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Cost-effectiveness research

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389 papers 25 to 100 followers Cost-effectiveness, cost-utility, value of information, willingness to pay, technology assessment, economic evaluation
By Jamie Jarmul Md / PhD student at UNC - Chapel Hill, PhD in Health Policy and Management
F Soleymani, A Rashidian, R Dinarvand, A Kebriaeezade, M Hosseini, M Abdollahi
No abstract text is available yet for this article.
November 2014: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Douglas K Owens, Evelyn P Whitlock, Jillian Henderson, Michael P Pignone, Alex H Krist, Kirsten Bibbins-Domingo, Susan J Curry, Karina W Davidson, Mark Ebell, Matthew W Gillman, David C Grossman, Alex R Kemper, Ann E Kurth, Michael Maciosek, Albert L Siu, Michael L LeFevre
The U.S. Preventive Services Task Force (USPSTF) develops evidence-based recommendations about preventive care based on comprehensive systematic reviews of the best available evidence. Decision models provide a complementary, quantitative approach to support the USPSTF as it deliberates about the evidence and develops recommendations for clinical and policy use. This article describes the rationale for using modeling, an approach to selecting topics for modeling, and how modeling may inform recommendations about clinical preventive services...
October 4, 2016: Annals of Internal Medicine
Alastair Heffernan, Ella Barber, Ranjeeta Thomas, Christophe Fraser, Michael Pickles, Anne Cori
Rapid diagnostic tools have been shown to improve linkage of patients to care. In the context of infectious diseases, assessing the impact and cost-effectiveness of such tools at the population level, accounting for both direct and indirect effects, is key to informing adoption of these tools. Point-of-care (POC) CD4 testing has been shown to be highly effective in increasing the proportion of HIV positive patients who initiate ART. We assess the impact and cost-effectiveness of introducing POC CD4 testing at the population level in South Africa in a range of care contexts, using a dynamic compartmental model of HIV transmission, calibrated to the South African HIV epidemic...
2016: PloS One
Henny J Wansink, Ruben M W A Drost, Aggie T G Paulus, Dirk Ruwaard, Clemens M H Hosman, Jan M A M Janssens, Silvia M A A Evers
BACKGROUND: The children of parents with a mental illness (COPMI) are at increased risk for developing costly psychiatric disorders because of multiple risk factors which threaten parenting quality and thereby child development. Preventive basic care management (PBCM) is an intervention aimed at reducing risk factors and addressing the needs of COPMI-families in different domains. The intervention may lead to financial consequences in the healthcare sector and in other sectors, also known as inter-sectoral costs and benefits (ICBs)...
July 7, 2016: BMC Health Services Research
Pricivel Carrera, Maarten J IJzerman
No abstract text is available yet for this article.
August 2016: Expert Review of Pharmacoeconomics & Outcomes Research
Miqdad Asaria, Susan Griffin, Richard Cookson
Distributional cost-effectiveness analysis (DCEA) is a framework for incorporating health inequality concerns into the economic evaluation of health sector interventions. In this tutorial, we describe the technical details of how to conduct DCEA, using an illustrative example comparing alternative ways of implementing the National Health Service (NHS) Bowel Cancer Screening Programme (BCSP). The 2 key stages in DCEA are 1) modeling social distributions of health associated with different interventions, and 2) evaluating social distributions of health with respect to the dual objectives of improving total population health and reducing unfair health inequality...
January 2016: Medical Decision Making: An International Journal of the Society for Medical Decision Making
Scott D Nelson, Daniel Malone, Joanne Lafleur
Economic and epidemiological models need various inputs to estimate the occurrence of events in different subsets of the population, such as the incidence of events for patients with risk factors compared with those without. However, the baseline event incidence for patients without risk factors (incidence_no_risk) may not be reported in the literature, therefore the event incidence in the population (incidence_pop) is commonly used in its place as the baseline. However, this is problematic because incidence_pop is a weighted average of a heterogeneous population...
September 2015: PharmacoEconomics
Ilke Akpinar, Philip Jacobs, Don Husereau
OBJECTIVES: Economic evaluations, although not formally used in purchasing decisions for medical devices in Canada, are still being conducted and published. The aim of this study was to examine the way that prices have been included in Canadian economic evaluations of medical devices. METHODS: We conducted a review of the economic concepts and implications of methods used for economic evaluations of the eleven most implanted medical devices from the Canadian perspective...
January 2015: International Journal of Technology Assessment in Health Care
Bruno Kovic, Feng Xie
PURPOSE: The Avastin in Glioblastoma trial has shown that patients newly diagnosed with glioblastoma multiforme (GBM) treated with bevacizumab plus radiotherapy and temozolomide versus radiotherapy and temozolomide alone showed improvement in progression-free survival, possibly leading to a new indication for first-line use of bevacizumab in GBM. The cost-utility of this new intervention remains unknown; therefore, we developed a Markov model estimating the incremental cost-utility ratio (ICUR) from a Canadian public payer perspective...
July 10, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Giuseppe Turchetti, M A Kroes, Valentina Lorenzoni, Leopoldo Trieste, Ann-Marie Chapman, Alison C Sweet, Geoff I Wilson, Danilo Neglia
Early and accurate diagnosis of stable coronary artery disease (CAD) is crucial to reduce morbidity, mortality and healthcare costs. This critical appraisal of health-economic literature concerning non-invasive diagnostic cardiac imaging aims to summarize current approaches to economic evaluation of diagnostic cardiac imaging and associated procedural risks, inform cardiologists how to use economic analyses for decision-making, highlight areas where new information could strengthen the economic evaluation and shed light on cost-effective approaches to diagnose stable CAD...
2015: Expert Review of Pharmacoeconomics & Outcomes Research
Janette Greenhalgh, Adrian Bagust, Angela Boland, Kerry Dwan, Sophie Beale, Nigel Fleeman, Joanne McEntee, Yenal Dundar, Marty Richardson, Michael Fisher
BACKGROUND: Acute coronary syndromes (ACSs) are life-threatening conditions associated with acute myocardial ischaemia. There are three main types of ACS: ST segment elevation myocardial infarction (STEMI), non-ST segment elevation myocardial infarction (NSTEMI) and unstable angina (UA). One treatment for ACS is percutaneous coronary intervention (PCI) plus adjunctive treatment with antiplatelet drugs. Dual therapy antiplatelet treatment [aspirin plus either prasugrel (Efient(®), Daiichi Sankyo Company Ltd UK/Eli Lilly and Company Ltd), clopidogrel or ticagrelor (Brilique(®), AstraZeneca)] is standard in UK clinical practice...
April 2015: Health Technology Assessment: HTA
Gerardus W J Frederix, Hossein Haji Ali Afzali, Erik J Dasbach, Robyn L Ward
No abstract text is available yet for this article.
August 2015: PharmacoEconomics
Kaleb Michaud, Vibeke Strand, Nancy A Shadick, Irina Degtiar, Kerri Ford, Steven N Michalopoulos, John Hornberger
OBJECTIVE: The multibiomarker disease activity (MBDA) blood test has been clinically validated as a measure of disease activity in patients with RA. We aimed to estimate the effect of the MBDA test on physical function for patients with RA (based on HAQ), quality-adjusted life years and costs over 10 years. METHODS: A decision analysis was conducted to quantify the effect of using the MBDA test on RA-related outcomes and costs to private payers and employers. Results of a clinical management study reporting changes to anti-rheumatic drug recommendations after use of the MBDA test informed clinical utility...
September 2015: Rheumatology
Brian Custer, Mart P Janssen
Analytical methods appropriate for health economic assessments of transfusion safety interventions have not previously been described in ways that facilitate their use. Within the context of risk-based decision-making (RBDM), health economics can be important for optimizing decisions among competing interventions. The objective of this review is to address key considerations and limitations of current methods as they apply to blood safety. Because a voluntary blood supply is an example of a public good, analyses should be conducted from the societal perspective when possible...
August 2015: Transfusion
Carlos J Lavernia, David A Iacobelli, Larry Brooks, Jesus M Villa
We estimated the cost of Quality-Adjusted-Life-Years gained according to preoperative disease severity. We studied 159 primary unilateral THA, mean follow-up: 4 years. A median split of preoperative WOMAC scores was done to set apart a low (better) and a high (worse) score group. The groups with worse preoperative WOMAC were consistently associated with a less cost-effective intervention. The highest mean cost-effectiveness was achieved by patients with better WOMAC-total ($8256.32/QALY-gained). As patients aged, the cost-effectiveness of THA decreased...
June 2015: Journal of Arthroplasty
Furio Zucco, Roberta Ciampichini, Angelo Lavano, Amedeo Costantini, Marisa De Rose, Paolo Poli, Gianpaolo Fortini, Laura Demartini, Enrico De Simone, Valentino Menardo, Piero Cisotto, Mario Meglio, Luciana Scalone, Lorenzo G Mantovani
OBJECTIVE: To assess the cost-effectiveness and cost-utility of Spinal Cord Stimulation (SCS) in patients with failed back surgery syndrome (FBSS) refractory to conventional medical management (CMM). MATERIALS AND METHODS: We conducted an observational, multicenter, longitudinal ambispective study, where patients with predominant leg pain refractory to CMM expecting to receive SCS+CMM were recruited in 9 Italian centers and followed up to 24 months after SCS. We collected data on clinical status (pain intensity, disability), Health-Related Quality-of-Life (HRQoL) and on direct and indirect costs before (pre-SCS) and after (post-SCS) the SCS intervention...
June 2015: Neuromodulation: Journal of the International Neuromodulation Society
Pietro Bortoletto, Brett D Einerson, Emily S Miller, Magdy P Milad
STUDY OBJECTIVE: To estimate the cost-effectiveness of eliminating morcellation in the surgical treatment of leiomyomas from a societal perspective. DESIGN: Cost-effectiveness analysis. DESIGN CLASSIFICATION: Not applicable. SETTING: A theoretical cohort of women undergoing hysterectomy for myoma disease large enough to require morcellation. PATIENTS: None. INTERVENTIONS: None...
July 2015: Journal of Minimally Invasive Gynecology
Wouter Hogendoorn, Anthi Lavida, M G Myriam Hunink, Frans L Moll, George Geroulakos, Bart E Muhs, Bauer E Sumpio
OBJECTIVE: Open repair (OPEN) and conservative management (CONS) have been the treatments of choice for splenic artery aneurysms (SAAs) for many years. Endovascular repair (EV) has been increasingly used with good short-term results. In this study, we evaluated the cost-effectiveness of OPEN, EV, and CONS for the treatment of SAAs. METHODS: A decision analysis model was developed using TreeAge Pro 2013 software (TreeAge Inc, Williamstown, Mass) to evaluate the cost-effectiveness of the different treatments for SAAs...
June 2015: Journal of Vascular Surgery
Jennifer Mason Lobo, Adam P Dicker, Christine Buerki, Elai Daviconi, R Jeffrey Karnes, Robert B Jenkins, Nirav Patel, Robert B Den, Timothy N Showalter
BACKGROUND: Currently there is controversy surrounding the optimal way to treat patients with prostate cancer in the post-prostatectomy setting. Adjuvant therapies carry possible benefits of improved curative results, but there is uncertainty in which patients should receive adjuvant therapy. There are concerns about giving toxicity to a whole population for the benefit of only a subset. We hypothesized that making post-prostatectomy treatment decisions using genomics-based risk prediction estimates would improve cancer and quality of life outcomes...
2015: PloS One
Jeffrey D Stone, Lisa M Vaccaro, R Colin Brabender, Alfred V Hess
PURPOSE: To evaluate the utility of radiographs taken 2 weeks following plate fixation of distal radius fractures. METHODS: A retrospective review of patients requiring operative fixation of distal radius fractures was performed with the objective of determining the utility of a 2-week postoperative radiograph in patient management. RESULTS: Three out of 268 (1%) patients had loss of fixation noted radiographically at the 2-week visit that resulted in a reoperation...
June 2015: Journal of Hand Surgery
2015-04-08 00:13:51
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