François-Laurent De Winter, Louise Emsell, Filip Bouckaert, Lene Claes, Saurabh Jain, Gill Farrar, Thibo Billiet, Stephan Evers, Jan Van den Stock, Pascal Sienaert, Jasmien Obbels, Stefan Sunaert, Katarzyna Adamczuk, Rik Vandenberghe, Koen Van Laere, Mathieu Vandenbulcke
OBJECTIVE: Hippocampal volume is commonly decreased in late-life depression. According to the depression-as-late-life-neuropsychiatric-disorder model, lower hippocampal volume in late-life depression is associated with neurodegenerative changes. The purpose of this prospective study was to examine whether lower hippocampal volume in late-life depression is associated with Alzheimer's disease pathology. METHOD: Of 108 subjects who participated, complete, good-quality data sets were available for 100: 48 currently depressed older adults and 52 age- and gender-matched healthy comparison subjects who underwent structural MRI, [18 F]flutemetamol amyloid positron emission tomography imaging, apolipoprotein E genotyping, and neuropsychological assessment...
March 1, 2017: American Journal of Psychiatry