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By Gabe Lediaz Dental hygienist
Songna Yin, Haibo Wu, Chao Song, Xin Chen, Yong Zhang
The underlying mechanism of thymic T cell regulation has been a hot topic of research in recent years. Fluoride is toxic at high concentrations and fluoride toxicity to thymic T cells was assessed in our study. To explore T cell responses to excess fluoride, different concentrations of fluoride were uptake by mice for 6 weeks. The expression of genes, including Foxn1, Cbx4, DLL4, and IL-7 gene, associated with the development and differentiation of T cells in thymic epithelial cells(TECs) was lower in the experimental groups than that in the control group...
March 2016: Biological Trace Element Research
C Albert Yeung
DESIGN: Single-blind, multi-centre, parallel, randomised controlled trial. Intervention Adult patients (18-75 years) with 10 or more natural teeth, and one or more root caries lesion in a tooth not crowned or compromised were included. Patients were randomised to receive a high fluoride toothpaste, 1.1% sodium fluoride (5000 ppm F) or a regular toothpaste (1350 ppm F). Packaging was identical and standard brushes were also provided. Patients were strictly instructed to refrain from using toothpastes or toothbrushes other than the ones provided and restricted from using mouth rinses...
March 2014: Evidence-based Dentistry
Dina Elkassas, Abla Arafa
OBJECTIVES: To assess enamel remineralization of different calcium-phosphate and fluoride delivery systems. METHODS: Artificial caries lesions were created on 115 extracted human molars. Specimens were assigned according to remineralizing agent into five groups: G1: Control (artificial saliva), G2: Clinpro™ white varnish, G3: Relief, G4: Tooth Mousse Plus, G5: Vanish™XT. Surface micro-hardness (SMH), surface roughness (Ra) and surface topography by scanning electron microscope (SEM) were evaluated at baseline, after demineralization, after 2 and 4 weeks remineralization and after acid challenge...
April 2014: Journal of Dentistry
Ngoc Phuong Thanh Chau, Santosh Pandit, Ji-Eun Jung, Jae-Gyu Jeon
OBJECTIVES: The aim of this study was to evaluate Streptococcus mutans adhesion to fluoride varnishes and subsequent change in biofilm accumulation and acidogenicity. METHODS: After producing fluoride varnish-coated hydroxyapatite discs using Fluor Protector (FP), Bifluorid 12 (BIF), Cavity Shield (CASH), or Flor-Opal Varnish White (FO), S. mutans biofilms were formed on the discs. To assess S. mutans adhesion to the discs, 4-h-old biofilms were analysed. To investigate the change in biofilm accumulation during subsequent biofilm formation, the biomass, colony forming units (CFU), and water-insoluble extracellular polysaccharides (EP) of 46-, 70-, and 94-h-old biofilms were analysed...
June 2014: Journal of Dentistry
Michael Levy, Bernard-Simon Leclerc
INTRODUCTION: It has been suggested that fluoride in drinking water may increase the risk of osteosarcoma in children and adolescents, although the evidence is inconclusive. We investigated the association between community water fluoridation (CWF) and osteosarcoma in childhood and adolescence in the continental U.S. METHODS: We used the cumulative osteosarcoma incidence rate data from the CDC Wonder database for 1999-2006, categorized by age group, sex and states...
April 2012: Cancer Epidemiology
Harry Comber, Sandra Deady, Erin Montgomery, Anna Gavin
The incidence of osteosarcoma in Northern Ireland was compared with that in the Republic of Ireland to establish if differences in incidence between the two regions could be related to their different drinking water fluoridation policies. Data from the Northern Ireland Cancer Registry (NICR) and the National Cancer Registry of Ireland (NCRI) on osteosarcoma incidence in the respective populations were used to estimate the age-standardised and age-specific incidence rates in areas with and without drinking water fluoridation...
June 2011: Cancer Causes & Control: CCC
D Chachra, H Limeback, T L Willett, M D Grynpas
Municipal water fluoridation has notably reduced the incidence of dental caries and is widely considered a public health success. However, ingested fluoride is sequestered into bone, as well as teeth, and data on the long-term effect of exposure to these very low doses of fluoride remain inconclusive. Epidemiological studies suggest that effects of fluoride on bone are minimal. We hypothesized that the direct measurement of bone tissue from individuals residing in municipalities with and without fluoridated water would reveal a relationship between fluoride content and structural or mechanical properties of bone...
November 2010: Journal of Dental Research
M C Mahoney, P C Nasca, W S Burnett, J M Melius
BACKGROUND: Recent animal studies of the potential carcinogenicity of fluoride prompted an examination of bone cancer incidence rates. METHODS: Trends in the incidence of primary bone cancers, including the incidence of osteosarcomas were examined among residents of New York State, exclusive of New York City. Average annual osteosarcoma incidence rates in fluoridated and non-fluoridated areas were also compared. RESULTS: Among persons less than 30 years of age at diagnosis, bone cancer incidence among males demonstrated a significant increase since 1955, while incidence among females has remained unchanged...
April 1991: American Journal of Public Health
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