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16 papers 500 to 1000 followers
By Faye Kehler Family Physician and GP Anesthetist since 1987 interested in all aspects of Medicine
François-Laurent De Winter, Louise Emsell, Filip Bouckaert, Lene Claes, Saurabh Jain, Gill Farrar, Thibo Billiet, Stephan Evers, Jan Van den Stock, Pascal Sienaert, Jasmien Obbels, Stefan Sunaert, Katarzyna Adamczuk, Rik Vandenberghe, Koen Van Laere, Mathieu Vandenbulcke
OBJECTIVE: Hippocampal volume is commonly decreased in late-life depression. According to the depression-as-late-life-neuropsychiatric-disorder model, lower hippocampal volume in late-life depression is associated with neurodegenerative changes. The purpose of this prospective study was to examine whether lower hippocampal volume in late-life depression is associated with Alzheimer's disease pathology. METHOD: Of 108 subjects who participated, complete, good-quality data sets were available for 100: 48 currently depressed older adults and 52 age- and gender-matched healthy comparison subjects who underwent structural MRI, [(18)F]flutemetamol amyloid positron emission tomography imaging, apolipoprotein E genotyping, and neuropsychological assessment...
August 19, 2016: American Journal of Psychiatry
Lindsay E Nicolle
Urinary infection is the most common bacterial infection in elderly populations. The high prevalence of asymptomatic bacteriuria in both men and women is benign and should not be treated. A diagnosis of symptomatic infection for elderly residents of long-term care facilities without catheters requires localizing genitourinary findings. Symptomatic urinary infection is overdiagnosed in elderly bacteriuric persons with nonlocalizing clinical presentations, with substantial inappropriate antimicrobial use. Residents with chronic indwelling catheters experience increased morbidity from urinary tract infection...
August 2016: Clinics in Geriatric Medicine
Young-Min Lee, Je-Min Park, Byung-Dae Lee, Eunsoo Moon, Hee-Jeong Jeong, Young-In Chung, Ji-Hoon Kim, Hak-Jin Kim, Chi-Woong Mun, Tae-Hyung Kim, Young-Hoon Kim
OBJECTIVE: The purpose of this study was to determine whether gray matter volumes are associated with treatment response of psychotic symptoms in Alzheimer's disease (AD) patients. METHOD: Risperidone, which is commonly used as an atypical antipsychotic drug, was administered in a clinical setting for 6 weeks from April 2012 to February 2013 to 25 antipsychotic-naïve AD patients with psychosis, diagnosed according to Jeste and Finkel's proposed diagnostic criteria for psychosis of Alzheimer's disease...
January 2016: Journal of Clinical Psychiatry
Nicolai Tegn, Michael Abdelnoor, Lars Aaberge, Knut Endresen, Pål Smith, Svend Aakhus, Erik Gjertsen, Ola Dahl-Hofseth, Anette Hylen Ranhoff, Lars Gullestad, Bjørn Bendz
BACKGROUND: Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina pectoris are frequent causes of hospital admission in the elderly. However, clinical trials targeting this population are scarce, and these patients are less likely to receive treatment according to guidelines. We aimed to investigate whether this population would benefit from an early invasive strategy versus a conservative strategy. METHODS: In this open-label randomised controlled multicentre trial, patients aged 80 years or older with NSTEMI or unstable angina admitted to 16 hospitals in the South-East Health Region of Norway were randomly assigned to an invasive strategy (including early coronary angiography with immediate assessment for percutaneous coronary intervention, coronary artery bypass graft, and optimum medical treatment) or to a conservative strategy (optimum medical treatment alone)...
March 12, 2016: Lancet
Bridget M Kuehn
No abstract text is available yet for this article.
December 15, 2015: JAMA: the Journal of the American Medical Association
Scott C Forbes, Jayna M Holroyd-Leduc, Marc J Poulin, David B Hogan
BACKGROUND: Observational studies have suggested that various nutrients, dietary supplements, and vitamins may delay the onset of age-associated cognitive decline and dementia. We systematically reviewed recent randomized controlled trials investigating the effect of nutritional interventions on cognitive performance in older non-demented adults. METHODS: We searched MEDLINE, CINAHL, Embase, and the Cochrane Library for articles published between 2003 and 2013. We included randomized trials of ≥ 3 months' duration that examined the cognitive effects of a nutritional intervention in non-demented adults > 40 years of age...
December 2015: Canadian Geriatrics Journal: CGJ
Melissa M Garrido, Holly G Prigerson, Joan D Penrod, Shatice C Jones, Kenneth S Boockvar
PURPOSE: The 2014 American Geriatrics Society's Choosing Wisely list cautions against the use of any benzodiazepines or other sedative-hypnotics (BSHs) as initial treatments for agitation, insomnia, or delirium in older adults. Because these symptoms are prevalent among hospitalized patients, seriously ill older adults are at risk of receiving these potentially inappropriate medications. The objectives of this study were to understand the extent to which potentially inappropriate BSHs are being used in hospitalized, seriously ill, older veterans and to understand what clinical and sociodemographic characteristics are associated with potentially inappropriate BSH use...
November 1, 2014: Clinical Therapeutics
Einstein F Camargos, Luciana L Louzada, Juliana L Quintas, Janeth O S Naves, Fernando M Louzada, Otávio T Nóbrega
OBJECTIVES: There are no randomized clinical trials regarding efficacy of trazodone in the treatment of sleep disturbances (SD) in patients with Alzheimer disease (AD). We tested the efficacy and safety of trazodone to treat SD in patients with AD. DESIGN: We conducted a double-blind, randomized and controlled trial during periods of 7-9 days at baseline and 2 weeks of treatment. SETTING: Geriatric medical center of the university's general hospital...
December 2014: American Journal of Geriatric Psychiatry
Yong Hyun Jang, Jin Sub Lee, Sang Lim Kim, Seong Geun Chi, Weon Ju Lee, Seok-Jong Lee, Shin-Woo Kim, Ki Bum Park, Won Kee Lee, Young Hoon Jeon, Do Won Kim
No abstract text is available yet for this article.
December 2015: Annals of Dermatology
(no author information available yet)
The 2015 American Geriatrics Society (AGS) Beers Criteria are presented. Like the 2012 AGS Beers Criteria, they include lists of potentially inappropriate medications to be avoided in older adults. New to the criteria are lists of select drugs that should be avoided or have their dose adjusted based on the individual's kidney function and select drug-drug interactions documented to be associated with harms in older adults. The specific aim was to have a 13-member interdisciplinary panel of experts in geriatric care and pharmacotherapy update the 2012 AGS Beers Criteria using a modified Delphi method to systematically review and grade the evidence and reach a consensus on each existing and new criterion...
November 2015: Journal of the American Geriatrics Society
Emanuele Cereda, Catherine Klersy, Marcella Serioli, Aldo Crespi, Federico D'Andrea
BACKGROUND: Trials on specific nutritional supplements for the treatment of pressure ulcers (PUs) have been small, inconsistent in their formulations, or unsuccessful in controlling for total supplement calorie or protein content. OBJECTIVE: To evaluate whether supplementation with arginine, zinc, and antioxidants within a high-calorie, high-protein formula improves PU healing. DESIGN: Multicenter, randomized, controlled, blinded trial. (ClinicalTrials...
February 3, 2015: Annals of Internal Medicine
Isla Rippon, Andrew Steptoe
No abstract text is available yet for this article.
February 2015: JAMA Internal Medicine
Marie Boltz, Barbara Resnick, Tracy Chippendale, James Galvin
A comparative trial using a repeated-measures design was designed to evaluate the feasibility and outcomes of the Family-Centered Function-Focused-Care (Fam-FFC) intervention, which is intended to promote functional recovery in hospitalized older adults. A family-centered resource nurse and a facility champion implemented a three-component intervention (environmental assessment and modification, staff education, individual and family education and partnership in care planning with follow-up after hospitalization for an acute illness)...
December 2014: Journal of the American Geriatrics Society
Graham Ellis, Martin A Whitehead, Desmond O'Neill, Peter Langhorne, David Robinson
BACKGROUND: Comprehensive geriatric assessment (CGA) is a multidimensional, interdisciplinary diagnostic process to determine the medical, psychological and functional capabilities of a frail elderly person in order to develop a co-ordinated and integrated plan for treatment and long-term follow up. OBJECTIVES: We sought to evaluate the effectiveness of CGA in hospital for older adults admitted as an emergency. SEARCH STRATEGY: We searched the Cochrane Effective Practice and Organisation of Care (EPOC) Group Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library), the Database of Abstracts of Reviews of Effects (DARE), MEDLINE, EMBASE, CINAHL and AARP Ageline, and handsearched high-yield journals...
2011: Cochrane Database of Systematic Reviews
Denis O'Mahony, David O'Sullivan, Stephen Byrne, Marie Noelle O'Connor, Cristin Ryan, Paul Gallagher
PURPOSE: Screening tool of older people's prescriptions (STOPP) and screening tool to alert to right treatment (START) criteria were first published in 2008. Due to an expanding therapeutics evidence base, updating of the criteria was required. METHODS: We reviewed the 2008 STOPP/START criteria to add new evidence-based criteria and remove any obsolete criteria. A thorough literature review was performed to reassess the evidence base of the 2008 criteria and the proposed new criteria...
March 2015: Age and Ageing
Una E Makris, Robert C Abrams, Barry Gurland, M Carrington Reid
IMPORTANCE: Persistent pain is highly prevalent, costly, and frequently disabling in later life. OBJECTIVE: To describe barriers to the management of persistent pain among older adults, summarize current management approaches, including pharmacologic and nonpharmacologic modalities; present rehabilitative approaches; and highlight aspects of the patient-physician relationship that can help to improve treatment outcomes. This review is relevant for physicians who seek an age-appropriate approach to delivering pain care for the older adult...
August 27, 2014: JAMA: the Journal of the American Medical Association
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