David Pacheu-Grau, Aurora Gómez-Durán, Eldris Iglesias, Ester López-Gallardo, Julio Montoya, Eduardo Ruiz-Pesini
Some ribosomal antibiotics used in clinical practice to fight pathogenic bacteria can provoke serious adverse drug reactions in patients. Sensitivity to the antibiotics is a multifactorial trait but the genetic variation of sensitive individuals to off-target effects of the drugs might be one of the factors contributing to this condition. Thus, the protein synthesis apparatus of mitochondria is similar to that of bacteria because of its endosymbiotic origin and, therefore, mitochondrial ribosomes are frequently unintended off-targets of these antibiotics...
March 15, 2013: Human Molecular Genetics