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Drug safety

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54 papers 25 to 100 followers
By Oswaldo Vargas Health system pharmacist currently working on Medication Safety as a part of Patient Safety work task force group
Molly Billstein-Leber, Col Jorge D Carrillo, Angela T Cassano, Kym Moline, Jennifer J Robertson
No abstract text is available yet for this article.
October 1, 2018: American Journal of Health-system Pharmacy: AJHP
Sandra L Kane-Gill
No abstract text is available yet for this article.
August 2018: Pharmacotherapy
Izabela C Leahy, Meghan Lavoie, David Zurakowski, Amanda W Baier, Robert M Brustowicz
STUDY OBJECTIVE: The objective of the study was to: a) characterize the frequency, type, and outcome of anesthetic medication errors spanning an 8.5-year period, b) describe the targeted error reduction strategies and c) measure the effects, if any, of a focused, continuous, multifaceted Medication Safety Program. DESIGN: Retrospective analysis. SETTING: All anesthetizing locations (57). PATIENTS: All anesthesia patients at all Boston Children's Hospital anesthetizing locations from January 2008 to June 2016 were included...
September 2018: Journal of Clinical Anesthesia
Estela R García, Stefanie Thalhauser, Hèctor R Loscertales, Pilar Modamio, Cecilia F Lastra, Eduardo L Mariño
As the elderly population and polypharmacy are increasing, it is predicted that interventions to enhance medication adherence, as dose administration aids (DAA), will grow. One of the limitations of repackaging medicines into DAA is to assure the stability of medicines, and, therefore, their quality, efficacy and safety. Area covered: This article collects and summarises data of all the stability studies of repackaged medicines into DAAs. Computerized search in databases: PubMed, Google Scholar, SciELO, and reference texts related to the field (keywords: drug stability, DAAs, compliance aids, and repackaging), open access databases and guidelines...
June 2018: Expert Opinion on Drug Delivery
Anne M Euser, Catrien G Reichart, Ingrid D C van Balkom
No abstract text is available yet for this article.
October 2017: Therapeutic Advances in Drug Safety
Gemma Donovan, Lindsay Parkin, Lyn Brierley-Jones, Scott Wilkes
OBJECTIVES: There is widespread use of unlicensed medicines within primary and secondary care but little information is available around how these medicines are used. This analysis examines and evaluates the content and quality of relevant guidance documentation currently in use within the UK. METHODS: Guidance documents were identified through a literature search as well as email requests to pharmacy organisations throughout the UK. Unlicensed medicine documentation suitable for inclusion in the analysis underwent thematic analysis and quality assessment using the AGREE II tool...
January 30, 2018: International Journal of Pharmacy Practice
Brett Mensh, Konrad Kording
No abstract text is available yet for this article.
September 2017: PLoS Computational Biology
Peggi Guenter, Phil Ayers, Joseph I Boullata, Kathleen M Gura, Beverly Holcombe, Gordon S Sacks
Parenteral nutrition (PN) is a complex, high-alert medication, and errors associated with the use of this therapy may lead to significant harm to patients. This document reviews error reports from the Institute for Safe Medication Practices' Medication Errors Reporting Program that are associated with the PN use process over the past 10 years. Actual PN-related errors are outlined, with most occurring in the PN-compounding/dispensing and PN administration steps. Clinicians involved in any phase of the PN use process should review their institutional or homecare company's processes for reporting of PN errors and collaborate with their medical safety officer and/or committees involved with medication error reporting...
December 2017: Nutrition in Clinical Practice
James J Chamberlain, William H Herman, Sandra Leal, Andrew S Rhinehart, Jay H Shubrook, Neil Skolnik, Rita Rastogi Kalyani
Description: The American Diabetes Association (ADA) annually updates the Standards of Medical Care in Diabetes to provide clinicians, patients, researchers, payers, and other interested parties with evidence-based recommendations for the diagnosis and management of patients with diabetes. Methods: For the 2017 Standards, the ADA Professional Practice Committee updated previous MEDLINE searches performed from 1 January 2016 to November 2016 to add, clarify, or revise recommendations based on new evidence...
April 18, 2017: Annals of Internal Medicine
Deborah Pardo, Lacey Miller, Dana Chiulli
BACKGROUND: The dangers of co-administration of opioid pain relievers (OPRs) and benzodiazepines (BZDs) are well documented. The combination of OPRs and BZDs make up the majority of medications involved in prescription drug-related overdose and are often used concomitantly. This pattern is consistent among the veteran population where mental health illness and substance abuse are prominent. The Veterans Health Administration implemented the Opioid Safety Initiative (OSI) aimed at improving patient safety surrounding OPRs...
April 2017: Substance Abuse
Sarah A Minner, Pamela Simone, Benjamin B Chung, Atman P Shah
A 69-year-old male underwent elective percutaneous coronary intervention requiring placement of a drug-eluting stent to the first obtuse marginal artery. Four hours following the administration of a ticagrelor loading dose, he developed dyspnea and sinus pauses. Aminophylline was administered and resulted in immediate and sustained symptom resolution. Ticagrelor has been associated with dyspnea and bradyarrhythmias, both attributed to increased adenosine exposure. Ticagrelor inhibits reuptake of intracellular adenosine...
February 2018: Journal of Pharmacy Practice
Dar-Wei Chen, Valerie J Chase, Mary E Burkhardt, Alma Z Agulto
No abstract text is available yet for this article.
2016: Joint Commission Journal on Quality and Patient Safety
Kerry-Anne Hogan, Julie Lapenskie, Joanne Leclair, Naomi Thick, Mohamed Gazarin, Penny Webster, Brian Devin
Developing and implementing a policy for safe pro re nata medications practices became a priority when 1 nurse questioned a regularly occurring double-range narcotic order. This article describes how double-range medications can compromise patient safety and how a small rural hospital with minimal resources was able to develop an interdisciplinary practice standard to ensure safe medication practices.
June 22, 2016: Journal of Patient Safety
Michael J Akers
Ready-to-use solutions are the most preferable and most common dosage forms for injectable and topical ophthalmic products. Drugs formulated as solution almost always have chemical and physical stability challenges as well as solubility limitations and the need to prevent inadvertent microbial contamination issues. The first in this series of articles took us through a discussion of optimizing the physical stability of solutions. This article concludes this series of articles with a discussion on foreign particles, protein aggregation, and immunogenicity; optimizing microbiological activity; and osmolality (tonicity) agents, and discusses how these challenges and issues are addressed...
March 2016: International Journal of Pharmaceutical Compounding
Lea Botermann, Katharina Monzel, Katrin Krueger, Christiane Eickhoff, Angelika Wachter, Charlotte Kloft, Ulrich Laufs, Martin Schulz
PURPOSE: A standardized medication plan for patients has been developed and recently enacted into German law depicting all medicines taken. It can only increase medication safety if patients use and understand it. We evaluated patients' comprehensibility of the medication plan and analyzed potential variables influencing patients' understanding. METHODS: The medication plan template v2.0 was first tested in N = 40 patients, and the "Evaluation Tool to test the handling of the Medication Plan" (ET-MP) was developed, rating patients' understanding from 0 to 100 %...
October 2016: European Journal of Clinical Pharmacology
Joseph I Boullata, Beverly Holcombe, Gordon Sacks, Jane Gervasio, Stephen C Adams, Michael Christensen, Sharon Durfee, Phil Ayers, Neil Marshall, Peggi Guenter
Parenteral nutrition (PN) is a high-alert medication with a complex drug use process. Key steps in the process include the review of each PN prescription followed by the preparation of the formulation. The preparation step includes compounding the PN or activating a standardized commercially available PN product. The verification and review, as well as preparation of this complex therapy, require competency that may be determined by using a standardized process for pharmacists and for pharmacy technicians involved with PN...
August 2016: Nutrition in Clinical Practice
Samuel Lapkin, Tracy Levett-Jones, Lynn Chenoweth, Maree Johnson
AIM: The aim of this overview was to examine the effectiveness of interventions designed to improve patient safety by reducing medication administration errors using data from systematic reviews. BACKGROUND: Medication administration errors remain unacceptably high despite the introduction of a range of interventions aimed at enhancing patient safety. Systematic reviews of strategies designed to improve medication safety report contradictory findings. A critical appraisal and synthesis of these findings are, therefore, warranted...
October 2016: Journal of Nursing Management
Michael J Akers
Ready-to-use solutions are the most preferable and most common dosage forms for injectable and topical ophthalmic products. Drugs formulated as solution almost always have chemical and physical stability challenges as well as solubility limitations and the need to prevent inadvertent microbial contamination issues. This article, which takes us through a discussion of optimizing the physical stability of solutions, represents the first of a series of articles discussing how these challenges and issues are addressed...
January 2016: International Journal of Pharmaceutical Compounding
Zheng Feng Lu, Stephen Thomas
The past decade has seen a significant growth in diagnostic CT imaging as a direct result of the clinical value provided by CT imaging. At the same time, many new techniques and resources are now available to make CT imaging safe. This article presents the basics of CT dosimetry and their usage in clinical practices, methods to implement CT dose reduction, followed by a summary of legislation, and guidelines related to patient safety in diagnostic CT imaging. Also, CT radiation dose diagnostic reference levels from published regional and national surveys are reviewed and applied in a CT dose tracking and monitoring program...
March 2016: Abdominal Radiology
Ercan Celikkayalar, Minna Myllyntausta, Matthew Grissinger, Marja Airaksinen
BACKGROUND: The US Institute for Safe Medication Practices' (ISMP) Medication Safety Self-Assessment (MSSA) tool for hospitals is a comprehensive tool for assessing safe medication practices in hospitals. AIMS: To adapt and remodel the ISMP MSSA tool for hospitals so that it can be used in individual wards in order to support long-term medication safety initiatives in Finland. METHODS: The MSSA tool was first adapted for Finnish hospital settings by a four-round (applicability, desirability and feasibility were evaluated) Delphi consensus method (14 panellists), and then remodelled by organizing the items into a new order which is consistent with the order of the ward-based pharmacotherapy plan recommended by the Ministry of Social Affairs and Health...
August 2016: International Journal of Pharmacy Practice
2016-02-04 03:47:45
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