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Cost-effectiveness research

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402 papers 25 to 100 followers Cost-effectiveness, cost-utility, value of information, willingness to pay, technology assessment, economic evaluation
By Jamie Jarmul Md / PhD student at UNC - Chapel Hill, PhD in Health Policy and Management
https://www.readbyqxmd.com/read/29102616/cost-effectiveness-of-screening-individuals-with-cystic-fibrosis-for-colorectal-cancer
#1
Andrea Gini, Ann G Zauber, Dayna R Cenin, Amir-Houshang Omidvari, Sarah E Hempstead, Aliza K Fink, Albert B Lowenfels, Iris Lansdorp-Vogelaar
BACKGROUND & AIMS: Individuals with cystic fibrosis are at increased risk of colorectal cancer (CRC) compared to the general population, and risk is higher among those who received an organ transplant. We performed a cost-effectiveness analysis to determine optimal CRC screening strategies for patients with cystic fibrosis. METHODS: We adjusted the existing MISCAN-Colon microsimulation model to reflect increased CRC risk and lower life-expectancy in patients with cystic fibrosis...
November 1, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29106516/cost-effectiveness-of-bezlotoxumab-compared-with-placebo-for-the-prevention-of-recurrent-clostridium-difficile-infection
#2
Vimalanand S Prabhu, Erik R Dubberke, Mary Beth Dorr, Elamin Elbasha, Nicole Cossrow, Yiling Jiang, Stephen Marcella
Background: Clostridium difficile infection (CDI) is the most commonly recognized cause of recurrent diarrhea. Bezlotoxumab, administered concurrently with antibiotics directed against C. difficile (standard of care [SoC]), has been shown to reduce the recurrence of CDI, compared with SoC alone. This study aimed to assess the cost-effectiveness of bezlotoxumab administered concurrently with SoC, compared with SoC alone, in subgroups of patients at risk of recurrence of CDI. Methods: A computer-based Markov health state transition model was designed to track the natural history of patients infected with CDI...
November 2, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29110140/economic-evaluation-of-implementing-a-novel-pharmacogenomic-test-idgenetix-%C3%A2-to-guide-treatment-of-patients-with-depression-and-or-anxiety
#3
Mehdi Najafzadeh, Jorge A Garces, Alejandra Maciel
BACKGROUND: The response to therapeutics varies widely in patients with depression and anxiety, making selection of an optimal treatment choice challenging. IDgenetix(®), a novel pharmacogenomic test, has been shown to improve outcomes by predicting the likelihood of response to different psychotherapeutic medications. OBJECTIVE: The objective of this study was to estimate the cost effectiveness of implementing a novel pharmacogenomic test (IDgenetix(®)) to guide treatment choices in patients with depression and/or anxiety compared with treatment as usual from the US societal perspective...
November 6, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29112646/transfusion-preparedness-strategies-for-obstetric-hemorrhage-a-cost-effectiveness-analysis
#4
Brett D Einerson, Zuzana Stehlikova, Richard E Nelson, Brandon K Bellows, Kensaku Kawamoto, Erin A S Clark
OBJECTIVE: To evaluate the cost-effectiveness of common obstetric transfusion preparedness strategies to prevent emergency-release transfusions. METHODS: A decision analytic model compared five commonly used transfusion preparedness strategies in a general obstetric population. Patients were classified as being at low, moderate, or high risk for transfusion. The most prepared strategy used a policy of universal type and screen plus crossmatch for high-risk patients...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29112652/effect-of-cervical-cancer-screening-programs-on-preterm-birth-a-decision-and-cost-effectiveness-analysis
#5
Esmé I Kamphuis, Steffie K Naber, Noor A Danhof, J Dik F Habbema, Christianne J M de Groot, Ben W J Mol
OBJECTIVE: To assess the effect of age at initiation and interval of cervical cancer screening in women of reproductive age on the risk of future preterm birth and subsequent adverse neonatal outcome relative to maternal life-years gained and cost of both screening and preterm birth. METHODS: In this decision and cost-effectiveness analysis, we compared eight cytology-based screening programs varying in age of onset (21, 24, 25, 27, or 30 years) and screening interval (3 or 5 years) in a fictive cohort of 100,000 women...
December 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29112658/adding-azithromycin-to-cephalosporin-for-cesarean-delivery-infection-prophylaxis-a-cost-effectiveness-analysis
#6
Ashley E Skeith, Brenda Niu, Amy M Valent, Methodius G Tuuli, Aaron B Caughey
OBJECTIVE: To investigate the cost-effectiveness of adding azithromycin to standard cephalosporin regimens of cesarean delivery prophylaxis by considering the maternal outcomes in the current and potential subsequent pregnancies. METHODS: A cost-effectiveness model was created using TreeAge to compare the outcomes of using azithromycin-cephalosporin with cephalosporin alone in a theoretical cohort of 700,000 women, the approximate number of nonelective cesarean deliveries annually in the United States that occur during labor or after membrane rupture...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29097450/clinical-outcomes-and-cost-effectiveness-of-fractional-flow-reserve-guided-percutaneous-coronary-intervention-in-patients-with-stable-coronary-artery-disease-three-year-follow-up-of-the-fame-2-trial-fractional-flow-reserve-versus-angiography-for-multivessel
#7
William F Fearon, Takeshi Nishi, Bernard De Bruyne, Derek B Boothroyd, Emanuele Barbato, Pim Tonino, Peter Jüni, Nico H J Pijls, Mark A Hlatky
BACKGROUND : Previous studies found that percutaneous coronary intervention (PCI) does not improve outcome compared with medical therapy (MT) in patients with stable coronary artery disease, but PCI was guided by angiography alone. FAME 2 trial (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) compared PCI guided by fractional flow reserve with best MT in patients with stable coronary artery disease to assess clinical outcomes and cost-effectiveness. METHODS : A total of 888 patients with stable single-vessel or multivessel coronary artery disease with reduced fractional flow reserve were randomly assigned to PCI plus MT (n=447) or MT alone (n=441)...
November 2, 2017: Circulation
https://www.readbyqxmd.com/read/29099396/the-value-of-decision-analytical-modeling-in-surgical-research-an-example-of-laparoscopic-versus-open-distal-pancreatectomy
#8
Casper Tax, Paulien H M Govaert, Martijn W J Stommel, Marc G H Besselink, Hein G Gooszen, Maroeska M Rovers
OBJECTIVE: To illustrate how decision modeling may identify relevant uncertainty and can preclude or identify areas of future research in surgery. SUMMARY BACKGROUND DATA: To optimize use of research resources, a tool is needed that assists in identifying relevant uncertainties and the added value of reducing these uncertainties. METHODS: The clinical pathway for laparoscopic distal pancreatectomy (LDP) versus open (ODP) for nonmalignant lesions was modeled in a decision tree...
November 2, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28801012/use-of-lymph-node-ultrasound-prior-to-sentinel-lymph-node-biopsy-in-384-patients-with-melanoma-a-cost-effectiveness-analysis
#9
D Olmedo, M Brotons-Seguí, C Del Toro, M González, C Requena, V Traves, A Pla, I Bolumar, D Moreno-Ramírez, E Nagore
BACKGROUND AND OBJECTIVES: Locoregional lymph node ultrasound is not typically included in guidelines as part of the staging process prior to sentinel lymph node biopsy (SLNB). The objective of the present study was to make a clinical and economic analysis of lymph node ultrasound prior to SLNB. MATERIALS AND METHODS: We performed a retrospective study of 384 patients with clinical stage I-II primary melanoma who underwent locorregional lymph node ultrasound (with or without ultrasound-guided biopsy) prior to SLNB between 2004 and 2015...
August 8, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28801235/cost-effectiveness-of-a-proactive-primary-care-program-for-frail-older-people-a-cluster-randomized-controlled-trial
#10
Nienke Bleijenberg, Irene Drubbel, Rabin Ej Neslo, Marieke J Schuurmans, Valerie H Ten Dam, Mattijs E Numans, G Ardine de Wit, Niek J de Wit
BACKGROUND: A proactive integrated approach has shown to preserve daily functioning among older people in the community. The aim is to determine the cost-effectiveness of a proactive integrated primary care program. METHODS: Economic evaluation embedded in a single-blind, 3-armed, cluster-randomized controlled trial with 12 months' follow-up in 39 general practices in the Netherlands. General practices were randomized to one of 3 trial arms: (1) an electronic frailty screening instrument using routine medical record data followed by standard general practitioner (GP) care; (2) this screening instrument followed by a nurse-led care program; or (3) usual care...
August 8, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28801424/a-cost-effectiveness-comparison-of-the-nice-2015-and-who-2013-diagnostic-criteria-for-women-with-gestational-diabetes-with-and-without-risk-factors
#11
Paul Brian Jacklin, Michael Ja Maresh, Chris C Patterson, Katharine P Stanley, Anne Dornhorst, Shona Burman-Roy, Rudy W Bilous
OBJECTIVES: To compare the cost-effectiveness (CE) of the National Institute for Health and Care Excellence (NICE) 2015 and the WHO 2013 diagnostic thresholds for gestational diabetes mellitus (GDM). SETTING: The analysis was from the perspective of the National Health Service in England and Wales. PARTICIPANTS: 6221 patients from four of the Hyperglycaemia and Adverse Pregnancy Outcomes (HAPO) study centres (two UK, two Australian), 6308 patients from the Atlantic Diabetes in Pregnancy study and 12 755 patients from UK clinical practice...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28803497/exploring-the-potential-value-of-improved-care-for-secondary-hyperparathyroidism-with-a-novel-calcimimetic-therapy
#12
Björn Stollenwerk, Sergio Iannazzo, Kerry Cooper, Vasily Belozeroff
AIMS: This study explored the use of a value-based pricing approach for the new calcimimetic etelcalcetide indicated for the treatment of secondary hyperparathyroidism (SHPT) in patients receiving hemodialysis. It used the US payer perspective and applied the cost-effectiveness framework. Because etelcalcetide is an intravenous therapy that can be titrated for individual patients, and because its utilization is yet to be assessed in real world settings, a range of plausible doses were estimated for etelcalcetide to define a range of prices...
August 14, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28797417/implications-of-coronary-artery-calcium%C3%A2-testing-for-treatment-decisions-among-statin-candidates-according-to%C3%A2-the%C3%A2-acc-aha-cholesterol-management%C3%A2-guidelines-a-cost-effectiveness-analysis
#13
REVIEW
Jonathan C Hong, Ron Blankstein, Leslee J Shaw, William V Padula, Alejandro Arrieta, Jonathan A Fialkow, Roger S Blumenthal, Michael J Blaha, Harlan M Krumholz, Khurram Nasir
This review evaluates the cost-effectiveness of using coronary artery calcium (CAC) to guide long-term statin therapy compared with treating all patients eligible for statins according to 2013 American College of Cardiology/American Heart Association cholesterol management guidelines for atherosclerotic cardiovascular disease. The authors used a microsimulation model to compare costs and effectiveness from a societal perspective over a lifetime horizon. Both strategies resulted in similar costs and quality-adjusted life years (QALYs)...
August 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27202993/assessing-the-effectiveness-and-cost-effectiveness-of-audit-and-feedback-on-physician-s-prescribing-indicators
#14
F Soleymani, A Rashidian, R Dinarvand, A Kebriaeezade, M Hosseini, M Abdollahi
No abstract text is available yet for this article.
November 2014: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27379742/use-of-decision-models-in-the-development-of-evidence-based-clinical-preventive-services-recommendations-methods-of-the-u-s-preventive-services-task-force
#15
Douglas K Owens, Evelyn P Whitlock, Jillian Henderson, Michael P Pignone, Alex H Krist, Kirsten Bibbins-Domingo, Susan J Curry, Karina W Davidson, Mark Ebell, Matthew W Gillman, David C Grossman, Alex R Kemper, Ann E Kurth, Michael Maciosek, Albert L Siu, Michael L LeFevre
The U.S. Preventive Services Task Force (USPSTF) develops evidence-based recommendations about preventive care based on comprehensive systematic reviews of the best available evidence. Decision models provide a complementary, quantitative approach to support the USPSTF as it deliberates about the evidence and develops recommendations for clinical and policy use. This article describes the rationale for using modeling, an approach to selecting topics for modeling, and how modeling may inform recommendations about clinical preventive services...
October 4, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27391129/impact-and-cost-effectiveness-of-point-of-care-cd4-testing-on-the-hiv-epidemic-in-south-africa
#16
Alastair Heffernan, Ella Barber, Ranjeeta Thomas, Christophe Fraser, Michael Pickles, Anne Cori
Rapid diagnostic tools have been shown to improve linkage of patients to care. In the context of infectious diseases, assessing the impact and cost-effectiveness of such tools at the population level, accounting for both direct and indirect effects, is key to informing adoption of these tools. Point-of-care (POC) CD4 testing has been shown to be highly effective in increasing the proportion of HIV positive patients who initiate ART. We assess the impact and cost-effectiveness of introducing POC CD4 testing at the population level in South Africa in a range of care contexts, using a dynamic compartmental model of HIV transmission, calibrated to the South African HIV epidemic...
2016: PloS One
https://www.readbyqxmd.com/read/27388373/cost-effectiveness-of-preventive-case-management-for-parents-with-a-mental-illness-a-randomized-controlled-trial-from-three-economic-perspectives
#17
RANDOMIZED CONTROLLED TRIAL
Henny J Wansink, Ruben M W A Drost, Aggie T G Paulus, Dirk Ruwaard, Clemens M H Hosman, Jan M A M Janssens, Silvia M A A Evers
BACKGROUND: The children of parents with a mental illness (COPMI) are at increased risk for developing costly psychiatric disorders because of multiple risk factors which threaten parenting quality and thereby child development. Preventive basic care management (PBCM) is an intervention aimed at reducing risk factors and addressing the needs of COPMI-families in different domains. The intervention may lead to financial consequences in the healthcare sector and in other sectors, also known as inter-sectoral costs and benefits (ICBs)...
July 7, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27118144/are-current-icer-thresholds-outdated-valuing-medicines-in-the-era-of-personalized-healthcare
#18
EDITORIAL
Pricivel Carrera, Maarten J IJzerman
No abstract text is available yet for this article.
August 2016: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/25908564/distributional-cost-effectiveness-analysis-a-tutorial
#19
Miqdad Asaria, Susan Griffin, Richard Cookson
Distributional cost-effectiveness analysis (DCEA) is a framework for incorporating health inequality concerns into the economic evaluation of health sector interventions. In this tutorial, we describe the technical details of how to conduct DCEA, using an illustrative example comparing alternative ways of implementing the National Health Service (NHS) Bowel Cancer Screening Programme (BCSP). The 2 key stages in DCEA are 1) modeling social distributions of health associated with different interventions, and 2) evaluating social distributions of health with respect to the dual objectives of improving total population health and reducing unfair health inequality...
January 2016: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/25943685/calculating-the-baseline-incidence-in-patients-without-risk-factors-a-strategy-for-economic-evaluation
#20
Scott D Nelson, Daniel Malone, Joanne Lafleur
Economic and epidemiological models need various inputs to estimate the occurrence of events in different subsets of the population, such as the incidence of events for patients with risk factors compared with those without. However, the baseline event incidence for patients without risk factors (incidence_no_risk) may not be reported in the literature, therefore the event incidence in the population (incidence_pop) is commonly used in its place as the baseline. However, this is problematic because incidence_pop is a weighted average of a heterogeneous population...
September 2015: PharmacoEconomics
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