Mitchell J Machiela, Sara Lindström, Naomi E Allen, Christopher A Haiman, Demetrius Albanes, Aurelio Barricarte, Sonja I Berndt, H Bas Bueno-de-Mesquita, Stephen Chanock, J Michael Gaziano, Susan M Gapstur, Edward Giovannucci, Brian E Henderson, Eric J Jacobs, Laurence N Kolonel, Vittorio Krogh, Jing Ma, Meir J Stampfer, Victoria L Stevens, Daniel O Stram, Anne Tjønneland, Ruth Travis, Walter C Willett, David J Hunter, Loic Le Marchand, Peter Kraft
Observational studies have found an inverse association between type 2 diabetes (T2D) and prostate cancer (PCa), and genome-wide association studies have found common variants near 3 loci associated with both diseases. The authors examined whether a genetic background that favors T2D is associated with risk of advanced PCa. Data from the National Cancer Institute's Breast and Prostate Cancer Cohort Consortium, a genome-wide association study of 2,782 advanced PCa cases and 4,458 controls, were used to evaluate whether individual single nucleotide polymorphisms or aggregations of these 36 T2D susceptibility loci are associated with PCa...
December 15, 2012: American Journal of Epidemiology