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Journal club 2.11.2014

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https://www.readbyqxmd.com/read/17931855/insulin-signaling-in-the-liver-and-uterus-of-ovariectomized-rats-treated-with-estradiol
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COMPARATIVE STUDY
G Koricanac, T Milosavljevic, M Stojiljkovic, Z Zakula, N Ribarac-Stepic, E R Isenovic
We used rat hepatic and uterine tissues to examine the impact of estradiol (E2) on insulin (INS) signaling. Ovariectomized (OVX) female Wistar rats were treated with E2 (20 microg/kg b.wt., i.p.) and used for the experiment 6h after E2 administration. To highlight E2 effects on tyrosine phosphorylation of INS receptor (IR) and INS receptor substrates (IRSs) and IRSs association with p85 subunit of phosphatidylinositol 3-kinase (PI3-K) in the context of INS signaling, E2-treated OVX rats were also injected with INS (20 IU, i...
January 2008: Journal of Steroid Biochemistry and Molecular Biology
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