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N Bhala, J Emberson, A Merhi, S Abramson, N Arber, J A Baron, C Bombardier, C Cannon, M E Farkouh, G A FitzGerald, P Goss, H Halls, E Hawk, C Hawkey, C Hennekens, M Hochberg, L E Holland, P M Kearney, L Laine, A Lanas, P Lance, A Laupacis, J Oates, C Patrono, T J Schnitzer, S Solomon, P Tugwell, K Wilson, J Wittes, C Baigent
BACKGROUND: The vascular and gastrointestinal effects of non-steroidal anti-inflammatory drugs (NSAIDs), including selective COX-2 inhibitors (coxibs) and traditional non-steroidal anti-inflammatory drugs (tNSAIDs), are not well characterised, particularly in patients at increased risk of vascular disease. We aimed to provide such information through meta-analyses of randomised trials. METHODS: We undertook meta-analyses of 280 trials of NSAIDs versus placebo (124,513 participants, 68,342 person-years) and 474 trials of one NSAID versus another NSAID (229,296 participants, 165,456 person-years)...
August 31, 2013: Lancet
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