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Naturopathic Medicine

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32 papers 1000+ followers Collection of RCTs and other papers + editorials
By Christopher Cook, BA,CADC, SAP Addiction professional. LPC, CADC, CRNP- student, Interventionist, project manager, owner, Director, eval/refer for SUDs/Eating D/o's
https://www.readbyqxmd.com/read/24676047/systematic-review-of-n-acetylcysteine-in-the-treatment-of-addictions
#1
REVIEW
Elson Asevedo, Ana C Mendes, Michael Berk, Elisa Brietzke
OBJECTIVE: To conduct the first systematic literature review of clinical trials of N-acetylcysteine (NAC) for the treatment of substance abuse disorders and addictive behaviors. METHODS: A search of the MEDLINE, Embase and PsycINFO databases was conducted. The inclusion criteria for the review were clinical trials that used NAC in the treatment of a disorder related to substance use and/or addictive behaviors, limited to texts in English, Spanish, or French. The selected studies were evaluated with respect to type of trial, sample size, diagnostic input, intervention, length of follow-up, outcome variables, and results...
April 2014: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/27309537/n-acetyl-cysteine-may-support-dopamine-neurons-in-parkinson-s-disease-preliminary-clinical-and-cell-line-data
#2
RANDOMIZED CONTROLLED TRIAL
Daniel A Monti, George Zabrecky, Daniel Kremens, Tsao-Wei Liang, Nancy A Wintering, Jingli Cai, Xiatao Wei, Anthony J Bazzan, Li Zhong, Brendan Bowen, Charles M Intenzo, Lorraine Iacovitti, Andrew B Newberg
BACKGOUND: The purpose of this study was to assess the biological and clinical effects of n-acetyl-cysteine (NAC) in Parkinson's disease (PD). METHODS: The overarching goal of this pilot study was to generate additional data about potentially protective properties of NAC in PD, using an in vitro and in vivo approach. In preparation for the clinical study we performed a cell tissue culture study with human embryonic stem cell (hESC)-derived midbrain dopamine (mDA) neurons that were treated with rotenone as a model for PD...
2016: PloS One
https://www.readbyqxmd.com/read/29078970/evaluation-of-acupuncture-in-the-treatment-of-restless-legs-syndrome-a-randomized-controlled-trial
#3
Gholam Reza Raissi, Bijan Forogh, Tannaz Ahadi, Samaneh Ghahramanpoori, Pouya Ghaboussi, Simin Sajadi
The aim of this study was to examine the additive effect of medical acupuncture on controlling the symptoms of restless legs syndrome (RLS). A total of 46 randomly allocated patients diagnosed with RLS were assigned to receive either 10 sessions of acupuncture plus gabapentin (300 mg/d), or gabapentin (300 mg/d) alone (23 patients in each group) over 4 weeks in a single-blind study. The symptoms of patients were assessed by the Visual Analogue Scale (VAS), the International Restless Legs Syndrome Rating Scale (IRLSRS), and the Pittsburgh Sleep Quality Index (PSQI) at baseline, just after the therapeutic course and 8 weeks later...
October 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28861803/electro-acupuncture-treatment-for-internet-addiction-evidence-of-normalization-of-impulse-control-disorder-in-adolescents
#4
Yang Yang, Hui Li, Xi-Xi Chen, Luo-Ming Zhang, Bing-Jie Huang, Tian-Min Zhu
OBJECTIVE: To observe the impacts of electro-acupuncture (EA) and psychological intervention (PI) on impulsive behavior among internet addiction (IA) adolescents. METHODS: Thirty-two IA adolescents were allocated to either EA (16 cases) or PI (16 cases) group by a randomized digital table. Subjects in the EA group received EA treatment and subjects in the PI group received cognition and behavior therapy. All adolescents underwent 45-d intervention. Sixteen healthy volunteers were recruited into a control group...
November 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28754994/-1-h-nmr-based-investigation-of-metabolic-response-to-electro-acupuncture-stimulation
#5
Caigui Lin, Zhiliang Wei, Kian-Kai Cheng, Jingjing Xu, Guiping Shen, Chang She, Huan Zhong, Xiaorong Chang, Jiyang Dong
Acupuncture is a traditional Chinese medicine therapy that has been found useful for treating various diseases. The treatments involve the insertion of fine needles at acupoints along specific meridians (meridian specificity). This study aims to investigate the metabolic basis of meridian specificity using proton nuclear magnetic resonance ((1)H NMR)-based metabolomics. Electro-acupuncture (EA) stimulations were performed at acupoints of either Stomach Meridian of Foot-Yangming (SMFY) or Gallbladder Meridian of Foot-Shaoyang (GMFS) in healthy male Sprague Dawley (SD) rats...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28293192/indole-alkaloids-from-plants-as-potential-leads-for-antidepressant-drugs-a-mini-review
#6
Hazrulrizawati A Hamid, Aizi N M Ramli, Mashitah M Yusoff
Depression is the most common illness observed in the elderly, adults, and children. Antidepressants prescribed are usually synthetic drugs and these can sometimes cause a wide range of unpleasant side effects. Current research is focussed on natural products from plants as they are a rich source of potent new drug leads. Besides Hypericum perforatum (St. John's wort), the plants studied include Passiflora incarnata L. (passion flower), Mitragyna speciosa (kratom), Piper methysticum G. Forst (kava) and Valeriana officinalis L...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27529277/spices-for-prevention-and-treatment-of-cancers
#7
REVIEW
Jie Zheng, Yue Zhou, Ya Li, Dong-Ping Xu, Sha Li, Hua-Bin Li
Spices have been widely used as food flavorings and folk medicines for thousands of years. Numerous studies have documented the antioxidant, anti-inflammatory and immunomodulatory effects of spices, which might be related to prevention and treatment of several cancers, including lung, liver, breast, stomach, colorectum, cervix, and prostate cancers. Several spices are potential sources for prevention and treatment of cancers, such as Curcuma longa (tumeric), Nigella sativa (black cumin), Zingiber officinale (ginger), Allium sativum (garlic), Crocus sativus (saffron), Piper nigrum (black pepper) and Capsicum annum (chili pepper), which contained several important bioactive compounds, such as curcumin, thymoquinone, piperine and capsaicin...
August 12, 2016: Nutrients
https://www.readbyqxmd.com/read/28388917/influence-of-diet-on-the-gut-microbiome-and-implications-for-human-health
#8
REVIEW
Rasnik K Singh, Hsin-Wen Chang, Di Yan, Kristina M Lee, Derya Ucmak, Kirsten Wong, Michael Abrouk, Benjamin Farahnik, Mio Nakamura, Tian Hao Zhu, Tina Bhutani, Wilson Liao
Recent studies have suggested that the intestinal microbiome plays an important role in modulating risk of several chronic diseases, including inflammatory bowel disease, obesity, type 2 diabetes, cardiovascular disease, and cancer. At the same time, it is now understood that diet plays a significant role in shaping the microbiome, with experiments showing that dietary alterations can induce large, temporary microbial shifts within 24 h. Given this association, there may be significant therapeutic utility in altering microbial composition through diet...
April 8, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28681245/an-overview-on-d-amino-acids
#9
REVIEW
Giuseppe Genchi
More than half a century ago researchers thought that D-amino acids had a minor function compared to L-enantiomers in biological processes. Many evidences have shown that D-amino acids are present in high concentration in microorganisms, plants, mammals and humans and fulfil specific biological functions. In the brain of mammals, D-serine (D-Ser) acts as a co-agonist of the N-methyl-D-aspartate (NMDA)-type glutamate receptors, responsible for learning, memory and behaviour. D-Ser metabolism is relevant for disorders associated with an altered function of the NMDA receptor, such as schizophrenia, ischemia, epilepsy and neurodegenerative disorders...
July 5, 2017: Amino Acids
https://www.readbyqxmd.com/read/28638432/mechanical-stimulation-of-the-ht7-acupuncture-point-to-reduce-ethanol-self-administration-in-rats
#10
Suk-Yun Kang, O Sang Kwon, Ji-Young Moon, Seong Jin Cho, Kwang-Ho Choi, Junbeom Kim, Seong-Hun Ahn, Yeonhee Ryu
BACKGROUND: Alcoholism, which is a disabling addiction disorder, is a major public health problem worldwide. The present study was designed to determine whether the application of acupuncture at the Shenmen (HT7) point suppresses voluntary alcohol consumption in addicted rats and whether this suppressive effect is potentiated by the administration of naltrexone. METHODS: Rats were initially trained to self-administer a sucrose solution by operating a lever. A mechanical acupuncture instrument (MAI) for objective mechanical stimulation was used on rats whose baseline response had been determined...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28654992/acupuncture-and-the-complex-connections-between-the-mind-and-the-body
#11
EDITORIAL
Josephine P Briggs, David Shurtleff
No abstract text is available yet for this article.
June 27, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28484399/biochemical-benefits-diagnosis-and-clinical-risks-evaluation-of-kratom
#12
REVIEW
Dimy Fluyau, Neelambika Revadigar
BACKGROUND: Kratom (Mitragyna speciosa) is a tropical tree with a long history of traditional use in parts of Africa and Southeast Asia. Kratom is also known as Thom, Thang, and Biak. Its leaves and the teas brewed from them have long been used by people in that region to manage pain and opioid withdrawal and to stave off fatigue. Kratom is actually consumed throughout the world for its stimulant effects and as an opioid substitute (in form of tea, chewed, smoked, or ingested in capsules)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28438745/management-of-chronic-pain-using-complementary-and-integrative-medicine
#13
REVIEW
Lucy Chen, Andreas Michalsen
Complementary and integrative medicine (CIM) encompasses both Western-style medicine and complementary health approaches as a new combined approach to treat a variety of clinical conditions. Chronic pain is the leading indication for use of CIM, and about 33% of adults and 12% of children in the US have used it in this context. Although advances have been made in treatments for chronic pain, it remains inadequately controlled for many people. Adverse effects and complications of analgesic drugs, such as addiction, kidney failure, and gastrointestinal bleeding, also limit their use...
April 24, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28317038/hypothesizing-that-a-pro-dopamine-regulator-kb220z-should-optimize-but-not-hyper-activate-the-activity-of-trace-amine-associated-receptor-1-taar-1-and-induce-anti-craving-of-psychostimulants-in-the-long-term
#14
Kenneth Blum, Rajendra D Badgaiyan, Eric R Braverman, Kristina Dushaj, Mona Li, Peter K Thanos, Zsolt Demetrovics, Marcelo Febo
Unlike other drugs of abuse such as alcohol, nicotine, opiates/opioids, the FDA has not approved any agent to treat psychostimulant dependence. Certainly, it is widely acceptable that dopaminergic signaling is a key factor in both the initiation and continued motivation to abuse this class of stimulant substances. It is also well accepted that psychostimulants such as cocaine affect not only the release of neuronal dopamine at the nucleus accumbens (NAc), but also has powerful inhibitory actions on the dopamine transporter system...
2016: Journal of Reward Deficiency Syndrome and Addiction Science
https://www.readbyqxmd.com/read/26814623/vitamin-d-has-the-new-dawn-for-dietary-recommendations-arrived
#15
EDITORIAL
S A Lanham-New, L R Wilson
No abstract text is available yet for this article.
February 2016: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/27012254/a-translational-neuroscience-perspective-on-mindfulness-meditation-as-a-prevention-strategy
#16
REVIEW
Yi-Yuan Tang, Leslie D Leve
Mindfulness meditation research mainly focuses on psychological outcomes such as behavioral, cognitive, and emotional functioning. However, the neuroscience literature on mindfulness meditation has grown in recent years. This paper provides an overview of relevant neuroscience and psychological research on the effects of mindfulness meditation. We propose a translational prevention framework of mindfulness and its effects. Drawing upon the principles of prevention science, this framework integrates neuroscience and prevention research and postulates underlying brain regulatory mechanisms that explain the impact of mindfulness on psychological outcomes via self-regulation mechanisms linked to underlying brain systems...
March 2016: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/27093642/association-between-polycystic-ovary-syndrome-and-gut-microbiota
#17
Yanjie Guo, Yane Qi, Xuefei Yang, Lihui Zhao, Shu Wen, Yinhui Liu, Li Tang
Polycystic ovary syndrome (PCOS) is the most frequent endocrinopathy in women of reproductive age. It is difficult to treat PCOS because of its complex etiology and pathogenesis. Here, we characterized the roles of gut microbiota on the pathogenesis and treatments in letrozole (a nonsteroidal aromatase inhibitor) induced PCOS rat model. Changes in estrous cycles, hormonal levels, ovarian morphology and gut microbiota by PCR-DGGE and real-time PCR were determined. The results showed that PCOS rats displayed abnormal estrous cycles with increasing androgen biosynthesis and exhibited multiple large cysts with diminished granulosa layers in ovarian tissues...
2016: PloS One
https://www.readbyqxmd.com/read/27065833/bread-and-other-edible-agents-of-mental-disease
#18
REVIEW
Paola Bressan, Peter Kramer
Perhaps because gastroenterology, immunology, toxicology, and the nutrition and agricultural sciences are outside of their competence and responsibility, psychologists and psychiatrists typically fail to appreciate the impact that food can have on their patients' condition. Here we attempt to help correct this situation by reviewing, in non-technical, plain English, how cereal grains-the world's most abundant food source-can affect human behavior and mental health. We present the implications for the psychological sciences of the findings that, in all of us, bread (1) makes the gut more permeable and can thus encourage the migration of food particles to sites where they are not expected, prompting the immune system to attack both these particles and brain-relevant substances that resemble them, and (2) releases opioid-like compounds, capable of causing mental derangement if they make it to the brain...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/26930301/high-leucine-diets-stimulate-cerebral-branched-chain-amino-acid-degradation-and-modify-serotonin-and-ketone-body-concentrations-in-a-pig-model
#19
Anna G Wessels, Holger Kluge, Frank Hirche, Andreas Kiowski, Alexandra Schutkowski, Etienne Corrent, Jörg Bartelt, Bettina König, Gabriele I Stangl
In addition to its role as an essential protein component, leucine (Leu) displays several other metabolic functions such as activation of protein synthesis. This property makes it an interesting amino acid for the therapy of human muscle atrophy and for livestock production. However, Leu can stimulate its own degradation via the branched-chain keto acid dehydrogenase complex (BCKDH). To examine the response of several tissues to excessive Leu, pigs were fed diets containing two- (L2) and four-fold (L4) higher Leu contents than the recommended amount (control)...
2016: PloS One
https://www.readbyqxmd.com/read/19940429/neurogenetics-of-dopaminergic-receptor-supersensitivity-in-activation-of-brain-reward-circuitry-and-relapse-proposing-deprivation-amplification-relapse-therapy-dart
#20
REVIEW
Kenneth Blum, Thomas J H Chen, B William Downs, Abdalla Bowirrat, Roger L Waite, Eric R Braverman, Margaret Madigan, Marlene Oscar-Berman, Nicholas DiNubile, Eric Stice, John Giordano, Siobhan Morse, Mark Gold
BACKGROUND AND HYPOTHESIS: It is well known that after prolonged abstinence, individuals who use their drug of choice experience a powerful euphoria that often precipitates relapse. While a biological explanation for this conundrum has remained elusive, we hypothesize that this clinically observed "supersensitivity" might be tied to genetic dopaminergic polymorphisms. Another therapeutic conundrum relates to the paradoxical finding that the dopaminergic agonist bromocriptine induces stronger activation of brain reward circuitry in individuals who carry the DRD2 A1 allele compared with DRD2 A2 allele carriers...
November 2009: Postgraduate Medicine
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