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GMG Interventional

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398 papers 25 to 100 followers Papers related to PCI therapy for CAD
By Gregory Gustafson Interventional Cardiologist
https://www.readbyqxmd.com/read/27797298/treatment-of-left-main-coronary-artery-disease
#1
Eugene Braunwald
No abstract text is available yet for this article.
October 31, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27609250/survival-after-varying-revascularization-strategies-in-patients-with-st-segment-elevation-myocardial-infarction-and-multivessel-coronary-artery-disease-a-pairwise-and-network-meta-analysis
#2
Giuseppe Tarantini, Gianpiero D'Amico, Sorin J Brener, Paola Tellaroli, Marco Basile, Alessandro Schiavo, Marco Mojoli, Chiara Fraccaro, Alfredo Marchese, Giuseppe Musumeci, Gregg W Stone
OBJECTIVES: The authors conducted a systematic pairwise and network meta-analysis to assess optimal treatment strategies in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease (MV-CAD) undergoing primary percutaneous coronary intervention (PCI). BACKGROUND: Patients with STEMI and MV-CAD have a worse prognosis than those with single-vessel CAD. The optimal revascularization strategy for these patients is uncertain...
September 12, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27840336/ticagrelor-compared-with-clopidogrel-in-patients-with-prior-lower-extremity-revascularization-for-peripheral-artery-disease
#3
W Schuyler Jones, Iris Baumgartner, William R Hiatt, Gretchen Heizer, Michael S Conte, Christopher J White, Jeffrey S Berger, Peter Held, Brian G Katona, Kenneth W Mahaffey, Lars Norgren, Juuso Blomster, Marcus Millegård, Craig Reist, Manesh R Patel, Gerry R Fowkes
BACKGROUND: -In patients with symptomatic peripheral artery disease (PAD) with a history of limb revascularization, the optimal antithrombotic regimen for long-term management is unknown. METHODS: -The Examining Use of tiCagreLor In paD (EUCLID) trial randomized 13,885 patients with PAD to treatment with ticagrelor 90mg twice daily or clopidogrel 75mg daily. Patients were enrolled based on an abnormal ankle-brachial index (ABI) ≤0.80 or a prior lower extremity revascularization...
November 13, 2016: Circulation
https://www.readbyqxmd.com/read/27821423/where-is-the-culprit-lesion
#4
Antoni Bayés de Luna, Miguel Fiol-Sala
No abstract text is available yet for this article.
November 8, 2016: Circulation
https://www.readbyqxmd.com/read/27771985/five-year-outcomes-after-off-pump-or-on-pump-coronary-artery-bypass-grafting
#5
André Lamy, P J Devereaux, Dorairaj Prabhakaran, David P Taggart, Shengshou Hu, Zbynek Straka, Leopoldo S Piegas, Alvaro Avezum, Ahmet R Akar, Fernando Lanas Zanetti, Anil R Jain, Nicolas Noiseux, Chandrasekar Padmanabhan, Juan-Carlos Bahamondes, Richard J Novick, Liang Tao, Pablo A Olavegogeascoechea, Balram Airan, Toomas-Andres Sulling, Richard P Whitlock, Yongning Ou, Peggy Gao, Shirley Pettit, Salim Yusuf
Background We previously reported that there was no significant difference at 30 days or at 1 year in the rate of the composite outcome of death, stroke, myocardial infarction, or renal failure between patients who underwent coronary-artery bypass grafting (CABG) performed with a beating-heart technique (off-pump) and those who underwent CABG performed with cardiopulmonary bypass (on-pump). We now report the results at 5 years (the end of the trial). Methods A total of 4752 patients (from 19 countries) who had coronary artery disease were randomly assigned to undergo off-pump or on-pump CABG...
October 23, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27663770/association-of-cyp2c19-variants-and-epoxyeicosatrienoic-acids-on-patients-with-microvascular-angina
#6
Tomonori Akasaka, Daisuke Sueta, Yuichiro Arima, Noriaki Tabata, Seiji Takashio, Yasuhiro Izumiya, Eiichiro Yamamoto, Megumi Yamamuro, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Ayami Kajiwara, Kazunori Morita, Kentaro Oniki, Junji Saruwatari, Kazuko Nakagawa, Yasuhiro Ogata, Kunihiko Matsui, Seiji Hokimoto
Categorization as a cytochrome P450 (CYP) 2C19 poor metabolizer (PM) is reported to be an independent risk factor for cardiovascular disease. Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by CYP2C19 epoxygenases and anti-inflammatory properties, especially in microvascular tissues. We examined the association of CYP2C19 polymorphisms and EETs on microvascular angina (MVA) caused by coronary microvascular dysfunction. We examined CYP2C19 genotypes in patients with MVA (n = 71) and healthy subjects as control (n = 71)...
December 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27694191/plasma-concentration-of-serotonin-is-a-novel-biomarker-for-coronary-microvascular-dysfunction-in-patients-with-suspected-angina-and-unobstructive-coronary-arteries
#7
Yuji Odaka, Jun Takahashi, Ryuji Tsuburaya, Kensuke Nishimiya, Kiyotaka Hao, Yasuharu Matsumoto, Kenta Ito, Yasuhiko Sakata, Satoshi Miyata, Daisuke Manita, Yuji Hirowatari, Hiroaki Shimokawa
AIMS: Although the importance of coronary microvascular dysfunction (CMD) has been emerging, reliable biomarkers for CMD remain to be developed. We examined the potential usefulness of plasma concentration of serotonin to diagnose CMD in patients with suspected angina and unobstructive coronary arteries. METHODS AND RESULTS: We enrolled 198 consecutive patients (M/F 116/82, 60.2 ± 13.3 years old) who underwent acetylcholine provocation test and measured plasma serotonin concentration...
October 2, 2016: European Heart Journal
https://www.readbyqxmd.com/read/26981290/tender-endothelium-syndrome-combination-of-hypotension-bradycardia-contrast-induced-chest-pain-and-microvascular-angina
#8
Shivesh Goberdhan, Soon Kwang Chiew, Jaffer Syed
Hypotension, bradycardia, and contrast induced chest pain are potential complications of cardiac catheterization and coronary angiography. Catheter-induced coronary spasm has been occasionally demonstrated, but its relationship to spontaneous coronary spasm is unclear. We describe a 64-year-old female who underwent coronary artery bypass surgery in 1998 on the basis of an angiographic diagnosis of severe left main disease, who recently presented with increasingly frequent typical angina. Repeat coronary angiography was immediately complicated by severe chest pain, hypotension, and bradycardia but demonstrated only mild disease of the left main artery and entire coronary tree with complete occlusion of her prior grafts...
2016: Case Reports in Cardiology
https://www.readbyqxmd.com/read/27057970/a-bridge-to-coronary-spasm-myocardial-bridging
#9
Hamza Duygu
No abstract text is available yet for this article.
July 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27660381/repetitive-vasospasm-as-a-cause-of-plaque-rupture-and-myocardial-infarction
#10
Nicola Ryan, Nieves Gonzalo, Afonso Freitas-Ferraz, Pedro Martinez, Javier Escaned
No abstract text is available yet for this article.
September 22, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27570160/optimal-timing-from-myocardial-infarction-to-coronary-artery-bypass-grafting-on-hospital-mortality
#11
Elizabeth L Nichols, Jock N McCullough, Cathy S Ross, Robert S Kramer, Benjamin M Westbrook, John D Klemperer, Bruce J Leavitt, Jeremiah R Brown, Elaine Olmstead, Felix Hernandez, Gerald L Sardella, Carmine Frumiento, David Malenka, Anthony DiScipio
BACKGROUND: Whether delaying coronary artery bypass grafting (CABG) after myocardial infarction (MI) is associated with better outcomes or is an unnecessary use of health care resources is unclear. This study investigated the relationship between MI-to-CABG timing on in-hospital death. METHODS: From the Northern New England Cardiovascular Disease Study Group (NNE) Cardiac Surgery Registry we identified 3,060 isolated CABG patients with prior MI from 2008 to 2014...
August 25, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27634829/transfemoral-tavi-is-superior-to-savr-in-elderly-high-risk-patients-with-symptomatic-severe-aortic-stenosis
#12
Neil Moat, Stephen Brecker
No abstract text is available yet for this article.
September 15, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27576777/prasugrel-versus-ticagrelor-in-patients-with-acute-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention-multicenter-randomized-prague-18-study
#13
Zuzana Motovska, Ota Hlinomaz, Roman Miklik, Milan Hromadka, Ivo Varvarovsky, Jaroslav Dusek, Jiri Knot, Jiri Jarkovsky, Petr Kala, Richard Rokyta, Frantisek Tousek, Petra Kramarikova, Bohumil Majtan, Stanislav Simek, Marian Branny, Jan Mrozek, Pavel Cervinka, Jiri Ostransky, Petr Widimsky
BACKGROUND: No randomized "head-to-head" comparison of the efficacy and safety of ticagrelor vs. prasugrel has been published in the seven years since the higher efficacy of these newer P2Y12 inhibitors were first demonstrated relative to clopidogrel. METHODS: This academic study was designed to compare the efficacy and safety of prasugrel and ticagrelor in acute myocardial infarction (AMI) treated with primary or immediate percutaneous coronary intervention (PCI)...
August 30, 2016: Circulation
https://www.readbyqxmd.com/read/27543480/no-reflow-phenomenon-in-percutaneous-coronary-interventions-in-st-segment-elevation-myocardial-infarction
#14
REVIEW
Sanjiv Gupta, Madan Mohan Gupta
Percutaneous coronary intervention (PCI) is effective in opening the infarct related artery and restoring thrombolysis in myocardial infarction flow 3 (TIMI-flow 3) in large majority of ST-elevation myocardial infarction (STEMI). However there remain a small but significant proportion of patients, who continue to manifest diminished myocardial reperfusion despite successful opening of the obstructed epicardial artery. This phenomenon is called no-reflow. Clinically it manifests with recurrence of chest pain and dyspnea and may progress to cardiogenic shock, cardiac arrest, serious arrhythmias and acute heart failure...
July 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27516946/characteristics-of-coronary-arterial-lesions-in-patients-with-coronary-heart-disease-and-hypertension
#15
Jing-Xia Zhang, Hong-Zhi Dong, Bing-Wei Chen, Hong-Liang Cong, Jing Xu
OBJECTIVE: The aim of this study was to investigate the correlations between risk factors such as hypertension and the complex degrees of coronary arterial lesions (CAL). METHODS: We selected 462 patients with coronary heart disease (CHD) with confirmed the stenosis (≥50 %) in at least one major coronary artery on coronary angiography and divided them into the "CHD with hypertension" group (CHD-HT, n = 306) and the CHD group (n = 156). The characteristics of CAL and the occurrence of 2-year postoperative major adverse cardiac cerebrovascular events (MACCE) in the two groups were observed...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27358682/coronary-artery-anomalies-overview-the-normal-and-the-abnormal
#16
REVIEW
Adriana Dm Villa, Eva Sammut, Arjun Nair, Ronak Rajani, Rodolfo Bonamini, Amedeo Chiribiri
The aim of this review is to give a comprehensive and concise overview of coronary embryology and normal coronary anatomy, describe common variants of normal and summarize typical patterns of anomalous coronary artery anatomy. Extensive iconography supports the text, with particular attention to images obtained in vivo using non-invasive imaging. We have divided this article into three groups, according to their frequency in the general population: Normal, normal variant and anomaly. Although congenital coronary artery anomalies are relatively uncommon, they are the second most common cause of sudden cardiac death among young athletes and therefore warrant detailed review...
June 28, 2016: World Journal of Radiology
https://www.readbyqxmd.com/read/27040723/coronary-artery-bypass-surgery-in-patients-with-ischemic-cardiomyopathy
#17
RANDOMIZED CONTROLLED TRIAL
Eric J Velazquez, Kerry L Lee, Robert H Jones, Hussein R Al-Khalidi, James A Hill, Julio A Panza, Robert E Michler, Robert O Bonow, Torsten Doenst, Mark C Petrie, Jae K Oh, Lilin She, Vanessa L Moore, Patrice Desvigne-Nickens, George Sopko, Jean L Rouleau
BACKGROUND: The survival benefit of a strategy of coronary-artery bypass grafting (CABG) added to guideline-directed medical therapy, as compared with medical therapy alone, in patients with coronary artery disease, heart failure, and severe left ventricular systolic dysfunction remains unclear. METHODS: From July 2002 to May 2007, a total of 1212 patients with an ejection fraction of 35% or less and coronary artery disease amenable to CABG were randomly assigned to undergo CABG plus medical therapy (CABG group, 610 patients) or medical therapy alone (medical-therapy group, 602 patients)...
April 21, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27502078/acute-myocardial-infarction
#18
Grant W Reed, Jeffrey E Rossi, Christopher P Cannon
Acute myocardial infarction has traditionally been divided into ST elevation or non-ST elevation myocardial infarction; however, therapies are similar between the two, and the overall management of acute myocardial infarction can be reviewed for simplicity. Acute myocardial infarction remains a leading cause of morbidity and mortality worldwide, despite substantial improvements in prognosis over the past decade. The progress is a result of several major trends, including improvements in risk stratification, more widespread use of an invasive strategy, implementation of care delivery systems prioritising immediate revascularisation through percutaneous coronary intervention (or fibrinolysis), advances in antiplatelet agents and anticoagulants, and greater use of secondary prevention strategies such as statins...
August 5, 2016: Lancet
https://www.readbyqxmd.com/read/27487772/iabp-history-evolution-pathophysiology-indications-what-we-need-to-know
#19
REVIEW
H Parissis, V Graham, S Lampridis, M Lau, G Hooks, P C Mhandu
Treatment with the intraaortic balloon pump (IABP) is the most common form of mechanical support for the failing heart. Augmentation of diastolic pressure during balloon inflation contributes to the coronary circulation and the presystolic deflation of the balloon reduces the resistance to systolic output. Consequently, the myocardial work is reduced. The overall effect of the IABP therapy is an increase in the myocardial oxygen supply/demand ratio and thus in endocardial viability.This is an overall synopsis of what we need to know regarding IABP...
August 4, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27482008/consistent-reduction-in-periprocedural-myocardial-infarction-with-cangrelor-as-assessed-by-multiple-definitions-findings-from-champion-phoenix-cangrelor-versus-standard-therapy-to-achieve-optimal-management-of-platelet-inhibition
#20
Matthew A Cavender, Deepak L Bhatt, Gregg W Stone, Harvey D White, Ph Gabriel Steg, C Michael Gibson, Christian W Hamm, Matthew J Price, Sergio Leonardi, Jayne Prats, Efthymios N Deliargyris, Kenneth W Mahaffey, Robert A Harrington
BACKGROUND: Cangrelor is an intravenous P2Y12 inhibitor approved to reduce periprocedural ischemic events in patients undergoing percutaneous coronary intervention not pretreated with a P2Y12 inhibitor. METHODS: A total of 11 145 patients were randomized to cangrelor or clopidogrel in the CHAMPION PHOENIX trial (Cangrelor versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition). We explored the effects of cangrelor on myocardial infarction (MI) using different definitions and performed sensitivity analyses on the primary end point of the trial...
September 6, 2016: Circulation
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