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Acute & Persistant Pain

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53 papers 25 to 100 followers A collection of articles of interest to those treating acute pain and concern for persistent pain
By Ron George Anesthesiologist with special interests in Obstetrics, Pain, and Global Health
Stephan A Schug
No abstract text is available yet for this article.
July 2012: Pain
Michael K Urban, Jacques T Ya Deau, Barbara Wukovits, Jane Y Lipnitsky
Management of acute postoperative pain is challenging, particularly in patients with preexisting narcotic dependency. Ketamine has been used at subanesthetic doses as a N-methyl D-aspartate (NMDA) receptor antagonist to block the processing of nociceptive input in chronic pain syndromes. This prospective randomized study was designed to assess the use of ketamine as an adjunct to acute pain management in narcotic tolerant patients after spinal fusions. Twenty-six patients for 1-2 level posterior lumbar fusions with segmental instrumentation were randomly assigned to receive ketamine or act as a control...
February 2008: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
Esther Pogatzki-Zahn, Chandani Chandrasena, Stephan A Schug
PURPOSE OF REVIEW: Postoperative pain remains poorly treated in many patients. One reason is the inadequate use of nonopioid analgesics. This review examines the most recent findings on nonopioid analgesics and how these translate into clinical practice. RECENT FINDINGS: Commonly used nonopioid analgesics are paracetamol, NSAIDs and metamizol (dipyrone). For paracetamol, the efficacy is obviously inferior to NSAIDs and the risk of adverse events might have been underestimated in the past...
October 2014: Current Opinion in Anaesthesiology
A Wehrfritz, S Schaefer, A Troester, N Noel, B Bessiere, G Apiou-Sbirlea, G Simonnet, J Schuettler, P Richebé
BACKGROUND: Opioids are known to relieve pain, and also aggravate pre-existing hyperalgesia. In animal studies, the N-methyl-d-aspartate-receptor antagonist nitrous oxide (N2 O) was able to prevent hyperalgesia. The present study evaluated the effect of N2 O on hyperalgesia after remifentanil infusion in healthy volunteers. METHODS: Twenty-one healthy volunteers were enrolled in this placebo-controlled cross-over study. Transcutaneous electrical stimulation at high current densities induced spontaneous acute pain and stable areas of hyperalgesia...
October 2016: European Journal of Pain: EJP
Henrik Kehlet, Girish P Joshi
No abstract text is available yet for this article.
October 2015: Anesthesia and Analgesia
C Richard Chapman, Gary W Donaldson, Jennifer J Davis, David H Bradshaw
UNLABELLED: The purpose of this study was to demonstrate a method for increasing the precision and information yield of postoperative pain assessment. We recorded pain intensity ratings over 6 days after surgery in 502 elective surgery patients and examined individual pain trajectories. A linear fit of an individual patient's scores defines a trajectory with two features: (1) the intercept or initial pain intensity; and (2) the slope, or rate of pain resolution. Three pain trajectory patterns emerged from examination of the pain trajectory slopes...
February 2011: Journal of Pain: Official Journal of the American Pain Society
C Richard Chapman, Jennifer Davis, Gary W Donaldson, Justin Naylor, Daniel Winchester
UNLABELLED: For 2 weeks following surgery, 55 patients with preexisting chronic pain (CP) reported daily postoperative pain with movement and at rest. Of these, 30 CP patients used opioid pharmacotherapy for CP management and 25 did not. We modeled pain resolution in each patient using a linear fit so that each patient yielded 2 scores for each pain rating: 1) an intercept, or initial level of pain, immediately after surgery; and 2) a slope, or rate of pain resolution. The patients not using opioid pharmacotherapy had a mean pain with movement intercept of 5...
December 2011: Journal of Pain: Official Journal of the American Pain Society
Sara Marchesan Oliveira, Carine Cristiane Drewes, Cássia Regina Silva, Gabriela Trevisan, Suelen Lucio Boschen, Camila Guimaraes Moreira, Daniela de Almeida Cabrini, Claudio Da Cunha, Juliano Ferreira
Recent studies have indicated that nearly half of all surgical patients still have inadequate pain relief; therefore, it is becoming increasingly more important to understand the mechanisms involved in postoperative pain in order to be better treated. Previous studies have shown that incisions can cause mast cell degranulation. Thus, the aim of this study was to investigate the involvement of mast cells in a model of postoperative pain in mice. The depletion of mast cell mediators produced by pre-treatment with compound 48/80 (intraplantar (i...
December 15, 2011: European Journal of Pharmacology
Nichola Elvery, Mark P Jensen, Dawn M Ehde, Melissa A Day
OBJECTIVES: It is not known if psychosocial chronic pain treatments produce benefits via the unique mechanisms specified by theory. Fundamental to gaining an accurate understanding of this issue is to first determine if the most widely used process measures assess unique constructs and predict unique variance in pain outcomes. This study examined the associations between the Pain Catastrophizing Scale (PCS), Five-Facet Mindfulness Questionnaire (FFMQ-SF) and the Chronic Pain Acceptance Questionnaire (CPAQ-8), and determined their unique contributions to the prediction of pain intensity, pain interference and depression...
August 31, 2016: Clinical Journal of Pain
M Gram, J Erlenwein, F Petzke, D Falla, M Przemeck, M I Emons, M Reuster, S S Olesen, A M Drewes
BACKGROUND: Opioids are often used for pain treatment, but the response is often insufficient and dependent on e.g. the pain condition, genetic factors and drug class. Thus, there is an urgent need to identify biomarkers to enable selection of the appropriate drug for the individual patient, a concept known as personalized medicine. Quantitative sensory testing (QST) and clinical parameters can provide some guidance for response, but better and more objective biomarkers are urgently warranted...
July 29, 2016: European Journal of Pain: EJP
Yun Wang, Laura P Sands, Linnea Vaurio, E Ann Mullen, Jacqueline M Leung
To determine risks for postoperative cognitive dysfunction (POCD), the authors conducted a prospective cohort study of 225 patients > or = 65 years of age undergoing noncardiac surgery. Cognitive testing using the Word List, Verbal Fluency, and Digit Symbol tests was conducted for each patient preoperatively and 1 and 2 days postoperatively in patients without postoperative delirium. POCD was defined as meeting statistical criteria for decline from the patient's preoperative performance levels on at least two of the three cognitive tests...
January 2007: American Journal of Geriatric Psychiatry
Marina Shpaner, Clare Kelly, Greg Lieberman, Hayley Perelman, Marcia Davis, Francis J Keefe, Magdalena R Naylor
Chronic pain is a complex physiological and psychological phenomenon. Implicit learning mechanisms contribute to the development of chronic pain and to persistent changes in the central nervous system. We hypothesized that these central abnormalities can be remedied with Cognitive Behavioral Therapy (CBT). Specifically, since regions of the anterior Default Mode Network (DMN) are centrally involved in emotional regulation via connections with limbic regions, such as the amygdala, remediation of maladaptive behavioral and cognitive patterns as a result of CBT for chronic pain would manifest itself as a change in the intrinsic functional connectivity (iFC) between these prefrontal and limbic regions...
2014: NeuroImage: Clinical
Todd Jackson, Panpan Tian, Yang Wang, Tony Iezzi, Wenyi Xie
UNLABELLED: Presurgery emotional distress has had variable associations with outcomes of surgery in past narrative reviews. This meta-analysis was designed to evaluate the overall strengths of relations between presurgical emotional distress and key postsurgical pain outcomes (ie, pain intensity, analgesic use, functional impairment) and to identify moderators that might explain effect size heterogeneity between studies. PubMed, Web of Science, PsychINFO, Google Scholar, and Science Direct databases were searched to identify studies subjected to meta-analysis...
August 2016: Journal of Pain: Official Journal of the American Pain Society
Bülent Doğan, İsmet Gün, Özkan Özdamar, Ali Yılmaz, Murat Muhçu
OBJECTIVE: To investigate whether spontaneous vaginal birth with mediolateral episiotomy has any long-term impact on urinary and/or fecal incontinence, sexual dysfunction and perineal pain in primiparous women. METHODS: This matched case-control study included 150 women between 25 and 35 years old who had a singleton childbirth at least five years previously. Patients were grouped as; women who had a spontaneous vaginal delivery with mediolateral episiotomy (Group 1), an elective cesarean delivery (Group 2), and who had no delivery (Group 3)...
April 25, 2016: Journal of Maternal-fetal & Neonatal Medicine
Carol A Mancuso, M Carrington Reid, Roland Duculan, Federico P Girardi
OBJECTIVES: Improvement in pain is a major expectation of patients undergoing lumbar spine surgery. METHODS: Among 422 patients, the goal of this prospective study was to measure 2-year postoperative pain and to determine whether this outcome varied according to patient and clinical characteristics, including amount of pain relief expected preoperatively. Before surgery patients completed valid questionnaires that addressed clinical characteristics and expectations for pain improvement...
March 28, 2016: Clinical Journal of Pain
Nora D Volkow, A Thomas McLellan
No abstract text is available yet for this article.
March 31, 2016: New England Journal of Medicine
Mei Gao, Damoon Rejaei, Hong Liu
After nearly half a century on the market, ketamine still occupies a unique corner in the medical armamentarium of anesthesiologists or clinicians treating pain. Over the last two decades, much research has been conducted highlighting the drug's mechanisms of action, specifically those of its enantiomers. Nowadays, ketamine is also being utilized for pediatric pain control in emergency department, with its anti-hyperalgesic and anti-inflammatory effects being revealed in acute and chronic pain management. Recently, new insights have been gained on ketamine's potential anti-depressive and antisuicidal effects...
July 2016: Acta Pharmacologica Sinica
R-R Nir, H Nahman-Averbuch, R Moont, E Sprecher, D Yarnitsky
Preoperative administration of pharmacological substances, such as non-steroidal anti-inflammatory drugs or opioids, has been gaining acclaim as a preemptive measure to minimize postoperative pain. This systematic review and meta-analysis aimed at evaluating the effectiveness of this approach in adults undergoing surgical procedures. MEDLINE, EMBASE and the Cochrane Central Register were searched from inception through January 2015. Data from randomized placebo-controlled trials were screened, extracted and assessed for risk of bias according to The Cochrane Collaboration's Tool by two independent authors...
August 2016: European Journal of Pain: EJP
Brian T Bateman, Jessica M Franklin, Katsiaryna Bykov, Jerry Avorn, William H Shrank, Troyen A Brennan, Joan E Landon, James P Rathmell, Krista F Huybrechts, Michael A Fischer, Niteesh K Choudhry
BACKGROUND: The incidence of opioid-related death in women has increased 5-fold over the past decade. For many women, their initial opioid exposure will occur in the setting of routine medical care. Approximately 1 in 3 deliveries in the United States is by cesarean, and opioids are commonly prescribed for postsurgical pain management. OBJECTIVE: The objective of this study was to determine the risk that opioid-naïve women prescribed opioids after cesarean delivery will subsequently become consistent prescription opioid users in the year following delivery and to identify predictors for this behavior...
September 2016: American Journal of Obstetrics and Gynecology
Samantha M Meints, Megan M Miller, Adam T Hirsh
UNLABELLED: Compared with white individuals, black individuals experience greater pain across clinical and experimental modalities. These race differences may be due to differences in pain-related coping. Several studies examined the relationship between race and pain coping; however, no meta-analytic review has summarized this relationship or attempted to account for differences across studies. The goal of this meta-analytic review was to quantify race differences in the overall use of pain coping strategies as well as specific coping strategies...
June 2016: Journal of Pain: Official Journal of the American Pain Society
2016-01-30 19:00:56
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