadav, Matiram Pun, Jeremy Farrar, Buddha Basnyat
OBJECTIVE: To study the effectiveness of ibuprofen versus placebo in preventing acute mountain sickness (AMS) and high altitude headache (HAH). METHODS: Double-blind, randomized, placebo-controlled trial. RESULTS: Two hundred ninety-four healthy Western trekkers were recruited on the Everest approach at 4280 m or 4358 m and randomly assigned to receive either 600 mg of ibuprofen or placebo 3 times daily before and during ascent to 4928 m. One hundred eighty-three of 294 participants completed the trial...
December 2012: Wilderness & Environmental Medicine