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Eclampsia Preeclampsia

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36 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Noémie Simon-Tillaux, Edouard Lecarpentier, Vassilis Tsatsaris, Alexandre Hertig
Preeclampsia is a hypertensive disorder of pregnancy and the clinical manifestation of severe endothelial dysfunction associated with maternal and foetal morbidity and mortality. The primum movens of the disease is the defect of invasion of the uterine arteries by foetal syncytiotrophoblasts, which causes a maladaptive placental response to chronic hypoxia and the secretion of the soluble form of type 1 vascular growth endothelial factor receptor, also called soluble fms-like tyrosine kinase 1 (sFlt-1), the major player in the pathophysiology of the disease...
November 6, 2018: Nephrology, Dialysis, Transplantation
Brian T Bateman, Uffe Heide-Jørgensen, Kristjana Einarsdóttir, Anders Engeland, Kari Furu, Mika Gissler, Sonia Hernandez-Diaz, Helle Kieler, Anna-Maria Lahesmaa-Korpinen, Helen Mogun, Mette Nørgaard, Johan Reutfors, Randi Selmer, Krista F Huybrechts, Helga Zoega
Background: β-Blockers are a class of antihypertensive medications that are commonly used in pregnancy. Objective: To estimate the risks for major congenital malformations associated with first-trimester exposure to β-blockers. Design: Cohort study. Setting: Health registries in the 5 Nordic countries and the U.S. Medicaid database. Patients: Pregnant women with a diagnosis of hypertension and their offspring...
November 20, 2018: Annals of Internal Medicine
David Churchill, Lelia Duley, Jim G Thornton, Mahmoud Moussa, Hind Sm Ali, Kate F Walker
BACKGROUND: Severe pre-eclampsia can cause significant mortality and morbidity for both mother and child, particularly when it occurs remote from term, between 24 and 34 weeks' gestation. The only known cure for this disease is delivery. Some obstetricians advocate early delivery to ensure that the development of serious maternal complications, such as eclampsia (fits) and kidney failure are prevented. Others prefer a more expectant approach, delaying delivery in an attempt to reduce the mortality and morbidity for the child that is associated with being born too early...
October 5, 2018: Cochrane Database of Systematic Reviews
Edgardo Abalos, Lelia Duley, D Wilhelm Steyn, Celina Gialdini
BACKGROUND: Antihypertensive drugs are often used in the belief that lowering blood pressure will prevent progression to more severe disease, and thereby improve pregnancy outcome. This Cochrane Review is an updated review, first published in 2001 and subsequently updated in 2007 and 2014. OBJECTIVES: To assess the effects of antihypertensive drug treatments for women with mild to moderate hypertension during pregnancy. SEARCH METHODS: We searched Cochrane Pregnancy and Childbirth's Trials Register, ClinicalTrials...
October 1, 2018: Cochrane Database of Systematic Reviews
Madhusudan Upadya, Sumesh T Rao
Hypertensive disorders of pregnancy (HDP) remain among the most significant and intriguing unsolved problems in obstetrics. In India, the prevalence of HDP was 7.8% with pre-eclampsia in 5.4% of the study population. The anaesthetic problems in HDP may be due to the effects on the cardiovascular, respiratory, neurologic, renal, haematologic, hepatic and uteroplacental systems. The basic management objectives should be facilitating the birth of an infant who subsequently thrives and completes restoration of health to the mother, or the termination of pregnancy with the least possible trauma to mother and foetus in severe pre-eclampsia...
September 2018: Indian Journal of Anaesthesia
Lauren O'brien, Jennifer Duong, Tessa Winterton, Anna Haring, Zachary Kuhlmann
INTRODUCTION: Preeclampsia with severe hypertension, which occurs in 5% to 8% of pregnancies, is a leading cause of maternal and perinatal morbidity and mortality in the US. Early recognition and treatment of hypertensive crises can significantly reduce poor outcomes. A protocol to ensure prompt treatment with antihypertensive medication (intravenous labetalol) was implemented at our institution. OBJECTIVE: To determine adherence to this protocol on the Labor and Delivery Unit...
September 13, 2018: Permanente Journal
Amir Afkham, Shadi Eghbal-Fard, Hanieh Heydarlou, Ramyar Azizi, Leili Aghebati-Maleki, Mehdi Yousefi
Toll-like receptors (TLRs) are innate immune cells receptors. They are expressed on leukocytes, epithelial cells, and more particularly on placental immune cells and chorion trophoblast. Upregulation of innate immune response occurs during normal pregnancy, but its excessive activity is involved in the pathology of pregnancy complications including pregnancy-induced hypertension and pre-eclampsia (PE). The recent studies about the overmuch inflammatory responses and aberrant placentation are associated with increased expression of TLRs in PE patients...
March 2019: Journal of Cellular Physiology
Jenny E Myers, Marcus Green, Lucy C Chappell
No abstract text is available yet for this article.
September 12, 2018: BMJ: British Medical Journal
Pierre-Yves Robillard, Gustaaf Dekker, Gérard Chaouat, Philippe Le Bouteiller, Marco Scioscia, Thomas C Hulsey
The authors delineate seven quantum leap forward and, or revolutions having occurred during the 20th century in the understanding of the physiopathology of preeclampsia. First the discovery of the inflatable arm band permitting to measure blood pressure in 1896. Second, the discovery that eclamptic (convulsions), and later "pre"eclamptic (proteinuria) women presented hypertension in 1897 and confirmed in 1903, discovery of the hypertensive disorders of pregnancy. Third, the eight major textbooks published all along the 20th century by delineating risk factors of preeclampsia with the concept of "preeclampsia, disease of primigravidae"...
July 2018: Pregnancy Hypertension
Semone Thakoordeen, Jagidesa Moodley, Thajasvarie Naicker
PURPOSE OF REVIEW: Regardless of the familial linkage reported in pre-eclampsia development, understanding the polymorphic genes associated with pre-eclampsia remains limited. Hence, this review aims to outline the main genetic factors that have been investigated in respect to pre-eclampsia development. RECENT FINDINGS: It is apparent that different genes show significance in varying populations. Notably, it is reported that apolipoprotein-1 gene polymorphisms are associated with pre-eclampsia development in an African-American population, which may be worthwhile to investigate in a Black South African cohort...
August 29, 2018: Current Hypertension Reports
Zaher Armaly, Jimmy E Jadaon, Adel Jabbour, Zaid A Abassi
Preeclampsia is a serious complication of pregnancy where it affects 5-8% of all pregnancies. It increases the morbidity and mortality of both the fetus and pregnant woman, especially in developing countries. It deleteriously affects several vital organs, including the kidneys, liver, brain, and lung. Although, the pathogenesis of preeclampsia has not yet been fully understood, growing evidence suggests that aberrations in the angiogenic factors levels and coagulopathy are responsible for the clinical manifestations of the disease...
2018: Frontiers in Physiology
Jennifer J Stuart, Lauren J Tanz, Stacey A Missmer, Eric B Rimm, Donna Spiegelman, Tamarra M James-Todd, Janet W Rich-Edwards
Background: Women with a history of hypertensive disorders of pregnancy (HDP) are nearly twice as likely to develop cardiovascular disease (CVD) as those who are normotensive during pregnancy. However, the emergence of CVD risk factors after HDP is less well-understood. Objective: To identify associations between HDP and maternal CVD risk factors and chart the trajectory of risk factor development after pregnancy. Design: Observational cohort study...
August 21, 2018: Annals of Internal Medicine
Jessica Sheehan Tangren, Wan Ahmad Hafiz Wan Md Adnan, Camille E Powe, Jeffrey Ecker, Kate Bramham, Michelle A Hladunewich, Elizabeth Ankers, S Ananth Karumanchi, Ravi Thadhani
An episode of clinically recovered acute kidney injury (r-AKI) has been identified as a risk factor for future hypertension and cardiovascular disease. Our objective was to assess whether r-AKI was associated with future preeclampsia and other adverse pregnancy outcomes and to identify whether severity of AKI or time interval between AKI and pregnancy was associated with pregnancy complications. We conducted a retrospective cohort study of women who delivered infants between 1998 and 2016 at Massachusetts General Hospital...
August 2018: Hypertension
Obinnaya Odigboegwu, Lu J Pan, Piyali Chatterjee
Treatment of pregnancy-related hypertensive disorders, such as preeclampsia (PE), remain a challenging problem in obstetrics. Typically, aggressive antihypertensive drug treatment options are avoided to prevent pharmacological-induced hypotension. Another major concern of administering antihypertensive drugs during pregnancy is possible adverse fetal outcome. In addition, management of hypertension during pregnancy in chronic hypertensive patients or in patients with prior kidney problems are carefully considered...
2018: Frontiers in Cardiovascular Medicine
Mohamed Rezk, Wael Gaber, Abdelhamid Shaheen, Ahmed Nofal, Mahmoud Emara, Awni Gamal, Hassan Badr
OBJECTIVE: To determine if second trimester mean platelet volume (MPV) and serum uric acid are reasonable predictors of preeclampsia (PE) or not, in patients at moderate and low risk. METHODS: This prospective study was conducted on 9522 women at low or moderate risk for developing PE who underwent dual measurements of MPV and serum uric acid at late first trimester (10-12 weeks) and at second trimester (18-20 weeks) and subsequently divided into two groups; PE group (n = 286) who later developed PE and non-PE group (n = 9236)...
August 2018: Hypertension in Pregnancy
Raja Ramachandran, Ashok K Yadav, Hariprasad Anakutti, Vanita Jain, Krishan L Gupta, Vivekanand Jha
No abstract text is available yet for this article.
June 2018: Nephrology
Rita M Silva, Sara R Pereira, Susana Rego, Nuno Clode
OBJECTIVE: To evaluate the accuracy of a 12-hour urine collection to diagnose pre-eclampsia and to determine whether time of collection influences the performance of this test. METHODS: A prospective observational study was conducted in a tertiary obstetric center in Portugal between November 1, 2015, and November 30, 2016. Pregnant women (≥20 weeks) admitted for observation with suspected pre-eclampsia were eligible for inclusion. Two consecutive 12-hour urine samples were collected (07:00-19:00 hours vs 19:00-07:00 hours)...
September 2018: International Journal of Gynaecology and Obstetrics
Andrea G Kattah, Vesna D Garovic
No abstract text is available yet for this article.
May 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Maryam Asgharnia, Fariba Mirblouk, Soudabeh Kazemi, Davood Pourmarzi, Mina Mahdipour Keivani, Seyedeh Fatemeh Dalil Heirati
Background: Preeclampsia is associated with maternal and neonatal complications. It has been indicated that increased uric acid might have a predictive role on preeclampsia. Objective: We aimed to investigate the relationship between the level of uric acid with maternal and neonatal complications in women with preeclampsia. Materials and Methods: In this cross-sectional study, 160 singleton preeclamptic women at more than 28 wk gestational age were included...
September 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
Carmela Vadalà, Valeria Cernaro, Rossella Siligato, Roberta Granese, Antonio Simone Laganà, Michele Buemi, Domenico Santoro
Pre-eclampsia (PE) is an important cause of acute renal failure and an important risk marker for subsequent chronic kidney disease. In normal pregnancy, there are marked changes in the renin-angiotensin system (RAS) including considerably elevated angiotensin II (ang II) levels. However, vascular resistance decreases markedly during normal pregnancy, suggesting that pregnant individuals are less sensitive to ang II than non-pregnant individuals. In contrast, during PE decreased circulating components of the RAS with enhanced sensitivity of ang II infusion have been reported...
December 5, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
2017-12-09 15:50:18
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