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Naturopathic Medicine

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44 papers 1000+ followers Collection of RCTs and other papers + editorials
By Christopher Cook, BA,CADC, SAP Addiction professional. LPC, CADC, CRNP- student, Interventionist, project manager, owner, Director, eval/refer for SUDs/Eating D/o's
https://www.readbyqxmd.com/read/26986673/long-term-effectiveness-of-combined-treatment-with-traditional-chinese-medicine-and-western-medicine-on-the-prognosis-of-patients-with-lung-cancer
#1
Woung-Ru Tang, Sien-Hung Yang, Chih-Teng Yu, Chin-Chou Wang, Sheng-Teng Huang, Tzu-Hsin Huang, Ming-Chu Chiang, Yue-Cune Chang
OBJECTIVES: The study aim was to compare the long-term effect of Western medicine and combined treatment with Traditional Chinese Medicine (TCM) and Western medicine on the prognosis (survival rate, symptom distress, physical function, and quality of life) of patients with lung cancer. DESIGN: Longitudinal study. SETTING/LOCATION: Two medical centers, one each in Northern and Southern Taiwan. PATIENTS: Patients newly diagnosed with lung cancer and treated with Western medicine (n = 54) or TCM plus Western medicine (n = 30)...
March 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/23730798/discovery-of-novel-insomnia-leads-from-screening-traditional-chinese-medicine-database
#2
Hsin-Yi Chen, Su-sen Chang, Yueh-Chiu Chan, Calvin Yu-Chian Chen
Insomnia is a prominent modern disease that affects an increasing population. Undesirable side effects of commercial drugs highlight the need to develop novel insomnia drugs. Virtual screening of traditional chinese medicine Database@Taiwan (TCM Database@Taiwan) identified 2-O-Caffeoyl tartaric acid (1), 2-O-Feruloyl tartaric acid (2), and Mumefural (3) as potential agonists for both gamma-amino butyric acid (GABA) or benzodiazepine (BZ) binding sites. The TCM candidates exhibited higher affinity than GABA and Zolpidem, a phenomenon that could be attributed to higher quantity of stabilizing H-bonds...
2014: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27659301/anti-ageing-active-ingredients-from-herbs-and-nutraceuticals-used-in-traditional-chinese-medicine-pharmacological-mechanisms-and-implications-for-drug-discovery
#3
REVIEW
Chun-Yan Shen, Jian-Guo Jiang, Li Yang, Da-Wei Wang, Wei Zhu
Ageing, an unanswered question in the medical field, is a multifactorial process that results in a progressive functional decline in cells, tissues and organisms. Although it is impossible to prevent ageing, slowing down the rate of ageing is entirely possible to achieve. Traditional Chinese medicine (TCM) is characterized by the nourishing of life and its role in anti-ageing is getting more and more attention. This article summarizes the work done on the natural products from TCM that are reported to have anti-ageing effects, in the past two decades...
June 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/24502784/pain-novel-analgesics-from-traditional-chinese-medicines
#4
COMMENT
Susan L Ingram
The search for analgesics with fewer side effects and less abuse potential has had limited success. A recent study identifies an analgesic alkaloid compound from Corydalis yanhusuo, a traditional Chinese medicinal herb that has a surprising mechanism of action.
February 3, 2014: Current Biology: CB
https://www.readbyqxmd.com/read/24388848/a-novel-analgesic-isolated-from-a-traditional-chinese-medicine
#5
Yan Zhang, Chaoran Wang, Lien Wang, Gregory Scott Parks, Xiuli Zhang, Zhimou Guo, Yanxiong Ke, Kang-Wu Li, Mi Kyeong Kim, Benjamin Vo, Emiliana Borrelli, Guangbo Ge, Ling Yang, Zhiwei Wang, M Julia Garcia-Fuster, Z David Luo, Xinmiao Liang, Olivier Civelli
BACKGROUND: Current pain management is limited, in particular, with regard to chronic pain. In an attempt to discover novel analgesics, we combined the approach developed to characterize traditional Chinese medicine (TCM), as part of the "herbalome" project, with the reverse pharmacology approach aimed at discovering new endogenous transmitters and hormones. RESULTS: In a plant used for centuries for its analgesic properties, we identify a compound, dehydrocorybulbine (DHCB), that is effective at alleviating thermally induced acute pain...
January 20, 2014: Current Biology: CB
https://www.readbyqxmd.com/read/28619197/traditional-chinese-medicine-for-cardiovascular-disease-evidence-and-potential-mechanisms
#6
REVIEW
Panpan Hao, Fan Jiang, Jing Cheng, Lianyue Ma, Yun Zhang, Yuxia Zhao
Traditional Chinese medicine (TCM) has more than 2,000 years of history and has gained widespread clinical applications. However, the explicit role of TCM in preventing and treating cardiovascular disease remains unclear due to a lack of sound scientific evidence. Currently available randomized controlled trials on TCM are flawed, with small sample sizes and diverse outcomes, making it difficult to draw definite conclusions about the actual benefits and harms of TCM. Here, we systematically assessed the efficacy and safety of TCM for cardiovascular disease, as well as the pharmacological effects of active TCM ingredients on the cardiovascular system and potential mechanisms...
June 20, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/30302404/phytochemical-analysis-of-canna-indica-l-roots-and-rhizomes-extract
#7
Subhash T Kumbhar, Shriniwas P Patil, Hemant D Une
Canna indica L. (Cannaceae) roots and rhizomes were reported to possess various biological properties like antimicrobial, anthelmintic potential and HIV-1 reverse transcriptase inhibition. In our previous studies, they showed antidiabetic activity on normal rats and rats co-addicted with caffeine and nicotine. In the pursuit of the phytochemical/s responsible for these biological activities, present study was aimed at phytochemical evaluation of hydroalcoholic extract (HAE) of C. indica L. roots and rhizomes; including preliminary screening, thin layer chromatography, H1 -NMR and HR-LC/MS-MS analysis...
December 2018: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/30171419/identification-of-protoberberine-alkaloids-as-novel-histone-methyltransferase-g9a-inhibitors-by-structure-based-virtual-screening
#8
Jie Chen, Xiao Lin, Kyoung Jin Park, Kang Ro Lee, Hyun-Ju Park
The protein lysine methyltransferase G9a, which controls gene expression by epigenetic regulation of H3K9 methylation, is related to various human diseases, including cancer, drug addiction, and mental retardation. In recent years, genetic, biological, and physiological evidence has established G9a inhibitors as potential chemotherapeutic agents for cancer treatment. In this study, we identified protoberberine alkaloid pseudodehydrocorydaline (CT13) as a novel G9a inhibitor, by structure-based virtual screening of in-house library containing natural product compounds...
September 2018: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/25974700/regulation-of-the-epigenome-by-vitamin-c
#9
REVIEW
Juan I Young, Stephan Züchner, Gaofeng Wang
Emerging evidence suggests that ascorbate, the dominant form of vitamin C under physiological pH conditions, influences activity of the genome via regulating epigenomic processes. Ascorbate serves as a cofactor for Ten-eleven translocation (TET) dioxygenases that catalyze the oxidation of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), and further to 5-formylcytosine (5fC) and to 5-carboxylcytosine (5caC), which are ultimately replaced by unmodified cytosine. The Jumonji C (JmjC)-domain-containing histone demethylases also require ascorbate as a cofactor for histone demethylation...
2015: Annual Review of Nutrition
https://www.readbyqxmd.com/read/29603319/role-of-melatonin-in-blood-pressure-regulation-an-adjunct-anti-hypertensive-agent
#10
REVIEW
Jacquie Baker, Kurt Kimpinski
Cardiovascular diseases account for approximately one-third of all deaths each year. Of this, hypertension accounts for approximately 9.4 million deaths. Melatonin, the primary circadian hormone, has been substantiated as an effective and safe adjunct anti-hypertensive agent. In support of this, melatonin receptors have been identified within the central and peripheral nervous system, as well as the cardiovascular system, including various vascular tissues. Therefore, it is not surprising that recent research has emerged highlighting a key role of melatonin in autonomic regulation of blood pressure...
August 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29726951/walnut-consumption-alters-the-gastrointestinal-microbiota-microbially-derived-secondary-bile-acids-and-health-markers-in-healthy-adults-a-randomized-controlled-trial
#11
Hannah D Holscher, Heather M Guetterman, Kelly S Swanson, Ruopeng An, Nirupa R Matthan, Alice H Lichtenstein, Janet A Novotny, David J Baer
Background: Epidemiologic data suggest that diets rich in nuts have beneficial health effects, including reducing total and cause-specific mortality from cancer and heart disease. Although there is accumulating preclinical evidence that walnuts beneficially affect the gastrointestinal microbiota and gut and metabolic health, these relations have not been investigated in humans. Objective: We aimed to assess the impact of walnut consumption on the human gastrointestinal microbiota and metabolic markers of health...
June 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29220861/do-we-need-plant-food-supplements-a-critical-examination-of-quality-safety-efficacy-and-necessity-for-a-new-regulatory-framework
#12
REVIEW
Mona Abdel-Tawab
Given the expanding market of plant food supplements (PFSs) not undergoing any pre-marketing authorization, the overall quality, safety and efficacy of PFSs were subjected to a critical examination. Although many high-quality PFSs exist on the legal market, quality concerns are in general justified. Besides economic adulteration, active ingredients dramatically differing from label claims and among products were reported in several studies. In addition, PFSs sold via the Internet may be intentionally adulterated with undeclared prescription drugs...
April 2018: Planta Medica
https://www.readbyqxmd.com/read/24676047/systematic-review-of-n-acetylcysteine-in-the-treatment-of-addictions
#13
REVIEW
Elson Asevedo, Ana C Mendes, Michael Berk, Elisa Brietzke
OBJECTIVE: To conduct the first systematic literature review of clinical trials of N-acetylcysteine (NAC) for the treatment of substance abuse disorders and addictive behaviors. METHODS: A search of the MEDLINE, Embase and PsycINFO databases was conducted. The inclusion criteria for the review were clinical trials that used NAC in the treatment of a disorder related to substance use and/or addictive behaviors, limited to texts in English, Spanish, or French. The selected studies were evaluated with respect to type of trial, sample size, diagnostic input, intervention, length of follow-up, outcome variables, and results...
April 2014: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/27309537/n-acetyl-cysteine-may-support-dopamine-neurons-in-parkinson-s-disease-preliminary-clinical-and-cell-line-data
#14
RANDOMIZED CONTROLLED TRIAL
Daniel A Monti, George Zabrecky, Daniel Kremens, Tsao-Wei Liang, Nancy A Wintering, Jingli Cai, Xiatao Wei, Anthony J Bazzan, Li Zhong, Brendan Bowen, Charles M Intenzo, Lorraine Iacovitti, Andrew B Newberg
BACKGOUND: The purpose of this study was to assess the biological and clinical effects of n-acetyl-cysteine (NAC) in Parkinson's disease (PD). METHODS: The overarching goal of this pilot study was to generate additional data about potentially protective properties of NAC in PD, using an in vitro and in vivo approach. In preparation for the clinical study we performed a cell tissue culture study with human embryonic stem cell (hESC)-derived midbrain dopamine (mDA) neurons that were treated with rotenone as a model for PD...
2016: PloS One
https://www.readbyqxmd.com/read/29078970/evaluation-of-acupuncture-in-the-treatment-of-restless-legs-syndrome-a-randomized-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Gholam Reza Raissi, Bijan Forogh, Tannaz Ahadi, Samaneh Ghahramanpoori, Pouya Ghaboussi, Simin Sajadi
The aim of this study was to examine the additive effect of medical acupuncture on controlling the symptoms of restless legs syndrome (RLS). A total of 46 randomly allocated patients diagnosed with RLS were assigned to receive either 10 sessions of acupuncture plus gabapentin (300 mg/d), or gabapentin (300 mg/d) alone (23 patients in each group) over 4 weeks in a single-blind study. The symptoms of patients were assessed by the Visual Analogue Scale (VAS), the International Restless Legs Syndrome Rating Scale (IRLSRS), and the Pittsburgh Sleep Quality Index (PSQI) at baseline, just after the therapeutic course and 8 weeks later...
October 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28861803/electro-acupuncture-treatment-for-internet-addiction-evidence-of-normalization-of-impulse-control-disorder-in-adolescents
#16
RANDOMIZED CONTROLLED TRIAL
Yang Yang, Hui Li, Xi-Xi Chen, Luo-Ming Zhang, Bing-Jie Huang, Tian-Min Zhu
OBJECTIVE: To observe the impacts of electro-acupuncture (EA) and psychological intervention (PI) on impulsive behavior among internet addiction (IA) adolescents. METHODS: Thirty-two IA adolescents were allocated to either EA (16 cases) or PI (16 cases) group by a randomized digital table. Subjects in the EA group received EA treatment and subjects in the PI group received cognition and behavior therapy. All adolescents underwent 45-d intervention. Sixteen healthy volunteers were recruited into a control group...
November 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28754994/-1-h-nmr-based-investigation-of-metabolic-response-to-electro-acupuncture-stimulation
#17
Caigui Lin, Zhiliang Wei, Kian-Kai Cheng, Jingjing Xu, Guiping Shen, Chang She, Huan Zhong, Xiaorong Chang, Jiyang Dong
Acupuncture is a traditional Chinese medicine therapy that has been found useful for treating various diseases. The treatments involve the insertion of fine needles at acupoints along specific meridians (meridian specificity). This study aims to investigate the metabolic basis of meridian specificity using proton nuclear magnetic resonance ((1)H NMR)-based metabolomics. Electro-acupuncture (EA) stimulations were performed at acupoints of either Stomach Meridian of Foot-Yangming (SMFY) or Gallbladder Meridian of Foot-Shaoyang (GMFS) in healthy male Sprague Dawley (SD) rats...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28293192/indole-alkaloids-from-plants-as-potential-leads-for-antidepressant-drugs-a-mini-review
#18
Hazrulrizawati A Hamid, Aizi N M Ramli, Mashitah M Yusoff
Depression is the most common illness observed in the elderly, adults, and children. Antidepressants prescribed are usually synthetic drugs and these can sometimes cause a wide range of unpleasant side effects. Current research is focussed on natural products from plants as they are a rich source of potent new drug leads. Besides Hypericum perforatum (St. John's wort), the plants studied include Passiflora incarnata L. (passion flower), Mitragyna speciosa (kratom), Piper methysticum G. Forst (kava) and Valeriana officinalis L...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27529277/spices-for-prevention-and-treatment-of-cancers
#19
REVIEW
Jie Zheng, Yue Zhou, Ya Li, Dong-Ping Xu, Sha Li, Hua-Bin Li
Spices have been widely used as food flavorings and folk medicines for thousands of years. Numerous studies have documented the antioxidant, anti-inflammatory and immunomodulatory effects of spices, which might be related to prevention and treatment of several cancers, including lung, liver, breast, stomach, colorectum, cervix, and prostate cancers. Several spices are potential sources for prevention and treatment of cancers, such as Curcuma longa (tumeric), Nigella sativa (black cumin), Zingiber officinale (ginger), Allium sativum (garlic), Crocus sativus (saffron), Piper nigrum (black pepper) and Capsicum annum (chili pepper), which contained several important bioactive compounds, such as curcumin, thymoquinone, piperine and capsaicin...
August 12, 2016: Nutrients
https://www.readbyqxmd.com/read/28388917/influence-of-diet-on-the-gut-microbiome-and-implications-for-human-health
#20
REVIEW
Rasnik K Singh, Hsin-Wen Chang, Di Yan, Kristina M Lee, Derya Ucmak, Kirsten Wong, Michael Abrouk, Benjamin Farahnik, Mio Nakamura, Tian Hao Zhu, Tina Bhutani, Wilson Liao
Recent studies have suggested that the intestinal microbiome plays an important role in modulating risk of several chronic diseases, including inflammatory bowel disease, obesity, type 2 diabetes, cardiovascular disease, and cancer. At the same time, it is now understood that diet plays a significant role in shaping the microbiome, with experiments showing that dietary alterations can induce large, temporary microbial shifts within 24 h. Given this association, there may be significant therapeutic utility in altering microbial composition through diet...
April 8, 2017: Journal of Translational Medicine
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