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11 papers 100 to 500 followers Focused on lower extremity, but applicable elsewhere as well.
By Alex McKanna Podiatry Resident @ Franciscan Alliance/MWU based in Dyer, IN USA
Rick Visser, Pilar M Arrabal, Jose Becerra, Ursula Rinas, Manuel Cifuentes
Reparation of bone defects remains a major clinical and economic concern, with more than 3 million bone grafts performed annually only in the United States and the EU. The search for alternatives to autologous bone grafting led to the approval by the FDA of an absorbable collagen carrier combined with rhBMP-2 for the treatment of certain bone diseases and fractures. The present work is focused on the production of a collagen-targeted rhBMP-2 based system to improve bone formation. We produced a modified rhBMP-2 with only an additional collagen-binding decapeptide derived from the von Willebrand factor and tested its affinity to collagen and its ability to induce ectopic bone formation in vivo when implanted in combination with absorbable collagen sponges or hydroxyapatite...
April 2009: Biomaterials
Jose M Moran, Raul Roncero Martin, Maria Pedrera-Canal, Javier Alonso-Terron, Francisco J Rodriguez-Velasco, Juan D Pedrera-Zamorano
Variations in sex hormones influence bone health in men. Aging in men is associated with a decrease in testosterone (T) levels. We examined the relationship between T levels and changes in bone health status as measured by quantitative ultrasound (QUS) at the phalanges and the os calcis and by peripheral bone mineral density (pBMD) at the phalanges in healthy elderly Spanish men. We examined 162 men aged 65-88 years and assessed total serum T concentrations. Total serum T < 300 ng/dL was used as the threshold for biochemical T deficiency...
March 2015: Biological Research for Nursing
Meghan Arnold, Adrian Barbul
The relationship between nutrition and wound healing--after injury or surgical intervention--has been recognized for centuries. There is no doubt that adequate carbohydrate, fat, and protein intake is required for healing to take place, but research in the laboratory has suggested that other specific nutritional interventions can have significant beneficial effects on wound healing. Successful translation into the clinical arena, however, has been rare. A review of normal metabolism as it relates to wound healing in normoglycemic and diabetic individuals is presented...
June 2006: Plastic and Reconstructive Surgery
Varun Puvanesarajah, Jay R Shapiro, Paul D Sponseller
BACKGROUND: Patients with osteogenesis imperfecta often develop nonunions, as internal fixation has limited applicability in this condition. We report the outcomes of a modified "sandwich technique" in the treatment of long-bone nonunions in patients with osteogenesis imperfecta; this technique brings circumferential stabilization and normal collagen to the nonunion site. METHODS: From May 2003 through February 2012, twelve patients (eight females, four males; median age, 39...
February 18, 2015: Journal of Bone and Joint Surgery. American Volume
Christopher Bibbo, Jonas Nelson, David Ehrlich, Brian Rougeux
The BMPs are a group of growth factors that have varied roles in the development and maintenance of many organ systems. Several of the BMPs have osteogenic potential, and exert their effects via complex and highly regulated pathways. At present, only rhBMP-2 and rhBMP-7 are available for clinical use, but only rhBMP-2 is readily available, and from a practical standpoint is considered the only commercially available BMP. Only a few studies exist on BMP use in foot and ankle surgery, but these have shown promising results with low complication rates...
January 2015: Clinics in Podiatric Medicine and Surgery
Javier La Fontaine, Nathan A Hunt, Stacey Curry, Tyler Kearney, Daniel Jupiter, Naohiro Shibuya, Lawrence A Lavery
BACKGROUND: Persons with diabetes have a higher incidence of fractures compared with persons without diabetes. However, there is little published information concerning the deleterious effect of late-stage diabetes on fracture healing. There are no studies using animal models that evaluate the effect of advanced diabetes on fracture healing. The purpose of our study was to evaluate cytokine expression, specifically macrophage inflammatory protein 1 (MIP-1) and vascular endothelial growth factor, in fracture healing in a type 2 diabetes rat model...
September 2014: Journal of the American Podiatric Medical Association
Shwan H Mohamad, Martyn Barnes, Stephen Jones, Suresh Mahendran
: This study aims to describe a new technique for the management of auricular hematoma using fibrin glue. Five difficult cases of auricular hematoma were managed using this technique, including 2 recurrent and 3 delayed presentations. After skin preparation and local anesthetic, an incision was made, the hematoma was evacuated, and the cavity was washed out with saline. Fibrin glue was applied liberally; a dental roll pressure dressing was applied and secured with a prolene bead suture. The patients were given a course of oral antibiotic and reviewed after 5 days for removal of the external dressing...
November 2014: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Raj Kumar Harshwal, Sohan Singh Sankhala, Divesh Jalan
INTRODUCTION: The management of nonunion has remained a constant challenge. The associated bone defect, shortening, deformity and infection complicate the management. A mono-lateral external fixator may minimise some of the problems frequently encountered in these patients. We report our results of prospectively evaluated 37 consecutive patients regarding nonunion of lower-extremity long bones managed using a mono-lateral external fixator. PATIENTS AND METHODS: A total of 37 patients (7 femurs and 30 tibias), mean age 36 years, were stabilised using a mono-lateral fixator for nonunion of long bones...
March 2014: Injury
Charlton Stucken, Dana C Olszewski, William R Creevy, Akira M Murakami, Paul Tornetta
BACKGROUND: The surgical treatment of a fracture nonunion is complicated in the presence of infection. The purpose of the present study is to report on the utility of a standardized protocol to rule out infection in high-risk patients and to evaluate the efficacy of each component of the protocol. METHODS: A single protocol of preoperative laboratory tests (white blood-cell count, C-reactive protein level, and erythrocyte sedimentation rate) and a combined white blood cell/sulfur colloid scan were performed for patients with a high risk of fracture nonunion...
August 7, 2013: Journal of Bone and Joint Surgery. American Volume
Emily R Dodwell, Julius Gene Latorre, Emilio Parisini, Elisabeth Zwettler, Divay Chandra, Kishore Mulpuri, Brian Snyder
Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used for postoperative pain control. However, concerns regarding the potential deleterious effects of NSAIDs on bone healing have compelled many physicians to avoid NSAIDs in patients with healing fractures, osteotomies, and fusions. We systematically reviewed and analyzed the best clinical evidence regarding the effects of NSAID exposure on bone healing. Medline, Embase, and Cochrane electronic databases were searched for prospective and retrospective clinical studies of fracture, osteotomy, and fusion studies of patients with NSAID exposure and nonunion as an outcome...
September 2010: Calcified Tissue International
Ph Hernigou, A Poignard, F Beaujean, H Rouard
BACKGROUND: Bone marrow aspirated from the iliac crest contains progenitor cells that can be used to obtain bone-healing of nonunions. However, there is little available information regarding the number and concentration of these cells that are necessary to obtain bone repair. The purpose of this study was to evaluate the number and concentration of progenitor cells that were transplanted for the treatment of nonunion, the callus volume obtained after the transplantation, and the clinical healing rate...
July 2005: Journal of Bone and Joint Surgery. American Volume
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