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REVIEW
Niklas Nielsen, Hans Friberg
PURPOSE OF REVIEW: Temperature management for patients comatose after cardiac arrest has been an integral component of postcardiac arrest care for the last decade. In this review, we present recent findings and discuss implications for future trials. RECENT FINDINGS: The two largest trials on temperature management after cardiac arrest were recently presented. The first investigated prehospital induction of hypothermia using ice-cold intravenous saline in 1364 patients...
June 2015: Current Opinion in Critical Care
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JOURNAL ARTICLE
Chien-Hua Huang, Chih-Yen Chiang, Ren-How Pen, Min-Shan Tsai, Huei-Wen Chen, Chiung-Yuan Hsu, Tzung-Dau Wang, Matthew Huei-Ming Ma, Shyr-Chyr Chen, Wen-Jone Chen
BACKGROUND: Haemorrhagic shock after traumatic injury carries a high mortality. Therapeutic hypothermia has been widely used in critical illness to improve the outcome in haemorrhagic shock by activation of cardiac pro-survival signalling pathways. However, the role played by the mitochondria in the cardioprotective effects of therapeutic hypothermia remains unclear. We investigated the effects of therapeutic hypothermia on mitochondrial function and integrity after haemorrhagic shock using an in vitro ischaemia-reperfusion model...
February 2015: Injury
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