Marco Catani, Flavio Dell'Acqua, Sanja Budisavljevic, Henrietta Howells, Michel Thiebaut de Schotten, Seán Froudist-Walsh, Lucio D'Anna, Abigail Thompson, Stefano Sandrone, Edward T Bullmore, John Suckling, Simon Baron-Cohen, Michael V Lombardo, Sally J Wheelwright, Bhismadev Chakrabarti, Meng-Chuan Lai, Amber N V Ruigrok, Alexander Leemans, Christine Ecker, Mrc Aims Consortium, Michael C Craig, Declan G M Murphy
It has been postulated that autism spectrum disorder is underpinned by an 'atypical connectivity' involving higher-order association brain regions. To test this hypothesis in a large cohort of adults with autism spectrum disorder we compared the white matter networks of 61 adult males with autism spectrum disorder and 61 neurotypical controls, using two complementary approaches to diffusion tensor magnetic resonance imaging. First, we applied tract-based spatial statistics, a 'whole brain' non-hypothesis driven method, to identify differences in white matter networks in adults with autism spectrum disorder...
February 2016: Brain