Yugo Matsunaga, Takao Tanaka, Koji Yoshinaga, Shigeru Ueki, Yuko Hori, Runa Eta, Yoshihiro Kawabata, Kazuyoshi Yoshii, Kenji Yoshida, Toshihiro Matsumura, Shigeru Furuta, Mineo Takei, Jan Tack, Zen Itoh
Acotiamide hydrochloride (acotiamide; N-[2-[bis(1-methylethyl) amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl) amino] thiazole-4-carboxamide monohydrochloride trihydrate, Z-338) has been reported to improve meal-related symptoms of functional dyspepsia in clinical studies. Here, we examined the gastroprokinetic effects of acotiamide and its antiacetylcholinesterase activity as a possible mechanism of action in conscious dogs. Acotiamide increased postprandial gastric motor activity in conscious dogs with chronically implanted force transducers and, like itopride, mosapride, and cisapride, exhibited gastroprokinetic activity in these dogs...
March 2011: Journal of Pharmacology and Experimental Therapeutics