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Basem Ishak, Benito Campos, Heike Brunn, Andreas W Unterberg, Rezvan Ahmadi
Chronic low back pain is challenging to treat. Minimal invasive neurostimulation therapies, such as subcutaneous peripheral nerve field stimulation (SPNS), improve pain relief and quality of life,. The goal of the present study was to assess the usefulness, safety, and efficacy of SPNS in patients with chronic low back pain (CLBP). Twenty-six consecutive patients with CLBP were prospectively included in the study. For trial neurostimulation, two electrodes were implanted vertically at a depth of 1 cm into the subcutaneous tissue, ≤ 10 cm from the region of maximum pain...
December 14, 2017: Neuroscience
Shaheen Ahmed, Thomas Yearwood, Dirk De Ridder, Sven Vanneste
Paresthesia-free spinal cord stimulation (SCS) techniques, such as burst and high-frequency (HF) SCS, have been developed and demonstrated to be successful for treating chronic pain, albeit via different mechanisms of action. The goal of this review is to discuss the mechanisms of action for pain suppression at both the cellular and systems levels for burst and HF SCS. In addition, we also discuss the neuromodulation devices that mimic these paradigms. Areas covered: The authors performed a literature review to unravel the mechanisms of action for burst and HF SCS coupled with booklets and user manuals from neuromodulation companies to understand the programmable parameters and operating ranges...
January 2018: Expert Review of Medical Devices
Dawn K Prusator, Beverley Greenwood-Van Meerveld
Alterations in amygdala activity are apparent in women who report a history of early life stress (ELS) and those diagnosed with chronic pain disorders. Chronic stress in adulthood induces visceral hypersensitivity by alterations in glucocorticoid receptor (GR) and corticotropin-releasing factor (CRF) expression within the central amygdala (CeA). Here, we hypothesized that unpredictable ELS, previously shown to induce visceral hypersensitivity in adult female rats, alters GR and CRF expression in the CeA. After neonatal ELS, visceral sensitivity and GR and CRF gene expression were quantified in adult female rats...
February 2017: Pain
Monica Rho, Alejandra Camacho-Soto, Abby Cheng, Mark Havran, Natalia E Morone, Eric Rodriguez, Joseph Shega, Debra K Weiner
OBJECTIVE: This article presents an evidence-based algorithm to assist primary care providers with the diagnosis and management of lateral hip and thigh pain in older adults. It is part of a series that focuses on coexisting pain patterns and contributors to chronic low back pain (CLBP) in the aging population. The objective of the series is to encourage clinicians to take a holistic approach when evaluating and treating CLBP in older adults. METHODS: A content expert panel and a primary care panel collaboratively used the modified Delphi approach to iteratively develop an evidence-based diagnostic and treatment algorithm...
June 21, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Kyung Hee Do, Sang Ho Ahn, Rodney Jones, Sung Ho Jang, Su Min Son, Dong Gyu Lee, Hee Kyung Cho, Gyu Sik Choi, Yun-Woo Cho
OBJECTIVES: Sacroiliac joint (SIJ) injections have been used to provide short-term relief of SIJ pain. In this study, the authors investigated a new technique using a superior approach. METHODS: Twenty four patients with chronic SI joint paint were recruited. Each patient was treated with a single SIJ intra-articular injection plus a periarticular injection of local anesthetic and corticosteroid in one procedure. Technical accuracy of the intra-articular procedure was determined by having 2 independent observers review and rate the quality of arthrograms obtained...
February 25, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Jonathan P Wanderer, James P Rathmell
No abstract text is available yet for this article.
November 2014: Anesthesiology
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