Paul Gutwein, Anja Schramme, Beren Voss, Mohamed Sadek Abdel-Bakky, Kai Doberstein, Andreas Ludwig, Peter Altevogt, Martin-Leo Hansmann, Holger Moch, Glen Kristiansen, Josef Pfeilschifter
Junctional adhesion molecule-A (JAM-A) is one component of tight junctions which are involved in important processes like paracellular permeability, cell polarity, adhesion, migration, and angiogenesis. Here we describe JAM-A expression in distal convoluted tubule, connecting tubule, and in cells of the collecting duct of the healthy human kidney. In addition, JAM-A was weakly expressed in cells of the proximal tubule. Using immunofluorescence, FACS and Western blot analysis we investigated JAM-A expression in tubular cells in vitro...
March 6, 2009: Biochemical and Biophysical Research Communications