Berdine A A Hueskes, Elisabeth A Roovers, Aukje K Mantel-Teeuwisse, Hein J E M Janssens, Eloy H van de Lisdonk, Matthijs Janssen
OBJECTIVE: To systematically review the literature investigating the relationship between use of diuretics and the risk of gouty arthritis. METHODS: PubMed (1950-October 2009), Embase (1974-October 2009), and the Cochrane Library (up to October 2009) were searched using keywords and MeSH terms diuretics, adverse effects, and gout. For this review, the technique of "best evidence synthesis" was used. Studies reporting frequency, absolute or relative risks, odds ratio, or rate ratio of gouty arthritis in diuretic users compared with nonusers were selected and evaluated...
June 2012: Seminars in Arthritis and Rheumatism