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ANCA Vasculitis Renal Involvement

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32 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Gül Özçelik, Hafize Emine Sönmez, Sezgin Şahin, Ayşim Özağarı, Meral Torun Bayram, Rümeysa Yasemin Çiçek, Evrim Kargın Çakıcı, Elif Çomak, Kenan Barut, Nihal Şahin, Sevcan Bakkaloğlu, İbrahim Gökçe, Ali Düzova, Yelda Bilginer, Ceyhun Açarı, Engin Melek, Beltinge Demircioğlu Kılıç, Semanur Özdel, Amra Adroviç, Özgür Kasapçopur, Erbil Ünsal, Harika Alpay, Diclehan Orhan, Rezan Topaloğlu, Ruhan Düşünsel, Seza Özen
OBJECTIVE: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are very rare in childhood with an increased risk of morbidity and mortality. We aimed to evaluate renal prognostic factors in childhood AAV from the perspective of ANCA serotype, histopathological classification, and five-factor score (FFS). METHODS: Pediatric AAV patients from 11 referral centers in Turkey had been included to the study. The demographics, clinical findings, AAV subtypes, outcomes, and FFS were evaluated retrospectively...
January 4, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Farid Arman, Marina Barsoum, Umut Selamet, Hania Shakeri, Olivia Wassef, Mira Mikhail, Anjay Rastogi, Ramy M Hanna
Circulating antineutrophil cytoplasmic antibodies (ANCAs) are the central pathogenic mechanism for a group of systemic and renal syndromes called the ANCA-associated vasculitis (AAV). The nomenclature has changed from eponymous labeling to granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, and microscopic polyangiitis. These syndromes predominantly affect the pulmonary and renal systems. We also review the molecular pathology behind ANCAs and associated antigens and infections...
2018: International Journal of Nephrology and Renovascular Disease
Annelies E Berden, Maria A C Wester Trejo, Ingeborg M Bajema
ANCA-associated vasculitis (AAV) describes a group of small-vessel vasculitides with frequent renal involvement. The first description of these conditions can be traced back to the 19th-century paper on necrotizing vasculitis by Kussmaul and Maier. Since then, our understanding of the pathogenesis has improved and the histopathological lesions have been described in detail. Characteristic histologic lesions in ANCA-associated glomerulonephritis (AAGN) are fibrinoid necrosis and crescents, often accompanied by tubulointerstitial inflammation...
February 2018: Best Practice & Research. Clinical Rheumatology
Pavel I Novikov, Nikolai M Bulanov, Anastasiia S Zykova, Sergey V Moiseev
No abstract text is available yet for this article.
November 24, 2018: Annals of the Rheumatic Diseases
Alexander Tracy, Anuradhaa Subramanian, Nicola J Adderley, Paul Cockwell, Charles Ferro, Simon Ball, Lorraine Harper, Krishnarajah Nirantharakumar
BACKGROUND: IgA vasculitis (IgAV, Henoch-Schönlein purpura) is a small-vessel vasculitis most common in children but also occurring in adults. Case series have suggested that IgAV may be associated with cardiovascular disease and venous thromboembolism, but this has not been evaluated in population-based studies. Renal disease and hypertension are possible complications of the disease with unknown incidence. METHODS: Using a large UK primary care database, we conducted an open retrospective matched cohort study of cardiovascular, venous thrombotic and renal outcomes in adult-onset and childhood-onset IgAV...
November 28, 2018: Annals of the Rheumatic Diseases
Andreas Kronbichler, David R W Jayne
Despite improved overall prognosis of patients with ANCA-associated vasculitis (AAV), those presenting with impaired renal function remain at risk of developing end-stage renal disease (ESRD). In addition to its role in diagnosis, renal histology provides prognostic information that has permitted definition of subgroups with differing risks of ESRD. In this issue, Brix et al. have developed and validated a risk score to predict the probability of ESRD. Against a background of outcome prediction in AAV, this commentary assesses different approaches to histologic risk and to what extent they assist with decisions on patient management...
December 2018: Kidney International
Takehisa Yamada, Tetsuya Kashiwagi, Akira Shimizu, Shuichi Tsuruoka
BACKGROUND: The physical condition of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated rapidly progressive glomerulonephritis (RPGN) is at times too critical for physicians to undertake a renal biopsy. In such cases, physicians need to start treatments without determining the pathological features of the disease. However, the prevalent clinical practice guidelines for ANCA-associated RPGN in Japan do not necessitate the pathological findings in a renal biopsy for determining first-line treatments...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Hafize Emine Sönmez, Berkan Armağan, Gizem Ayan, Kenan Barut, Ezgi Deniz Batu, Abdulsamet Erden, Serdal Uğurlu, Yelda Bilginer, Özgur Kasapçopur, Ömer Karadağ, Sule Apras Bilgen, Huri Özdoğan, Seza Ozen
OBJECTIVES: Polyarteritis nodosa is a necrotising vasculitis of predominantly medium size vessels. The present study aimed to summarise the characteristics of PAN patients, and also analyse the trend of decreasing PAN frequency in the last 25 years. METHODS: PAN patients followed up between 1990 and 2015 were included. The demographics, clinical findings and outcomes were retrospectively evaluated. RESULTS: One hundred thirty-three patients, including 66 children, were enrolled in the study...
October 30, 2018: Clinical and Experimental Rheumatology
Anna Salmela, Tom Törnroth, Tuija Poussa, Agneta Ekstrand
Aim: We describe the clinical pattern of ANCA-associated vasculitis (AAV) and assess long-term prognostic factors of patients and renal survival and relapse. Methods: Data from 85 patients with renal biopsy-proven AAV at a single center with up to 20-year [median 16.2 years (95% CI 14.9-17.7)] follow-up were retrospectively collected. Results: Overall, 55% of the patients had microscopic polyangiitis (MPA) and 45% had granulomatosis with polyangiitis (GPA)...
2018: International Journal of Nephrology
Alexandre Karras
Microscopic polyangiitis (MPA) is one of the main clinical presentations of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides. Although the disease is defined by clinical and pathological criteria, the anti-myeloperoxidase (MPO) specificity of ANCAs is observed in almost 80% of MPA patients. The direct pathogenic role of anti-MPO antibodies has been proven in animal models, in which the disease was transmitted by transfer of anti-MPO antibodies or anti-MPO-specific splenocytes. The most frequently affected organs in this disease are the kidneys and the lungs...
August 2018: Seminars in Respiratory and Critical Care Medicine
Silke R Brix, Mercedes Noriega, Pierre Tennstedt, Eik Vettorazzi, Martin Busch, Martin Nitschke, Wolfram J Jabs, Fedai Özcan, Ralph Wendt, Martin Hausberg, Lorenz Sellin, Ulf Panzer, Tobias B Huber, Rüdiger Waldherr, Helmut Hopfer, Rolf A K Stahl, Thorsten Wiech
Predicting renal outcome in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN) remains a major challenge. We aimed to identify reliable predictors of end-stage renal disease (ESRD) and to develop and validate a clinicopathologic score to predict renal outcome in ANCA-associated GN. In a prospective training cohort of 115 patients, the percentage of normal glomeruli (without scarring, crescents, or necrosis within the tuft) was the strongest independent predictor of death-censored ESRD...
December 2018: Kidney International
Yong-Xi Chen, Xiao-Nong Chen
Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a group of autoimmune disorders that predominantly affects small vessels. The onset of the disease is closely associated with ANCA. Renal involvement, also known as ANCA-associated glomerulonephritis (AGN), is one of the most common manifestations of AAV. In this mini-review, we described the clinical and pathological features of AGN. We then focused on recent studies on the mechanism of acute kidney lesions, including fibrinoid necrosis and crescent formation...
September 2018: Chronic diseases and translational medicine
Marc Hilhorst, Alexandre Tj Maria, Niloufar Kavian, Frederic Batteux, Didier Borderie, Alain Le Quellec, Pieter van Paassen, Philippe Guilpain
Glomerulonephritis is a severe complication of microscopic polyangiitis (MPA), a small-vessel vasculitis associated with anti-myeloperoxidase antibodies (MPO-ANCA). We previously showed the pathogenic effects of MPO-ANCA that activate MPO to trigger an oxidative burst mainly through HOCl production, contributing to endothelial injury and lung fibrosis. The aim of this study was to investigate the relationship between MPO-induced oxidative stress, anti-oxidant defenses and renal histological lesions in MPA patients...
September 12, 2018: American Journal of Physiology. Renal Physiology
Alvise Berti, Emilie Cornec-Le Gall, Divi Cornec, Marta Casal Moura, Eric L Matteson, Cynthia S Crowson, Aishwarya Ravindran, Sanjeev Sethi, Fernando C Fervenza, Ulrich Specks
Background: True population-based clinical and outcomes data are lacking for anti-neutrophil cytoplasmic autoantibody (ANCA)-associated glomerulonephritis (AAGN). Therefore we aimed to estimate the incidence, prevalence and mortality of AAGN, as well as the relationship between the grade of chronic renal damage at presentation and renal and non-renal outcomes. Methods: Patients with AAGN were identified among a population-based incident cohort of 57 Olmsted County residents diagnosed with ANCA-associated vasculitis (AAV) in 1996-2015...
August 8, 2018: Nephrology, Dialysis, Transplantation
Juliana Draibe, Xavier Rodó, Xavier Fulladosa, Laura Martínez-Valenzuela, Montserrat Diaz-Encarnación, Lara Santos, Helena Marco, Luis Quintana, Eva Rodriguez, Xoana Barros, Rosa Garcia, Anna Balius, Josep M Cruzado, Joan Torras
Background: The closure of long-standing gaps in our knowledge of aetiological factors behind anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a major challenge. Descriptive and analytical epidemiological studies can improve our understanding of environmental influences. Reported seasonal variations in AAV, mainly related to Wegener's disease, have shown an increasing number of cases in the winter months, which could be related to an extrinsic factor underlying infection...
August 2018: Clinical Kidney Journal
Verónica Aguirre, Miriam Alvo, Leopoldo Ardiles, Alberto Fierro, Annelise Goecke, Mirentxu Iruretagoyena, Roberto Jalil, Loreto Massardo, Gonzalo P Méndez, Sergio Palma, Emilio Roessler, Francisco Silva, Andrés Wurgaft
Renal involvement is a frequent complication in antineutrophil cytoplasmic antibodies (ANCA)associated vasculitides, adding morbidity and mortality, such as chronic kidney disease and the need for renal replacement therapy. With the aim of reaching a consensus on relevant issues regarding the diagnosis, treatment and follow-up of patients with these diseases, the Chilean Societies of Nephrology and Rheumatology formed a working group that, based on a critical review of the available literature and their experience, raised and answered consensually a set of questions relevant to the subject...
February 2018: Revista Médica de Chile
Rune Bjørneklett, Vilde Solbakken, Leif Bostad, Anne-Siri Fismen
Background: Classification of patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) into histological classes is useful for predicting a patient's risk of progression to end-stage renal disease (ESRD). However, even in the worst prognostic group, the 5-year end-stage renal disease-free survival rate is as high as 50%. Objectives: To investigate those prognostic factors indicative of progression to ESRD in patients with ANCA-GN and sclerosing histology...
2018: Pathology Research International
Liu Yang, Honglang Xie, Zhengzhao Liu, Yinghua Chen, Jinquan Wang, Haitao Zhang, Yongchun Ge, Weixin Hu
BACKGROUND: Severe infections are common complications of immunosuppressive treatment for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with renal involvement. We investigated the clinical characteristics and risk factors of severe infection in Chinese patients with AAV after immunosuppressive therapy. METHODS: A total of 248 patients with a new diagnosis of ANCA-associated vasculitis were included in this study. The incidence, time, site, and risk factors of severe infection by the induction therapies were analysed...
June 14, 2018: BMC Nephrology
Francisco Vileimar Andrade de Azevedo, Diego Germano Maia, Jozelio Freire de Carvalho, Carlos Ewerton Maia Rodrigues
This is a review of scientific publications on renal involvement in antiphospholipid syndrome (APS), with focus on clinical and histopathological findings and treatment. A search for English-language articles on renal involvement in APS covering the period 1980-2017 was conducted in Medline/PubMed and Scopus databases using the MeSH terms "antiphospholipid syndrome", "antiphospholipid antibodies", "glomerulonephritis" and "thrombotic microangiopathy" (TMA). APS nephropathy is primarily the result of thromboses in renal arteries or veins, intraparenchymatous arteries and glomerular capillaries...
October 2018: Rheumatology International
Maurizio Salvadori, Aris Tsalouchos
Renal involvement with rapidly progressive glomerulonephritis is a common manifestation of antineutrophil cytoplasmic antibody (ANCA) associated vasculitides, which is characterized by end-stage renal disease and high mortality rates in untreated and/or late referral patients. The long-term renal survival has improved dramatically since the addition of cyclophosphamide (CYC) and recently of rituximab (RTX) in association with corticosteroids in the remission induction therapeutic regimens. However, renal prognosis remains unfavorable for many patients and the mortality rate is still significantly high...
May 6, 2018: World Journal of Nephrology
2018-05-09 09:11:02
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