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Postoperative cognitive decline (POCD)

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2 papers 0 to 25 followers
By Scott Bentley Rural GP Anaesthetist & Medical Officer in Aeromedical Retrieval Medicine
B S Silbert, L A Evered, D A Scott
BACKGROUND: Since general anaesthesia invariably accompanies surgery, the contribution of each to the development of postoperative cognitive dysfunction (POCD) has been difficult to identify. METHODS: A prospective randomized controlled trial was undertaken in elderly patients undergoing extracorporeal shock wave lithotripsy (ESWL). Between 2005 and 2011, 2706 individuals were screened to recruit 100 eligible patients. Patients were randomly assigned to receive general or spinal anaesthesia alone...
November 2014: British Journal of Anaesthesia
M R Nadelson, R D Sanders, M S Avidan
Approximately a quarter of a billion people undergo surgery every year hoping that the operation will alleviate symptoms, cure diseases, and improve quality-of-life. A concern has arisen that, despite the benefits of surgery, elderly patients might suffer neurological injury from surgery and general anaesthesia leading to persistent cognitive decline. However, many studies of postoperative cognition have had methodological weaknesses, including lack of suitable control groups, dissociation of cognitive outcomes from surgical outcomes, sub-optimal statistical techniques, and absence of longitudinal preoperative cognitive assessments...
March 2014: British Journal of Anaesthesia
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