Nadine Kaesler, Mingbo Cheng, James Nagai, James O'Sullivan, Fabian Peisker, Eric M J Bindels, Anne Babler, Julia Moellmann, Patrick Droste, Giulia Franciosa, Aurelien Dugourd, Julio Saez-Rodriguez, Sabine Neuss, Michael Lehrke, Peter Boor, Claudia Goettsch, Jesper V Olsen, Thimoteus Speer, Tzong-Shi Lu, Kenneth Lim, Jürgen Floege, Laura Denby, Ivan Costa, Rafael Kramann
Patients with advanced chronic kidney disease (CKD) mostly die from sudden cardiac death and recurrent heart failure. The mechanisms of cardiac remodeling are largely unclear. To dissect molecular and cellular mechanisms of cardiac remodeling in CKD in an unbiased fashion, we performed left ventricular single-nuclear RNA sequencing in two mouse models of CKD. Our data showed a hypertrophic response trajectory of cardiomyocytes with stress signaling and metabolic changes driven by soluble uremia-related factors...
November 24, 2023: Science Advances