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Viral & Communicable Diseases

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https://www.readbyqxmd.com/read/25062117/ribosomal-protein-s19-binding-domain-provides-insights-into-hantavirus-nucleocapsid-protein-mediated-translation-initiation-mechanism
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Safder S Ganaie, Absarul Haque, Erdong Cheng, Tania S Bonny, Nilshad N Salim, Mohammad A Mir
The hantaviral zoonotic diseases pose a significant threat to human health due to the lack of potential antiviral therapeutics or a vaccine against hantaviruses. N (Sin Nombre hantavirus nucleocapsid protein) augments mRNA translation. N binds to both the mRNA 5' cap and 40S ribosomal subunit via RPS19 (ribosomal protein S19). N with the assistance of the viral mRNA 5'-UTR preferentially favours the translation of a downstream ORF. We identified and characterized the RPS19-binding domain at the N-terminus of N...
November 15, 2014: Biochemical Journal
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