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HIV immune activation

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10 papers 0 to 25 followers I am trying to collect all of those notable literatures on HIV infection associated immune activation.
Claude Béténé A Dooko, Stephane De Wit, Jacqueline Neuhaus, Adrian Palfreeman, Rosalie Pepe, James S Pankow, James D Neaton
BACKGROUND: HIV infection is associated with increased levels of inflammatory markers. Inflammation is hypothesized to play a role in the development of type 2 diabetes. Data addressing this issue among HIV-positive participants are limited. METHODS: A cohort of 3695 participants without diabetes, taking antiretroviral therapy and with an average CD4⁺ count of 523 cells/mm³, were followed for an average of 4.6 years. Diabetes risk associated with baseline levels of high sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) was assessed using Cox proportional hazards regression models...
December 15, 2014: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Emmanuel Biver, Alexandra Calmy, Cecile Delhumeau, Claire Durosier, Sophie Zawadynski, Rene Rizzoli
OBJECTIVE: Progress in antiretroviral therapy (ART) has resulted in an almost normal life expectancy for HIV-infected individuals, but an increased risk of fragility fractures has been identified. We investigated the influence of long-term HIV infection on successful ART on bone microstructure in elderly men. DESIGN: A cross-sectional, case–control study. METHODS: Dual-energy X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT) were performed in 28 HIV-positive men between 60 and 70 years old on successful ART...
October 23, 2014: AIDS
Michèle D Zeier, Matthys H Botha, Susan Engelbrecht, Rhoderick N Machekano, Graeme B Jacobs, Shahieda Isaacs, Marije van Schalkwyk, Haynes van der Merwe, Deidre Mason, Jean B Nachega
OBJECTIVE: Data on the effect of combination antiretroviral therapy (cART) on cervical human papilloma virus (HPV) infection are both limited and conflicting. We aimed to determine the effect of the initiation of cART for HPV genotype detection on cervical samples in HIV-infected South African women. DESIGN: Prospective cohort study. METHODS: Generalized estimating equation was performed to estimate parameters of mixed-effects logistic regression models of cART on HPV cervical detection risk, adjusting for time-dependent covariates CD4 T-cell count, sexual activity and excision treatment...
January 2, 2015: AIDS
Ma Somsouk, Jacob D Estes, Claire Deleage, Richard M Dunham, Rebecca Albright, John M Inadomi, Jeffrey N Martin, Steven G Deeks, Joseph M McCune, Peter W Hunt
OBJECTIVE: Microbial translocation and innate immune action characterize HIV infection. Continued gut mucosal dysfunction during treatment and its relationship to CD4 T-cell recovery has not been well described. DESIGN: A cross-sectional study was performed of antiretroviral therapy (ART)-suppressed (immunologic responders with CD4 > 500 cells/μl and immunologic nonresponders with CD4 < 350 cells/μl), untreated HIV-infected, and seronegative participants consenting to gut biopsies and a blood draw...
January 2, 2015: AIDS
E V Saidakova, L B Korolevskaya, N G Shmagel, K V Shmagel, V A Chereshnev
No abstract text is available yet for this article.
September 2014: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
Keri N Althoff, Kathleen A McGinnis, Christina M Wyatt, Matthew S Freiberg, Cynthia Gilbert, Krisann K Oursler, David Rimland, Maria C Rodriguez-Barradas, Robert Dubrow, Lesley S Park, Melissa Skanderson, Meredith S Shiels, Stephen J Gange, Kelly A Gebo, Amy C Justice
BACKGROUND: Although it has been shown that human immunodeficiency virus (HIV)-infected adults are at greater risk for aging-associated events, it remains unclear as to whether these events happen at similar, or younger ages, in HIV-infected compared with uninfected adults. The objective of this study was to compare the median age at, and risk of, incident diagnosis of 3 age-associated diseases in HIV-infected and demographically similar uninfected adults. METHODS: The study was nested in the clinical prospective Veterans Aging Cohort Study of HIV-infected and demographically matched uninfected veterans, from 1 April 2003 to 31 December 2010...
February 15, 2015: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Amélie De Saint Jean, Frédéric Lucht, Thomas Bourlet, Olivier Delézay
OBJECTIVE: Recent data describe CD169 (also called sialoadhesin or Siglec-1) as the main HIV-1 receptor expressed by mucosal dendritic cells involved in the capture of the virus and its transmission to target cells. In this study, we investigated the effect of transforming growth factor beta 1 (TGF-β1), a cytokine found in abundance in semen, on the expression of CD169 on dendritic cells in order to characterize its potential role in the capture of HIV-1 particles by these antigen-presenting cells...
October 23, 2014: AIDS
Supriya Krishnan, Jeffrey T Schouten, Benjamin Atkinson, Todd T Brown, David A Wohl, Grace A McComsey, Marshall J Glesby, Cecilia Shikuma, Richard Haubrich, Denise L Jacobson
BACKGROUND: Data on changes in metabolic syndrome (MetS) status in HIV-infected adults on antiretroviral therapy (ART) are limited. METHODS: MetS was assessed at ART initiation and every 48 weeks on ART in ART-naive HIV-infected individuals from the AIDS Clinical Trials Group Longitudinal Linked Randomized Trials (ALLRT) cohort. MetS, defined using the Adult Treatment Panel III criteria, required at least 3 of the following: elevated fasting glucose, hypertension, elevated waist circumference, elevated triglycerides, low high-density lipoprotein (HDL) cholesterol...
January 1, 2015: Journal of Acquired Immune Deficiency Syndromes: JAIDS
José-Ramón Blanco, Inma Jarrin, Alfredo Martinez, Eva Siles, Ignacio M Larrayoz, Ana Cañuelo, Félix Gutierrez, Juan Gonzalez-Garcia, Francesc Vidal, Santiago Moreno
BACKGROUND: Successful combined antiretroviral therapy (cART) does not always result in complete CD4 T-cell recovery despite the effective control of HIV replication. Because telomere dysregulation can lead to an abnormal cell proliferation, we hypothesized that the lack of CD4 recovery may be related to telomere defects; We thus evaluated the association between telomere length (TL) and CD4 T-cell recovery 48 weeks after cART initiation in virologically suppressed patients, and its possible relationship to oxidative stress (OS) and nitrosative stress (NOx) markers...
January 1, 2015: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Roksana Karim, Wendy J Mack, Naoko Kono, Phyllis C Tien, Kathryn Anastos, Jason Lazar, Mary Young, Seema Desai, Elizabeth T Golub, Robert C Kaplan, Howard N Hodis, Andrea Kovacs
OBJECTIVE: T-cell activation is a major pathway driving HIV disease progression. Little is known regarding the impact of T-cell activation on HIV-associated atherosclerosis and cardiovascular disease, a common comorbidity in HIV infection. We hypothesized that T-cell activation will predict vascular stiffness, a measure of subclinical atherosclerosis. DESIGN: Linear regression models evaluated the covariate-adjusted association of T-cell activation with vascular stiffness...
November 1, 2014: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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