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By Tony Vas Family Physician
https://www.readbyqxmd.com/read/30132035/sglt2-inhibitors-the-future-for-treatment-of-type-2-diabetes-mellitus-and-other-chronic-diseases
#1
REVIEW
Christoph Wanner, Nikolaus Marx
Individuals with diabetes mellitus exhibit an increased propensity to develop cardiovascular disorders such as coronary artery disease, stroke and heart failure. Over recent decades, numerous cardiovascular outcome trials in individuals with type 2 diabetes have been published, with data showing a reduction of cardiovascular morbidity and mortality by sodium-glucose cotransporter 2 (SGLT2) inhibitors. These results not only provide novel therapeutic options for this high-risk population but also advance our current understanding of cardiovascular risk reduction in diabetes...
October 2018: Diabetologia
https://www.readbyqxmd.com/read/21482743/a-predictive-model-for-progression-of-chronic-kidney-disease-to-kidney-failure
#2
Navdeep Tangri, Lesley A Stevens, John Griffith, Hocine Tighiouart, Ognjenka Djurdjev, David Naimark, Adeera Levin, Andrew S Levey
CONTEXT: Chronic kidney disease (CKD) is common. Kidney disease severity can be classified by estimated glomerular filtration rate (GFR) and albuminuria, but more accurate information regarding risk for progression to kidney failure is required for clinical decisions about testing, treatment, and referral. OBJECTIVE: To develop and validate predictive models for progression of CKD. DESIGN, SETTING, AND PARTICIPANTS: Development and validation of prediction models using demographic, clinical, and laboratory data from 2 independent Canadian cohorts of patients with CKD stages 3 to 5 (estimated GFR, 10-59 mL/min/1...
April 20, 2011: JAMA: the Journal of the American Medical Association
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