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GMG Nutritional/Cardiac

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257 papers 25 to 100 followers
By Gregory Gustafson Interventional Cardiologist
https://www.readbyqxmd.com/read/29983721/a-study-on-the-relationship-between-waist-phenotype-hypertriglyceridemia-coronary-artery-lesions-and-serum-free-fatty-acids-in-adult-and-elderly-patients-with-coronary-diseases
#1
Rui-Feng Yang, Hanlei Zhang, Zhongchun Wang, Xiao-Yong Liu, Zhi Lin
Background: Abdominal obesity is an independent risk factor for coronary heart disease (CHD) and high serum triglyceride (TG) and free fatty acid levels may precipitate or aggravate CHD. Methods: We enrolled patients with coronary heart disease in our hospital from October 2008 to July 2009. Patients with high TG and increased WC, i.e. waist phenotype WP were included in group A. In group B, were included patients with high TG but not WP. Group C consisted of patients with WP but not high TG...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29971434/association-of-coffee-drinking-with-mortality-by-genetic-variation-in-caffeine-metabolism-findings-from-the-uk-biobank
#2
Erikka Loftfield, Marilyn C Cornelis, Neil Caporaso, Kai Yu, Rashmi Sinha, Neal Freedman
Importance: Prospective cohorts in North America, Europe, and Asia show consistent inverse associations between coffee drinking and mortality, including deaths from cardiovascular disease and some cancers. However, concerns about coffee, particularly among people with common genetic polymorphisms affecting caffeine metabolism and among those drinking more than 5 cups per day, remain. Objective: To evaluate associations of coffee drinking with mortality by genetic caffeine metabolism score...
August 1, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/30019767/polyunsaturated-fatty-acids-for-the-primary-and-secondary-prevention-of-cardiovascular-disease
#3
REVIEW
Asmaa S Abdelhamid, Nicole Martin, Charlene Bridges, Julii S Brainard, Xia Wang, Tracey J Brown, Sarah Hanson, Oluseyi F Jimoh, Sarah M Ajabnoor, Katherine Ho Deane, Fujian Song, Lee Hooper
BACKGROUND: Evidence on the health effects of total polyunsaturated fatty acids (PUFA) is equivocal. Fish oils are rich in omega-3 PUFA and plant oils in omega-6 PUFA. Evidence suggests that increasing PUFA-rich foods, supplements or supplemented foods can reduce serum cholesterol, but may increase body weight, so overall cardiovascular effects are unclear. OBJECTIVES: To assess effects of increasing total PUFA intake on cardiovascular disease and all-cause mortality, lipids and adiposity in adults...
July 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30094804/high-methionine-low-folate-and-low-vitamin-b6-b12-hm-lf-lv-diet-causes-neurodegeneration-and-subsequent-short-term-memory-loss
#4
Mohammed Nuru, Nino Muradashvili, Anuradha Kalani, David Lominadze, Neetu Tyagi
Methionine is an essential amino acid found in rich quantities in average American diet such as meats, fish and eggs. Excessive consumption of such food often exceeds the normal requirement of the methionine in our body; which found to be related to the development of neurodegenerative disorders. However, the mechanistic pathways of methionine's influence on the brain are unclear. The present study is focus on the effects of high methionine, low folate and low vitamin B6/B12 (HM-LF-LV) diet on the dysfunction of neuronal and vascular specific markers in the brain...
December 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/30019765/omega-6-fats-for-the-primary-and-secondary-prevention-of-cardiovascular-disease
#5
REVIEW
Lee Hooper, Lena Al-Khudairy, Asmaa S Abdelhamid, Karen Rees, Julii S Brainard, Tracey J Brown, Sarah M Ajabnoor, Alex T O'Brien, Lauren E Winstanley, Daisy H Donaldson, Fujian Song, Katherine Ho Deane
BACKGROUND: Omega-6 fats are polyunsaturated fats vital for many physiological functions, but their effect on cardiovascular disease (CVD) risk is debated. OBJECTIVES: To assess effects of increasing omega-6 fats (linoleic acid (LA), gamma-linolenic acid (GLA), dihomo-gamma-linolenic acid (DGLA) and arachidonic acid (AA)) on CVD and all-cause mortality. SEARCH METHODS: We searched CENTRAL, MEDLINE and Embase to May 2017 and clinicaltrials...
July 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29930142/atherosclerosis-and-inflammation-overview-and-updates
#6
REVIEW
Glaucylara Reis Geovanini, Peter Libby
The concept that inflammation participates pivotally in the pathogenesis of atherosclerosis and its complications has gained considerable attention, but has not yet entered clinical practice. Experimental work has elucidated molecular and cellular pathways of inflammation that promote atherosclerosis. The recognition of atherogenesis as an active process rather than a cholesterol storage disease or a repository of calcium has highlighted some key inflammatory mechanisms. For example, mononuclear phagocytes contribute to all stages of this disease, illustrating the link between inflammation and atherosclerosis...
June 29, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29935936/unmet-need-for-adjunctive-dyslipidemia-therapy-in-hypertriglyceridemia-management
#7
REVIEW
Om P Ganda, Deepak L Bhatt, R Preston Mason, Michael Miller, William E Boden
Despite the important role of high-intensity statins in reducing atherosclerotic cardiovascular disease events in secondary and primary prevention, substantial residual risk persists, particularly among high-risk patients with type 2 diabetes mellitus, metabolic syndrome, and obesity. Considerable attention is currently directed to the role that elevated triglycerides (TGs) and non-high-density lipoprotein cholesterol levels play as important mediators of residual atherosclerotic cardiovascular disease risk, which is further strongly supported by genetic linkage studies...
July 17, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29957236/the-role-of-nutraceuticals-in-statin-intolerant-patients
#8
REVIEW
Maciej Banach, Angelo Maria Patti, Rosaria Vincenza Giglio, Arrigo F G Cicero, Atanas G Atanasov, Gani Bajraktari, Eric Bruckert, Olivier Descamps, Dragan M Djuric, Marat Ezhov, Zlatko Fras, Stephan von Haehling, Niki Katsiki, Michel Langlois, Gustavs Latkovskis, G B John Mancini, Dimitri P Mikhailidis, Olena Mitchenko, Patrick M Moriarty, Paul Muntner, Dragana Nikolic, Demosthenes B Panagiotakos, Gyorgy Paragh, Bernhard Paulweber, Daniel Pella, Christos Pitsavos, Željko Reiner, Giuseppe M C Rosano, Robert S Rosenson, Jacek Rysz, Amirhossein Sahebkar, Maria-Corina Serban, Dragos Vinereanu, Michal Vrablík, Gerald F Watts, Nathan D Wong, Manfredi Rizzo
Statins are the most common drugs administered for patients with cardiovascular disease. However, due to statin-associated muscle symptoms, adherence to statin therapy is challenging in clinical practice. Certain nutraceuticals, such as red yeast rice, bergamot, berberine, artichoke, soluble fiber, and plant sterols and stanols alone or in combination with each other, as well as with ezetimibe, might be considered as an alternative or add-on therapy to statins, although there is still insufficient evidence available with respect to long-term safety and effectiveness on cardiovascular disease prevention and treatment...
July 3, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28616955/niacin-for-primary-and-secondary-prevention-of-cardiovascular-events
#9
REVIEW
Stefan Schandelmaier, Matthias Briel, Ramon Saccilotto, Kelechi K Olu, Armon Arpagaus, Lars G Hemkens, Alain J Nordmann
BACKGROUND: Nicotinic acid (niacin) is known to decrease LDL-cholesterol, and triglycerides, and increase HDL-cholesterol levels. The evidence of benefits with niacin monotherapy or add-on to statin-based therapy is controversial. OBJECTIVES: To assess the effectiveness of niacin therapy versus placebo, administered as monotherapy or add-on to statin-based therapy in people with or at risk of cardiovascular disease (CVD) in terms of mortality, CVD events, and side effects...
June 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29785957/associations-of-egg-consumption-with-cardiovascular-disease-in-a-cohort-study-of-0-5-million-chinese-adults
#10
Chenxi Qin, Jun Lv, Yu Guo, Zheng Bian, Jiahui Si, Ling Yang, Yiping Chen, Yonglin Zhou, Hao Zhang, Jianjun Liu, Junshi Chen, Zhengming Chen, Canqing Yu, Liming Li
OBJECTIVE: To examine the associations between egg consumption and cardiovascular disease (CVD), ischaemic heart disease (IHD), major coronary events (MCE), haemorrhagic stroke as well as ischaemic stroke. METHODS: During 2004-2008, over 0.5 million adults aged 30-79 years were recruited from 10 diverse survey sites in China. Participants were asked about the frequency of egg consumption and were followed up via linkages to multiple registries and active investigation...
November 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29773586/seafood-long-chain-n-3-polyunsaturated-fatty-acids-and-cardiovascular-disease-a-science-advisory-from-the-american-heart-association
#11
REVIEW
Eric B Rimm, Lawrence J Appel, Stephanie E Chiuve, Luc Djoussé, Mary B Engler, Penny M Kris-Etherton, Dariush Mozaffarian, David S Siscovick, Alice H Lichtenstein
Since the 2002 American Heart Association scientific statement "Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease," evidence from observational and experimental studies and from randomized controlled trials continues to emerge to further substantiate the beneficial effects of seafood long-chain n-3 polyunsaturated fatty acids and cardiovascular disease. A recent American Heart Association science advisory addressed the specific effect of n-3 polyunsaturated fatty acid supplementation on clinical cardiovascular events...
July 3, 2018: Circulation
https://www.readbyqxmd.com/read/29755576/cold-pressed-minke-whale-oil-reduces-circulating-ldl-vldl-cholesterol-lipid-oxidation-and-atherogenesis-in-apolipoprotein-e-deficient-mice-fed-a-western-type-diet-for-13-weeks
#12
Mari Johannessen Walquist, Svein Kristian Stormo, Bjarne Østerud, Edel O Elvevoll, Karl-Erik Eilertsen
Background: Long-chain n3-polyunsaturated fatty acids (LC n3-PUFA) are well known for their anti-inflammatory activity and their impact on cardiovascular disease. Cold-pressed whale oil (CWO) has half the amount of LC n3-PUFA compared to cod liver oil (CLO). Still, there has been observed more pronounced beneficial effects on cardiovascular disease markers from intake of CWO compared to intake of CLO in human intervention studies. Extracts from CWO deprived of fatty acids have also been shown to display antioxidative and anti-inflammatory effects in vitro...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29627296/relationship-between-lipoprotein-subfraction-cholesterol-and-residual-risk-for-cardiovascular-outcomes-a-post-hoc-analysis-of-the-aim-high-trial
#13
Peter P Toth, Steven R Jones, April Slee, Jerome Fleg, Santica M Marcovina, Megan Lacy, Ruth McBride, William E Boden
BACKGROUND: The AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides and Impact on Global Health Outcomes) trial failed to demonstrate incremental clinical benefit of extended-release niacin (ERN) in 3414 statin-treated patients with established cardiovascular (CV) disease who had low baseline levels of high-density lipoprotein cholesterol (HDL-C) as compared to placebo. A previous secondary analysis suggested that ERN provided outcome benefits in ERN-treated patients with high triglycerides (TGs; >200 mg/dL) and very low HDL-C (<32 mg/dL) at baseline...
May 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29277442/plasma-levels-of-n-3-fatty-acids-and-risk-of-coronary-heart-disease-among-japanese-the-japan-public-health-center-based-jphc-study
#14
Kei Hamazaki, Hiroyasu Iso, Ehab S Eshak, Satoyo Ikehara, Ai Ikeda, Motoki Iwasaki, Tomohito Hamazaki, Shoichiro Tsugane
BACKGROUND AND AIMS: Higher intake of fish or n-3 polyunsaturated fatty acids (PUFAs) has been associated with reduced risk of coronary heart disease (CHD). However, it is unclear whether increased blood levels of n-3 PUFAs are associated with reduced risk of CHD in the Japanese population. METHODS: The relationship between circulating levels of n-3 PUFAs (eicosapentaenoic acid + docosapentaenoic acid + docosahexaenoic acid) and risk of CHD was examined in a nested case-control study among participants in the Japan Public Health Center (JPHC)-based Study Cohort...
May 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29141976/25-hydroxyvitamin-d-as-a-biomarker-of-vitamin-d-status-and-its-modeling-to-inform-strategies-for-prevention-of-vitamin-d-deficiency-within-the-population
#15
REVIEW
Kevin D Cashman, Ellen Ghm van den Heuvel, Ruud Jw Schoemaker, Damien P Prévéraud, Helen M Macdonald, Jayashree Arcot
There is substantial evidence that the prevalence of vitamin D deficiency is unacceptably high in the population, and this requires action from a public health perspective. Circulating 25-hydroxyvitamin D [25(OH)D] is a robust and reliable marker of vitamin D status and has been used by numerous agencies in the establishment of vitamin D dietary requirements and for population surveillance of vitamin D deficiency or inadequacy. In a wider context, modeling of serum 25(OH)D data and its contributory sources, namely dietary vitamin D supply and UVB availability, can inform our understanding of population vitamin D status...
November 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28916255/impact-of-nonfasting-triglycerides-high-density-lipoprotein-cholesterol-ratio-on-secondary-prevention-in-patients-treated-with-statins
#16
Ichiro Matsumoto, Atsushi Misaki, Mizuki Kurozumi, Tsunetatsu Nanba, Yuichiro Takagi
BACKGROUND: Some studies have demonstrated that low-density lipoprotein cholesterol (LDL-C) lowering therapy is one of the most important strategies to prevent coronary artery disease. Also, serum triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) are recognized as independent risk factors of cardiovascular diseases. The aim of this study was to investigate whether the nonfasting TG/HDL-C ratio could affect the incidence of cardiovascular events after percutaneous coronary intervention (PCI) even in patients treated with statins...
January 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/28826313/effect-of-omega-3-polyunsaturated-fatty-acids-supplementation-on-body-composition-and-circulating-levels-of-follistatin-like-1-in-males-with-coronary-artery-disease-a-randomized-double-blind-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Shirin Jafari Salim, Shahab Alizadeh, Mahmoud Djalali, Ebrahim Nematipour, Mohammad Hassan Javanbakht
Adipokines are mediators of body composition and are involved in obesity-related complications such as cardiovascular disease. Omega-3 supplementation has not been studied in the setting of body composition and follistatin-like 1 (FSTL1) levels in patients with coronary artery disease (CAD). This study aimed to investigate the effect of omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on body composition indices and serum levels of FSTL1 in CAD patients. A total of 42 male (aged 45-65 years) subjects with angiographically confirmed CAD were included in this randomized, double-blind, placebo-controlled trial study...
November 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28514624/evacetrapib-and-cardiovascular-outcomes-in-high-risk-vascular-disease
#18
RANDOMIZED CONTROLLED TRIAL
A Michael Lincoff, Stephen J Nicholls, Jeffrey S Riesmeyer, Philip J Barter, H Bryan Brewer, Keith A A Fox, C Michael Gibson, Christopher Granger, Venu Menon, Gilles Montalescot, Daniel Rader, Alan R Tall, Ellen McErlean, Kathy Wolski, Giacomo Ruotolo, Burkhard Vangerow, Govinda Weerakkody, Shaun G Goodman, Diego Conde, Darren K McGuire, Jose C Nicolau, Jose L Leiva-Pons, Yves Pesant, Weimin Li, David Kandath, Simon Kouz, Naeem Tahirkheli, Denise Mason, Steven E Nissen
BACKGROUND: The cholesteryl ester transfer protein inhibitor evacetrapib substantially raises the high-density lipoprotein (HDL) cholesterol level, reduces the low-density lipoprotein (LDL) cholesterol level, and enhances cellular cholesterol efflux capacity. We sought to determine the effect of evacetrapib on major adverse cardiovascular outcomes in patients with high-risk vascular disease. METHODS: In a multicenter, randomized, double-blind, placebo-controlled phase 3 trial, we enrolled 12,092 patients who had at least one of the following conditions: an acute coronary syndrome within the previous 30 to 365 days, cerebrovascular atherosclerotic disease, peripheral vascular arterial disease, or diabetes mellitus with coronary artery disease...
May 18, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28300080/hypertriglyceridaemia-and-risk-of-coronary-artery-disease
#19
REVIEW
Željko Reiner
An elevated serum level of LDL cholesterol is a well-known risk factor for cardiovascular disease (CVD), but the role of elevated triglyceride levels is debated. Controversies regarding hypertriglyceridaemia as an independent risk factor for CVD have occurred partly because elevated triglyceride levels are often a component of atherogenic dyslipidaemia - they are associated with decreased levels of HDL cholesterol and increased levels of small dense LDL particles, which are highly atherogenic. Findings from several large studies indicate that elevated levels of triglycerides (either fasting or nonfasting) or, more specifically, triglyceride-rich lipoproteins and their remnants, are independently associated with increased risk of CVD...
July 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28506386/serum-triglyceride-high-density-lipoprotein-cholesterol-apolipoprotein-b-and-coronary-heart-disease-in-a-chinese-population-undergoing-coronary-angiography
#20
Yan Ling, Jingjing Jiang, Bingjie Wu, Xin Gao
BACKGROUND: Increased serum triglyceride and apolipoprotein B (apoB) levels and decreased high-density lipoprotein cholesterol (HDL-C) levels are risk factors for cardiovascular diseases. The major types of dyslipidemia in Chinese population are hypertriglyceridemia and low HDL-C. OBJECTIVE: This study aimed to evaluate the effect of HDL-C, triglyceride, and apoB levels on the risk of coronary heart disease (CHD) in a Chinese population undergoing coronary angiography...
May 2017: Journal of Clinical Lipidology
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