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Troponin and CKD

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29 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/29079658/renal-dysfunction-influences-the-diagnostic-and-prognostic-performance-of-high-sensitivity-cardiac-troponin-i
#1
Ian Gunsolus, Yader Sandoval, Stephen W Smith, Anne Sexter, Karen Schulz, Charles A Herzog, Fred S Apple
Measures of cardiac troponin (cTn) may have lower specificity for myocardial infarction in patients with CKD. We examined the diagnostic accuracy of baseline and serial high-sensitivity cTnI (hs-cTnI) measurements for myocardial infarction and 30- and 180-day mortality according to renal function. hs-cTnI was measured (Abbott assay) using sex-specific 99th percentiles (women, 16 ng/L; men, 34 ng/L) in 1555 adults presenting to the emergency department with symptoms suggesting ischemia (NCT02060760). Myocardial infarction was adjudicated along universal definition classification...
October 27, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29028161/effect-of-haemodialysis-and-residual-renal-function-on-serum-levels-of-galectin-3-b-type-natriuretic-peptides-and-cardiac-troponin-t
#2
Matthew A Roberts, Piyush M Srivastava, David L Hare, Francesco L Ierino
AIM: Levels of plasma markers of myocardial fibrosis (galectin-3), stretch (B-type natriuretic peptide (BNP)) and injury (troponin T (TnT)) may be affected by haemodialysis and residual renal function (RRF) in addition to cardiac pathology. We aimed to determine the association of RRF, urine output and haemodialysis itself on clinically important cardiac biomarkers in haemodialysis patients. METHODS: Adult haemodialysis patients underwent venesection pre- and post- haemodialysis followed by echocardiography and inter-dialytic urine collection to calculate RRF (mL/minute/1...
October 13, 2017: Nephrology
https://www.readbyqxmd.com/read/28957803/troponin-i-levels-in-asymptomatic-hemodialysis-patients
#3
Diego Castini, Simone Persampieri, Riccardo Floreani, Andrea Galassi, Maria Luisa Biondi, Stefano Carugo, Mario Cozzolino
BACKGROUND: End-stage renal disease (ESRD) represents a situation in which persistently elevated levels of cardiac troponins I (cTnI) are frequently found in the absence of clinically evident cardiac disease. Moreover, the effect of hemodialysis (HD) on cTnI levels is not definitively elucidated. The aim of this study was to investigate the effects of HD on cTnI levels in ESRD patients. METHODS: We enrolled 30 asymptomatic ESRD patients on maintenance HD. All the patients were dialyzed thrice weekly...
2017: Blood Purification
https://www.readbyqxmd.com/read/28692218/-interpretation-of-high-sensitivity-troponin-in-patients-with-chronic-kidney-failure
#4
Manon Kolb, Alexandre Guinand, Marco Roffi, Patrick Saudan, Mathieu Nendaz
New assays with lower levels of detection of troponin (« high-sensitivity troponin ») increase the difficulty of interpretation of this test for the diagnosis of acute coronary syndrome in patients with chronic kidney disease (CKD). Their baseline concentration of troponin is frequently above the upper reference level, which lowers its specificity. To improve its diagnostic performance after clinical and electrocardiographic evaluation, cut-off levels 2 to 3 times higher than the standard reference have been suggested...
October 19, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28281735/high-sensitive-troponin-levels-in-patients-with-chest-pain-and-kidney-disease-a-multicenter-registry-the-tropic-study
#5
Flavia Ballocca, Fabrizio D'Ascenzo, Claudio Moretti, Roberto Diletti, Carlo Budano, Alberto Palazzuoli, Matthew J Reed, Tullio Palmerini, Dariusz Dudek, Alfredo Galassi, Pierluigi Omedè, Nicolas M Mieghem, David Ferenbach, Marco Pavani, Diego Della Riva, Nick L Mills, Ron T Van Domburgh, Andrea Mariani, Artur Dziewierz, Marco di Cuia, Robert Jan van Geuns, Felix Zijlstra, Serena Bergerone, Sebastiano Marra, Giuseppe Biondi Zoccai, Fiorenzo Gaita
BACKGROUND: Accuracy of high sensitive troponin (hs-cTn) to detect coronary artery disease (CAD) in patients with renal insufficiency is not established. The aim of this study was to evaluate the prognostic role of hs-cTn T and I in patients with chronic kidney disease (CKD). METHODS: All consecutive patients with chest pain, renal insufficiency (eGFR < 60 mL/min/1.73 m2) and high sensitive troponin level were included. The predictive value of baseline and interval troponin (hs-cTnT and hs-cTnI) for the presence of CAD was assessed...
2017: Cardiology Journal
https://www.readbyqxmd.com/read/28192777/renal-function-and-scaled-troponin-in-patients-presenting-to-the-emergency-department-with-symptoms-of-myocardial-infarction
#6
Anupama Vasudevan, Adam J Singer, Christopher DeFilippi, Gary Headden, Jeffrey M Schussler, Lori B Daniels, Michael Reed, Martin P Than, Robert Birkhahn, Stephen W Smith, Tyler W Barrett, William Arnold, W Frank Peacock, Peter A McCullough
BACKGROUND: Cardiac troponins are often found to be elevated in patients with renal dysfunction, even in the absence of acute myocardial injury. The objective of this report was to characterize the scaled troponin values and proportion of adjudicated acute myocardial infarction (AMI) among patients with and without renal dysfunction. METHODS: The data was from a multicenter prospective study including patients presenting to the emergency department with symptoms of AMI...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28145489/improving-the-diagnostic-accuracy-of-acute-myocardial-infarction-with-the-use-of-high-sensitive-cardiac-troponin-t-in-different-chronic-kidney-disease-stages
#7
Hongliu Yang, Jing Liu, Han Luo, Xiaoxi Zeng, Xi Tang, Liang Ma, Hongxia Mai, Shenju Gou, Fang Liu, Ping Fu
High-sensitive cardiac troponin T (hs-TnT) is a critical biomarker in diagnosis of acute myocardial infarction (AMI). However, CKD individuals usually have elevated hs-TnT even in the absence of AMI. Our study aimed to explore the optimal cutoff-value of hs-TnT and further to improve diagnostic accuracy of AMI in CKD patients. Clinical data of 489 patients were collected from the maintained database between September 2010 and June 2014. CKD patients with AMI were assigned to CKD+AMI group and CKD patients without AMI were assigned to CKD group...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27866393/potentially-pathogenic-circulating-autoantibodies-to-cardiac-troponin-are-present-in-hemodialysis-patients
#8
Helen J Jefferies, Risto Tertti, Saara Wittfooth, James O Burton, Kaj Metsärinne, Kim Pettersson, Christopher W McIntyre
INTRODUCTION: Repetitive dialysis-induced cardiac injury is associated with elevated troponin levels, inflammation, and longitudinal reduction in cardiac function. Pathogenic autoantibodies to cardiac troponins (cTnAAb) produce inflammatory cardiomyopathy in murine models. This study aimed to explore the possibility that analogous autoimmune processes might occur in hemodialysis (HD) patients, by initially investigating cTnAAb prevalence, and exploring potential links with HD-induced myocardial stunning...
October 2017: Hemodialysis International
https://www.readbyqxmd.com/read/27846783/point-of-care-assessment-of-cardiac-troponin-t-level-in-ckd-patients-with-chest-symptom
#9
Masaki Iwasaki, Kenji Yamazaki, Nobutaka Ikeda, Yuri Tanaka, Toshihide Hayashi, Shun Kubo, Ai Matsukane, Hiroki Hase, Nobuhiko Joki
We challenged to identify the cutoff value of cTnT in chronic kidney disease (CKD) patients by point of care assessment way. A single center, prospective cross-sectional study was planned and performed. 201 consecutive patients who were visited emergency room for chest symptoms were enrolled in this study. All patients were performed routine practice for differential diagnosis of chest symptom by cardiologist. Simultaneously, semiquantitative measurement of cTnT was performed using same blood sampling on the blind condition to cardiologists for this study...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/27811207/interpreting-cardiac-biomarkers-in-the-setting-of-chronic-kidney-disease
#10
REVIEW
Christopher R deFilippi, Charles A Herzog
BACKGROUND: Chronic kidney disease (CKD) is common, particularly in those of advanced age. Because patients with CKD frequently have cardiac comorbidities and acute or chronic symptoms that may represent heart failure or an acute myocardial infarction (AMI), testing for concentrations of cardiac troponins and natriuretic peptides is frequent. Interpretation of these biomarkers can be challenging when differentiating acute from chronic processes, potentially resulting in missed opportunities to direct appropriate treatment...
January 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/27718506/serial-versus-single-troponin-measurements-for-the-prediction-of-cardiovascular-events-and-mortality-in-stable-chronic-haemodialysis-patients
#11
Thomas A Mavrakanas, Allan D Sniderman, Paul E Barré, Ahsan Alam
AIM: This study aims to describe the variability of pre-dialysis troponin values in stable haemodialysis patients and compare the performance of single versus fluctuating or persistently elevated troponins in predicting a composite of mortality and cardiac arrest, myocardial infarction, or stroke. METHODS: 128 stable ambulatory chronic haemodialysis patients were enrolled. Pre-dialysis troponin I was measured for three consecutive months. The patients were followed for one year...
October 8, 2016: Nephrology
https://www.readbyqxmd.com/read/27553182/systolic-time-intervals-derived-from-electrocardiographic-gated-intra-renal-artery-doppler-waveform-associated-with-left-ventricular-systolic-function
#12
Wen-Hsien Lee, Po-Chao Hsu, Chun-Yuan Chu, Szu-Chia Chen, Hung-Hao Lee, Meng-Kuang Lee, Chee-Siong Lee, Hsueh-Wei Yen, Tsung-Hsien Lin, Wen-Chol Voon, Wen-Ter Lai, Sheng-Hsiung Sheu, Ho-Ming Su
The aims of this study were to investigate the correlation between renal and cardiac STIs, including pre-ejection period (PEP), ejection time (ET), and PEP/ET, and to assess the diagnostic values of renal STIs in predicting left ventricular ejection fraction (LVEF) <50%. The cross sectional observation study enrolled 230 participants. The renal STIs, including renal PEP (rPEP), renal ET (rET), and rPEP/rET, were measured from electrocardiographic gated renal Doppler ultrasound and cardiac PEP, ET, and PEP/ET were measured from echocardiography...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27566538/ventricular-arrhythmia-burden-in-patients-with-heart-failure-and-cardiac-resynchronization-devices-the-importance-of-renal-function
#13
Girish Ganesha Babu, Matthew Webber, Rui Providencia, Sanjeev Kumar, Aerakondal Gopalamurugan, Dominic P Rogers, Holly Louise Daw, Syed Ahsan, Fakhar Khan, Anthony Chow, Martin Lowe, Edward Rowland, Pier Lambiase, Oliver R Segal
BACKGROUND: Chronic kidney disease (CKD) is a risk factor for arrhythmias in patients with heart failure (HF). However, the effects of CKD on ventricular arrhythmia (VA) burden in patients with cardiac resynchronization therapy and defibrillator (CRT-D) devices in a primary prevention setting are unknown. OBJECTIVE: To determine whether baseline CKD is associated with increased risk of VA in patients implanted with primary prevention CRT-D devices. METHODS AND RESULTS: In this retrospective study, 199 consecutive primary prevention CRT-D recipients (2005-2010) were stratified by estimated glomerular filtration rate (eGFR) levels prior to device implantation with 106 (53...
October 6, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27492694/how-to-interpret-cardiac-biomarkers-in-renal-failure-and-elderly
#14
REVIEW
Anne-Sophie Bargnoux, Nils Kuster, Marion Moréna, Gregory Baptista, Leila Chenine, Stéphanie Badiou, Hélène Leray, Anne-Marie Dupuy, Jean-Paul Cristol
New highly sensitive (hs) assays have challenged the interpretation of cardiac troponins (cTn) as markers of injury while natriuretic peptides remain the markers of choice for myocardial dysfunction. However, variability extracardiac factors such as age, gender and renal function may alter circulating levels. In chronic kidney disease (CKD), the increase in circulating levels of these biomarkers in the absence of cardiac disease underlines the problem of discriminative value for diagnosis as well as the need to redefine the thresholds...
August 1, 2016: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/27290203/influence-of-acute-kidney-injury-on-high-sensitive-troponin-after-cardiac-surgery-a-single-center-retrospective-observational-study
#15
A S Omar, P Sivadasan, S Hanoura, S Sudarsanan, Y Shouman, H Ragab, A K Tuli, R Singh, A Al Khulaifi
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27162803/association-between-troponin-i-level-and-cardiovascular-risk-factors-in-asymptomatic-hemodialysis-patients
#16
Shahram Taheri, Ali Asghar Pilehvarian, Nafiseh Akbari, Samane Musavi, Afsoon Emami Naeini
OBJECTIVE: Patients on hemodialysis (HD) have a high risk for cardiovascular morbidity and mortality. Cardiac troponins are biomarkers for diagnosing acute myocardial injury or infarction. There is considerable controversy that exists in the frequency and significance of cardiac troponins in predicting cardiac injury and ischemia in HD patients. METHODS: In this cross-sectional study, all HD patients more than 18-year-old, who were at least 3 months under HD, and had no sign and symptom of active cardiovascular disease (CVD), in two HD centers were enrolled...
April 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27064739/high-ultrafiltration-rates-increase-troponin-levels-in-stable-hemodialysis-patients
#17
Thomas A Mavrakanas, Allan D Sniderman, Paul E Barré, Murray Vasilevsky, Ahsan Alam
BACKGROUND: An elevated troponin level is commonly found in asymptomatic patients on hemodialysis (HD) and is associated with higher risk of mortality and major adverse cardiovascular events. The underlying mechanism for the association between adverse outcomes and elevated troponin levels has not been elucidated. METHODS: Two hundred thirty-six stable chronic HD patients from 2 tertiary care centers were enrolled in this study. We measured pre-dialysis troponin I levels with routine monthly bloods for 3 consecutive months...
2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27064955/elevated-troponin-levels-in-stable-patients-undergoing-hemodialysis-a-red-flag-or-a-red-herring
#18
Muthiah Vaduganathan, Deepak L Bhatt
No abstract text is available yet for this article.
2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/26984066/assessed-value-of-high-sensitivity-cardiac-troponin-t-for-cardiovascular-disease-among-ckd-patients
#19
Li Sun, Xiao Tan, Xuesen Cao, Jianzhou Zou
Objective To analyze the relationship between serum high-sensitivity cardiac troponin T (hs-cTnT) and cardiovascular disease (CVD) among non-dialysis chronic kidney disease (CKD) patients, and to further explore its value of evaluating and predicting CVD in this population. Methods Five hundred and fifty-seven non-dialysis CKD patients were involved in this cross-sectional study. The relationship between serum hs-cTnT and CVD was analyzed using comparison between groups and regression analysis, and its value on assessing cardiac structure and function was evaluated by ROC curves...
June 2016: Renal Failure
https://www.readbyqxmd.com/read/26933084/relative-lack-of-culprit-and-obstructive-coronary-lesions-in-patients-with-acute-ischemic-stroke-and-elevated-cardiac-troponin
#20
EDITORIAL
Marion A Hofmann Bowman, James K Liao
No abstract text is available yet for this article.
March 29, 2016: Circulation
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