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Drug safety

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43 papers 25 to 100 followers
By Oswaldo Vargas Health system pharmacist currently working on Medication Safety as a part of Patient Safety work task force group
Dar-Wei Chen, Valerie J Chase, Mary E Burkhardt, Alma Z Agulto
No abstract text is available yet for this article.
2016: Joint Commission Journal on Quality and Patient Safety
Kerry-Anne Hogan, Julie Lapenskie, Joanne Leclair, Naomi Thick, Mohamed Gazarin, Penny Webster, Brian Devin
Developing and implementing a policy for safe pro re nata medications practices became a priority when 1 nurse questioned a regularly occurring double-range narcotic order. This article describes how double-range medications can compromise patient safety and how a small rural hospital with minimal resources was able to develop an interdisciplinary practice standard to ensure safe medication practices.
June 22, 2016: Journal of Patient Safety
Michael J Akers
Ready-to-use solutions are the most preferable and most common dosage forms for injectable and topical ophthalmic products. Drugs formulated as solution almost always have chemical and physical stability challenges as well as solubility limitations and the need to prevent inadvertent microbial contamination issues. The first in this series of articles took us through a discussion of optimizing the physical stability of solutions. This article concludes this series of articles with a discussion on foreign particles, protein aggregation, and immunogenicity; optimizing microbiological activity; and osmolality (tonicity) agents, and discusses how these challenges and issues are addressed...
March 2016: International Journal of Pharmaceutical Compounding
Lea Botermann, Katharina Monzel, Katrin Krueger, Christiane Eickhoff, Angelika Wachter, Charlotte Kloft, Ulrich Laufs, Martin Schulz
PURPOSE: A standardized medication plan for patients has been developed and recently enacted into German law depicting all medicines taken. It can only increase medication safety if patients use and understand it. We evaluated patients' comprehensibility of the medication plan and analyzed potential variables influencing patients' understanding. METHODS: The medication plan template v2.0 was first tested in N = 40 patients, and the "Evaluation Tool to test the handling of the Medication Plan" (ET-MP) was developed, rating patients' understanding from 0 to 100 %...
October 2016: European Journal of Clinical Pharmacology
Joseph I Boullata, Beverly Holcombe, Gordon Sacks, Jane Gervasio, Stephen C Adams, Michael Christensen, Sharon Durfee, Phil Ayers, Neil Marshall, Peggi Guenter
Parenteral nutrition (PN) is a high-alert medication with a complex drug use process. Key steps in the process include the review of each PN prescription followed by the preparation of the formulation. The preparation step includes compounding the PN or activating a standardized commercially available PN product. The verification and review, as well as preparation of this complex therapy, require competency that may be determined by using a standardized process for pharmacists and for pharmacy technicians involved with PN...
August 2016: Nutrition in Clinical Practice
Samuel Lapkin, Tracy Levett-Jones, Lynn Chenoweth, Maree Johnson
AIM: The aim of this overview was to examine the effectiveness of interventions designed to improve patient safety by reducing medication administration errors using data from systematic reviews. BACKGROUND: Medication administration errors remain unacceptably high despite the introduction of a range of interventions aimed at enhancing patient safety. Systematic reviews of strategies designed to improve medication safety report contradictory findings. A critical appraisal and synthesis of these findings are, therefore, warranted...
May 11, 2016: Journal of Nursing Management
Michael J Akers
Ready-to-use solutions are the most preferable and most common dosage forms for injectable and topical ophthalmic products. Drugs formulated as solution almost always have chemical and physical stability challenges as well as solubility limitations and the need to prevent inadvertent microbial contamination issues. This article, which takes us through a discussion of optimizing the physical stability of solutions, represents the first of a series of articles discussing how these challenges and issues are addressed...
January 2016: International Journal of Pharmaceutical Compounding
Zheng Feng Lu, Stephen Thomas
The past decade has seen a significant growth in diagnostic CT imaging as a direct result of the clinical value provided by CT imaging. At the same time, many new techniques and resources are now available to make CT imaging safe. This article presents the basics of CT dosimetry and their usage in clinical practices, methods to implement CT dose reduction, followed by a summary of legislation, and guidelines related to patient safety in diagnostic CT imaging. Also, CT radiation dose diagnostic reference levels from published regional and national surveys are reviewed and applied in a CT dose tracking and monitoring program...
March 2016: Abdominal Radiology
Ercan Celikkayalar, Minna Myllyntausta, Matthew Grissinger, Marja Airaksinen
BACKGROUND: The US Institute for Safe Medication Practices' (ISMP) Medication Safety Self-Assessment (MSSA) tool for hospitals is a comprehensive tool for assessing safe medication practices in hospitals. AIMS: To adapt and remodel the ISMP MSSA tool for hospitals so that it can be used in individual wards in order to support long-term medication safety initiatives in Finland. METHODS: The MSSA tool was first adapted for Finnish hospital settings by a four-round (applicability, desirability and feasibility were evaluated) Delphi consensus method (14 panellists), and then remodelled by organizing the items into a new order which is consistent with the order of the ward-based pharmacotherapy plan recommended by the Ministry of Social Affairs and Health...
August 2016: International Journal of Pharmacy Practice
E Shirneshan, P Kyrychenko, O S Matlin, J P Avila, T A Brennan, W H Shrank
WHAT IS KNOWN AND OBJECTIVE: There is conclusive evidence demonstrating that formulary restrictions are associated with reduced utilization and pharmacy spending of the restricted drugs. However, prior efforts to implement restrictive formularies have been associated with inconsistent rates of therapy discontinuation and mixed impacts on adherence to therapy. Also, the impact of transferring patients from an already restrictive formulary to a more aggressive model has not been previously examined...
February 2016: Journal of Clinical Pharmacy and Therapeutics
(no author information available yet)
No abstract text is available yet for this article.
March 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
Nirav N Shah, Erica Casella, Donna Capozzi, Suzanne McGettigan, Tara C Gangadhar, Lynn Schuchter, Jennifer S Myers
PURPOSE: Over the last decade, the use of oral chemotherapy (OC) for the treatment of cancer has dramatically increased. Despite their route of administration, OCs pose many of the same risks as intravenous agents. In this quality improvement project, we sought to examine our current process for the prescription of OC at the Abramson Cancer Center of the University of Pennsylvania and to improve on its safety. METHODS: A multidisciplinary team that included oncologists, advanced-practice providers, and pharmacists was formed to analyze the current state of our OC practice...
January 2016: Journal of Oncology Practice
Maurizio Rossini, Giovanni Adami, Silvano Adami, Ombretta Viapiana, Davide Gatti
INTRODUCTION: Osteoporosis is a disease that has spread worldwide and has become a relevant public health problem. Over the last 2 decades, a number of drugs have been licensed for its treatment owing to their efficacy in preventing fragility fractures. The safety profiles of these drugs are well defined with data from extensive programs of pharmacovigilance to support it. AREAS COVERED: In this article we reviewed the long-term safety of Bisphosphonates, Calcium, Vitamin D, Selective Estrogen Receptor Modulators, Teriparatide and Denosumab...
2016: Expert Opinion on Drug Safety
Gloria Uccello-Barretta, Federica Balzano, Federica Aiello, Niccolò Falugiani, Ielizza Desideri
In total parenteral nutrition (TPN), especially in the case of preterm infants, simultaneous administration of vitamins and trace elements is still a problematic issue: guidelines put in evidence the lack of specific documentation. In this work NMR spectroscopy was applied to the study of vitamins (pyridoxine hydrochloride, thiamine nitrate, riboflavin-5'-phosphate and nicotinamide) stability in presence of salts and trace elements. Vitamins in D2O were first analyzed by (1)H NMR spectroscopy in absence of salts and trace elements; changes in chemical shifts or in diffusion coefficients, measured by NMR DOSY technique, were analyzed...
March 25, 2015: Journal of Pharmaceutical and Biomedical Analysis
N Farhan, R Leonhart, L Puffe, M Boeker, M Wirsching
INTRODUCTION: The number of foreign doctors in Germany has increased steadily in recent years. To obtain the German medical license, sufficient language competence is mandatory. Nevertheless, in practice, foreign doctors have considerable difficulties in their communication with patients, medical colleagues and other health professionals. This can lead to misunderstandings and thus impair patient safety. To overcome this problem, the "patient communication test" was developed and piloted as an additional requirement to be granted license to practice medicine in Germany...
April 2016: Das Gesundheitswesen
(no author information available yet)
No abstract text is available yet for this article.
October 1, 2015: American Journal of Health-system Pharmacy: AJHP
Cornelia Jäger, Jost Steinhaeuser, Tobias Freund, Joachim Szecsenyi, Katja Goetz
INTRODUCTION: Medication lists and structured medication counselling (SMC) including "brown bag reviews" (BBR) are important instruments for medication safety. The aim of this study was to explore whether patients' use of a medication list is associated with their beliefs about their medicine and their memory of SMC. METHODS: Baseline data of 344 patients enrolled into the "Polypharmacy in Multimorbid Patients study" were analysed. Linear regression models were calculated for the "specific necessity subscale" (SNS) and the "specific concerns subscale" (SCS) of the German "Beliefs About Medicine Questionnaire," including self-developed variables assessing patients' use of a medication list, their memory of SMC, and sociodemographic data...
2015: BioMed Research International
M T Esqué Ruiz, M G Moretones Suñol, J M Rodríguez Miguélez, E Sánchez Ortiz, M Izco Urroz, M de Lamo Camino, J Figueras Aloy
INTRODUCTION: Neonatal units are one of the hospital areas most exposed to the committing of treatment errors. A medication error (ME) is defined as the avoidable incident secondary to drug misuse that causes or may cause harm to the patient. The aim of this paper is to present the incidence of ME (including feeding) reported in our neonatal unit and its characteristics and possible causal factors. A list of the strategies implemented for prevention is presented. MATERIAL AND METHODS: An analysis was performed on the ME declared in a neonatal unit...
April 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Sami Sneck, Reetta Saarnio, Arja Isola, Risto Boigu
BACKGROUND: Medication administration is an important task of registered nurses. According to previous studies, nurses lack theoretical knowledge and drug calculation skills and knowledge-based mistakes do occur in clinical practice. Finnish health care organizations started to develop a systematic verification processes for medication competence at the end of the last decade. No studies have yet been made of nurses' theoretical knowledge and drug calculation skills according to these online exams...
January 2016: Nurse Education Today
Joe Cabaleiro
No abstract text is available yet for this article.
November 2014: International Journal of Pharmaceutical Compounding
2015-10-12 00:27:15
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