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Thyroid cancer

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5 papers 0 to 25 followers
https://www.readbyqxmd.com/read/27919446/immunohistochemistry-as-an-accurate-tool-for-evaluating-braf-v600e-mutation-in-130-samples-of-papillary-thyroid-cancer
#1
Zakaria Y Abd Elmageed, Andrew B Sholl, Koji Tsumagari, Zaid Al-Qurayshi, Fulvio Basolo, Krzysztof Moroz, A Hamid Boulares, Paul Friedlander, Paulo Miccoli, Emad Kandil
BACKGROUND: BRAF(V600E) mutation has been investigated by immunohistochemistry and has shown high sensitivity and specificity. We aim to investigate the accuracy of immunohistochemistry versus molecular testing of BRAF(V600E) in papillary thyroid cancer using a large number of polymerase chain reaction-positive BRAF(V600E) papillary thyroid cancer tissues. METHODS: We stained 130 formalin-fixed papillary thyroid cancer specimens using the VE1 antibody: 100 BRAF(V600E) positive and 30 BRAF(V600E) negative confirmed by PCR...
December 2, 2016: Surgery
https://www.readbyqxmd.com/read/27920093/metformin-reduces-glycometabolism-of-papillary-thyroid-carcinoma-in-vitro-and-in-vivo
#2
Chen-Tian Shen, Wei-Jun Wei, Zhong-Ling Qiu, Hong-Jun Song, Xin-Yun Zhang, Zhen-Kui Sun, Quan-Yong Luo
More aggressive thyroid cancer cells show a higher activity of glycometabolism. Targeting cancer cell metabolism has emerged as a novel approach to prevent or treat malignant tumors. Glucose metabolism regulation effect of metformin in papillary thyroid cancer was investigated in the current study. Human papillary thyroid carcinoma (PTC) cell lines BCPAP and KTC1 were used. Cell viability was detected by CCK8 assay. Glucose uptake and relative gene expression were measured in metformin (0-10 mM for 48 h)-treated cells by (18)F-FDG uptake assay and western blotting analysis, respectively...
January 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/27875244/a-six-genotype-genetic-prognostic-model-for-papillary-thyroid-cancer
#3
Xiaopei Shen, Rengyun Liu, Mingzhao Xing
A unique prognostic role of the genetic duet of BRAF V600E and TERT promoter mutations in papillary thyroid cancer (PTC) has been recently established, but the role of RAS mutation in this genetic interplay remains to be established. Using The Cancer Genome Atlas (TCGA) data of patients with PTC from 19 medical centers, we investigated the interactions among the three mutations in clinical outcomes of PTC. We found that BRAF and RAS mutations were mutually exclusive, but both were associated with TERT promoter mutations, with the genetic duet of BRAF/RAS and TERT mutations occurring in 34/388 (8...
January 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/25384944/genetics-the-cancer-genome-atlas-maps-papillary-thyroid-cancer
#4
COMMENT
David Killock
No abstract text is available yet for this article.
December 2014: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/25386189/association-of-atm-gene-polymorphism-with-ptc-metastasis-in-female-patients
#5
Yulu Gu, Xiaoli Liu, Yaqin Yu, Jieping Shi, Lizhe Ai, Hui Sun, Joseph Sam Kanu, Chong Wang, Yawen Liu
Ataxia telangiectasia mutated (ATM) gene is critical in the process of recognizing and repairing DNA lesions and is related to invasion and metastasis of malignancy. The incidence rate of papillary thyroid cancer (PTC) has increased for several decades and is higher in females than males. In this study, we want to investigate whether ATM polymorphisms are associated with gender-specific metastasis of PTC. 358 PTC patients in Northern China, including 109 males and 249 females, were included in our study. Four ATM single nucleotide polymorphisms (SNPs) were genotyped using Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS)...
2014: International Journal of Endocrinology
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